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Investigation on the gastroprotective and antidiarrhoeal properties of Aegle marmelos unripe fruit extract. 蜜桔生果提取物的胃保护和抗腹泻作用研究。
Hindustan antibiotics bulletin Pub Date : 2003-02-01
J N Dhuley
{"title":"Investigation on the gastroprotective and antidiarrhoeal properties of Aegle marmelos unripe fruit extract.","authors":"J N Dhuley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Study was designed to verify the gastroprotective and antidiarrhoeal effects of unripe fruit extract of Aegle marmelos Corr. The gastroprotective function of this extract was evaluated in rats against gastric mucosal damage induced by hypothermic restraint stress, absolute ethanol, and indomethacin, whereas the antidiarrhoeal activity was investigated by studying the influence on gastrointestinal transit as measured by a charcoal marker and on castor oil-induced accumulation of intestinal fluid in mice and also on contractile responses evoked by acetylcholine, histamine, serotonin, and barium chloride in isolated guinea-pig ileum, the results demonstrated that pretreatment of animals with unripe fruit extract (50 and 100 mg/kg, i.p.) produces a significant inhibition of gastric lesion induced by ethanol but not those induced by restraint stress or indomethacin and suggest a probable involvement of a prostaglandin-independent mechanism of gastroprotection. At similar doses, both the intestinal transit as well as the accumulation of intestinal fluids induced by castor oil in mice were significantly inhibited by raw fruit extract. Furthermore, the extract antagonized the contractile responses evoked by different agonists on guinea-pig ileum in vitro and its inhibitory potential for the drugs are in the order of acetylcholine > histamine > serotonin > barium chloride. Taken together, these results point out a possible antidiarrhoeal effect of unripe fruit extract of A. marmelos Corr., since inhibition of intestinal motility and secretion can control clinical diarrhoea.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"45-46 1-4","pages":"41-6"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25683550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healing-promoting action of rhinax with dual action on chronic gastric and duodenal ulcers induced by acetic acid in rats. 鼻汤对大鼠醋酸致慢性胃溃疡和十二指肠溃疡的双重促愈作用。
Hindustan antibiotics bulletin Pub Date : 2003-02-01
J N Dhuley
{"title":"Healing-promoting action of rhinax with dual action on chronic gastric and duodenal ulcers induced by acetic acid in rats.","authors":"J N Dhuley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Healing promoting actions of Rhinax, a multiconstituent herbal preparation, was investigated in chronic gastric and duodenal ulcer models induced by acetic acid in rats and the effects were compared with those of famotidine by gross of histological evaluation. Rhinax markedly promoted the well balanced healing of gastric ulcer at oral does of 25-100 mg/kg x 2 /day, as evidenced by the reduction of ulcer, regeneration of mucosa and proliferation of connecitve tissue. Rhinax caused an increase in gastric mucosa secretion in all the regenerated mucosa around the gastric ulcers. Famotidine failed to promote the healing of gastric ulcers at 100 mg/kg x 2/ day p.o. Rhinax also significantly accelerated the healing of acetic acid -induced duodenal ulcers as well famotidine. These results indicate that Rhinax is characterised by a potent promoting action on the healing of chronic ulcers, suggesting that the increase in gastric mucus secretion might be associated with the antiulcer action of Rhinax in rats.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"45-46 1-4","pages":"34-40"},"PeriodicalIF":0.0,"publicationDate":"2003-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25683625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production of asparginase by four anoxygenic phototrophic bacteria. 四种无氧光养细菌生产天冬氨酸酶。
Hindustan antibiotics bulletin Pub Date : 2002-02-01
Srinivas Munjam, D Vasavi, S Girisham, S M Reddy
{"title":"Production of asparginase by four anoxygenic phototrophic bacteria.","authors":"Srinivas Munjam,&nbsp;D Vasavi,&nbsp;S Girisham,&nbsp;S M Reddy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"44 1-4","pages":"34-6"},"PeriodicalIF":0.0,"publicationDate":"2002-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24449833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invitro drug sensitivity of Trichophyton species against griseofulvin and ketoconazole. 毛癣菌对灰黄霉素和酮康唑的体外药物敏感性。
Hindustan antibiotics bulletin Pub Date : 2002-02-01
Sumita Dodia, Ritu Bajpai, B Geetha Singh
{"title":"Invitro drug sensitivity of Trichophyton species against griseofulvin and ketoconazole.","authors":"Sumita Dodia,&nbsp;Ritu Bajpai,&nbsp;B Geetha Singh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The in vitro activity of griseofulvin and ketoconazole was investigated against Trichophyton mentagrophytes (Robin) Blanchard and T. Simii (Pinoy) Stockdale, Mackenzie and Austwick. A gradual decrease in growth was observed with increase in concentration of both antibiotics. Ketoconazole was the more effective antibiotic than griseofulvin as it observed to inhibit > 50% mycelial weight even at a lower concentration of 100 ppm. While griseofulvin was effective to cause > 50% growth inhibition only at higher dosage of 400 ppm.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"44 1-4","pages":"47-8"},"PeriodicalIF":0.0,"publicationDate":"2002-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24449834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production and optimization studies of cephalosporin C by solid state fermentation. 头孢菌素C固态发酵生产及优化研究。
Hindustan antibiotics bulletin Pub Date : 2002-02-01
P Ellaiah, J Premkumar, P V L Kanthachari, K Adinarayana
{"title":"Production and optimization studies of cephalosporin C by solid state fermentation.","authors":"P Ellaiah,&nbsp;J Premkumar,&nbsp;P V L Kanthachari,&nbsp;K Adinarayana","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Production of cephalosporin C employing a strain, Cephalosporium sp. NCIM 1039 under solid state fermentation was optimized. Different substrates like wheat bran, wheat grains, rice grains, barley and rice bran were studied to optimize the best substrate. Wheat bran showed the highest antibiotic yield. The physical and chemical parameters were optimized. The maximum productivity of cephalosporin C (750 U/g) was achieved by employing wheat bran and with optimized nutritional and process parameters such as potato starch as additive 1% w/w, urea as additive 1% w/w, incubation period of 7 days, incubation temperature at 30 degrees C, inoculum level 10% w/v, moisture content of solid substrate 80% and pH 7.0.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"44 1-4","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2002-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24449827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioactive rare actinomycetes from indigenous natural substrates of Andhra Pradesh. 来自安得拉邦本土天然基质的生物活性稀有放线菌。
Hindustan antibiotics bulletin Pub Date : 2002-02-01
P Ellaiah, K V V S N Bapi Raju, K Adinarayana, G Adinarayana, T Prabhakar, J Premkumar
{"title":"Bioactive rare actinomycetes from indigenous natural substrates of Andhra Pradesh.","authors":"P Ellaiah,&nbsp;K V V S N Bapi Raju,&nbsp;K Adinarayana,&nbsp;G Adinarayana,&nbsp;T Prabhakar,&nbsp;J Premkumar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This investigation reports the occurrence of bioactive rare actinomycetes from different indigenous natural substrates of Andhra Pradesh. During the course of our investigation on 20 terrestrial soil samples, 5 marine samples and 3 fresh water samples, a total of 92 rare actinomycetes belonging to Micromonospora, Nocardia, Actinomadura and Thermoactinomyces genera were isolated. The antimicrobial and enzymatic activities were studied for all the isolates. The antibacterial and antifungal activities were studied preliminarily by cross-streak method followed by submerged fermentation studies employing standard cup-plate method for the assay. It was found that 34 isolates (36.95%) showed excellent antibacterial activity and 29 isolates (31.52%) showed good antifungal activity. Proteolytic and amylolytic activities were also studied. It was observed that 79 isolates (85.86%) showed proteolytic activity and 75 isolates (81.52%) showed amylolytic activity.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"44 1-4","pages":"17-24"},"PeriodicalIF":0.0,"publicationDate":"2002-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24449829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survey of antimicrobial streptomycetes from soils of West Bengal: characterization and identification of potent broad spectrum antibiotic producing Streptomyces albidoflavus 321.2. 西孟加拉邦土壤中抗菌链菌的调查:强效广谱抗生素产链霉菌albidoflavus 321.2的表征和鉴定。
Hindustan antibiotics bulletin Pub Date : 2002-02-01
R N Roy, S K Sen
{"title":"Survey of antimicrobial streptomycetes from soils of West Bengal: characterization and identification of potent broad spectrum antibiotic producing Streptomyces albidoflavus 321.2.","authors":"R N Roy,&nbsp;S K Sen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Survey of 611 streptomycetes isolates from 330 soil samples from various parts of West Bengal were done for their antimicrobial activity against Gram positive, Gram negative bacteria, unicellular and filamentous fungi. The strain 321.2 showed inhibition against all the test organisms used and found as potent. The morphological, cultural, physiological and biochemical characters were studied, compared with known species and identified as Streptomyces albidoflavus. This strain produces an antibiotic.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"44 1-4","pages":"25-33"},"PeriodicalIF":0.0,"publicationDate":"2002-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24449830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production of indole acetic acid and free amino acids by three thermophilic fungi. 三种嗜热真菌生产吲哚乙酸和游离氨基酸。
Hindustan antibiotics bulletin Pub Date : 2002-02-01
E Sujatha, S Girisham, S M Reddy
{"title":"Production of indole acetic acid and free amino acids by three thermophilic fungi.","authors":"E Sujatha,&nbsp;S Girisham,&nbsp;S M Reddy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"44 1-4","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2002-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24449832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensitivity of ornithophillic fungi to some drugs. 嗜鸟真菌对某些药物的敏感性。
Hindustan antibiotics bulletin Pub Date : 2002-02-01
Avni Patel, S C Agrawal
{"title":"Sensitivity of ornithophillic fungi to some drugs.","authors":"Avni Patel,&nbsp;S C Agrawal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The occurrence of ornithophillic fungi and related dermatophytes was evaluated from the poultry farm soil samples. Two test species of Microsporum were tested by 'Spore germination' and 'Disc diffusion method' against the two well known antifungal antibiotics i.e. griseofulvin and mycostatin (polyene antibiotic). The data showed cent percent inhibition of fungal spore germination and increased zone of inhibition at higher doses. The antimicrobial drugs including acetyl salicylic acid, benzoic acid and boric acid were also assessed at different doses against the test organisms. Acetyl salicylic acid and boric acid were found to be toxic at higher doses, while these pathogens seems to be somewhat resistant for benzoic acid. It is suggested that the effective doses of these drugs should also be tried for allergic effects on birds and other animals before commercial use.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"44 1-4","pages":"49-52"},"PeriodicalIF":0.0,"publicationDate":"2002-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24449835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro evaluation of sulfadrugs against fungi causing otomycosis. 磺胺类药物抗耳真菌病的体外评价。
Hindustan antibiotics bulletin Pub Date : 2002-02-01
Sudhir K Jain, S C Agrawal, P C Jain
{"title":"In vitro evaluation of sulfadrugs against fungi causing otomycosis.","authors":"Sudhir K Jain,&nbsp;S C Agrawal,&nbsp;P C Jain","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The efficacy of four sulfadrugs i.e., sulfadiazine, sulfamethoxazole, sulfaguanidine and sulfamoxole were taken in different doses (500, 1000, 1500, 2000 and 2500 ppm) to test their effectiveness against five pathogenic organisms for the control of mycelial growth and sporulation. Amongst the drugs tested sulfamethoxazole seems to be most effective against most of the test fungi showing 96.78, 90.53, 86.62, 54.16 and 43.91 percent inhibition in mycelial growth of P. nigricans, A. flavus, A. corymbifera, A. niger and C. albicans, respectively at its 2500 ppm dose in the basal medium. Gradual reduction in sporulation in all the test organisms almost in all the sulfadrugs have caused inhibition in sporulation, in comparison to their respective controls. Maximum inhibitory effect of sulfadiazine was recorded in A. niger showing 77.26 percent inhibition in the mycelial growth at a dose of 2500 ppm. Sulfaguanidine at its higher dose i.e., 2500 ppm proved to be most toxic against A. corymbifera causing 56.39 percent inhibition in the mycelial growth, while the same dose could not be found much effective against other test fungi. Sulfamoxole was found to be quite effective against most of the test fungi causing 47.16 to 85.86 percent inhibition in the mycelial growth. A gradual inhibition in the vegetative growth and sporulation or budding in all the test fungi was noted by increasing the concentrations of the test sulfadrugs.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"44 1-4","pages":"42-6"},"PeriodicalIF":0.0,"publicationDate":"2002-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24449831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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