Elizabeth V Young, Matea A Djokic, Erica C Heinrich, Traci Marin, Cecilia Anza-Ramirez, Jeremy E Orr, Dillon Gilbertson, Pamela N DeYoung, Gustavo Vizcardo-Galindo, Rómulo Figueroa-Mujica, Francisco C Villafuerte, Atul Malhotra, Tatum S Simonson
{"title":"The Effects of Nocturnal Hypoxemia on Cognitive Performance in Andean Highlanders.","authors":"Elizabeth V Young, Matea A Djokic, Erica C Heinrich, Traci Marin, Cecilia Anza-Ramirez, Jeremy E Orr, Dillon Gilbertson, Pamela N DeYoung, Gustavo Vizcardo-Galindo, Rómulo Figueroa-Mujica, Francisco C Villafuerte, Atul Malhotra, Tatum S Simonson","doi":"10.1089/ham.2024.0077","DOIUrl":null,"url":null,"abstract":"<p><p><b><i>Background:</i></b> Many Andean highlanders exposed to chronic hypoxemia are susceptible to excessive erythrocytosis (EE) and chronic mountain sickness (CMS). Nocturnal hypoxemia is more marked than diurnal hypoxemia and includes sustained and intermittent components. The potential for cognitive impairments related to nocturnal hypoxemia in this population has not been extensively studied, but improved understanding may provide opportunities for the prevention of long-term effects of EE and CMS. <b><i>Methods:</i></b> To examine this relationship, 48 participants residing permanently at 4,340 m completed an overnight sleep study and a battery of cognitive function tests that examined a broad range of cognitive domains. <b><i>Results:</i></b> Greater nocturnal hypoxemia was associated with longer reaction times on Balloon Analogue Risk Task (BART) (<i>p</i> < 0.01) and Emotion Recognition Test (ERT) (<i>p</i> < 0.01). Longer completion times of Trail Making Task were also associated with increased nocturnal hypoxemia (<i>p</i> = 0.03). Increased hematocrit was similarly associated with longer reaction times on the ERT (<i>p</i> = 0.01) and the BART (<i>p</i> = 0.01). <b><i>Conclusion:</i></b> Overall, our results showed that increased nocturnal hypoxemia and higher hematocrit were associated with impairments in cognitive performance in individuals residing permanently at high altitude.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"High altitude medicine & biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1089/ham.2024.0077","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOPHYSICS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Many Andean highlanders exposed to chronic hypoxemia are susceptible to excessive erythrocytosis (EE) and chronic mountain sickness (CMS). Nocturnal hypoxemia is more marked than diurnal hypoxemia and includes sustained and intermittent components. The potential for cognitive impairments related to nocturnal hypoxemia in this population has not been extensively studied, but improved understanding may provide opportunities for the prevention of long-term effects of EE and CMS. Methods: To examine this relationship, 48 participants residing permanently at 4,340 m completed an overnight sleep study and a battery of cognitive function tests that examined a broad range of cognitive domains. Results: Greater nocturnal hypoxemia was associated with longer reaction times on Balloon Analogue Risk Task (BART) (p < 0.01) and Emotion Recognition Test (ERT) (p < 0.01). Longer completion times of Trail Making Task were also associated with increased nocturnal hypoxemia (p = 0.03). Increased hematocrit was similarly associated with longer reaction times on the ERT (p = 0.01) and the BART (p = 0.01). Conclusion: Overall, our results showed that increased nocturnal hypoxemia and higher hematocrit were associated with impairments in cognitive performance in individuals residing permanently at high altitude.
期刊介绍:
High Altitude Medicine & Biology is the only peer-reviewed journal covering the medical and biological issues that impact human life at high altitudes. The Journal delivers critical findings on the impact of high altitude on lung and heart disease, appetite and weight loss, pulmonary and cerebral edema, hypertension, dehydration, infertility, and other diseases. It covers the full spectrum of high altitude life sciences from pathology to human and animal ecology.