Heterocyclic Communications最新文献

Synthesis and conformational analysis of N-BOC-protected-3,5-bis(arylidene)-4-piperidone EF-24 analogs as anti-cancer agents n - boc保护的-3,5-双(芳基)-4-哌酮EF-24类似物的合成及构象分析

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2023-01-01 DOI: 10.1515/hc-2022-0162

Robert B. Smith, William Roberts, M. Upenieks, M. Gibson, Michael T. Wentzel, Kyle A. Grice, S. Zingales

引用次数: 0

Crude extract of J1 fermentation promotes apoptosis of cervical cancer cells J1发酵粗提物促进宫颈癌细胞凋亡

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2023-01-01 DOI: 10.1515/hc-2022-0161

Xia Yu, Qing He, W. Zhao, Shuo Zhang, Haixia Du, Zhe-Fu Lin, Xiaojiang Han, Jingjun Peng

{"title":"Crude extract of J1 fermentation promotes apoptosis of cervical cancer cells","authors":"Xia Yu, Qing He, W. Zhao, Shuo Zhang, Haixia Du, Zhe-Fu Lin, Xiaojiang Han, Jingjun Peng","doi":"10.1515/hc-2022-0161","DOIUrl":"https://doi.org/10.1515/hc-2022-0161","url":null,"abstract":"Abstract Cervical cancer is a typical cancer characterized by abnormal cell growth in the cervical area. Ginkgo biloba L. is a deciduous tree of the genus Ginkgo, possessing anti-cancer effects. The aim of this study was to explore the effect of strain J1 from Ginkgo biloba L. on apoptosis of cervical cancer cells. Bacteriostatic activity test, MTT assay and Flow cytometry were used in this study. Crude extract of J1 fermentation reduced cell growth in cervical cancer. The crude extract of the fermentation broth of strain J1 had a good inhibitory effect on Staphylococcus aureus. The crude extract of the J1 fermentation had no toxic effect on normal WISH cells in the range of anti-cervical cancer concentration. Crude extract of J1 fermentation induced apoptosis and regulated cell cycle in cervical cancer. The active compounds were separated and identified by preparative chromatography, and more than ten compounds were obtained. Our study suggests that the crude extract of J1 fermentation from Endophytic fungi of Ginkgo biloba reduced cell growth, and promoted apoptosis of cervical cancer, and is a potential therapeutic strategy for the treatment of cervical carcinoma.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48710607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Design, synthesis, and antiviral activities evaluation of novel quinazoline derivatives containing sulfonamide moiety 新型磺胺类喹唑啉衍生物的设计、合成及抗病毒活性评价

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2023-01-01 DOI: 10.1515/hc-2022-0160

Yixiang Deng, Shitao Yin, Xinyun Jing, Yu-Tao Zheng

引用次数: 0

Preparation of novel acyl pyrazoles and triazoles by means of oxidative functionalization reactions 氧化官能化反应制备新型酰基吡唑和三唑

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2023-01-01 DOI: 10.1515/hc-2022-0158

Geoffrey P Wadey, Katrina E. Doherty, A. Sandoval, N. Leadbeater

引用次数: 0

Design, synthesis, biological evaluation, and bio-computational modeling of imidazo, thieno, pyrimidopyrimidine, pyrimidodiazepene, and motifs as antimicrobial agents 咪唑、噻吩、嘧啶嘧啶、嘧啶二氮杂烯和基序抗菌药物的设计、合成、生物学评价和生物计算建模

3区化学

Heterocyclic Communications Pub Date : 2023-01-01 DOI: 10.1515/hc-2022-0156

Maged F. El-Ahwany, Mohamed G. Assy, Mohamed H. Sherif, Mohamed R. Soliman, Abderrahim Titi, Rachid Touzani, Marwa S. El-Gendey, Wesam S. Shehab, Magda H. Abdellattif

{"title":"Design, synthesis, biological evaluation, and bio-computational modeling of imidazo, thieno, pyrimidopyrimidine, pyrimidodiazepene, and motifs as antimicrobial agents","authors":"Maged F. El-Ahwany, Mohamed G. Assy, Mohamed H. Sherif, Mohamed R. Soliman, Abderrahim Titi, Rachid Touzani, Marwa S. El-Gendey, Wesam S. Shehab, Magda H. Abdellattif","doi":"10.1515/hc-2022-0156","DOIUrl":"https://doi.org/10.1515/hc-2022-0156","url":null,"abstract":"Abstract In the drug chemistry industry, synthesizing a talented exclusive series of aza-polyheterocyclic compounds was crucial. Aminopyrimidine nucleus reacted with two equivalents of benzaldehyde in the presence of KOH as a starting material to bring about imidazopyrimidine derivative, which experienced intermolecular cyclization using carbon disulfide, Br 2 /AcOH, and/or HNO 2 to produce thiazole, thieno, and/or nitro pyrimidine derivative, respectively. Accordingly, the nucleus of Aminopyrimidine was prepared and used to develop the novel polyheterocyclic systems acylated with two moles of succinic anhydride to furnish the imidazolopyrimidine derivative. Benzylidene ethyl cyanoacetate and aminopyrimidine undergo (3 + 4) intermolecular cycloaddition 1,3 H shift followed by hydrolysis and after CO 2 evolution provided diazepine derivative. The diazepine derivative was attained due to the cyclo-condensation of the starting material and acetylacetone. Moreover, the structure of the novel synthesized compound series was exploited and verified via spectroscopic approaches. The synthesized series were tested for antimicrobial activity against gram-positive and gram-negative bacterial strains and antifungal activity. The thienopyrimidine derivatives and diazepine exhibited unusual antimicrobial activity. Furthermore, the molecular docking studies confirmed the biological studies with Molecular Operating Environment and petro orisis molinspiration studies, which proved the activity of compounds 4, 5, 7, 10, 13 , and 16 .","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135102658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of a novel phosphate-containing ligand rhodium catalyst and exploration of its optimal reaction conditions and mechanism for the polymerization of phenylacetylene 一种新型含磷酸盐配体铑催化剂的合成及其聚合苯乙炔的最佳反应条件和机理的探索

3区化学

Heterocyclic Communications Pub Date : 2023-01-01 DOI: 10.1515/hc-2022-0163

Mingyu Zhang, Yuqi Tang, Rui Xu, Dong Yan, Shuangping Xu, Yanqing Qu, Jingyu Xu, Hongge Jia

{"title":"Synthesis of a novel phosphate-containing ligand rhodium catalyst and exploration of its optimal reaction conditions and mechanism for the polymerization of phenylacetylene","authors":"Mingyu Zhang, Yuqi Tang, Rui Xu, Dong Yan, Shuangping Xu, Yanqing Qu, Jingyu Xu, Hongge Jia","doi":"10.1515/hc-2022-0163","DOIUrl":"https://doi.org/10.1515/hc-2022-0163","url":null,"abstract":"Abstract Due to the chemical properties of Group VIII transition metals and their importance in catalytic processes, the reactions of rhodium and its neighboring organic complexes have received much attention as model systems. In the present experiments, we successfully prepared two new rhodium complexes named [Rh(cod)(TTP)Cl] and [Rh(cod)(CDP)Cl] using tri( o -tolyl)phosphine and clohexyldiphenylphosphine as ligands, respectively, and the proofs of their structures were completed using 1 H NMR and 13 C NMR. Subsequently, it was applied to the polymerization reaction of phenylacetylene (PA), and the effects of different solvents, time, and temperature on the yield and molecular weight of the polymerization reaction products were discussed. The experimental results show that both complexes can play a catalytic role in the polymerization of PA. From the point of view of polymer molecular weight, the best reaction conditions for both catalysts were 3 h at 20°C in THF solvent (molecular weight up to 2.40 × 10 5 ). From the point of view of yield, the best reaction conditions for both catalysts were 4 h at 35°C in THF solvent (yield up to 89.2%).","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135498094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis, and anticancer activity of novel 4,6-dimorpholinyl-1,3,5-triazine compounds 新型4,6-二吗啉-1,3,5-三嗪类化合物的设计、合成及其抗癌活性

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2023-01-01 DOI: 10.1515/hc-2022-0152

Jinjing Li, Linbo Li, Yuxiao Liu, Jie Zhang, Cheng Shi, Shujing Zhou, Hongbin Qiu

{"title":"Design, synthesis, and anticancer activity of novel 4,6-dimorpholinyl-1,3,5-triazine compounds","authors":"Jinjing Li, Linbo Li, Yuxiao Liu, Jie Zhang, Cheng Shi, Shujing Zhou, Hongbin Qiu","doi":"10.1515/hc-2022-0152","DOIUrl":"https://doi.org/10.1515/hc-2022-0152","url":null,"abstract":"Abstract A series of novel 4,6-dimorpholinyl-1,3,5-triazine derivatives 6a–6r were obtained through N-substitution and Claisen-Schmidt condensation. 1H NMR, 13C NMR, and mass spectrometry were used to characterize the molecular structures of the derivatives. The in vitro antiproliferation activity of derivatives was evaluated using the MTT assay against SW620 (human colon cancer cells), A549 (human nonsmall cell lung cancer cells), HeLa (human cervical cancer cells), and MCF-7 (human breast cancer cells). Compound 6o bearing a pyridyl group exhibited good cytotoxicity against four cancer cells, with IC50 values of 8.71, 9.55, 15.67, and 21.77 μM, sequentially. In addition, compound 6a showed some selectivity against SW620. Graphical abstract The chalcone structure was introduced into the 4,6-dimorpholinyl-1,3,5-triazine molecule through the C-N bond, and a series of new compounds were obtained. Among them, the pyridyl-containing 6o exhibits anti-proliferation activity similar to that of cisplatin on SW620. Interestingly, the phenyl-containing 6a exhibits a certain selectivity for the anti-proliferation activity of SW620.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49372391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of octreotide on apoptosis and metabolome expression in lipopolysaccharide-induced A549 cells 奥曲肽对脂多糖诱导的A549细胞凋亡及代谢组表达的影响

IF 2.3 3区化学

Heterocyclic Communications Pub Date : 2023-01-01 DOI: 10.1515/hc-2022-0159

Luoyang Ruan, Xiaomeng Xu, Jinliang Cao, Xiaohong Xu

{"title":"Influence of octreotide on apoptosis and metabolome expression in lipopolysaccharide-induced A549 cells","authors":"Luoyang Ruan, Xiaomeng Xu, Jinliang Cao, Xiaohong Xu","doi":"10.1515/hc-2022-0159","DOIUrl":"https://doi.org/10.1515/hc-2022-0159","url":null,"abstract":"Abstract Lung cancer shows a high rate of incidence and mortality. This study aimed to investigate the influence of octreotide (OCT) on lipopolysaccharide (LPS)-induced apoptosis and metabolome expression in A549 cells. After A549 cells were treated by LPS or co-cultured with LPS and OCT, cell apoptosis was tested by flow cytometry, and gas chromatography-mass spectrometer (GC/MS) and high-performance liquid chromatography-mass spectrometer (LC/MS) were subjected to determine the differently expressed metabolites, and the interaction network was constructed. Results found that OCT promoted the apoptosis of A549 cells and significantly affected LPS-regulated cell apoptosis. Following the further investigation by orthogonal partial least squares discriminant analysis (OPLS-DA), the metabolites with different expression levels were obtained, and most of which belong to amino acids, phospholipids, organic acid, and saccharides. Fourteen components with the role of the marker metabolites included serotonin, indole, threonine, serine, glucose, phenylalanine, lactose, fumarate, 4-hydroxyphenyllactate, aspartate, asparagine, putrescine, proline, and succinate. It is indicated that OCT promotes apoptosis through five metabolism pathways and 14 key metabolism elements in A549 cells.","PeriodicalId":12914,"journal":{"name":"Heterocyclic Communications","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42898801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis, and antiproliferative activity of novel 1,2,4-triazole-chalcone compounds 新型1,2,4-三唑-查尔酮化合物的设计、合成及其抗增殖活性

3区化学

Heterocyclic Communications Pub Date : 2023-01-01 DOI: 10.1515/hc-2022-0165

Jinjing Li, Pingping Fan, Yuxiao Liu, Yan Zhao, Chengyang Shi, Shujing Zhou, Hongbin Qiu

引用次数: 0

Synthesis of metal–organic nanofiber/rGO nanocomposite as the sensing element for electrochemical determination of hypoxanthine 金属-有机纳米纤维/氧化石墨烯纳米复合材料电化学测定次黄嘌呤传感元件的合成

3区化学

Heterocyclic Communications Pub Date : 2023-01-01 DOI: 10.1515/hc-2022-0166

Zhili Fang, Hui Zhang, Ping Wang, Xiaoguang Li, Qixiang Nie

引用次数: 0