Hacettepe Journal of Biology and Chemistry最新文献_第2页

Investigation on the Binding properties of a Coumarin Derivative to Insulin by Spectroscopic and Computational Approaches 用光谱和计算方法研究香豆素衍生物与胰岛素的结合特性

Hacettepe Journal of Biology and Chemistry Pub Date : 2023-06-08 DOI: 10.15671/hjbc.1272350

Elmas Gökoğlu, Buse Aklar, Tuğba Taşkın Tok

引用次数: 0

Ticari Meyve Sularında HPLC ile Şeker Analizi için Standart Bir Metot Teyidi

Hacettepe Journal of Biology and Chemistry Pub Date : 2023-06-08 DOI: 10.15671/hjbc.1270348

Tuğba Doğan, Tamay Şeker

引用次数: 0

Sedril Formatın Mikrobiyal Dönüşümü

Hacettepe Journal of Biology and Chemistry Pub Date : 2023-04-17 DOI: 10.15671/hjbc.1244894

Özge ÖZŞEN BATUR, İsmail Kiran, K. H. C. Başer, Fatih Demi̇rci̇

引用次数: 0

Antidiabetic and antioxidant effect of Origanum minutiflorum O. Schwarz & P. H. Davis in streptozotocin-induced diabetic rats 杜鹃花对链脲佐菌素诱导的糖尿病大鼠的降糖和抗氧化作用

Hacettepe Journal of Biology and Chemistry Pub Date : 2023-04-10 DOI: 10.15671/hjbc.1239345

I. Güllü, S. Albayrak, E. Kaymak, A. Yay

引用次数: 0

11-(triethoxysilyl) undecanal agent-based biosensor system using disposable ITO-PET electrode for tumour necrosis factor-alpha detection 使用一次性ITO-PET电极检测肿瘤坏死因子- α的11-(三乙氧基硅基)非醛剂生物传感器系统

Hacettepe Journal of Biology and Chemistry Pub Date : 2023-04-10 DOI: 10.15671/hjbc.1240299

Burçak Demirbakan

{"title":"11-(triethoxysilyl) undecanal agent-based biosensor system using disposable ITO-PET electrode for tumour necrosis factor-alpha detection","authors":"Burçak Demirbakan","doi":"10.15671/hjbc.1240299","DOIUrl":"https://doi.org/10.15671/hjbc.1240299","url":null,"abstract":"In this study, a label-free electrochemical biosensor system based on a disposable indium tin oxide polyethylene terephthalate (ITO-PET) electrode modified with the 11-(triethoxysilyl) undecanal (11-TESU) agent was developed for the detection of tumour necrosis factor-alpha (TNF-α) in serum. The developed biosensor was observed with electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) techniques, square wave voltammetry (SWV) and single frequency impedance (SFI) technique which is utilized for the specific interaction between anti-TNF-α and TNF-α antigen. In addition, scanning electron microscopy was used to look at how the morphology of each ITO-PET surface changed (SEM). All parameters such as 11-TESU concentration, anti-TNF-α concentration and anti-TNF-α incubation time, were optimized. The biosensor system was characterized by measuring its linear determination range, repeatability, reproducibility, reusability, storage stability, and surface coverage. The TNF-αelectrochemical biosensor showed high levels of repeatability and reproducibility as well as a large dynamic range of detection (from 0.03 pg mL-1 to 3 pg mL-1). The LOD and LOQ for the biosensor were extremely low at 1x10-4 pg mL-1 and 5x10-4 pg mL-1, respectively. It was applied to real samples to determine whether the proposed biosensor would be useful in clinical settings.","PeriodicalId":12939,"journal":{"name":"Hacettepe Journal of Biology and Chemistry","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74362209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thiol/Disulfide Balance in Induced Phenylketonuria Model 诱导苯丙酮尿模型中硫醇/二硫平衡

Hacettepe Journal of Biology and Chemistry Pub Date : 2023-04-08 DOI: 10.15671/hjbc.1254604

Cigdem Cicek

引用次数: 0

Thermal and Flocculation Properties of Acacia Gum Grafted with Cationic Polyacrylamide 阳离子聚丙烯酰胺接枝金合欢胶的热絮凝性能

Hacettepe Journal of Biology and Chemistry Pub Date : 2023-02-28 DOI: 10.15671/hjbc.1197157

S. Uzan

引用次数: 0

Integrative profiling of CEACAM1 in different malignancies with implications on the SARS-CoV-2 infection genes ACE2 and TMPRSS2 CEACAM1在不同恶性肿瘤中的整合分析及其对SARS-CoV-2感染基因ACE2和TMPRSS2的影响

Hacettepe Journal of Biology and Chemistry Pub Date : 2023-02-23 DOI: 10.15671/hjbc.1232843

A. Acar

{"title":"Integrative profiling of CEACAM1 in different malignancies with implications on the SARS-CoV-2 infection genes ACE2 and TMPRSS2","authors":"A. Acar","doi":"10.15671/hjbc.1232843","DOIUrl":"https://doi.org/10.15671/hjbc.1232843","url":null,"abstract":"Increasing number of evidence demonstrated increased SARS-CoV-2 infection risk in cancer. Despite various studies shed light on SARS-CoV-2 mediated pathways upregulated in cancer, there is still ongoing efforts to reveal underlying mechanisms of elevated risk for COVID-19 disease in cancer. Given critical role of CEACAM1 in immune exhaustion and immune deregulation observed both in cancer and COVID-19, systematic characterization of CEACAM1 in different malignancies was performed with an ultimate aim to identify the involvement of CEACAM1 in enhanced COVID-19 susceptibility in cancer patients. Here we show that CEACAM1 expression was upregulated in a number of TCGA samples. In addition, CEACAM1 expression was positively correlated with SARS-CoV-2 infection genes in TCGA samples. Single-cell RNA sequencing analysis results of COVID-19 positive patients indicated upregulation of CEACAM1 expression. Furthermore, CEACAM1 expression was associated with HAVCR2, an immune checkpoint marker, and there was a correlation between CEACAM1 and HAVCR2 levels in different TCGA samples. Collectively, CEACAM1 might provide increased susceptibility of COVID-19 disease in cancer patients which might be explained with its interaction with HAVCR2.","PeriodicalId":12939,"journal":{"name":"Hacettepe Journal of Biology and Chemistry","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90469119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Investigation of the Therapeutic Value of Verbascum pyramidatum Bieb. for Obesity 锥体草治疗价值的探讨。对肥胖症

Hacettepe Journal of Biology and Chemistry Pub Date : 2023-01-31 DOI: 10.15671/hjbc.1196913

S. Şener, M. Badem, M. Çatalbaş, Ş. Kanbolat, U. Özgen, Nevin ULAŞ ÇOLAK

{"title":"Investigation of the Therapeutic Value of Verbascum pyramidatum Bieb. for Obesity","authors":"S. Şener, M. Badem, M. Çatalbaş, Ş. Kanbolat, U. Özgen, Nevin ULAŞ ÇOLAK","doi":"10.15671/hjbc.1196913","DOIUrl":"https://doi.org/10.15671/hjbc.1196913","url":null,"abstract":"Nowadays, one of the therapeutic approaches for obesity is the use pancreatic lipase inhibitors which reduce the digestion and absorption of fats. Most research indicates that natural sources which have a lipase inhibitory effect, may be utilized to treat obesity. Verbascum pyramidatum is one of the potential natural sources for obesity, and it has been demonstrated to have anti-inflammatory, antidiabetic, and regulatory effects on lipid metabolism. With this study, V. pyramidatum's potential lipase inhibitor effect, it is aimed to reveal its value in the treatment of obesity. \u0000In vitro spectroscopic method was used to determine the lipase inhibitory effect of V. pyramidatum. The quantitative investigation of V. pyramidatum's phenolic metabolites with antiobesity activity was carried out utilizing the Reverse Phase-High Performance Liquid Chromatography method. \u0000In this reported study, it was proven that extract and all fractions had an impact that inhibited lipase, with the ethyl acetate extract showing the highest inhibitory effect. Additionally, it was revealed through HPLC analysis that the species included p-OH benzoic acid, coumaric acid, quercetin, sinapic acid, and syringaldehyde. It has been demonstrated that V. pyramidatum may be a promising candidate for obesity treatment, but further investigations are required to use it as a therapeutic agent.","PeriodicalId":12939,"journal":{"name":"Hacettepe Journal of Biology and Chemistry","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89479161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SELF-TUNING PID (STPID) CONTROL OF PH IN RECOVERING PROCESS OF MAGNESIUM HYDROXIDE (MG(OH)2) BY COAGULATION FROM SALT 混凝法回收氢氧化镁(mg (oh)2)过程ph值的自整定pid控制

Hacettepe Journal of Biology and Chemistry Pub Date : 2023-01-21 DOI: 10.15671/hjbc.1164234

Yasemin Selay Çakiroğlu

引用次数: 0