Sedril Formatın Mikrobiyal Dönüşümü

Abstract

Cedryl formate is a synthetic fragrance compound, which is an ester derivative of the sesquiterpenoid cedrol, found in different parts of the cedar tree/cedarwood with a characteristic fragrance. Cedryl formate is used in cosmetics and personal care products like fragrances, perfumes, as well as in the chemical and agriculture industries in various forms. In the present work, the microbial transformation of the formate was evaluated by 13 fungal cultures to produce new derivatives. Among the evaluated, the plant pathogenic fungus Aspergillus niger NRRL 326, biotransformed to the metabolite 8-cedren-3β-ol derivative with 6.2% yield. The structure of the chromatographically purified metabolite was elucidated by NMR and spectroscopic methods.