Long-term yogurt intake and colorectal cancer incidence subclassified by Bifidobacterium abundance in tumor.

IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Microbes Pub Date : 2025-12-01 Epub Date: 2025-02-12 DOI:10.1080/19490976.2025.2452237
Satoko Ugai, Li Liu, Keisuke Kosumi, Hidetaka Kawamura, Tsuyoshi Hamada, Kosuke Mima, Kota Arima, Kazuo Okadome, Qian Yao, Kosuke Matsuda, Yuxue Zhong, Hiroki Mizuno, Andrew T Chan, Wendy S Garrett, Mingyang Song, Marios Giannakis, Edward L Giovannucci, Xuehong Zhang, Shuji Ogino, Tomotaka Ugai
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引用次数: 0

Abstract

Evidence suggests a tumor-suppressive effect of the intake of yogurt, which typically contains Bifidobacterium. We hypothesized that long-term yogurt intake might be associated with colorectal cancer incidence differentially by tumor subgroups according to the amount of tissue Bifidobacterium. We utilized the prospective cohort incident-tumor biobank method and resources of two prospective cohort studies. Inverse probability weighted multivariable Cox proportional hazards regression was used to assess differential associations of yogurt intake with the incidence of colorectal carcinomas subclassified by the abundance of tumor tissue Bifidobacterium. During follow-up of 132,056 individuals, we documented 3,079 incident colorectal cancer cases, including 1,121 with available tissue Bifidobacterium data. The association between long-term yogurt intake and colorectal cancer incidence differed by Bifidobacterium abundance (P heterogeneity = 0.0002). Multivariable-adjusted hazard ratios (HRs) (with 95% confidence intervals) in individuals who consumed ≥2 servings/week (vs. <1 serving/month) of yogurt were 0.80 (0.50-1.28) for Bifidobacterium-positive tumor and 1.09 (0.81-1.46) for Bifidobacterium-negative tumor. This differential association was also observed in a subgroup analysis of proximal colon cancer (P heterogeneity = 0.018). Long-term yogurt intake may be differentially associated with the incidence of proximal colon cancer according to Bifidobacterium abundance, suggesting the antitumor effect of yogurt intake on the specific tumor subgroup.

根据肿瘤中双歧杆菌的丰度,长期摄入酸奶与结直肠癌发病率的关系。
有证据表明,摄入含有双歧杆菌的酸奶有抑制肿瘤的作用。我们假设,根据组织双歧杆菌的数量,长期酸奶摄入量可能与不同肿瘤亚组的结直肠癌发病率存在差异。我们利用前瞻性队列事件肿瘤生物库方法和两项前瞻性队列研究的资源。采用逆概率加权多变量Cox比例风险回归来评估酸奶摄入量与按肿瘤组织双歧杆菌丰度分类的结直肠癌发病率的差异相关性。在对132056人的随访中,我们记录了3079例结直肠癌病例,其中1121例有可用的组织双歧杆菌数据。长期酸奶摄入量与结直肠癌发病率之间的关系因双歧杆菌丰度而异(P异质性= 0.0002)。多变量校正风险比(HRs)(95%可信区间):≥2份/周的个体(与双歧杆菌阳性肿瘤相比,双歧杆菌阴性肿瘤为1.09(0.81-1.46)。在近端结肠癌的亚组分析中也观察到这种差异相关性(P异质性= 0.018)。根据双歧杆菌丰度的不同,长期摄入酸奶与近端结肠癌的发病率可能存在差异,提示酸奶摄入对特定肿瘤亚组的抗肿瘤作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Gut Microbes
Gut Microbes Medicine-Microbiology (medical)
CiteScore
18.20
自引率
3.30%
发文量
196
审稿时长
10 weeks
期刊介绍: The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more. Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.
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