氧化官能化反应制备新型酰基吡唑和三唑

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2023-01-01 DOI:10.1515/hc-2022-0158

Geoffrey P Wadey, Katrina E. Doherty, A. Sandoval, N. Leadbeater

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引用次数: 0

摘要

摘要在必需的唑的存在下，通过醛的氧化酰胺化反应制备了新的酰基吡唑和酰基三唑。在这两种情况下，产率范围从中等到良好，并且发现了衬底范围的一些限制。以硝酸钾为负离子的氧铵盐为原料，用乙醛和吡唑的混合物制备酰基吡唑。在酰基三唑的情况下，氧化功能化是使用过硫酸钠作为终端氧化剂，在催化量的氮氧化物存在下进行的。

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Preparation of novel acyl pyrazoles and triazoles by means of oxidative functionalization reactions

Abstract Novel acyl pyrazoles and acyl triazoles have been prepared by means of the oxidative amidation of aldehydes in the presence of the requisite azole. Yields range from modest to good in both cases, and some limitations of the substrate scope have been discovered. Acyl pyrazoles were prepared by treatment of a mixture of aldehyde and pyrazole with an oxoammonium salt bearing the nitrate anion. In the case of acyl triazoles, the oxidative functionalization was performed using sodium persulfate as a terminal oxidant in the presence of a catalytic quantity of a nitroxide.

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.