The Effects of Nocturnal Hypoxemia on Cognitive Performance in Andean Highlanders.

IF 1.6 4区 医学 Q4 BIOPHYSICS
Elizabeth V Young, Matea A Djokic, Erica C Heinrich, Traci Marin, Cecilia Anza-Ramirez, Jeremy E Orr, Dillon Gilbertson, Pamela N DeYoung, Gustavo Vizcardo-Galindo, Rómulo Figueroa-Mujica, Francisco C Villafuerte, Atul Malhotra, Tatum S Simonson
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Abstract

Background: Many Andean highlanders exposed to chronic hypoxemia are susceptible to excessive erythrocytosis (EE) and chronic mountain sickness (CMS). Nocturnal hypoxemia is more marked than diurnal hypoxemia and includes sustained and intermittent components. The potential for cognitive impairments related to nocturnal hypoxemia in this population has not been extensively studied, but improved understanding may provide opportunities for the prevention of long-term effects of EE and CMS. Methods: To examine this relationship, 48 participants residing permanently at 4,340 m completed an overnight sleep study and a battery of cognitive function tests that examined a broad range of cognitive domains. Results: Greater nocturnal hypoxemia was associated with longer reaction times on Balloon Analogue Risk Task (BART) (p < 0.01) and Emotion Recognition Test (ERT) (p < 0.01). Longer completion times of Trail Making Task were also associated with increased nocturnal hypoxemia (p = 0.03). Increased hematocrit was similarly associated with longer reaction times on the ERT (p = 0.01) and the BART (p = 0.01). Conclusion: Overall, our results showed that increased nocturnal hypoxemia and higher hematocrit were associated with impairments in cognitive performance in individuals residing permanently at high altitude.

安第斯高地人夜间低氧血症对认知能力的影响。
背景:许多暴露于慢性低氧血症的安第斯高地人易患过度红细胞增多症(EE)和慢性高原病(CMS)。夜间低氧血症比白天低氧血症更明显,包括持续和间歇性成分。在这一人群中,与夜间低氧血症相关的认知障碍的可能性尚未得到广泛研究,但更好的理解可能为预防EE和CMS的长期影响提供机会。方法:为了研究这种关系,48名长期居住在4340米的参与者完成了一项夜间睡眠研究和一系列认知功能测试,这些测试检查了广泛的认知领域。结果:较大的夜间低氧血症与气球模拟风险任务(BART) (p < 0.01)和情绪识别测试(ERT) (p < 0.01)的反应时间延长相关。较长的“造径任务”完成时间也与夜间低氧血症增加有关(p = 0.03)。红细胞压积的增加与ERT (p = 0.01)和BART (p = 0.01)的反应时间延长相似。结论:总的来说,我们的研究结果表明,长期居住在高海拔地区的人,夜间低氧血症增加和红细胞压积升高与认知能力受损有关。
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来源期刊
High altitude medicine & biology
High altitude medicine & biology 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.80
自引率
9.50%
发文量
44
审稿时长
>12 weeks
期刊介绍: High Altitude Medicine & Biology is the only peer-reviewed journal covering the medical and biological issues that impact human life at high altitudes. The Journal delivers critical findings on the impact of high altitude on lung and heart disease, appetite and weight loss, pulmonary and cerebral edema, hypertension, dehydration, infertility, and other diseases. It covers the full spectrum of high altitude life sciences from pathology to human and animal ecology.
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