High altitude medicine & biology最新文献

{"title":"Efficacy and Safety of Extended-Release Acetazolamide Capsules for the Prevention of Acute Mountain Sickness: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial.","authors":"Zhuoga Danzeng, Rui Zhang, Luobu Gesang, Jin Wang, Bai Ci, Zejuan Wang, Zhuoma Ciren, Quzhen Gesang, Yangzong Suona, Xiaona Liu, Quzong Zhaxi, Cuomu Baima, Binyun Liu, Zhuoga Baima, Wei Cong, Qiangba Dingzeng","doi":"10.1177/15578682251375409","DOIUrl":"10.1177/15578682251375409","url":null,"abstract":"<p><p>Danzeng, Zhuoga, Rui Zhang, Luobu Gesang, Jin Wang, Bai Ci, Zejuan Wang, Zhuoma Ciren, Quzhen Gesang, Yangzong Suona, Xiaona Liu, Quzong Zhaxi, Cuomu Baima, Binyun Liu, Zhuoga Baima, Wei Cong, and Qiangba Dingzeng. Efficacy and safety of extended-release acetazolamide capsules for the prevention of acute mountain sickness: a randomized, double-blind, placebo-controlled phase III trial. <i>High Alt Med Biol.</i> 27:1-7, 2026.</p><p><strong>Background: </strong>Acute mountain sickness (AMS) frequently affects individuals ascending rapidly to high altitudes. Data on acetazolamide prophylaxis in Asian populations remain limited. To evaluate the efficacy and safety of acetazolamide for the prevention of AMS in the Han Chinese population.</p><p><strong>Methods: </strong>In this multicenter, randomized, double-blind, placebo-controlled phase III trial, 288 healthy Chinese Han adults traveled from Peking (43.5 m) to Lhasa (3,670 m). Participants received either extended-release acetazolamide (500 mg once daily) or placebo, starting 2 days before ascent and continuing for 4 days postarrival. The primary endpoint was AMS incidence (Lake Louise Score [LLS] ≥3 with headache).</p><p><strong>Results: </strong>Among 284 completers, AMS incidence was significantly lower with acetazolamide (36.9% vs. 55.9%, <i>p</i> = 0.0013). Moderate/severe AMS (LLS > 5) was also reduced (9.9% vs. 24.5%, <i>p</i> = 0.0012). SpO₂ levels were consistently higher in the treatment group (<i>p</i> < 0.0001). Adverse events, including paresthesia and polyuria, were mild and self-limiting.</p><p><strong>Conclusion: </strong>Once-daily extended-release acetazolamide (500 mg) effectively prevents AMS and is well-tolerated in healthy Asian individuals. This regimen may enhance adherence and serve as a practical prophylactic option for high-altitude travelers.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Mendelian Randomization to Dissect the Relationship Between High-Altitude Adaptation and Liver Diseases/Traits.","authors":"Tianzhun Wu, Ruofan Li, Qingfeng Song, Li Xu, Chaofan Shi, Juanjuan Liu, Xing Gao, Shilin Huang, Shizhou Li, Dandan Zeng, Wenfeng Luo, Yan Lin, Jiazhou Ye, Minggen Hu, Rong Liang","doi":"10.1177/15578682251385415","DOIUrl":"10.1177/15578682251385415","url":null,"abstract":"<p><p>Wu, Tianzhun, Ruofan Li, Qingfeng Song, Li Xu, Chaofan Shi, Juanjuan Liu, Xing Gao, Shilin Huang, Shizhou Li, Dandan Zeng, Wenfeng Luo, Yan Lin, Jiazhou Ye, Minggen Hu, and Rong Liang. Using Mendelian randomization to dissect the relationship between high-altitude adaptation and liver diseases/traits. <i>High Alt Med Biol.</i> 27:42-48, 2026.</p><p><strong>Background: </strong>It has been reported that high-altitude adaptation (HAA) and susceptibility to multiple liver diseases/traits differ between individuals at higher altitudes compared to those at lower altitudes. To investigate this association, we conducted a Mendelian randomization study.</p><p><strong>Methods: </strong>To investigate the association between HAA and liver diseases/traits, we utilized genome-wide association studies focusing on East Asian ancestry. Our study included six liver disease-related phenotypes: autoimmune hepatitis, chronic hepatitis B, chronic hepatitis C, acute hepatitis by hepatitis A virus, hepatic cancer, and hepatic bile duct cancer, as well as five liver traits: alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transpeptidase (GGT), and total bilirubin. A Bonferroni-corrected significance was set at <i>p</i> < 4.55 × 10^-3.</p><p><strong>Results: </strong>Our study identified a significant genetically predicted causal impact of HAA on GGT (odds ratio [OR] = 1.601; 95% confidence interval [CI] = 1.204-2.129; <i>p</i> = 0.0012). Interestingly, the association remained statistically significant even when the causal direction was reversed, with GGT predicting HAA (OR = 1.01; 95% CI = 1.003-1.011; <i>p</i> = 0.0013). Both findings surpassed the Bonferroni-corrected threshold.</p><p><strong>Conclusion: </strong>In conclusion, our study provides suggestive evidence for a potentially causal bidirectional association between HAA and GGT. These novel insights may inform the development of targeted preventive measures and therapeutic interventions for liver diseases and high-altitude adaptation.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"42-48"},"PeriodicalIF":1.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145329119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Decreased Pulse Oximetry and Acute Mountain Sickness Upon Rapid Ascent to 4,086 m Among Young Chinese Men.","authors":"Xu-Gang Tang, Xiu-Chuan Li, Bao-Mei Song, Shuang Li, Qiang Wang, Yong-Jian Yang","doi":"10.1177/15578682251398399","DOIUrl":"10.1177/15578682251398399","url":null,"abstract":"<p><p>Tang, Xu-gang, Xiu-chuan Li, Bao-mei Song, Shuang Li, Qiang Wang, and Yong-jian Yang. Association between decreased pulse oximetry and acute mountain sickness upon rapid ascent to 4,086 m among young Chinese men. <i>High Alt Med Biol.</i> 27:49-46, 2026.</p><p><strong>Background: </strong>Research on predicting acute mountain sickness (AMS) based on the decreased pulse oximeter saturation (SpO₂) during rapid train travel to high altitudes is limited and inconsistent. We aimed to assess whether lower SpO₂ levels are associated with AMS in a young Chinese male population following a rapid ascent to high altitude by train.</p><p><strong>Methods: </strong>The study involved 375 young Chinese men with a median age of 21. The participants spent 43 hours ascending from an altitude of 400 m to 4,086 m, including 41 hours by train and 2 hours by car. They were divided into AMS+ and AMS- groups based on the Lake Louise AMS score (LLS) after being exposed to 4,086 m for 24 hours. Participants' SpO₂ and heart rate (HR) were measured. AMS was assessed using the LLS. Data were analyzed using Spearman's correlation, logistic regression, and receiver operating characteristic (ROC) analysis.</p><p><strong>Results: </strong>At 4,086 m, the overall AMS prevalence was 31%. The HR was significantly higher in the AMS+ group compared to the AMS- group. Conversely, SpO₂ was lower in the AMS+ group. Correlation analysis showed that LLS was positively correlated with HR and negatively correlated with SpO₂. Adjusted logistic regression identified lower SpO₂ (OR = 0.909, 95% CI: 0.867-0.953, <i>p</i> < 0.001) and HR (OR = 1.031, 95% CI: 1.010-1.052, <i>p</i> < 0.01) as independent risk factors for AMS. ROC analysis indicated that lower SpO₂ is a significant marker for diagnosing moderate to severe AMS. The optimal cut-off value for SpO₂ was 81.5%, with a sensitivity of 66.7%, a specificity of 75.7%, and an AUC of 0.724, with lower and upper confidence limits of 0.555 and 0.893, respectively.</p><p><strong>Conclusion: </strong>This study suggests that lower SpO₂ levels are associated with AMS in young Chinese men who rapidly ascend to 4,086 m, primarily by train.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"49-56"},"PeriodicalIF":1.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145540442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sickle Cell Trait Is a Risk Factor for Another Form of Altitude Illness.","authors":"Grégoire P Millet, Philippe Connes","doi":"10.1177/15578682251400299","DOIUrl":"10.1177/15578682251400299","url":null,"abstract":"<p><p>Millet, Grégoire P, and Philippe Connes. Sickle cell trait is a risk factor for another form of altitude illness. <i>High Alt Med Biol.</i> 27:57-59, 2026.-Acute mountain sickness, high-altitude pulmonary edema, and high-altitude cerebral edema have been widely investigated. In this letter, we claim that beyond these three altitude illnesses, one cannot rule out an additional serious concern related to altitude exposure in a particular population; the individuals with sickle cell trait.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"57-59"},"PeriodicalIF":1.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mediating Role of Cognitive Function in the Relationship Between Acute High-Altitude Stress and Casualty Care Capability Following Rapid Ascent.","authors":"Tianjing Du, Haoqing Shi, Linlin Liu, Zeyu Yang","doi":"10.1177/15578682261416451","DOIUrl":"https://doi.org/10.1177/15578682261416451","url":null,"abstract":"<p><p>Du, Tianjing, Haoqing Shi, Linlin Liu, and Zeyu Yang. The mediating role of cognitive function in the relationship between acute high-altitude stress and casualty care capability following rapid ascent. <i>High Alt Med Biol.</i> 00:00-00, 2026.</p><p><strong>Background: </strong>The impact of high-altitude rescue missions on medical personnel's cognitive function and casualty care capabilities remains unclear.</p><p><strong>Methods: </strong>This multicenter, randomized, sham-controlled clinical trial established high-altitude intervention (HAI), high-altitude (HA), and sea level (SL) groups (<i>n</i> = 92 per group). The HAI group received an integrated cognitive-stress management training, and the HA group implemented a sham training regimen before rapid ascent to high altitude (RAHA). The SL group served as a blank control group. Primary outcomes included casualty care capability score, plasma cortisol level, and cognitive ability score. Longitudinal mediation analysis examined the role of cognitive function in stress and casualty care capabilities.</p><p><strong>Results: </strong>In the HA group, cognitive ability mediated strong negative indirect effects at 24 hours, alongside a positive direct effect of stress. At 48 hours, the negative indirect effect remained dominant, whereas the direct effect of stress was not significant. At 72 hours, the indirect effect weakened but remained significant, whereas the direct effect of stress became significantly negative. By 96 hours, the indirect effect disappeared, with the total effect explained by stress. In the HAI group, the total and indirect effects were significant at 24 and 48 hours, whereas the direct effects were not. At 72 and 96 hours, no effects were statistically significant.</p><p><strong>Conclusion: </strong>During the initial phase of RAHA, cognitive ability serves as a mediating factor through which stress impairs casualty care capabilities. Over time, the mediating effect of cognition gradually diminishes, while the direct negative impact of the stress response continues to strengthen. The integrated cognitive-stress training can effectively preserve cognitive function and mitigate the stress response, thereby enhancing medical personnel's casualty care capabilities.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"15578682261416451"},"PeriodicalIF":1.4,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Mental Status at High Altitude: Obstructive Hydrocephalus Mimicking High-Altitude Cerebral Edema (HACE).","authors":"Taylor Barg, Jaclyn Walker, Samara Levine, David Ryan Ormond, James P Maloney","doi":"10.1177/15578682251411939","DOIUrl":"https://doi.org/10.1177/15578682251411939","url":null,"abstract":"<p><p>Barg, Taylor, Jaclyn Walker, Samara Levine, David Ryan Ormond, and James P Maloney. Altered Mental Status at High Altitude: Obstructive Hydrocephalus Mimicking High Altitude Cerebral Edema (HACE). <i>High Alt Med Biol.</i> 00:00-00, 2025.-A 29-year-old female presented to a Colorado emergency department with amnesia, headache, confusion, and dysarthria after rapidly ascending a 4,404 m (14,267 ft) peak. Head CT revealed cerebral edema and hydrocephalus. She was hypotensive and required vasopressors prior to evacuation to a lower-altitude intensive care unit and received initial treatment for high-altitude cerebral edema (HACE) with dexamethasone. Imaging and clinical workup revealed obstructive hydrocephalus due to a colloid cyst with minimal radiographical evidence of cerebral edema except due to the compressive effects of hydrocephalus. She transiently developed stress-induced cardiomyopathy and mixed neurocardiogenic shock. This case emphasizes the importance of considering HACE mimics at high altitude triggered by hypoxia-mediated increases in intracranial pressure.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145862815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of Altitude Medicine Knowledge Among Mountaineers in the Italian Alps.","authors":"Remco R Berendsen, Dirk C A A de Vries, Alea Steger, Nadine Herold, Feico J J Halbertsma, Adriaan F Norbart, Hannes Gatterer, Bengt Kayser","doi":"10.1089/ham.2025.0028","DOIUrl":"10.1089/ham.2025.0028","url":null,"abstract":"<p><p>Berendsen, Remco R., Dirk C.A.A. de Vries, Alea Steger, Nadine Herold, Feico J.J. Halbertsma, Adriaan F. Norbart, Hannes Gatterer, and Bengt Kayser. Lack of altitude medicine knowledge among mountaineers in the Italian Alps. <i>High Alt Med Biol.</i> 26:361-373, 2025. <b><i>Introduction:</i></b> In 2022, expert consensus defined a set of minimum altitude medicine knowledge statements for laypersons traveling to high altitudes (STAK: strengthening altitude knowledge). We used these statements to assess knowledge among mountaineers in the Italian Alps. <b><i>Methods:</i></b> Mountaineers in a hut (3,647 m) completed an online STAK-based questionnaire, also indicating their confidence after each answer. A score of ≥19/28 was used as a statistical threshold, exceeding chance alone. Logistic regression assessed the link between confidence and correctness; multivariate regression explored demographic, educational, and behavioral predictors of achieving an above-threshold score. <b><i>Results:</i></b> Of 576 participants, 412 (72%) were included in the final analysis and 115 (28%) scored ≥19. Among them, 59% of medical professionals, 36% of mountain guides, and 23% of general participants reached the threshold; the medical professionals scored significantly higher than the general participants (<i>p</i> < 0.001). Both being a mountain guide (odds ratios [OR]: 2.3, 95% confidence intervals [CI]: 1.0-5.0, <i>p</i> < 0.05) and being a medical professional (OR: 4.5, 95% CI: 2.1-10.0, <i>p</i> < 0.001) were associated with higher scores. <b><i>Conclusion:</i></b> Using STAK as a benchmark, we found a substantial lack of altitude medicine knowledge in mountaineers, even among guides and medical professionals. These findings suggest a potential for targeted educational interventions.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"361-373"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taste and Appetite at Altitude: A Comprehensive Review of Sensory and Hunger Modulation in High-Altitude Environments.","authors":"Joshua T Murphey, Jennifer L Temple, David Hostler","doi":"10.1089/ham.2024.0018","DOIUrl":"10.1089/ham.2024.0018","url":null,"abstract":"<p><p>Murphey, Joshua T., Jennifer L. Temple, and David Hostler. Taste and appetite at altitude: A comprehensive review of sensory and hunger modulation in high-altitude environments. <i>High Alt Med Biol</i>. 26:393-407, 2025. <b><i>Introduction:</i></b> Individuals living or working at high altitudes typically experience altered taste perceptions and reduced appetite. These changes can lead to nutritional deficiencies, affecting the energy balance and body composition. <b><i>Methods:</i></b> We conducted a nonsystematic review of PubMed to explore these phenomena and expound on their findings to offer additional insights. <b><i>Results:</i></b> Changes in taste and perception are common and typically lead to loss of mass. There are limited practical solutions to mitigate these challenges. <b><i>Discussion:</i></b> Gradual acclimatization and tailored nutritional strategies are required to enhance health and performance in high-altitude environments. This review provides critical insights into the intersection of altitude, nutrition, and health.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"393-407"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xenon Inhalation for Expeditions to High Altitude: A Position Statement from the International Climbing and Mountaineering Federation (Union Internationale des Associations d'Alpinisme, UIAA) Medical Commission.","authors":"Matthias P Hilty, Urs Hefti, Pierre Bouzat, Hannes Gatterer, Lenka Horakova, Linda E Keyes, Justin Lawley, Benjamin D Levine, George Rodway, Daniel Trevena, Eduardo Vinhaes, Benoit Champigneulle","doi":"10.1089/ham.2025.0018","DOIUrl":"10.1089/ham.2025.0018","url":null,"abstract":"<p><p>Hilty, Matthias P., Urs Hefti, Pierre Bouzat, Hannes Gatterer, Lenka Horakova, Linda E. Keyes, Justin Lawley, Benjamin D. Levine, George Rodway, Daniel Trevena, Eduardo Vinhaes, and Benoit Champigneulle. Xenon inhalation for expeditions to high altitude: A position statement from the International Climbing and Mountaineering Federation (Union Internationale des Associations d'Alpinisme, UIAA) Medical Commission. <i>High Alt Med Biol.</i> 26:385-387, 2025. <b><i>Background and Methods:</i></b> Recently, xenon inhalation has been advertised for use as a pre-acclimatization method for high-altitude climbs, but this use is controversial and not without risks. The International Climbing and Mountaineering Federation (<i>Union Internationale des Associations d'Alpinisme</i>, UIAA) Medical Commission convened a panel, including external experts, to develop a position statement on xenon inhalation as a pre-acclimatization method. <b><i>Results:</i></b> In this statement, we summarize the current state of research and discuss possible directions of future investigations. A pre-acclimatization strategy using xenon inhalation includes risks of respiratory depression, hypoxemia, systemic hypertension, and neurological impairment. The potential benefits of xenon inhalation, such as erythropoiesis, an increase in hemoglobin mass, or increased oxygen availability to the tissues, are not supported by the existing, current evidence. <b><i>Conclusion:</i></b> The UIAA Medical Commission recommends against the use of xenon inhalation in preparation for or during expeditions to high altitude unless part of a controlled study with appropriately qualified medical support such as anesthesia personnel.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"385-387"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Everest 1924: Observations and Impressions from the <i>Journal of Expedition Physician</i> and Naturalist R.W.G. Hingston.","authors":"Maxwell Oliver Beresford, Rhona Loxton, George W Rodway","doi":"10.1177/15578682251368337","DOIUrl":"10.1177/15578682251368337","url":null,"abstract":"<p><p>Beresford, Maxwell Oliver, Rhona Loxton, and George W. Rodway. Everest 1924: Observations and impressions from the <i>Journal of Expedition Physician</i> and Naturalist R.W.G. Hingston. <i>High Alt Med Biol.</i> 26:416-423, 2025.-The 1924 British expedition to Mount Everest was the second serious attempt to summit the mountain, following on from the expedition of 1922. Initially led by General Charles Bruce, the party was composed of some of the most prestigious climbers of its day. Major Richard W.G. Hingston, although not a mountaineer by trade, acted as medical officer on the expedition. Hingston maintained a meticulous journal on the expedition, describing medical cases, the events on Everest, and the extensive flora and fauna he collected. He also performed basic physiological testing on the climbers, exploring the impact of altitude on their bodies. While the heights the climbers reached broke records, the expedition was ultimately shrouded in tragedy with the loss of Mallory and Irvine. This article follows Major Hingston's personal account of events on Everest, including his impressions of Mallory and Irvine. This article considers his observations and findings in their current medical context and emphasizes his passion for the natural world.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"416-423"},"PeriodicalIF":1.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144845685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}