High altitude medicine & biology最新文献

{"title":"Preexisting Hyperuricemia Before High-Altitude Ascent is Associated with a Slower Recovery of Estimated Glomerular Filtration Rate Following Descent.","authors":"Linggong Zhao, Yujie Huang, Xiaoling Tan","doi":"10.1089/ham.2024.0006","DOIUrl":"10.1089/ham.2024.0006","url":null,"abstract":"<p><p>Zhao, Linggong, Yujie Huang, and Xiaoling Tan. Preexisting hyperuricemia before high-altitude ascent is associated with a slower recovery of estimated glomerular filtration rate following descent. <i>High Alt Med Biol.</i> 25:308-318, 2024. <b><i>Objectives:</i></b> Hypoxia at high altitudes results in elevated uric acid (UA) and reduced estimated glomerular filtration rate (eGFR). However, the impact of a prolonged high-altitude sojourn on UA levels and renal function in patients with preexisting hyperuricemia warrants further exploration. The study was to investigate the eGFR and related factors in patients with preexisting hyperuricemia following exposure to high altitude. <b><i>Methods:</i></b> The study included 345 participants, who worked at a high altitude for 1 year. Anthropometric and laboratory indices were collected before ascent (i.e., baseline), as well as 20 and 80 days after descent. The participants were categorized into individuals with hyperuricemia (HUA) or normal uric acid (NUA) group based on the presence or absence of hyperuricemia at baseline. <b><i>Results:</i></b> No difference in baseline eGFR was observed between the two groups before ascend or on day 20 after descent (<i>p</i> > 0.05). However, on day 80, eGFR of the HUA group was lower compared with the NUA group (<i>p</i> < 0.05). Correlations existed between post-descent eGFR levels and variables, including sampling time, UA levels, total and direct bilirubin, and baseline grouping. <b><i>Conclusions:</i></b> After high-altitude exposure, the recovery of eGFR was delayed in participants with preexisting hyperuricemia. Preexisting hyperuricemia and high-altitude hypoxia jointly contribute to renal impairment.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"308-318"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Continuous Positive Airway Pressure in Alleviating Hypoxemia and Improving Exertional Capacity at Altitude.","authors":"Brian Strickland, Elan Small, Mary Ryan, Ryan Paterson","doi":"10.1089/ham.2024.0007","DOIUrl":"10.1089/ham.2024.0007","url":null,"abstract":"<p><p>Strickland, Brian, Elan Small, Mary Ryan, and Ryan Paterson. Effectiveness of continuous positive airway pressure in alleviating hypoxemia and improving exertional capacity at altitude. <i>High Alt Med Biol.</i> 25:319-325, 2024. <b><i>Introduction:</i></b> Decreased oxygen saturation and exercise tolerance are commonly experienced at high altitude. Continuous positive airway pressure (CPAP) devices have become increasingly portable and battery powered, providing a potentially unique new therapeutic modality for treatment of altitude-related illnesses. This study evaluated the potential use of CPAP devices to improve and maintain oxygen saturation at altitude, both at rest and with exertion, to evaluate the feasibility of using this device at altitude. <b><i>Methods:</i></b> Subjects were taken to Mount Blue Sky and monitored while they hiked to the summit (4,350 m), maintaining a consistent level of exertion. Subjects hiked for 0.7 km both with and without CPAP set to 10 cmH₂O pressure. Continuous vital signs were collected during the hike and recovery period. <b><i>Results:</i></b> All subjects completed the hike wearing CPAP devices at a vigorous level of exertion. Mean oxygen saturation of the CPAP group (M = 83.8%, SD = 3.72) was significantly higher than that of the control group during exertion (M = 78.7%, SD = 2.97); <i>p</i> = 0.005. Recovery after exertion was quicker in the CPAP group than the control group. Three subjects experienced claustrophobia requiring a brief pause, but were able to complete their exercise trial without removing equipment or experiencing adverse events. When pauses from claustrophobia were excluded, there was no difference in completion time between the groups (<i>p</i> = 0.06). <b><i>Conclusion:</i></b> CPAP reliably improved oxygen saturation at rest and during vigorous exertion at high altitude. Its ability to correct hypoxemia, even with physical exertion, may prove useful after further study as a portable self-carried device to prevent and treat altitude-related illness, or to improve safety in high-altitude rescues.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"319-325"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mismanagement of Patients with High Altitude Illness Evacuated from the Mount Everest Region in Nepal.","authors":"Samriddha Raj Pant, Suraj Shrestha, Suman Acharya, Ghan Bahadur Thapa, Buddha Basnyat","doi":"10.1089/ham.2024.0034","DOIUrl":"10.1089/ham.2024.0034","url":null,"abstract":"","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"348-349"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Hypobaric Hypoxia Stimulates Differential Expression of Cognitive Proteins in Hippocampal Tissue.","authors":"Yaqi Wan, Ri-Li Ge, Yaxin Cao, Lan Luo, Weizhong Ji","doi":"10.1089/ham.2024.0105","DOIUrl":"https://doi.org/10.1089/ham.2024.0105","url":null,"abstract":"<p><p><b><i>Objective:</i></b> We aimed to determine changes in cognitive function resulting from chronic hypobaric hypoxia through proteomic analysis of hippocampal tissue. We screened cognition-related proteins to provide ideas and directions that could help prevent and treat hypoxia-associated cognitive impairment. <b><i>Methods:</i></b> We analyzed hippocampal tissues from mice exposed to high altitudes and control mice using 4 D label-free quantitative proteomics. The data were analyzed by protein quantitative analysis, functional annotation, differential protein screening, clustering analyses, and functional classification and enrichment. Differential protein expression was investigated using targeted quantitative omics based on parallel response monitoring. <b><i>Results:</i></b> We identified and quantified 20 target proteins in 12 samples, of which 18 were significant validated proteins that were or might be related to cognitive functions. Signaling pathways that were significantly enriched in differentially expressed proteins were pyrimidine metabolism, 5'-Adenosine Triphosphate-activated protein kinase signaling, phospholipase D signaling, purine metabolism, inflammatory mediator regulation of transient receptor potential channels, hedgehog signaling pathways, dilated cardiomyopathy, platelet activation, insulin resistance, mRNA surveillance pathways, drug metabolism-other enzymes, and drug metabolism-cytochrome P450. <b><i>Conclusion:</i></b> Chronic hypoxia alters protein expression in murine hippocampal tissues. Eighteen differentially expressed cognition-related proteins might be related to cognitive impairment in mice exposed to chronic high-altitude hypoxia.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplemental Oxygen on the Annie Smith Peck Expedition of 1903 to 6,367 m (20,892 ft) Mount Sorata (Illampu).","authors":"Harvey V Lankford, Hannah Kimberley","doi":"10.1089/ham.2024.0098","DOIUrl":"https://doi.org/10.1089/ham.2024.0098","url":null,"abstract":"<p><p>Lankford, Harvey V, Hannah Kimberley. Supplemental Oxygen on the Annie Smith Peck Expedition of 1903 to 6,367 m (20,892 ft) Mount Sorata (Illampu). <i>High Alt Med Biol.</i> 00:00-00, 2024. The 1903 expedition to 6,367 m (20,892 ft) Mount Sorata (Illampu) in Bolivia that was conceived, organized, and led by American mountaineer Annie Smith Peck appears to have been the first to take a supplemental oxygen apparatus to a great mountain. The expedition did not have heavy cylinders of compressed oxygen or closed-circuit rebreathers with chemically generated oxygen but took an apparatus to produce oxygen on the mountain apparently by a 19th century heated chlorate chemical method. Oxygen was to be manufactured in camp, stored in rubber bags, and used with an open-circuit breathing set while climbing. The equipment was taken, but once in Bolivia, a late change in plans resulted in a summit attempt on 6,427 m (21,086 ft) Ancohuma rather than Illampu on the twin-peaked Sorata massif. The summit attempt ended prematurely at 4,700 m (15,350 ft), and the oxygen system was not used. The present paper reviews some of the supplemental oxygen options that were available in 1903 and examines the Sorata expedition, a little-known part of the early history of mountaineering oxygen use.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of High Altitude on Children's Sleep: A Community-Based Study on Preschoolers in the Tibetan Plateau.","authors":"Ping Su, Masako Taniike, Yuko Ohno, Ikuko Mohri","doi":"10.1089/ham.2024.0106","DOIUrl":"https://doi.org/10.1089/ham.2024.0106","url":null,"abstract":"<p><p>Su, Ping, Masako Taniike, Yuko Ohno, and Ikuko Mohri. The effects of high altitude on children's sleep: A community-based study on preschoolers in the Tibetan Plateau. <i>High Alt Med Biol.</i> 00:00-00, 2024. <b><i>Objective/Background:</i></b> It has been reported that high altitude affects breathing during sleep in children. To evaluate the symptoms suspected sleep-disordered breathing (SDB) and sleep quality of preschool children living in high altitude of 2,261-3,800 m above sea level (masl) in the Tibetan Plateau, we conducted the community-based survey using a questionnaire. <b><i>Patients/Methods:</i></b> Sleep problems were assessed in 3,113 children aged 3-6 years in Qinghai province using the Chinese version of the Japanese Sleep Questionnaire for Preschoolers (JSQ-P-C), focusing on obstructive sleep apnea (OSA) and OSA-related symptoms. The effect of altitude on these scores was analyzed. <b><i>Results:</i></b> The subscale scores of OSA, morning symptoms, and daytime excessive sleepiness in the JSQ-P-C were higher in children living in areas above 3,000 masl than in those living below 3,000 masl and in Japanese children. Altitude, but not family income or maternal education level, significantly affected the scores of OSA, morning symptoms, and daytime excessive sleepiness. <b><i>Conclusions:</i></b> Living at altitudes higher than 3,000 masl may adversely affect children's sleep quality.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Letter to the Editor:</i> Solastalgia and Serendipity-at Altitude and in Academia.","authors":"Grégoire P Millet","doi":"10.1089/ham.2024.0133","DOIUrl":"https://doi.org/10.1089/ham.2024.0133","url":null,"abstract":"","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Environmental Impact of a High-Altitude Medical Research Expedition.","authors":"Kelsey E Joyce, Catherine A Campbell, Arthur R Bradwell, Samuel J E Lucas, Christopher T Lewis, Rebekah A I Lucas, Mark Edsell","doi":"10.1089/ham.2024.0049","DOIUrl":"https://doi.org/10.1089/ham.2024.0049","url":null,"abstract":"<p><p>Joyce, Kelsey E., Catherine A. Campbell, Arthur R. Bradwell, Samuel J.E. Lucas, Christopher T. Lewis, Rebekah A.I. Lucas, and Mark Edsell. The environmental impact of a high-altitude medical research expedition. <i>High Alt Med Biol.</i> 00:00-00, 2024. <b><i>Introduction:</i></b> Scientists must begin examining the environmental cost(s) of their research. The purpose of this study was to evaluate a component of the environmental impact of a high-altitude medical research expedition by totaling the carbon dioxide (CO₂) emissions calculated from as many direct and indirect sources as possible. <b><i>Methods:</i></b> Eighteen individuals flew from London to Bagdogra (via Delhi), and then drove onward to Lachung (via Gangtok) where they began their ascent on foot to 4,800 m (Kanchenjunga National Park, Sikkim). Several research experiments were conducted throughout the expedition, which required use of a laboratory centrifuge, solid CO₂ (specimen storage), rechargeable laptop computers and battery-powered oximeters. International Civil Aviation Organization calculators estimated aviation CO₂ production. Land emissions were calculated for <i>Mahindra</i> vehicles. Solid waste was weighed and CO₂ emissions estimated for its incineration. <b><i>Results</i>:</b> Total CO₂ emissions equated to ∼16.7 tonnes from the following sources: air and land transportation of expedition team (87.3%); sublimation and transportation of solid CO₂ (7.7%), waste incineration (0.58%), generator transportation and gasoline (12 l) combustion (0.48%), and battery transportation (3.3%). <b><i>Conclusions</i>:</b> Air travel contributed the most to the overall environmental cost of the research expedition. Further investigation is required to contextualize these findings in relation to lab-based alternative(s).</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altitude and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in China: A Population-Based Study.","authors":"Yufei Wang, Qiong Meng, Jin Zhang, Bing Guo, Nanyan Li, Qian Deng, Julinling Hu, Quzong Deji, Han Guan, Wangjiu Danzhen, Hui Yu, Zhifeng Li, Junmin Zhou","doi":"10.1089/ham.2024.0054","DOIUrl":"https://doi.org/10.1089/ham.2024.0054","url":null,"abstract":"<p><p>Yufei Wang, Qiong Meng, Jin Zhang, Bing Guo, Nanyan Li, Qian Deng, Julinling Hu, Deji Quzong, Han Guan, Danzhen Wangjiu, Hui Yu, Zhifeng Li, and Junmin Zhou. Altitude and metabolic dysfunction-associated fatty liver disease (MAFLD) in China: a population-based study. <i>High Alt Med Biol.</i> 00:00-00, 2024. <b><i>Objectives:</i></b> The epidemiological evidence for the relationship between altitude and metabolic dysfunction-associated fatty liver disease (MAFLD) is scarce. This study aims to examine the altitude-MAFLD relationship and explore the potential mediators explaining the relationship. <b><i>Methods:</i></b> Data were derived from the China Multi-Ethnic Cohort. The participants' altitude information was extracted from their residential addresses. MAFLD was diagnosed based on radiographically confirmed hepatic steatosis and any one of the following three items: overweight/obese status, diabetes mellitus, or metabolic dysregulation. We performed multivariable logistic regression and mediation analyses to assess the altitude-MAFLD associations and potential mediators, respectively. In the mediation analysis, mediation proportion is an estimate of the extent to which the total effect (altitude-MAFLD association) is accounted for by the pathway through the mediators. <b><i>Results:</i></b> In total, 87,679 participants (female: 60.7%, mean age: 51.36 years) were included. The odds ratio of MAFLD was 1.61 (95% confidence interval [CI]: 1.52-1.71) between high and low altitudes, 1.52 (95% CI: 1.43-1.62) between high and middle altitudes, and 1.06 (95% CI: 1.01-1.10) between middle and low altitudes. Of the total estimated effect between high and low altitude, physical activity and vegetable intake accounted for 15.7% (95% CI: 12.8-19.1) and 3.8% (95% CI: 1.2-6.6), respectively. Of the total estimated effect between high and middle altitude, physical activity and vegetable intake accounted for 31.4% (95% CI: 26.2-34.8) and 2.3% (95% CI: 0.6-3.8), respectively. Of the total estimated effect between middle and low altitude, vegetable intake accounted for 11.8% (95% CI: 3.2-61.5). <b><i>Conclusion:</i></b> Higher altitude was associated with increased odds of MAFLD, and physical activity and vegetable intake mediated such association. Multifaceted efforts should be taken in public health to promote healthy lifestyles among higher altitude residents.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142463917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Effect of Descent in Infants with Bronchiolitis Diagnosed at Altitude: A Prospective Multicenter Study.","authors":"Anne Poirier, Amélie Basso, Sarah Bonnet-Ducrot, Ellen Katranji, Sophia Cherif-Alami, Sophie Chateigner-Coelsch, Manon Navarre, Cécile Ricard, Corentin Tanné","doi":"10.1089/ham.2024.0083","DOIUrl":"https://doi.org/10.1089/ham.2024.0083","url":null,"abstract":"<p><p>Poirier, Anne, Amélie Basso, Sarah Bonnet-Ducrot, Ellen Katranji, Sophia Cherif-Alami, Sophie Chateigner-Coelsch, Manon Navarre, Cécile Ricard, and Corentin Tanné. Clinical Effect of Descent in Infants with Bronchiolitis Diagnosed at Altitude: A Prospective Multicenter Study. <i>High Alt Med Biol.</i> 00:00-00, 2024. <b><i>Objective:</i></b> This study aims to assess the clinical impact of descending to a lower altitude in infants with bronchiolitis diagnosed at an altitude above 1,000 m. <b><i>Methods:</i></b> We performed a prospective, observational, multicenter study during two consecutive winters (2022-2023 and 2023-2024). The diagnosis was made by local general practitioners (GPs) who then sent the patients who were younger than 1 year and had a Wang respiratory score (WRS) ≥4 to any of the five emergency departments (EDs) located at lower altitudes. The WRS, peripheral oxygen saturation (SpO₂), and respiratory rate (RR) recorded by the GPs and at the EDs were compared. <b><i>Results:</i></b> We included 74 infants (59% females, median age 5.4 [3.6-8.0] months). Compared with the median values recorded by the GPs at altitudes above 1,000 m, the median values at the lower-altitude EDs were significantly better for the WRS (5.0 vs. 6.0, <i>p</i> = 0.002), RR (50/min vs. 60/min, <i>p</i> = 0.001), and SpO₂ (97.0% vs. 91.5%, <i>p</i> < 0.001). <b><i>Conclusion:</i></b> Descending to a lower altitude significantly improved respiratory function in infants younger than 1 year with bronchiolitis diagnosed at altitudes above 1,000 m.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142463918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}