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Simultaneous spectrophotometric estimation of Hydrochlorothiazide, Atenolol and Losartan potassium in tablet dosage form. 同时分光光度法测定片剂中氢氯噻嗪、阿替洛尔和氯沙坦钾含量。
Hindustan antibiotics bulletin Pub Date : 2009-07-01 DOI: 10.18579/JPCRKC/2009/8/3/79734
Asha B. Thomas, U. B. Chavan, R. Nanda, L. Kothapalli, A. Deshpande, S. N. Jagdale, S. B. Dighe
{"title":"Simultaneous spectrophotometric estimation of Hydrochlorothiazide, Atenolol and Losartan potassium in tablet dosage form.","authors":"Asha B. Thomas, U. B. Chavan, R. Nanda, L. Kothapalli, A. Deshpande, S. N. Jagdale, S. B. Dighe","doi":"10.18579/JPCRKC/2009/8/3/79734","DOIUrl":"https://doi.org/10.18579/JPCRKC/2009/8/3/79734","url":null,"abstract":"Two simple, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Hydrochlorothiazide (Hctz), Atenolol (Atn) and Losartan potassium (Los) in combined tablet dosage forms. The first method involves determination using the simultaneous equation method, the sampling wavelengths selected are, 272.5 nm, 224 nm and 250 nm over the concentration ranges of 0.5-30 microg/ml, 1-50 microg/ ml and 1-60 microg/ml for Hctz, Atn and Los respectively. The second method is the First order derivative method, the sampling wavelengths selected for estimation of Hctz, Atn and Los are 280.5 nm, 233 nm and 244 nm with linearity in the concentration ranges of 0.5-30 microg/ ml, 1-50 microg/ml and 1-60 microg/ml respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines.","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"6 1","pages":"33-8"},"PeriodicalIF":0.0,"publicationDate":"2009-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83442393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Significance of cephalosporin antibiotics in human healthcare. 头孢菌素类抗生素在人类保健中的意义。
Hindustan antibiotics bulletin Pub Date : 2009-01-01
Girish M Bhopale
{"title":"Significance of cephalosporin antibiotics in human healthcare.","authors":"Girish M Bhopale","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cephalosporins have been most frequently used antibiotics for the treatment of a wide variety of bacterial infections. The present article summarises general information on selected aspects of cephalosporin antibiotics viz. general features, uses and bacterial resistance.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"51 1-4","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29627131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Media optimization studies for Serratiopeptidase production from Serratia marcescens ATCC 13880. 粘质沙雷菌ATCC 13880产塞拉菌肽酶的培养基优化研究。
Hindustan antibiotics bulletin Pub Date : 2009-01-01
Ravindra V Badhe, Rabindra K Nanda, Manasi B Kulkarni, Mayur N Bhujbal, Pradeep S Patil, Sonali R Badhe
{"title":"Media optimization studies for Serratiopeptidase production from Serratia marcescens ATCC 13880.","authors":"Ravindra V Badhe,&nbsp;Rabindra K Nanda,&nbsp;Manasi B Kulkarni,&nbsp;Mayur N Bhujbal,&nbsp;Pradeep S Patil,&nbsp;Sonali R Badhe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Production of an anti-inflammatory enzyme serratiopeptidase by fermentation with Serratia marcescens ATCC 13880 was studied to ascertain optimal nutritional conditions for large scale production. To study biosynthesis and production of serratiopeptidase by Serratia marcescens ATCC 13880, different physicochemical parameters were studied and optimized. The optimized medium contain, (g/l) glycerine 10.0, maltose 10.0 as carbon source, peptone 10.0 as organic nitrogen source, ammonium sulphate 10.0 as inorganic nitrogen source, dihydrogen phosphate 10.0, sodium bicarbonate 10.0, sodium acetate 10.0 as inorganic salt source, ascorbic acid 10.0 as stabilizer, distilled water 1000 ml and the optimized fermentation conditions were pH 7.0, temperature 37 degrees C and duration 24 hr. The modified fermentation medium produced 27.36 IU/ml of serratiopeptidase compared to 17.97 IU/ml in basal medium and the molecular weight of the purified serratiopeptidase was found to be 52 kD.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"51 1-4","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29627133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous estimation of Cefixime and Erdosteine in capsule dosage form by spectrophotometric method. 分光光度法同时测定胶囊剂型中头孢克肟和埃尔多斯汀的含量。
Hindustan antibiotics bulletin Pub Date : 2009-01-01
Madhura V Dhoka, Vandana T Gawande, Pranav P Joshi, Santosh V Gandhi, Neelam G Patil
{"title":"Simultaneous estimation of Cefixime and Erdosteine in capsule dosage form by spectrophotometric method.","authors":"Madhura V Dhoka,&nbsp;Vandana T Gawande,&nbsp;Pranav P Joshi,&nbsp;Santosh V Gandhi,&nbsp;Neelam G Patil","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two accurate, precise, rapid and economical methods viz. Absorption correction method and Dual wavelength method were developed for the estimation of Cefixime (CEF) and Erdosteine (ERDO) in capsule dosage form. In both the methods linearity was observed in the concentration range of 2-25 microg/ml for Cefixime and 3-37.5 microg/ml for Erdosteine. The results of the analysis have been validated statistically and by recovery studies. The percentage assay was found to be 100.03 +/- 0.68 for Cefixime and 99.5 +/- 1.0 for Erdosteine (Mean +/- S.D) by method A and 99.54 +/- 0.84 for Cefixime and 100.54 +/- 1.3 for Erdosteine (Mean +/- S.D) by method B respectively.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"51 1-4","pages":"29-32"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29627135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of nutrients on production of Hamycin antibiotic by Streptomyces pimprina Thirum. 营养物质对红链霉菌生产抗生素哈霉素的影响。
Hindustan antibiotics bulletin Pub Date : 2009-01-01
Ramesh G Dongare, Smita P Bhalange, Girish M Bhopale
{"title":"Effect of nutrients on production of Hamycin antibiotic by Streptomyces pimprina Thirum.","authors":"Ramesh G Dongare,&nbsp;Smita P Bhalange,&nbsp;Girish M Bhopale","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"51 1-4","pages":"39-41"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29627137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous spectrophotometric estimation of Hydrochlorothiazide, Atenolol and Losartan potassium in tablet dosage form. 同时分光光度法测定片剂中氢氯噻嗪、阿替洛尔和氯沙坦钾含量。
Hindustan antibiotics bulletin Pub Date : 2009-01-01
Asha B Thomas, Umesh B Chavan, Rabindra K Nanda, Lata P Kothapalli, Avinash D Deshpande, Sheetal N Jagdale, Shweta B Dighe
{"title":"Simultaneous spectrophotometric estimation of Hydrochlorothiazide, Atenolol and Losartan potassium in tablet dosage form.","authors":"Asha B Thomas,&nbsp;Umesh B Chavan,&nbsp;Rabindra K Nanda,&nbsp;Lata P Kothapalli,&nbsp;Avinash D Deshpande,&nbsp;Sheetal N Jagdale,&nbsp;Shweta B Dighe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two simple, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Hydrochlorothiazide (Hctz), Atenolol (Atn) and Losartan potassium (Los) in combined tablet dosage forms. The first method involves determination using the simultaneous equation method, the sampling wavelengths selected are, 272.5 nm, 224 nm and 250 nm over the concentration ranges of 0.5-30 microg/ml, 1-50 microg/ ml and 1-60 microg/ml for Hctz, Atn and Los respectively. The second method is the First order derivative method, the sampling wavelengths selected for estimation of Hctz, Atn and Los are 280.5 nm, 233 nm and 244 nm with linearity in the concentration ranges of 0.5-30 microg/ ml, 1-50 microg/ml and 1-60 microg/ml respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guidelines.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"51 1-4","pages":"33-8"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29627136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Purification and partial characterization of thermostable serine alkaline protease from a newly isolated Bacillus species HSRB08 from hotspring. 新分离的温泉芽孢杆菌HSRB08耐热丝氨酸碱性蛋白酶的纯化及部分特性研究。
Hindustan antibiotics bulletin Pub Date : 2009-01-01
Ravindra V Badhe, Sunil L Harer, Rabindra K Nanda, Sonali R Badhe, Sumitra J Jangam, Avinash D Deshpande
{"title":"Purification and partial characterization of thermostable serine alkaline protease from a newly isolated Bacillus species HSRB08 from hotspring.","authors":"Ravindra V Badhe,&nbsp;Sunil L Harer,&nbsp;Rabindra K Nanda,&nbsp;Sonali R Badhe,&nbsp;Sumitra J Jangam,&nbsp;Avinash D Deshpande","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of the research was to study the purification and partial characterization of thermostable serine alkaline protease from a newly isolated Bacillus species HSRB08, which was isolated from hotspring. The enzyme was purified in a 2-step procedure involving ammonium sulfate precipitation and Sephadex G-200 chromatography. The enzyme was shown to have molecular weight of 66 kD by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and Gelatin Zymogram and was purified 15.3-fold with a yield of 7.5%. It was most active at 45 degrees C, pH 9.0, with casein as substrate. It was strongly activated by metal ions such as Ca2+, Mg2+, and Mn2+. Enzyme activity was inhibited strongly by phenylmethyl sulphonyl fluoride (PMSF) but was not inhibited by ethylene diamine tetra acetic acid (EDTA), while a slight inhibition was observed with beta-mercaptoethanol (beta-ME). The compatibility of the enzyme was studied with commercial and local detergents in the presence of 10 mM CaCl2. The addition of 10 mM CaCl2 individually and in combination, was found to be very effective in improving the enzyme stability. This enzyme improved the cleansing power of various detergents. It removed blood stains completely when used with detergents in the presence of 10 mM CaCl2.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"51 1-4","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29627132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous spectrophotometric determination of Cefpodoxime proxetil and Potassium clavulanate. 同时分光光度法测定头孢泊肟酯和克拉维酸钾。
Hindustan antibiotics bulletin Pub Date : 2009-01-01
Santosh V Gandhi, Upasana P Patil, Neelam G Patil
{"title":"Simultaneous spectrophotometric determination of Cefpodoxime proxetil and Potassium clavulanate.","authors":"Santosh V Gandhi, Upasana P Patil, Neelam G Patil","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two accurate, precise, sensitive and economical procedures for simultaneous estimation of Cefpodoxime proxetil and Potassium clavulanate in tablet dosage form have been developed. The methods employed were absorbance correction method (I) and first order derivative spectroscopic method (II). The first method employs wavelength 288 nm for direct estimation of Cefpodoxime proxetil where Potassium clavulanate shows nil absorbance. Estimation of Potassium clavulanate is carried out after correction for absorbance of Cefpodoxime proxetil at 218 nm. The second method is based on first order derivative spectroscopy. Wavelengths 235.6 nm and 308.2 nm were selected for the estimation of the Potassium clavulanate and Cefpodoxime proxetil, respectively. Both the drugs obey Beer's law in the concentration range 5-50 microg/ml. The results of analysis have been validated statistically and by recovery studies. The percentage assay was found to be 99.54 +/- 0.285 for Cefpodoxime proxetil and 98.53 +/- 0.760 for Potassium clavulanate (Mean +/- SD) by method I and 99.93 +/- 0.270 for Cefpodoxime proxetil and 99.40 +/- 0.723 for Potassium clavulanate (Mean +/- S.D) by method II respectively.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"51 1-4","pages":"24-8"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29627134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overview of clinical studies and liposomal formulations of hamycin. 哈霉素的临床研究和脂质体制剂综述。
Hindustan antibiotics bulletin Pub Date : 2007-02-01
Girish M Bhopale
{"title":"Overview of clinical studies and liposomal formulations of hamycin.","authors":"Girish M Bhopale","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hamycin, an antifungal agent, has been widely used for tropical applications in fungal infections of human. The present article briefly summarises its clinical studies, progress in the development of liposomal formulations and future research strategy in which both the clinicians and the scientists should be interested.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"49-50 1-4","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28545116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation of actinomycetes from various soil samples of Ranchi district (Jharkhand) and studies on their antimicrobial activities. 贾坎德邦兰契地区不同土壤样品中放线菌的分离及其抑菌活性研究。
Hindustan antibiotics bulletin Pub Date : 2007-02-01
Pratyoosh Shukla, Sujay Dutta, Naveen Kango
{"title":"Isolation of actinomycetes from various soil samples of Ranchi district (Jharkhand) and studies on their antimicrobial activities.","authors":"Pratyoosh Shukla,&nbsp;Sujay Dutta,&nbsp;Naveen Kango","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In an effort to study prevalence of antibiotic producing actinomycetes a total of 21 actiomycetes were isolated from 42 soil samples collected from Ranchi District (Jharkhand). These isolates were studied for their cultural, morphological and antagonistic behaviour towards bacteria, yeast and fungi including E. coli, S. aureus, S. typhi, A. niger MTCC 281, A. fumigatus MTCC 3002, S. cerevisiae MTCC 36, R. eutropa MTCC 1285. Cultural characteristics and microscopic features revealed that most of the isolates belonged to genus Streptomyces. Among the test actinomycetes, 12 isolates were found positive for complete or partial inhibition of at least one or more test microorganism. Isolate SD 9 completely inhibited E. coli, S. aureus and S. cerevisiae MTCC 36 while S. typhi was partially inhibited.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"49-50 1-4","pages":"5-9"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28545117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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