Sensitivity of ornithophillic fungi to some drugs.

Hindustan antibiotics bulletin Pub Date : 2002-02-01
Avni Patel, S C Agrawal
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Abstract

The occurrence of ornithophillic fungi and related dermatophytes was evaluated from the poultry farm soil samples. Two test species of Microsporum were tested by 'Spore germination' and 'Disc diffusion method' against the two well known antifungal antibiotics i.e. griseofulvin and mycostatin (polyene antibiotic). The data showed cent percent inhibition of fungal spore germination and increased zone of inhibition at higher doses. The antimicrobial drugs including acetyl salicylic acid, benzoic acid and boric acid were also assessed at different doses against the test organisms. Acetyl salicylic acid and boric acid were found to be toxic at higher doses, while these pathogens seems to be somewhat resistant for benzoic acid. It is suggested that the effective doses of these drugs should also be tried for allergic effects on birds and other animals before commercial use.

嗜鸟真菌对某些药物的敏感性。
对禽场土壤样品中嗜鸟真菌及相关皮肤真菌的发生情况进行了评价。采用“孢子萌发法”和“圆盘扩散法”对两种常用的抗真菌抗生素灰黄霉素和真菌抑菌素(多烯抗生素)进行了试验。数据显示,在较高的剂量下,真菌孢子萌发的抑制率为100%,抑制范围增大。并对不同剂量的乙酰水杨酸、苯甲酸和硼酸等抗菌药物对试验菌的作用进行了评价。乙酰水杨酸和硼酸在高剂量时被发现是有毒的,而这些病原体似乎对苯甲酸有一定的抗性。建议在商业使用之前,还应试验这些药物的有效剂量对鸟类和其他动物的过敏作用。
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