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Simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form by spectrophotometry. 分光光度法同时测定胶囊剂型中雷贝拉唑钠和盐酸伊托必利的含量。
Hindustan antibiotics bulletin Pub Date : 2007-02-01
Shweta S Sabnis, Santosh V Gandhi, A R Madgulkar, K G Bothara
{"title":"Simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form by spectrophotometry.","authors":"Shweta S Sabnis,&nbsp;Santosh V Gandhi,&nbsp;A R Madgulkar,&nbsp;K G Bothara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Three methods viz. Absorbance Ratio Method (I), Dual Wavelength Method (II) and First Order Derivative Spectroscopic Method (III) for simultaneous estimation of Rabeprazole sodium and Itopride hydrochloride have been developed. The drugs obey Beer's law in the concentration range 2-20 microg/ml for RAB and 5-75 microg/ml for ITO. The results of analysis of drugs have been validated statistically and by recovery studies.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"49-50 1-4","pages":"34-8"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28546115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of antifungal activity of polyenzyme preparation Candidaseb using in vitro methods. 体外法测定多酶制剂Candidaseb抗真菌活性。
Hindustan antibiotics bulletin Pub Date : 2007-02-01
Anita Joshi, Smita Deshpande, Vaishali Dohe, Shilpa Risbud, Renu Bharadwaj
{"title":"Determination of antifungal activity of polyenzyme preparation Candidaseb using in vitro methods.","authors":"Anita Joshi,&nbsp;Smita Deshpande,&nbsp;Vaishali Dohe,&nbsp;Shilpa Risbud,&nbsp;Renu Bharadwaj","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new polyenzyme formulation 'Candidaseb' was tested for its ability to inhibit clinically important fungi. After its antifungal activity was established, an assay was standardized to determine whether any potentiation effect was possible if Candidaseb was used in conjunction with three standard antifungal agents viz, Amphotericin B, Miconazole and Ketoconazole against 5 clinically significant fungi viz., Candida albicans, Cryptococcus neoformans, Aspergillusniger, Microsporum gypseum and Trichophyton rubrum. A synergistic effect could be established when a combination of Candidaseb and antifungal was used against all 5 pathogenic fungi. A reduction in MIC values of standard drugs could be observed. Also, Miconazole, which had proved ineffective against Candida and Cryptococcus became effective when it was used in combination with Candidaseb indicating a potentiating effect on the drug.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"49-50 1-4","pages":"10-3"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28545119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antidiarrhoeal activity of Acacia nilotica Willd. bark methanol extract. 尼罗卡金合欢的抗腹泻作用。树皮甲醇提取物。
Hindustan antibiotics bulletin Pub Date : 2007-02-01
Ashwini Misar, Rani Bhagat, A M Mujumdar
{"title":"Antidiarrhoeal activity of Acacia nilotica Willd. bark methanol extract.","authors":"Ashwini Misar,&nbsp;Rani Bhagat,&nbsp;A M Mujumdar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Acacia nilotica Willd. Subsp. indica (Family- Mimosaceae) bark is used for treatment of diarrhoea, dysentery, liver disorders, inflammation in ethnomedicinal practices. This bark was undertaken to study antidiarrhoeal activity using suitable battery of test. Bark powder of Acacia nilotica was successively extracted with petroleum ether, methanol and distilled water. Solvents from these extracts were removed under reduced temperature and pressure. Exploratory studies revealed presence of significant antidiarrhoeal activity only to methanol extract of Acacia nilotica (AN). This extract was studied using battery of tests consisting of castor oil and magnesium sulphate induced diarrhoea and barium chloride induced peristalsis using Swiss albino mice and in vitro antimicrobial activity against common micro-organisms causing diarrhoea. This extract showed action against castor oil, magnesium sulphate induced diarrhoea and enteropooling activity due to castor oil treatment as well as on normal as well as barium chloride induced peristalsis of small intestine significantly in mice, so also antimicrobial activity against common pathogens responsible for diarrhoea in vitro. Thus, results of above study are supporting the ethnomedicinal use of Acacia nilotica bark for the treatment of diarrhoea.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"49-50 1-4","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28546112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous estimation of Montelukast sodium and Bambuterol hydrochloride in tablets by spectrophotometry. 分光光度法同时测定片中孟鲁司特钠和盐酸班布特罗的含量。
Hindustan antibiotics bulletin Pub Date : 2007-02-01
R K Nanda, V B Pangarkar, A B Thomas, L P Kothapalli, A A Pawar
{"title":"Simultaneous estimation of Montelukast sodium and Bambuterol hydrochloride in tablets by spectrophotometry.","authors":"R K Nanda,&nbsp;V B Pangarkar,&nbsp;A B Thomas,&nbsp;L P Kothapalli,&nbsp;A A Pawar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two simple, rapid, accurate and precise methods have been developed for simultaneous estimation of Montelukast sodium and Bambuterol hydrochloride from tablet dosage form. In the first method, the first derivative spectrum was determined. Montelukast sodium showed zero crossing point at 209.5 nm and Bambuterol hydrochloride showed zero crossing point at 238.5 nm. The dA/dlambda was measured at 209.5 nm for Bambuterol hydrochloride and 238.5 nm for Montelukast sodium and calibration curves were plotted as dA/dlambda versus concentration respectively. Quantitative determination of Montelukast sodium and Bambuterol hydrochloride in tablets was carried out using calibration curve by interpolation method. In the second method, Multicomponent mode of analysis was used and the measurement of absorbances at two wavelengths, 283.6 nm (lambda-max of MKST) and 211.8 nm (working wavelength selected for BHC) in 95% methanol, was carried out. These methods were validated statistically as per ICH guidelines. The recovery studies confirm the accuracy of the proposed method.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"49-50 1-4","pages":"29-33"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28546113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on formulation development of mouth dissolving tablets of Carvedilol. 卡维地洛口腔溶片的处方研究。
Hindustan antibiotics bulletin Pub Date : 2007-02-01
Varsha Pokharkar, Sheetal Dhar, Leenata Mandpe
{"title":"Studies on formulation development of mouth dissolving tablets of Carvedilol.","authors":"Varsha Pokharkar,&nbsp;Sheetal Dhar,&nbsp;Leenata Mandpe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Carvedilol a poorly water soluble drug undergoes extensive first pass metabolism, which reduces its bioavailability to 25-30%. Mouth dissolving tablets of Carvedilol were prepared with the purpose of delivering the drug directly into the systemic circulation and bypassing the hepatic first pass metabolism with a concomitant increase in bioavailability. The solubility of Carvedilol was improved by forming inclusion complex with cyclodextrin which was then further used for the formulation of mouth dissolving tablet. Differential scanning calorimetry and Infrared spectroscopy results indicated no incompatibilities between drug-excipient mixtures. Effect of three different superdisintegrants on disintegration was studied. The formulations were evaluated for drug content, content uniformity, friability, disintegration time and in-vitro dissolution. Tablets containing Carvedilol-beta-cyclodextrin complex exhibited good tablet properties, with 90% drug dissolved within 5 min. This demonstrated the effectiveness of using various superdisintegrants and Carvedilol-beta-cyclodextrin complex in formulation of mouth dissolving tablet.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"49-50 1-4","pages":"21-8"},"PeriodicalIF":0.0,"publicationDate":"2007-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28546116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological control of dermatophytic fungus Trichophyton species by Bacillus subtilis. 枯草芽孢杆菌对皮肤真菌毛癣菌的生物防治。
Hindustan antibiotics bulletin Pub Date : 2005-02-01
Ajay Kumar, Pragati Saini, J N Shrivastava
{"title":"Biological control of dermatophytic fungus Trichophyton species by Bacillus subtilis.","authors":"Ajay Kumar,&nbsp;Pragati Saini,&nbsp;J N Shrivastava","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A potent Bacillus subtilis-2 isolated from soil samples, showed 14 mm inhibition zone by spot inoculation method and 22 mm inhibition zone by well agar diffusion method against pathogenic test fungii. i.e. Trichophyton species. Among four media tested, the maximum growth and antibiotic production was found in trypticase soya broth (TSB) medium at 37 degrees C, pH 7 and 48 hrs of incubation. The MIC of antifungal substance was 35 microl/ml. The isolated Bacillus subtilis -2 has strong antifungal activity against dermatophytic fungi Trichophyton sp. and requires chemical characterization for its bioactive principle.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"47-48 1-4","pages":"36-40"},"PeriodicalIF":0.0,"publicationDate":"2005-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27592055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of myoinositol on sporangiospore-yeast transformation of Mucor circinelloides Tieghem cultivated in synthetic broth. 肌醇对合成肉汤培养的环状毛霉孢子-酵母转化的影响。
Hindustan antibiotics bulletin Pub Date : 2005-02-01
C O Omoifo, M B Aruna, I B Omamor
{"title":"Effect of myoinositol on sporangiospore-yeast transformation of Mucor circinelloides Tieghem cultivated in synthetic broth.","authors":"C O Omoifo,&nbsp;M B Aruna,&nbsp;I B Omamor","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mucor species exhibit fungal dimorphism in controlled environments. In this work, we examined the effect of myoinositol supplementation on the growth and morphology of Mucor circinelloides. Using sporangiospores as inoculums, diverse morphologies were induced in synthetic broth incubated at pH 4.5, temp. 20 degrees C, ambient. The morphologies included thallic suptypes (holoblastic-, holothallic-, enterothallic conidia as well as vesicular conidial headgroups), which were determinate in growth, and proliferating yeast forms. Analysis of variance, p<0.05, showed that time had significant impact on growth. A separation of means, l.s.d. 14.34, p<0.05, indicated that myoinositol supplementation at 500 microM supported the least growth, but 2.0-3.0 mM levels had the higher values, and this was followed by the control, 300 microM, 1.0, 2.0, 5.0 mM supplementations. Although the predominant morphology, that is, terminal budding yeast cells was not quantitated, observation showed that it was more preponderant, had optimal size and cell shape became more regular at 2.0 mM myoinositol supplementation.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"47-48 1-4","pages":"24-31"},"PeriodicalIF":0.0,"publicationDate":"2005-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27592152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fungitoxicity of some higher plants and synergistic activity of their essential oils against Sclerotium rolfsii sacc. causing foot-rot disease of barley. 一些高等植物的真菌毒力及其精油对罗氏菌核菌的协同作用。引起大麦腐脚病。
Hindustan antibiotics bulletin Pub Date : 2005-02-01
R K Singh
{"title":"Fungitoxicity of some higher plants and synergistic activity of their essential oils against Sclerotium rolfsii sacc. causing foot-rot disease of barley.","authors":"R K Singh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twenty five plant species were screened for their volatile components against hyphal growth and sclerotia formation of Sclerotium rolfsii causing foot rot disease of barley (Hordeum vulgare). Leaves of Chenopodium ambrosioides (CA), Lippia alba (LA), Azadirachta indica (AI) and Eucalyptus globulus (EG) were found to be strongly toxic. Their volatile active factors were isolated in the form of essential oils which were tested for toxicity individually and in six combinations (1:1 v/v) viz. CA-LA, LA-AI, CA-AI, CA-EG, and EG-AI. The oil combinations were found to be more fungitoxic than the individual oils. The CA-LA, LA-AI, EG-AI, and CA-EG combinations exhibited a broad fnngitoxic spectrum while CA-AI, LA-EG combinations possessed a narrow range of toxicity. None of the six oil combinations showed phytotoxic behaviour on seed germination, seedling growth and general morphology of Hordeum vulgare.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"47-48 1-4","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2005-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27592059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of crude sesquiterpenoid extract of Phellinus fastuosus as a natural preservative. 白葡萄倍半萜粗提取物作为天然防腐剂的评价。
Hindustan antibiotics bulletin Pub Date : 2005-02-01
Asghar Sharifi, S R Bhosle, J G Vaidya
{"title":"Evaluation of crude sesquiterpenoid extract of Phellinus fastuosus as a natural preservative.","authors":"Asghar Sharifi,&nbsp;S R Bhosle,&nbsp;J G Vaidya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It has been revealed that the use of synthetic food preservatives has variety of various side effects and hence search of safe and effective natural preservative has become a need. With the afore said objective the present study to screen the possibility of using sesquiterpenoid extract of local folk mushroom Phellinus fastuosus as food preservative was undertaken. Microbial growth inhibition by sesquiterpenoid extract of Phellinus was evaluated in the media with natural ingredient such as milk agar (MA), tomato juice agar (TJA), wheat flour agar (WFA) and pineapple juice agar (PAJA) with the composition with Phellinus extract, sodium benzoate and combinations. Three strains of bacteria and one strain of fungus were used astest organisms. The sesquiterpenoid extract of Phellinus at 0.02% concentration significantly inhibited the growth of all test organisms on natural media and the results were comparable with sodium benzoate. Similarly combination of Phellinus extract and sodium benzoate completely inhibited the growth of all microorganisms in all media, suggesting the possibility of using the Phellinus extract as food preservative.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"47-48 1-4","pages":"20-3"},"PeriodicalIF":0.0,"publicationDate":"2005-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27592153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resolution of DL-Phenylglycine by Penicillin G acylase. 青霉素G酰化酶拆分dl -苯甘氨酸。
Hindustan antibiotics bulletin Pub Date : 2005-02-01
R S Kulkarni, U R Kalkote
{"title":"Resolution of DL-Phenylglycine by Penicillin G acylase.","authors":"R S Kulkarni,&nbsp;U R Kalkote","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The parameters for complete hydrolysis of L-phenyl acetyl phenylglycine (L-PAPG) using immobilized penicillin G acylase (IMEPGA) were investigated. IMEPGA exhibited maximum activity at pH 8.5 and 50 degrees C. The apparent Km value observed was 10 mM. Quantitative hydrolysis (>97%) of the L-PAPG was achieved within 45 min, at pH 7.8 and 37 degrees C, when 0.5% (w/v) of DL-PAPG was used and the concentration of IMEPGA was 133 IU/gm of DL-PAPG. The IMEPGA was used for 50 cycles.</p>","PeriodicalId":12923,"journal":{"name":"Hindustan antibiotics bulletin","volume":"47-48 1-4","pages":"41-4"},"PeriodicalIF":0.0,"publicationDate":"2005-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27592057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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