Design, Synthesis and Study of Antibacterial and Antitubercular Activity of Quinoline Hydrazone Hybrids

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2020-01-01 DOI:10.1515/hc-2020-0109

Shruthi T G, S. Subramanian, S. Eswaran

引用次数: 10

Abstract

Abstract Emerging bacterial resistance is causing widespread problems for the treatment of various infections. Therefore, the search for antimicrobials is a never-ending task. Hydrazones and quinolines possess a wide variety of biological activities. Herewith, eleven quinoline hydrazone derivatives have been designed, synthesized, characterized and evaluated for their antibacterial activity and antitubercular potential against Mtb WT H37Rv. Compounds QH-02, QH-04 and QH-05 were found to be promising compounds with an MIC value of 4 μg/mL against Mtb WT H37Rv. Compounds QH-02, QH-04, QH-05, and QH-11 were also found to be active against bacterial strains including Acinetobacter baumanii, Escherichia coli and Staphylococcus aureus. Further, we have carried out experiments to confirm the cytotoxicity of the active compounds and found them to be non-toxic.

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喹啉腙杂合物的设计、合成及抗菌抗结核活性研究

摘要新出现的细菌耐药性在治疗各种感染方面引起了广泛的问题。因此，寻找抗菌药物是一项永无止境的任务。腙和喹啉具有多种多样的生物活性。据此，设计、合成、表征并评价了11种喹啉腙衍生物对Mtb WT H37Rv的抗菌活性和抗结核潜力。发现化合物QH-02、QH-04和QH-05是有前景的化合物，其对Mtb WT H37Rv的MIC值为4μg/mL。还发现化合物QH-02、QH-04、QH-05和QH-11对包括鲍曼不动杆菌、大肠杆菌和金黄色葡萄球菌在内的细菌菌株具有活性。此外，我们进行了实验来证实活性化合物的细胞毒性，并发现它们是无毒的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.