Heterocyclic Communications最新文献_第5页

Synergistic promoting effect of ball milling and Fe(ii) catalysis for cross-dehydrogenative-coupling of 1,4-benzoxazinones with indoles 球磨和Fe（ii）催化对1,4-苯并恶嗪酮与吲哚交叉脱氢偶联的协同促进作用

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2021-01-01 DOI: 10.1515/hc-2020-0123

A. Sharifi, Zahra Babaalian, M. S. Abaee, M. Moazami, M. Mirzaei

引用次数: 1

One-pot synthesis of benzofurans via heteroannulation of benzoquinones 苯并醌杂环化一锅法合成苯并呋喃

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2021-01-01 DOI: 10.1515/hc-2020-0120

M. Pirouz, M. Saeed Abaee, P. Harris, M. M. Mojtahedi

引用次数: 2

Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase 新型噻唑-磺酰胺衍生物通过抑制醛糖还原酶对Wistar大鼠糖尿病性白内障的保护作用的设计与研制

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2021-01-01 DOI: 10.1515/hc-2020-0124

L. Yin, Mingxue Zhang, Tian-geng He

引用次数: 1

Organic electrochemistry: Synthesis and functionalization of β-lactams in the twenty-first century 有机电化学:21世纪β-内酰胺类化合物的合成与功能化

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2021-01-01 DOI: 10.1515/hc-2020-0121

Martina Bortolami, I. Chiarotto, L. Mattiello, R. Petrucci, D. Rocco, Fabrizio Vetica, M. Feroci

{"title":"Organic electrochemistry: Synthesis and functionalization of β-lactams in the twenty-first century","authors":"Martina Bortolami, I. Chiarotto, L. Mattiello, R. Petrucci, D. Rocco, Fabrizio Vetica, M. Feroci","doi":"10.1515/hc-2020-0121","DOIUrl":"https://doi.org/10.1515/hc-2020-0121","url":null,"abstract":"Abstract Organic electrochemistry is a technique that allows for the heterogeneous redox reactions avoiding both the use of stoichiometric amounts of redox reagents and the resulting formation of stoichiometric by-products. In fact, the redox reagent in these reactions is the electron, which is naturally eco-friendly and produces no side compounds. It is therefore quite obvious that electrochemistry can be classified as a “green” technology. The use of this methodology in the synthesis of β-lactams is not a novelty, but the growing interest in this class of biologically active compounds, due to the discovery of new fields of application (after a moment of decrease in interest due to antibiotic resistance) has been a stimulus for the search for more efficient electrochemical ways to synthesize and transform β-lactams. Thus, this review deals with the twenty-first-century applications of electroorganic technique to the chemistry of β-lactams, by analyzing first the syntheses classified by the type of reactions (cyclization, cycloaddition, etc.) and then by manipulating the β-lactam structure, using it as a synthon. Lastly, the importance of this technique is demonstrated by a study of a pilot plant scale reduction of a cephalosporanic acid derivative to a commercially important antibiotic.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"27 1","pages":"32 - 44"},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/hc-2020-0121","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45780672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Synthesis, characteristic fragmentation patterns, and antibacterial activity of new azo compounds from the coupling reaction of diazobenzothiazole ions and acetaminophen 重氮苯并噻唑离子与对乙酰氨基酚偶联反应新偶氮化合物的合成、断裂模式特征及抗菌活性

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2021-01-01 DOI: 10.1515/hc-2020-0127

Joseph Tsemeugne, P. K. Nangmo, P. Mkounga, J. Tamokou, Iréne Chinda Kengne, G. Edwards, Emmanuel F Sopbue, A. Nkengfack

{"title":"Synthesis, characteristic fragmentation patterns, and antibacterial activity of new azo compounds from the coupling reaction of diazobenzothiazole ions and acetaminophen","authors":"Joseph Tsemeugne, P. K. Nangmo, P. Mkounga, J. Tamokou, Iréne Chinda Kengne, G. Edwards, Emmanuel F Sopbue, A. Nkengfack","doi":"10.1515/hc-2020-0127","DOIUrl":"https://doi.org/10.1515/hc-2020-0127","url":null,"abstract":"Abstract In this study, a series of azobenzothiazole dyes 4 were synthesized via diazotization of substituted benzothiazole derivatives followed by azo coupling with acetaminophen. The chemical structures of all synthesized compounds were confirmed using analytical data and spectroscopic techniques, including UV-visible, IR, mass spectra, and 1H- and 13C-NMR. The in situ formed diazobenzothiazole ions regiospecifically react with acetaminophen derivatives in the Hollemann-guided electrophilic aromatic substitution mechanism. The regio-orientations were established, on the one hand, by a rigorous interpretation of 1H-NMR spectra and, on the other hand, by the characteristic fragmentation patterns observed on the electrospray mass spectra. In the cases of 4a and 4b, multisubstitutions occurred. The antimicrobial activity of compound 4, along with all the starting materials, was investigated on Pseudomonas aeruginosa PA01, Staphylococcus aureus 18, Escherichia coli 64R, and S. aureus ATCC 25923. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The most active antibacterial agent against both targeted organisms was compound 4a′.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"27 1","pages":"79 - 89"},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43763014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Quantum chemistry study on the promoted reactivity of substituted cyclooctynes in bioorthogonal cycloaddition reactions 取代环辛基在生物正交环加成反应中促进反应活性的量子化学研究

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2021-01-01 DOI: 10.1515/hc-2020-0129

T. Hosseinnejad, Marzieh Omrani-Pachin

引用次数: 0

Isatin as a simple, highly selective and sensitive colorimetric sensor for fluoride anion Isatin作为一种简单、高选择性、灵敏的氟离子比色传感器

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2020-01-01 DOI: 10.1515/hc-2020-0003

A. Haider, Mukhtiar Ahmed, M. Faisal, M. Naseer

{"title":"Isatin as a simple, highly selective and sensitive colorimetric sensor for fluoride anion","authors":"A. Haider, Mukhtiar Ahmed, M. Faisal, M. Naseer","doi":"10.1515/hc-2020-0003","DOIUrl":"https://doi.org/10.1515/hc-2020-0003","url":null,"abstract":"Abstract Herein, we report the fluoride anion sensing properties of a commercially available and inexpensive organic compound, isatin, which is found to be a highly selective and sensitive sensor. In naked-eye experiments, by addition of fluoride anions, isatin shows a dramatic color change from pale yellow to violet at room temperature, while the addition of other anions, i.e. C l − , $mathrm{Cl}^-,$ B r − , I − , C l O 4 − , H 2 P O 4 − a n d P F 6 − , $mathrm{Br}^-,mathrm I^-,mathrm{ClO}_4^-,{mathrm H}_2mathrm{PO}_4^-,mathrm{and},mathrm{PF}_6^-,$did not induce any colour change. Additionally, recognition and titration studies have also been done through UV/Vis spectroscopy. Isatin displayed a new absorption band at 533 nm after the addition of fluoride anions, which is presumably due to acid-base interaction between isatin and fluoride anions, while other anions did not trigger noticeable spectral changes. The detection limit was observed to be 0.367 ppm. DFT calculations were also performed to further explain the behavior of receptor 1 towards the Fˉ anion. Owing to high sensitivity and selectivity, isatin can be useful in the detection of biologically or environmentally important fluoride anions at very low concentration.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"26 1","pages":"14 - 19"},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/hc-2020-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45628638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Design, Synthesis and Study of Antibacterial and Antitubercular Activity of Quinoline Hydrazone Hybrids 喹啉腙杂合物的设计、合成及抗菌抗结核活性研究

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2020-01-01 DOI: 10.1515/hc-2020-0109

Shruthi T G, S. Subramanian, S. Eswaran

引用次数: 10

The oxidative coupling between benzaldehyde derivatives and phenylacetylene catalyzed by rhodium complexes via C-H bond activation 铑配合物通过C-H键活化催化苯甲醛衍生物与苯乙炔的氧化偶联

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2020-01-01 DOI: 10.1515/hc-2020-0004

Xinyi Zhao, Hongge Jia, Q. Wang, Heming Song, Yanan Tang, Liqun Ma, Yongqian Shi, Guoxing Yang, Yazhen Wang, Y. Zang, Shuangping Xu

引用次数: 1

Coumarin sulfonamide derivatives: An emerging class of therapeutic agents 香豆素磺酰胺衍生物：一类新兴的治疗剂

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2020-01-01 DOI: 10.1515/hc-2020-0008

Ali Irfan, Laila Rubab, Mishbah Ur Rehman, R. Anjum, S. Ullah, Mahwish Marjana, Saba Qadeer, Sadia Sana

{"title":"Coumarin sulfonamide derivatives: An emerging class of therapeutic agents","authors":"Ali Irfan, Laila Rubab, Mishbah Ur Rehman, R. Anjum, S. Ullah, Mahwish Marjana, Saba Qadeer, Sadia Sana","doi":"10.1515/hc-2020-0008","DOIUrl":"https://doi.org/10.1515/hc-2020-0008","url":null,"abstract":"Abstract Coumarin sulfonamide is a heterocyclic pharmacophore and an important structural motif which is a core and integral part of different therapeutic scaffolds and analogues. Coumarin sulfonamides are privileged and pivotal templates which have a broad spectrum of applications in the fields of medicine, pharmacology and pharmaceutics. Coumarin sulfonamide exhibited versatile and myriad biomedical activities such as anti-bacterial, antiviral, antifungal, anti-inflammatory and anti-cancer. This review article focuses on the structural features of coumarin sulfonamide derivatives in the treatment of different lethal diseases on the basis of structure-activity relationships (SAR). The plethora of research cited in this review article summarizes and discusses the various substitutions around the coumarin sulfonamide nucleus which have provided a wide spectrum of biological activities and therapeutic potential that has proved attractive to many researchers looking to exploit the coumarin sulfonamide skeleton for drug discovery and the development of novel therapeutic agents.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"26 1","pages":"46 - 59"},"PeriodicalIF":2.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/hc-2020-0008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44260994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18