Simultaneous estimation of Montelukast sodium and Bambuterol hydrochloride in tablets by spectrophotometry.

Hindustan antibiotics bulletin Pub Date : 2007-02-01
R K Nanda, V B Pangarkar, A B Thomas, L P Kothapalli, A A Pawar
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Abstract

Two simple, rapid, accurate and precise methods have been developed for simultaneous estimation of Montelukast sodium and Bambuterol hydrochloride from tablet dosage form. In the first method, the first derivative spectrum was determined. Montelukast sodium showed zero crossing point at 209.5 nm and Bambuterol hydrochloride showed zero crossing point at 238.5 nm. The dA/dlambda was measured at 209.5 nm for Bambuterol hydrochloride and 238.5 nm for Montelukast sodium and calibration curves were plotted as dA/dlambda versus concentration respectively. Quantitative determination of Montelukast sodium and Bambuterol hydrochloride in tablets was carried out using calibration curve by interpolation method. In the second method, Multicomponent mode of analysis was used and the measurement of absorbances at two wavelengths, 283.6 nm (lambda-max of MKST) and 211.8 nm (working wavelength selected for BHC) in 95% methanol, was carried out. These methods were validated statistically as per ICH guidelines. The recovery studies confirm the accuracy of the proposed method.

分光光度法同时测定片中孟鲁司特钠和盐酸班布特罗的含量。
建立了两种简便、快速、准确、精密度高的同时测定片剂剂型中孟鲁司特钠和盐酸班布特罗含量的方法。在第一种方法中,确定了一阶导数谱。孟鲁司特钠在209.5 nm处出现零交叉点,盐酸班布特罗在238.5 nm处出现零交叉点。盐酸班布特罗在209.5 nm处测定dA/dlambda,孟鲁司特钠在238.5 nm处测定dA/dlambda,分别绘制dA/dlambda随浓度的曲线。采用校准曲线插值法对孟鲁司特钠和盐酸班布特罗片剂的含量进行了定量测定。第二种方法采用多组分分析模式,在95%甲醇中测量283.6 nm (MKST的λ -max)和211.8 nm (BHC选择的工作波长)两个波长的吸光度。根据ICH指南对这些方法进行了统计验证。回收率研究证实了该方法的准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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