Synergistic promoting effect of ball milling and Fe(ii) catalysis for cross-dehydrogenative-coupling of 1,4-benzoxazinones with indoles

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2021-01-01 DOI:10.1515/hc-2020-0123

A. Sharifi, Zahra Babaalian, M. S. Abaee, M. Moazami, M. Mirzaei

引用次数: 1

Abstract

Abstract In this work, a novel C(sp3)–C(sp2) cross-dehydrogenative-coupling method is developed to react benzoxazin-2-one derivatives with various indoles. As a result, combined use of ball milling and Fe(ii) catalysis leads to rapid coupling of 1,4-benzoxazinones with derivatives of indole. Under the conditions, derivatives of 1 couple with various indoles at room temperature to produce good yields of the desired compounds within 0.5–2 h time period. Thus, derivatives of both starting materials couple smoothly under relatively mild conditions to give good yields of 3.

查看原文本刊更多论文

球磨和Fe（ii）催化对1,4-苯并恶嗪酮与吲哚交叉脱氢偶联的协同促进作用

摘要本工作开发了一种新的C（sp3）–C（sp2）交叉脱氢偶联方法，使苯并恶嗪-2-酮衍生物与各种吲哚反应。因此，球磨和Fe（ii）催化的结合使用导致1,4-苯并恶嗪酮与吲哚衍生物的快速偶联。在这种条件下，1的衍生物在室温下与各种吲哚偶联，在0.5-2范围内产生所需化合物的良好产率 h时间段。因此，两种起始材料的衍生物在相对温和的条件下平稳偶联，得到3的良好产率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.