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Gut Microbes最新文献

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Normalization of short-chain fatty acid concentration by bacterial count of stool samples improves discrimination between eubiotic and dysbiotic gut microbiota caused by Clostridioides difficile infection. 通过粪便样本细菌计数对短链脂肪酸浓度进行归一化处理，可提高对艰难梭菌感染引起的优生和菌群失调肠道微生物群的鉴别能力。
IF 12.2 1区 医学
Gut Microbes Pub Date : 2024-10-12 DOI: 10.1080/19490976.2024.2415488
Anna Sayol-Altarriba,Andrea Aira,Anna Villasante,Rosa Albarracín,Joana Faneca,Gregori Casals,José Luis Villanueva-Cañas,Climent Casals-Pascual
{"title":"Normalization of short-chain fatty acid concentration by bacterial count of stool samples improves discrimination between eubiotic and dysbiotic gut microbiota caused by Clostridioides difficile infection.","authors":"Anna Sayol-Altarriba,Andrea Aira,Anna Villasante,Rosa Albarracín,Joana Faneca,Gregori Casals,José Luis Villanueva-Cañas,Climent Casals-Pascual","doi":"10.1080/19490976.2024.2415488","DOIUrl":"https://doi.org/10.1080/19490976.2024.2415488","url":null,"abstract":"Short-chain fatty acids (SCFAs) represent a cornerstone of gut health, serving as critical mediators of immune modulation and overall host homeostasis. Patients with dysbiosis caused by Clostridioides difficile infection (CDI) typically exhibit lower SCFAs levels compared to healthy stool donors and, thus, the concentration of SCFAs has been proposed as a proxy marker of a healthy microbiota. However, there is no consistency in the methods used to quantify SCFAs in stool samples and usually, the results are normalized by the weight of the stool samples, which does not address differences in water and fiber content and ignores bacterial counts in the sample (the main component of stool that contributes to the composition of these metabolites in the sample). Here, we show that normalized SCFAs concentrations by the bacterial count improve discrimination between healthy and dysbiotic samples (patients with CDI), particularly when using acetate and propionate levels. After normalization, butyrate is the metabolite that best discriminates eubiotic and dysbiotic samples according to the area under the receiver operating characteristic (ROC) curve (AUC-ROC = 0.860, [95% CI: 0.786-0.934], p < .0001).","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"33 1","pages":"2415488"},"PeriodicalIF":12.2,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiome's role in musculoskeletal health through the gut-bone axis insights. 通过肠道-骨骼轴洞察微生物组在肌肉骨骼健康中的作用。
IF 12.2 1区 医学
Gut Microbes Pub Date : 2024-10-10 DOI: 10.1080/19490976.2024.2410478
Zhengrui Li,Qi Wang,Xufeng Huang,Yinteng Wu,Dan Shan
{"title":"Microbiome's role in musculoskeletal health through the gut-bone axis insights.","authors":"Zhengrui Li,Qi Wang,Xufeng Huang,Yinteng Wu,Dan Shan","doi":"10.1080/19490976.2024.2410478","DOIUrl":"https://doi.org/10.1080/19490976.2024.2410478","url":null,"abstract":"The interplay between the human microbiome and the musculoskeletal system represents a burgeoning field of research with profound implications for understanding and treating musculoskeletal disorders. This review articulates the pivotal role of the microbiome in modulating bone health, highlighting the gut-bone axis as a critical nexus for potential therapeutic intervention. Through a meticulous analysis of recent clinical research, we underscore the microbiome's influence on osteoporosis, sarcopenia, osteoarthritis, and rheumatoid arthritis, delineating both the direct and indirect mechanisms by which microbiota could impact musculoskeletal integrity and function. Our investigation reveals novel insights into the microbiota's contribution to bone density regulation, hormone production, immune modulation, and nutrient absorption, laying the groundwork for innovative microbiome-based strategies in musculoskeletal disease management. Significantly, we identify the challenges hindering the translation of research into clinical practice, including the limitations of current microbial sequencing techniques and the need for standardized methodologies in microbiome studies. Furthermore, we highlight promising directions for future research, particularly in the realm of personalized medicine, where the microbiome's variability offers unique opportunities for tailored treatment approaches. This review sets a new agenda for leveraging gut microbiota in the diagnosis, prevention, and treatment of musculoskeletal conditions, marking a pivotal step toward integrating microbiome science into clinical musculoskeletal care.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"23 1","pages":"2410478"},"PeriodicalIF":12.2,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142436108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiome therapy: fecal microbiota transplantation vs live biotherapeutic products. 肠道微生物群疗法：粪便微生物群移植与活体生物治疗产品。
IF 12.2 1区 医学
Gut Microbes Pub Date : 2024-10-08 DOI: 10.1080/19490976.2024.2412376
Do-Yeon Kim,So-Yeon Lee,Jae-Yun Lee,Tae Woong Whon,June-Young Lee,Che Ok Jeon,Jin-Woo Bae
{"title":"Gut microbiome therapy: fecal microbiota transplantation vs live biotherapeutic products.","authors":"Do-Yeon Kim,So-Yeon Lee,Jae-Yun Lee,Tae Woong Whon,June-Young Lee,Che Ok Jeon,Jin-Woo Bae","doi":"10.1080/19490976.2024.2412376","DOIUrl":"https://doi.org/10.1080/19490976.2024.2412376","url":null,"abstract":"The human intestine hosts a complex ecosystem of various microorganisms, collectively known as the gut microbiome, which significantly impacts human health. Disruptions in the gut microbiome are linked to various disorders, including gastrointestinal diseases, such as Clostridioides difficile infection and inflammatory bowel disease, as well as metabolic, neurological, oncologic conditions. Fecal microbiota transplantation (FMT) and live biotherapeutic products (LBPs) have emerged as prospective therapeutic procedures to restore microbial and metabolic balance in the gut. This review assesses the latest advancements, challenges, and therapeutic efficacy of FMT and LBPs, highlighting the need for standardization, safety, and long-term evaluation to optimize their clinical application.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"20 1","pages":"2412376"},"PeriodicalIF":12.2,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142385144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of the duodenojejunal microbiome with the oral and fecal microbiomes reveals its stronger association with obesity and nutrition 十二指肠空肠微生物组与口腔和粪便微生物组的比较分析表明，十二指肠空肠微生物组与肥胖和营养的关系更为密切
IF 12.2 1区 医学
Gut Microbes Pub Date : 2024-10-07 DOI: 10.1080/19490976.2024.2405547
Emilie Steinbach, Eugeni Belda, Rohia Alili, Solia Adriouch, Charlène J. G. Dauriat, Gianfranco Donatelli, Jean-Loup Dumont, Filippo Pacini, Thierry Tuszynski, Véronique Pelloux, Flavien Jacques, Laura Creusot, Emavieve Coles, Paul Taillandier, Marta Vazquez Gomez, Davide Masi, Véronique Mateo, Sébastien André, Melissa Kordahi, Christine Rouault, Jean-Daniel Zucker, Harry Sokol, Laurent Genser, Benoit Chassaing, Tiphaine Le Roy, Karine Clément
{"title":"Comparative analysis of the duodenojejunal microbiome with the oral and fecal microbiomes reveals its stronger association with obesity and nutrition","authors":"Emilie Steinbach, Eugeni Belda, Rohia Alili, Solia Adriouch, Charlène J. G. Dauriat, Gianfranco Donatelli, Jean-Loup Dumont, Filippo Pacini, Thierry Tuszynski, Véronique Pelloux, Flavien Jacques, Laura Creusot, Emavieve Coles, Paul Taillandier, Marta Vazquez Gomez, Davide Masi, Véronique Mateo, Sébastien André, Melissa Kordahi, Christine Rouault, Jean-Daniel Zucker, Harry Sokol, Laurent Genser, Benoit Chassaing, Tiphaine Le Roy, Karine Clément","doi":"10.1080/19490976.2024.2405547","DOIUrl":"https://doi.org/10.1080/19490976.2024.2405547","url":null,"abstract":"The intestinal microbiota is increasingly recognized as a crucial player in the development and maintenance of various chronic conditions, including obesity and associated metabolic diseases. While...","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"55 1","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142383806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial extracellular vesicles at the interface of gut microbiota and immunity 肠道微生物群与免疫界面上的细菌胞外囊泡
IF 12.2 1区 医学
Gut Microbes Pub Date : 2024-09-28 DOI: 10.1080/19490976.2024.2396494
Inês Melo-Marques, Sandra Morais Cardoso, Nuno Empadinhas
{"title":"Bacterial extracellular vesicles at the interface of gut microbiota and immunity","authors":"Inês Melo-Marques, Sandra Morais Cardoso, Nuno Empadinhas","doi":"10.1080/19490976.2024.2396494","DOIUrl":"https://doi.org/10.1080/19490976.2024.2396494","url":null,"abstract":"Bacterial extracellular vesicles (BEVs) are nano-sized lipid-shielded structures released by bacteria and that play an important role in intercellular communication. Their broad taxonomic origins a...","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"66 1","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142329986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in intestinal permeability and gut microbiota following diet-induced weight loss in patients with metabolic dysfunction-associated steatohepatitis and liver fibrosis 代谢功能障碍相关性脂肪性肝炎和肝纤维化患者节食减肥后肠道通透性和肠道微生物群的变化
IF 12.2 1区 医学
Gut Microbes Pub Date : 2024-09-28 DOI: 10.1080/19490976.2024.2392864
Dimitrios A. Koutoukidis, Sandi Yen, Paula Gomez Castro, Mariya Misheva, Susan A. Jebb, Paul Aveyard, Jeremy W. Tomlinson, Ferenc E. Mozes, Jeremy F. Cobbold, Jethro S. Johnson, Julian R. Marchesi
{"title":"Changes in intestinal permeability and gut microbiota following diet-induced weight loss in patients with metabolic dysfunction-associated steatohepatitis and liver fibrosis","authors":"Dimitrios A. Koutoukidis, Sandi Yen, Paula Gomez Castro, Mariya Misheva, Susan A. Jebb, Paul Aveyard, Jeremy W. Tomlinson, Ferenc E. Mozes, Jeremy F. Cobbold, Jethro S. Johnson, Julian R. Marchesi","doi":"10.1080/19490976.2024.2392864","DOIUrl":"https://doi.org/10.1080/19490976.2024.2392864","url":null,"abstract":"Weight loss improves metabolic dysfunction-associated steatohepatitis (MASH). We investigated whether there were associated changes in intestinal permeability, short-chain fatty acids (SCFAs), and ...","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"1 1","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142329850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FMT rescues mice from DSS-induced colitis in a STING-dependent manner FMT 以 STING 依赖性方式挽救小鼠免于 DSS 引起的结肠炎
IF 12.2 1区 医学
Gut Microbes Pub Date : 2024-09-26 DOI: 10.1080/19490976.2024.2397879
Dan Pu, Yao Yao, Chuan Zhou, Ruixian Liu, Zhihong Wang, Yan Liu, Dandan Wang, Binbin Wang, Yaohe Wang, Zhanju Liu, Zhe Zhang, Baisui Feng
{"title":"FMT rescues mice from DSS-induced colitis in a STING-dependent manner","authors":"Dan Pu, Yao Yao, Chuan Zhou, Ruixian Liu, Zhihong Wang, Yan Liu, Dandan Wang, Binbin Wang, Yaohe Wang, Zhanju Liu, Zhe Zhang, Baisui Feng","doi":"10.1080/19490976.2024.2397879","DOIUrl":"https://doi.org/10.1080/19490976.2024.2397879","url":null,"abstract":"Fecal microbiota transplantation (FMT) is currently a promising therapy for inflammatory bowel disease (IBD). However, clinical studies have shown that there is an obvious individual difference in ...","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"33 1","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142321377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice. 雌性小鼠肠道 deguelin 对乙酰氨基酚诱导的肝毒性具有抗性。
IF 12.2 1区 医学
Gut Microbes Pub Date : 2024-09-21 DOI: 10.1080/19490976.2024.2404138
Shenhai Gong,Yunong Zeng,Ze Wang,Yanru Li,Rong Wu,Lei Li,Hongbin Hu,Ping Qin,Zhichao Yu,Xintao Huang,Peiheng Guo,Hong Yang,Yi He,Zhibin Zhao,Weidong Xiao,Xiaoshan Zhao,Lei Gao,Shumin Cai,Zhenhua Zeng
{"title":"Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice.","authors":"Shenhai Gong,Yunong Zeng,Ze Wang,Yanru Li,Rong Wu,Lei Li,Hongbin Hu,Ping Qin,Zhichao Yu,Xintao Huang,Peiheng Guo,Hong Yang,Yi He,Zhibin Zhao,Weidong Xiao,Xiaoshan Zhao,Lei Gao,Shumin Cai,Zhenhua Zeng","doi":"10.1080/19490976.2024.2404138","DOIUrl":"https://doi.org/10.1080/19490976.2024.2404138","url":null,"abstract":"Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI), with gender-specific differences in susceptibility. However, the mechanism underlying this phenomenon remains unclear. Our study reveals that the gender-specific differences in susceptibility to APAP-induced hepatotoxicity are due to differences in the gut microbiota. Through microbial multi-omics and cultivation, we observed increased gut microbiota-derived deguelin content in both women and female mice. Administration of deguelin was capable of alleviating hepatotoxicity in APAP-treated male mice, and this protective effect was associated with the inhibition of hepatocyte oxidative stress. Mechanistically, deguelin reduced the expression of thyrotropin receptor (TSHR) in hepatocytes with APAP treatment through direct interaction. Pharmacologic suppression of TSHR expression using ML224 significantly increased hepatic glutathione (GSH) in APAP-treated male mice. These findings suggest that gut microbiota-derived deguelin plays a crucial role in reducing APAP-induced hepatotoxicity in female mice, offering new insights into therapeutic strategies for DILI.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"34 1","pages":"2404138"},"PeriodicalIF":12.2,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Akkermansia in the gastrointestinal tract as a modifier of human health 胃肠道中的 Akkermansia 是人类健康的调节剂
IF 12.2 1区 医学
Gut Microbes Pub Date : 2024-09-21 DOI: 10.1080/19490976.2024.2406379
Maria E. Panzetta, Raphael H. Valdivia
{"title":"Akkermansia in the gastrointestinal tract as a modifier of human health","authors":"Maria E. Panzetta, Raphael H. Valdivia","doi":"10.1080/19490976.2024.2406379","DOIUrl":"https://doi.org/10.1080/19490976.2024.2406379","url":null,"abstract":"Akkermansia sp are common members of the human gut microbiota. Multiple reports have emerged linking the abundance of A. muciniphila to health benefits and disease risk in humans and animals. This ...","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"51 1","pages":""},"PeriodicalIF":12.2,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new perspective in intestinal microecology: lifting the veil of exercise regulation of cardiometabolic diseases. 肠道微生态学的新视角：揭开运动调节心脏代谢疾病的面纱。
IF 12.2 1区 医学
Gut Microbes Pub Date : 2024-09-21 DOI: 10.1080/19490976.2024.2404141
Can Gao,Jinwen Wei,Changxu Lu,Lijie Wang,Dan Dong,Mingli Sun
{"title":"A new perspective in intestinal microecology: lifting the veil of exercise regulation of cardiometabolic diseases.","authors":"Can Gao,Jinwen Wei,Changxu Lu,Lijie Wang,Dan Dong,Mingli Sun","doi":"10.1080/19490976.2024.2404141","DOIUrl":"https://doi.org/10.1080/19490976.2024.2404141","url":null,"abstract":"Cardiometabolic diseases (CMDs), encompassing cardiovascular and metabolic dysfunctions, characterized by insulin resistance, dyslipidemia, hepatic steatosis, and inflammation, have been identified with boosting morbidity and mortality due to the dearth of efficacious therapeutic interventions. In recent years, studies have shown that variations in gut microbiota and its own metabolites can influence the occurrence of CMDs. Intriguingly, the composition and function of the gut microbiota are susceptible to exercise patterns, thus affecting inflammatory, immune, and metabolic responses within the host. In this review, we introduce the key mechanisms of intestinal microecology involved in the onset and development of CMDs, discuss the relationship between exercise and intestinal microecology, and then analyze the role of intestinal microecology in the beneficial effects of exercise on CMDs, aiming at elucidating the gut-heart axis mechanisms of exercise mediated protective effect on CMDs, building avenues for the application of exercise in the management of CMDs.","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"20 1","pages":"2404141"},"PeriodicalIF":12.2,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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