High Blood Pressure & Cardiovascular Prevention最新文献

{"title":"Assessment of Triglyceride/High-Density Lipoprotein Cholesterol Ratio and Triglyceride-Glucose Index Threshold in Patients with Chronic Kidney Disease: Evaluation of Clinical Features and Outcomes.","authors":"E Assanto, C Brigato, G Gammaitoni, C Pellicano, E Rosato, F Iannazzo, M Muscaritoli, R Cianci, Antonietta Gigante","doi":"10.1007/s40292-025-00771-4","DOIUrl":"10.1007/s40292-025-00771-4","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic kidney disease (CKD) is associated with dyslipidaemia. Renal dysfunction changes the level, composition and quality of blood lipids in favor of a more atherogenic profile, resulting in increased risk of cardiovascular diseases (CVD). There is emerging interest in identifying protective cut-off levels of triglycerides (TG), cholesterol, both low density lipoprotein (LDL) and high density lipoprotein (HDL) and new prognostic markers like TyG index and TG/HDL ratio in CVD.</p><p><strong>Aim: </strong>To evaluate if higher levels of TG, TG/HDL-ratio and TyG index are associated with increased in-hospital mortality and to identify a prognostic cut-off value of TG and TG/HDL ratio for in-hospital mortality in a population of patients with CKD.</p><p><strong>Methods: </strong>We retrospectively analyzed medical records of consecutive hospitalized CKD patients. Clinical and laboratory data were collected and TyG index, TG/HDL-ratio were calculated.</p><p><strong>Results: </strong>We collected data of 122 inpatients with a median age of 75.5 years (70-84); 73 females (65.2%). In-hospital mortality was observed in 18 cases (16.1%) and patients who died showed increased value of TG and TG/HDL ratio (p = 0.024 and p = 0.022). ROC curve analysis showed that a TG level of 115.5mg/dl (AUC = 0.67; 95% CI 0.52-0.8; p = 0.024) and a TG/HDL ratio of 3.19 (AUC = 0.67; 95% CI 0.51-0.83; p = 0.022) had the highest predictive power for in-hospital mortality. The primary outcome in-hospital mortality was more frequently observed in patients with TG ≥ 115.5 mg/dl (p = 0.006) and in patients with TG/HDL ratio ≥ 3.19 (p = 0.032). Multivariate logistic regression models showed that TG levels [OR 1.025 (CI 1.007; 1.044), p = 0.008] were significantly associated with in-hospital death.</p><p><strong>Conclusions: </strong>TG levels were found to be prognostic for in-hospital mortality in our population. Crucially, this study identified specific thresholds of TG (≥ 115.5 mg/dL) and the TG/HDL ratio (≥ 3.19) as prognostic values for in-hospital mortality in CKD patients. The ability of these biomarkers to identify hospitalized patients with an elevated mortality risk underscores the need for their early detection to facilitate effective assessment of both cardiovascular risk and mortality.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"217-225"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Prevention in Children, Adolescents, and Young Adults. A Call-to-Action of the Italian Societies of Pediatrics (SIP), Hypertension (SIIA), Study of Atherosclerosis (SISA), and Cardiovascular Prevention (SIPREC).","authors":"Simonetta Genovesi, Roberto Volpe, Davide Agnoletti, Simonetta Bellone, Gianni Bona, Manuela Casula, Luigi Gentile, Francesca Saladini, Rino Agostiniani, Agostino Virdis, Alberico L Catapano, Massimo Volpe, Marco Giussani","doi":"10.1007/s40292-025-00773-2","DOIUrl":"10.1007/s40292-025-00773-2","url":null,"abstract":"<p><p>Cardiovascular and cerebrovascular diseases (CVDs), primarily driven by atherosclerosis, remain the leading cause of mortality worldwide and represent a major healthcare burden. Mounting evidence demonstrates that atherosclerotic processes begin in childhood, with lipid streaks detectable as early as the first decade of life. The increasing prevalence of obesity, hypertension, dyslipidemia, insulin resistance, and other modifiable cardiovascular risk factors (CVRFs) in children and adolescents highlights the urgent need for prevention strategies starting early in life. This document, jointly produced by the Italian Society of Pediatrics (SIP), the Italian Society of Hypertension (SIIA), the Italian Society for the Study of Atherosclerosis (SISA), and the Italian Society for Cardiovascular Prevention (SIPREC), emphasizes that atherosclerosis should be considered a disease with its roots in childhood and that true primary prevention must begin from pregnancy and birth. Two possible and complementary levels of intervention should be considered: (1) population-wide promotion of healthy diets, lifestyles, and supportive environments; and (2) early identification and management of specific CVRFs in children and adolescents. The involvement of multiple stakeholders-families, pediatricians, schools, healthcare professionals, policymakers, patient associations, and the media-is crucial to ensure the effectiveness of prevention interventions. Particular attention must be given to obesity, as both an independent risk factor and a driver of additional metabolic and vascular risks. Fighting CVDs requires a paradigm shift: preventive action must start early, be comprehensive, and mobilize all sectors of society. Only by addressing cardiovascular risk during childhood can the future burden of CVDs be effectively reduced.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"133-151"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Validation and Local Adaptation of Estimated Pulse Wave Velocity Models in a Brazilian Population.","authors":"Valerio Garrone Barauna, Jeremias da Silva Leão, Divanei Zaniqueli, Camila Maciel de Oliveira, Alexandre Costa Pereira, José Geraldo Mill, Rafael de Oliveira Alvim","doi":"10.1007/s40292-025-00767-0","DOIUrl":"10.1007/s40292-025-00767-0","url":null,"abstract":"<p><strong>Introduction: </strong>Estimated pulse wave velocity (ePWV) is a non-invasive and low-cost method that uses age and blood pressure to assess cardiovascular risk. However, as it is not a true measure of arterial mechanics, its accuracy in diverse cohorts, such as Brazilian populations, is uncertain due to inherent genetic and environmental differences.</p><p><strong>Aim: </strong>to externally validate existing European ePWV equations and develop new, population-specific models for ePWV estimation in a large, admixed Brazilian cohort.</p><p><strong>Methods: </strong>We analyzed data from 2122 Brazilian adults, assessing carotid-femoral pulse wave velocity (cfPWV), age, mean arterial pressure (MAP), and sex. Linear regression models were developed, incorporating all these variables as predictors. Model performance was evaluated using root mean square error (RMSE) and coefficient of determination (R²). Bland-Altman analyses assessed agreement between estimated and measured cfPWV.</p><p><strong>Results: </strong>The newly developed equations demonstrated superior performance compared to existing European models. Our best-performing model (Equation 2) achieved an RMSE of 0.744 in individuals without cardiovascular risk factor, demonstrating superior performance to the model derived by the Arterial Stiffness Collaboration Group (ASCG) (RMSE: 0.879). Inclusion of sex as a predictor further improved model accuracy. Bland-Altman analyses revealed narrower limits of agreement for the new models. Notably, higher prediction errors were observed in subgroups underrepresented in the sample, such as individuals with very high cfPWV, advanced age, or elevated MAP.</p><p><strong>Conclusions: </strong>Population-specific ePWV equations tailored to the Brazilian cohort provide more accurate estimations of arterial stiffness. This improved precision is clinically meaningful, allowing for better stratification of cardiovascular risk using a low-cost tool readily applicable in the public health system. These findings underscore the importance of developing and validating cardiovascular risk assessment tools within diverse populations to enhance predictive accuracy and clinical utility.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"207-216"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145677394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Real-Life Survey on the Management of Arterial Hypertension in Italy.","authors":"Giovanna Gallo, Claudio Ferri, Gianfranco Parati, Stefano Taddei, Massimo Volpe","doi":"10.1007/s40292-025-00762-5","DOIUrl":"10.1007/s40292-025-00762-5","url":null,"abstract":"<p><strong>Introduction: </strong>The use of epidemiological surveys might contribute to identify ineffective clinical behaviors and to improve them with educational interventions.</p><p><strong>Aim: </strong>In the present survey, we evaluated the clinical attitudes for the management of patients with hypertension, in a sample of physicians in Italy who were included in an educational program in 2023.</p><p><strong>Methods: </strong>Data from a total of 995 hypertensives (mean age 64.8 ± 13.3 years; 58.4% men) were reported in the survey. Complete data on antihypertensive treatment use and achievement of blood pressure (BP) goals at follow-up were available for only 494 individuals, whose data were therefore analyzed and compared with baseline.</p><p><strong>Results: </strong>At baseline, 381 patients received BP-lowering treatment, 146 (31.6%) were treated with monotherapy, 129 (26.1%) with free dose combinations and 106 (21.4%) with single-pill FDCs. BP values < 140/80 mmHg and < 130/80 mmHg were detected in 70 (14.2%) and 23 (4.6%) subjects, respectively. At follow-up evaluation, the number of treated patients rise to 462, 44 receiving monotherapy, 35 free dose combinations and 383 single-pill FDCs (p < 0.05 compared to baseline). A significant improvement of BP control was achieved, and BP values < 140/80 mmHg and < 130/80 mmHg were recorded in 470 (95.1%) and 383 (77.5%) individuals, respectively (p < 0.05 compared to baseline).</p><p><strong>Conclusions: </strong>The survey identified a high prevalence of uncontrolled hypertension in the examined sample with a low use of FDCs also by specialist physicians qualified to treat high BP. After the attendance to an educational program, the prescription of FDCs significantly raised in parallel with the increase in the proportion of patients who reached recommended BP targets.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"129-132"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145563703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Gap: Exploring Right Ventricular-Pulmonary Artery Coupling in Acute Coronary syndrome-A Pilot Study.","authors":"Linda Piras, Nicola Tartaglia, Giuliano Tocci, Emanuele Barbato, Allegra Battistoni","doi":"10.1007/s40292-025-00760-7","DOIUrl":"10.1007/s40292-025-00760-7","url":null,"abstract":"<p><strong>Introduction: </strong>Right ventricular-pulmonary artery (RV-PA) coupling evaluates the relationship between right ventricular contractility and afterload. It is normal when both are well-matched. A reduction in RV contractility or an increase in RV afterload leads to RV-PA uncoupling, decreasing left ventricular filling, stroke volume, and causing peripheral hypoperfusion and congestion. The TAPSE/PASP ratio is a reliable non-invasive method to assess this coupling. An impaired TAPSE/PASP ratio is associated with poor prognosis in conditions of elevated RV afterload, but its role in acute coronary syndrome (ACS) is unclear.</p><p><strong>Aim: </strong>The aim of this study is to investigate the in-hospital prognostic value of the TAPSE/PASP ratio and the predictors of a low TAPSE/PASP ratio.</p><p><strong>Methods: </strong>This retrospective, pilot study included 152 patients admitted for ACS (77.6% STEMI, 22.4% NSTEMI) between November 2023 and March 2025, with available TAPSE/PASP data from echocardiography performed at admission. The primary objective was to assess whether the TAPSE/PASP ratio predicts in-hospital major adverse cardiovascular events (MACE). Secondary objectives included evaluating whether TAPSE/PASP predicts in-hospital ventricular arrhythmias, intraventricular thrombosis, prolonged hospital stay, and identifying predictors of a low TAPSE/PASP ratio.</p><p><strong>Results: </strong>TAPSE/PASP < 0.55 was significantly associated with MACE and prolonged hospital stay in univariate analysis, but not in multivariate analysis. TAPSE/PASP < 0.55 was largely explained by E/e' >14 (OR 6.600; p = 0.0008), RV involvement (OR 9.430; p = 0.0007), and age >75 years (OR 3.243; p = 0.0389).</p><p><strong>Conclusions: </strong>Low RV-PA coupling (TAPSE/PASP < 0.55) is associated with MACE and prolonged hospital stay in ACS, but lacks independent prognostic value in multivariate analysis.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"105-116"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12883505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating Role of Insulin Resistance in the Association Between Body Composition and Hypertension.","authors":"Qingfang Deng, Hao Kang, Yu Cao, Rui Tian, Dengke Chen, Hui Yu, Jioajiao Zhu, Yanling He, Jie Zhang, Xing Liu, Jie Sheng, Sufang Wang","doi":"10.1007/s40292-025-00754-5","DOIUrl":"10.1007/s40292-025-00754-5","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension, a major cardiovascular risk, is affected by body composition and metabolism.</p><p><strong>Aim: </strong>We assessed the associations of body composition with hypertension and the mediating role of insulin resistance (IR).</p><p><strong>Methods: </strong>In Hefei Hongsifang Company, 743 employees aged 40-60 were recruited consecutively. Logistic regression was used to assess the association between body composition and hypertension risk. Mediation analysis was conducted to explore the mediating role of IR between body composition and hypertension risk.</p><p><strong>Results: </strong>Individuals with higher body fat percentage (BF%) (OR = 2.44, 95% CI 1.64-3.65, P < 0.001) and Visceral adiposity index (VAI) (OR = 2.22, 95% CI 1.39-3.55, P < 0.001) had significantly higher odds of hypertension. Conversely, higher levels of skeletal muscle mass percentage (SMM%) (OR = 0.35, 95% CI 0.21-0.56, P < 0.001), total body water percentage (TBW%) (OR = 0.36, 95% CI 0.23-0.59, P < 0.001), and bone mineral content percentage (BMC%) (OR = 0.34, 95% CI 0.21-0.54, P < 0.001) were all linked to lower odds of hypertension. IR significantly mediated the associations between body composition and hypertension risk. The mediation proportions were as follows: 29.4% for BF%, 61.5% for VAI, 33.7% for SMM%, 34.9% for TBW%, and 31.4% for BMC%.</p><p><strong>Conclusion: </strong>Our study demonstrated that, in middle-aged individuals, lower BF% and VAI, as well as higher SMM%, TBW%, and BMC%, were independently associated with a reduced risk of hypertension. IR partially mediated the associations between body composition and hypertension.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"83-92"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Medical Treatment of Arterial Hypertension and Hypercholesterolemia in Germany: a Nationwide questionnaire-based Survey in Medical Practices.","authors":"Christian Beger, Olaf Randerath, Astrid Mayerböck, Konrad Klein, Florian P Limbourg","doi":"10.1007/s40292-025-00750-9","DOIUrl":"10.1007/s40292-025-00750-9","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension and hypercholesterolemia are endemic key risk factors influencing cardiovascular prognosis.</p><p><strong>Aim: </strong>Our study aimed to detect the co-occurrence of these two risk factors in medical practices and to determine the rate of guideline-compliant medical treatment.</p><p><strong>Methods: </strong>We conducted a nationwide survey in German outpatient medical facilities. Data on the prevalence, control, and management of hypertension and hypercholesterolemia were collected using an anonymized questionnaire and analyzed. Results are presented as numbers and percentages for categorical variables, and as means with standard deviations (SD) for continuous variables.</p><p><strong>Results: </strong>A total of 5,020 questionnaires from 534 German physicians were analyzed. Hypertension and hypercholesterolemia were concurrently diagnosed in 56% of patients. Despite antihypertensive therapy, only 53% of hypertensive patients achieved controlled office blood pressure values (< 140/90 mmHg). Nevertheless, physicians rated blood pressure control as adequate in 77% of cases; one-third of these patients had uncontrolled OBP. Fewer than 26% of patients with arterial hypertension received a combination therapy recommended by current clinical guidelines. 1,079 out of 4,287 hypertensive patients were treated with monotherapy only. Among patients at high cardiovascular risk (e.g., with a history of myocardial infarction), 10% achieved the recommended LDL cholesterol target of < 55 mg/dl, while 8% had LDL levels ≥ 160 mg/dl.</p><p><strong>Conclusion: </strong>These findings suggest a persistent gap between evidence-based guidelines and their implementation in everyday practice. These data are largely consistent with findings from previous decades, indicating that insufficient progress has likely occurred in improving disease control at the population level.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"57-65"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12883503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bedtime Versus Morning Dosing of Anti-hypertensives: A GRADE-Assessed Meta-Analysis of Randomized Controlled Trials with Trial Sequential Evidence.","authors":"Mohamed Saad Rakab, Basel Hatem Elsalakawi, Abdalhakim Shubietah, Alaa Maamoun, Mohab Mattar, AlMothana Manasrah, Ubaid Khan, Ameer Awashra, Mohammed Ruzieh, Mohamed Abuelazm","doi":"10.1007/s40292-025-00755-4","DOIUrl":"10.1007/s40292-025-00755-4","url":null,"abstract":"<p><strong>Introduction: </strong>The timing of anti-hypertensive medication may influence cardiovascular outcomes and blood pressure control, yet the evidence remains inconclusive.</p><p><strong>Aim: </strong>We conducted a meta-analysis to compare the effects of bedtime versus morning dosing of anti-hypertensives on mortality, cardiovascular events, and ambulatory blood pressure.</p><p><strong>Methods: </strong>We conducted a meta-analysis of randomized controlled trials (RCTs) comparing bedtime versus morning administration of antihypertensive therapy. A comprehensive literature search was performed in PubMed, Embase, Cochrane Library, Scopus, and Web of Science databases up to June 2025. Pooled risk ratios (RRs) were calculated for categorical outcomes, and mean differences (MDs) for continuous variables. All statistical analyses were performed using R version 4.3.3. PROSPERO registration ID: CRD420251113957.</p><p><strong>Results: </strong>Pooled analysis of six RCTs with 49,983 patients was included. Bedtime dosing of anti-hypertensive medications resulted in a lower incidence of heart failure (1.3% vs. 2.0%; RR 0.63, 95% CI 0.47-0.85) but not myocardial infarction (1.4% vs. 1.6%; RR 0.87, 95% CI 0.64-1.17), stroke or transient ischemic attack (0.9% vs. 1.3%; RR 0.71, 95% CI 0.49-1.05), all-cause mortality (2.6% vs. 3.1%; RR 0.75, 95% CI 0.53-1.06), or cardiovascular mortality (1.0% vs. 1.5%; RR 0.52, 95% CI 0.22-1.21). For blood pressure, bedtime dosing significantly reduced evening systolic blood pressure (MD - 4.71 mmHg, 95% CI - 6.64 to - 2.78) and evening diastolic blood pressure (MD - 1.66 mmHg, 95% CI - 1.92 to - 1.40), with no significant differences observed in morning readings.</p><p><strong>Conclusion: </strong>Bedtime administration of anti-hypertensive medications may be associated with reduction in MACE and heart failure incidence. No significant effect was observed in mortality, myocardial infarction, or stroke.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"41-55"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Patients with Arterial Hypertension in Italy: A Consensus Document of the Italian Society of Hypertension (SIIA) and the Italian Society for Cardiovascular Prevention (SIPREC) About the Recommended Care Pathway and Areas for Improvement.","authors":"Massimo Volpe, Maria Lorenza Muiesan, Giuliano Tocci, Guido Grassi, Francesca Viazzi, Manuela Petino, Alessandro Rubino, Antonino Di Guardo, Agostino Virdis","doi":"10.1007/s40292-025-00756-3","DOIUrl":"10.1007/s40292-025-00756-3","url":null,"abstract":"<p><p>Chronic diseases represent one of the most significant challenges for Public Health in Italy, involving approximately 24 million people and generating an annual cost of more than 66.7 billion euros. Among these, arterial hypertension affects 31% of the population, and it is the leading risk factor for cardiovascular diseases. However, the management of arterial hypertension presents several challenges, including inconsistencies in care pathways, poor integration between healthcare settings, and low therapeutic adherence. This document aims to share the findings of a national-level project that defined the recommended care pathway for managing hypertensive patients, identified potential areas for improvement, and proposed supporting solutions, including a list of indicators for evaluation and monitoring. The key areas for improvement, particularly the promotion of therapeutic adherence and the strengthening of communication between community-based and hospital services, serve as a foundation for optimizing the management of this condition and fostering more effective collaboration among the various stakeholders and levels of care within the healthcare system.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"1-11"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12883499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Metabolic Syndrome Components, Clinical Characteristics, and Telomere Length: Factor Analysis of Mixed Data Based Cluster Analysis of LIPIDOGEN2015 Cross-Sectional Study.","authors":"Tadeusz Osadnik, Maciej Banach, Anna Goc, Ewa Boniewska-Bernacka, Anna Pańczyszyn, Marcin Goławski, Martyna Fronczek, Joanna Katarzyna Strzelczyk, Mateusz Lejawa, Marek Gierlotka, Kamila Osadnik, Nikodem Baron, Karol Krystek, Agnieszka Gach, Tomasz Czapor, Natalia Pawlas, Francesco Paneni, Jacek Jóźwiak","doi":"10.1007/s40292-025-00753-6","DOIUrl":"10.1007/s40292-025-00753-6","url":null,"abstract":"<p><strong>Introduction: </strong>Telomere length is an acclaimed marker of aging, which has been previously shown to correlate with cardiovascular diseases and metabolic syndrome traits.</p><p><strong>Aim: </strong>To identify the relationship between patient characteristics and telomere length.</p><p><strong>Methods: </strong>The LIPIDOGEN was a random patient sample substudy of LIPIDOGRAM 2015 study (n = 13,724) conducted in primary care facilities in Poland. Data on risk factors, chronic diseases, treatment, and lifestyle were collected. Telomere length was determined with routine PCR from saliva. Factor Analysis for Mixed Data analysis was utilized to discern the principal components of patient clinical profiles. Furthermore, hierarchical clustering was used to obtain clusters of patients based on principal components.</p><p><strong>Results: </strong>1556 patients (60% female, mean age 51 years) were included in the analysis after the exclusion of outliers and low DNA quality samples. Three clusters of patients were identified. Cluster 1 was characterized by low cardiovascular risk, without significant risk factors. Cluster 2 consisted of patients with a higher incidence of metabolic syndrome (MetS, 62%) and the highest smoking rate (22%). Cluster 3 had the highest incidence of MetS (94%), treatment with statin (62%), and diabetes mellitus (61%), and contained nearly all patients with myocardial infarction (17% of this cluster). Patients in Cluster 1 had significantly longer telomeres than patients in Cluster 2 and 3 (p = 0.01 and p < 0.001 respectively).</p><p><strong>Conclusions: </strong>The pattern of clinical characteristics marked by classical cardiovascular risk factors including components of MetS, is inversely related to telomere length, underlining the potential role of metabolic disturbances in cellular aging.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"67-81"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12883513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}