High Blood Pressure & Cardiovascular Prevention最新文献

{"title":"Pulse Wave Velocity Progression Determinants: No Significant Association with Novel Lipids Parameter.","authors":"Ilaria Garofani, Chiara Tognola, Martina Morelli, Atea Shkodra, Michela Algeri, Marco Bellomare, Valentina Colombo, Filippo Brucato, Serena Guasti, Andrea Bonelli, Cristina Giannattasio, Alessandro Maloberti","doi":"10.1007/s40292-025-00741-w","DOIUrl":"https://doi.org/10.1007/s40292-025-00741-w","url":null,"abstract":"<p><strong>Introduction: </strong>Whether novel lipid parameters are related to arterial stiffness (pulse wave velocity-PWV), changes during follow-up (i.e ΔPWV) has never been evaluated.</p><p><strong>Aim: </strong>To evaluate the relationship between standard and emerging lipid parameters (non-HDL/HDL, LDL/HDL, total cholesterol/HDL, TG/HDL, Log(TG)/HDL, Log(TG/HDL) and the triglyceride-glucose index [TyG]) and ΔPWV among hypertensive patients.</p><p><strong>Methods: </strong>We included 469 hypertensive patients enrolled from September 2006 to October 2010 from the Hypertension Unit of San Gerardo Hospital (Monza, Italy). PWV was measured at baseline and after a mean follow-up of 3.8 years (I-III quartiles 3.5-4.2 years) and the relative change (ΔPWV) was calculated.</p><p><strong>Results: </strong>The study cohort had a mean age of 53.6 ± 12.9 years and 58.4% were male. PWV significantly increased from baseline to follow-up (8.6 ± 2.1 vs. 9.2 ± 2.4 m/s; p=0.0001), with 51.6% of patients exhibiting a ΔPWV≥0.5 m/s. These patients had a significantly lower HDL cholesterol (51.5 ± 13.5 vs. 54.7 ± 13.3 mg/dL) with higher LDL/HDL ratio (2.5 ± 0.9 vs. 2.3 ± 0.9 p=0.049), non-HDL/HDL ratio (3.0 ± 1.1 vs. 2.8 ± 1.1), total cholesterol/HDL ratio (4.0 ± 1.1 vs. 3.8 ± 1.1), Log(TG)/HDL (0.043 ± 0.015 vs. 0.039 ± 0.014) and Log(TG/HDL) (0.351 ± 0.290 vs. 0.295 ± 0.278, p<0.05 for all comparison). A significant univariate association was found between ΔPWV and ΔPWV≥0.5 and Log(TG)/HDL (r = 0.121, p =  0.009 and r = 0.094, p =  0.042, respectively) but it didn't persist at multivariable analysis adjusted for age, sex, Δ systolic blood pressure, anti-hypertensive therapies and statins, diabetes, and glomerular filtration rate.</p><p><strong>Conclusions: </strong>Our study found no significant associations between emerging lipid parameters and PWV/ΔPWV. Age and blood pressure values remains the main determinants of PWV and its changes over time.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and Left Ventricular Mechanics in Children and Adolescents: A Systematic Review and Meta-Analysis.","authors":"Andrea Faggiano, Elisa Gherbesi, Carla Sala, Stefano Carugo, Guido Grassi, Marijana Tadic, Cesare Cuspidi","doi":"10.1007/s40292-025-00726-9","DOIUrl":"10.1007/s40292-025-00726-9","url":null,"abstract":"<p><strong>Introduction: </strong>Evidence on left ventricular (LV) myocardial deformation, assessed by speckle tracking echocardiography (STE), in children and adolescents with obesity is scanty.</p><p><strong>Aim: </strong>This meta-analysis aimed to provide a new piece of information on LV systolic function, phenotyped by global longitudinal strain (GLS) and LV ejection fraction (LVEF), in pediatric obesity.</p><p><strong>Methods: </strong>Following the PRISMA guidelines, systematic searches were conducted in Pub-Med, OVID, EMBASE, and Cochrane Library to identify eligible studies from inception up to February 28^th 2025. Studies comparing LV mechanics in pediatric obesity and normal weight controls were included. Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated using random-effects models to assess differences in GLS and LVEF.</p><p><strong>Prospero-id: </strong>635938.</p><p><strong>Results: </strong>Twenty-seven studies including 1398 individuals with obesity and 2376 age-matched healthy controls were considered for the analysis. Pooled average GLS values were 20±0.4% in the control group and 17±0.5% in the obese group (SMD - 1.28±0.14, CI - 1.57/- 1.0, p<0.0001). Overall, LVEF was lower in the obese group (SMD - 0.14±0.15, CI - 0.22/- 0.05, p <0.001), although this parameter, at difference from GLS, in the majority of studies did not reach the statistical significance between groups. The metaregression analysis of GLS on BMI showed a significant inverse correlation between the two parameters (coefficient= - 0.33±0.11, p=0.003), this was not the case for LVEF.</p><p><strong>Conclusions: </strong>Our data suggest that targeting LV mechanics may more accurately assess the systolic function in pediatric obesity; implementing STE in clinical practice may be highly useful in unmasking early LV functional alterations in this setting.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"495-509"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Pulse Pressure and Risk of Chronic Kidney Disease by Hypertension Status: A Longitudinal Study in Japanese Adults.","authors":"Yukari Okawa, Toshiharu Mitsuhashi","doi":"10.1007/s40292-025-00735-8","DOIUrl":"10.1007/s40292-025-00735-8","url":null,"abstract":"<p><strong>Introduction: </strong>Little is known about the relationship between pulse pressure (PP) and incident chronic kidney disease (CKD) in Asian populations, particularly when analyzed separately by hypertension status.</p><p><strong>Aim: </strong>This study aimed to assess the association between PP and subsequent onset of CKD in Japanese adults.</p><p><strong>Methods: </strong>This longitudinal study included middle-aged and older Japanese citizens who participated in administrative checkups (1998-2024) conducted by Zentsuji City. The relationship between PP (diastolic blood pressure subtracted from systolic blood pressure) and incident CKD (estimated glomerular filtration rate < 60 mL/min/1.73 m²) was evaluated by hypertension status, using the Weibull accelerated failure time model. PP was treated as a time-varying variable and categorized into < 40 (reference), 40-< 60, and ≥ 60 mmHg. In addition to the crude model, two adjusted models were created to control for potential confounders.</p><p><strong>Results: </strong>Among 15,788 participants, 8881 (men: 42.7%) were examined in the study. The mean follow-up time was 6.21 years for non-hypertensive participants and 6.27 years for hypertensive participants. Higher PP was associated with higher rate of CKD incidence regardless of prevalent hypertension. In non-hypertensive participants, PP ≥ 60 mmHg had a 10% shorter time to CKD onset (95% confidence interval: 3-16%) compared with PP < 40 mmHg. In hypertensive participants, attenuated results were observed, with all 95% confidence intervals crossing the null value.</p><p><strong>Conclusions: </strong>Elevated PP may serve as a useful indicator for CKD development in non-hypertensive Japanese subjects. Regular BP monitoring may assist in developing public health strategies for CKD prevention, especially among non-hypertensive Asian populations.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"563-575"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Chinese Visceral Adiposity Index and Risk of Incident Hypertension Among Older Adults: A Prospective Cohort Study.","authors":"Datian Gao, Xuejiao Chen, Dechen Liu, Donghai Su, Yulin Cheng, Yufang Cui, Wanli Hu, Zihao Li, Gefei Li, Xiaoke Zhang, Haiyun Gao, Songhe Shi","doi":"10.1007/s40292-025-00734-9","DOIUrl":"10.1007/s40292-025-00734-9","url":null,"abstract":"<p><strong>Introduction: </strong>The Chinese visceral adiposity index (CVAI), a favorable surrogate index for assessing visceral fat distribution and function, has been proven to be associated with various conditions, including diabetes mellitus, cardiovascular diseases, and strokes. Nevertheless, evidence on the association of CVAI with the risk of incident hypertension among older adults is limited.</p><p><strong>Aim: </strong>This study aimed to explore the association between CVAI and the risk of incident hypertension among older adults.</p><p><strong>Methods: </strong>Data were collected from the annual health examination dataset in Xinzheng, Henan Province from 2018 to 2023. A total of 10,353 participants aged ≥ 60 years were included. Cox proportional hazard models were used to examine the association between CVAI and the risk of incident hypertension by using hazard ratios (HRs) and 95% confidence intervals (CIs). Subgroup and sensitivity analyses were performed to confirm the association's robustness. Additionally, the restricted cubic spline (RCS) was used to fit the dose-response association between CVAI and the risk of incident hypertension.</p><p><strong>Results: </strong>During a median of 2.72 years of follow-up, hypertension developed in 6990 participants. In the fully-adjusted model, compared with participants in the tertile 1 of CVAI, the tertile 3 (HR = 1.26, 95% CI: 1.19-1.34) of CVAI was associated with an increased risk of incident hypertension and per standard deviation (SD) increase was associated with a 12% (HR = 1.12, 95% CI: 1.09-1.15) increased risk of incident hypertension. Similar significant associations were observed in subgroup and sensitivity analyses. Additionally, the RCS analysis showed a significant dose-response association of CVAI with the risk of incident hypertension (P overall < 0.001 and P nonlinear = 0.238).</p><p><strong>Conclusions: </strong>These results suggested a positive association between CVAI and the risk of incident hypertension among older adults.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"553-562"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Cardiovascular Health: Insights into Post-COVID Public Health Challenges.","authors":"Zayera Naushad, Jaya Malik, Abhishek Kumar Mishra, Shilpy Singh, Dharmsheel Shrivastav, Chetan Kumar Sharma, Ved Vrat Verma, Ravi Kant Pal, Biswajit Roy, Varun Kumar Sharma","doi":"10.1007/s40292-025-00738-5","DOIUrl":"10.1007/s40292-025-00738-5","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) continue to be the topmost cause of the worldwide morbidity and mortality. Risk factors such as diabetes, hypertension, obesity and smoking are significantly worsening the situation. The COVID-19 pandemic has powerfully highlighted the undeniable connection between viral infections and cardiovascular health. Current literature highlights that SARS-CoV-2 contributes to myocardial injury, endothelial dysfunction, thrombosis, and systemic inflammation, increasing the severity of CVD outcomes. Long COVID has also been associated with persistent cardiovascular complications, including myocarditis, arrhythmias, thromboembolic events, and accelerated atherosclerosis. Addressing these challenges requires continued research and public health strategies to mitigate long-term risks. Artificial intelligence (AI) is changing cardiovascular medicine and community health through progressive machine learning (ML) and deep learning (DL) applications. AI enhances risk prediction, facilitates biomarker discovery, and improves imaging techniques such as echocardiography, CT, and MRI for detecting coronary artery disease and myocardial injury on time. Remote monitoring and wearable devices powered by AI enable real-time cardiovascular assessment and personalized treatment. In public health, AI optimizes disease surveillance, epidemiological modeling, and healthcare resource allocation. AI-driven clinical decision support systems improve diagnostic accuracy and health equity by enabling targeted interventions. The integration of AI into cardiovascular medicine and public health offers data-driven, efficient, and patient-centered solutions to mitigate post-COVID cardiovascular complications.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"475-494"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three months of bempedoic acid treatment does not affect cystatin C-based estimation of glomerular filtration rate.","authors":"Leandra Serio, Antonella Paolucci, Maria Ester Carugno, Sofia Cappannari, Alessia Cecchini, Marianna Litterio, Rita Del Pinto, Claudio Ferri","doi":"10.1007/s40292-025-00732-x","DOIUrl":"10.1007/s40292-025-00732-x","url":null,"abstract":"<p><strong>Introduction: </strong>Bempedoic acid can interfere with creatinine excretion, thereby potentially altering the calculation of glomerular filtration rate (eGFR), but is not known to have an effect on cystatin C metabolism.</p><p><strong>Aim: </strong>The aim of this pilot observational study was to assess the impact of 3-months bempedoic acid treatment on renal function assessed by serum creatinine and cystatin C.</p><p><strong>Methods: </strong>Consecutive hypercholesterolemic outpatients with indication to be started on bempedoic acid and available serum creatinine and cystatin C levels were enrolled. Follow-up (45-90 days) renal function markers were assessed. Lipid profile, uric acid levels, and CRP levels were also recorded.</p><p><strong>Results: </strong>Bempedoic acid reduced LDL-c and total cholesterol levels by day 45. No changes were observed in HDL-c, triglycerides, Lp(a), serum creatinine, eGFR_cr, BUN, uric acid, or CRP levels throughout the study. The sensitivity analysis on individuals with complete data for cystatin C during follow-up (42%) confirmed the overall observations, while also showing neutral effects of bempedoic acid eGFR_cys and eGFR_cr-cys.</p><p><strong>Conclusions: </strong>Three-months administration of bempedoic acid did not affect cystatin C levels. Adequately powered studies are needed to test these findings and, ultimately, the renal safety of bempedoic acid.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"533-541"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different Polymorphisms of the Renin-Angiotensin-Aldosterone System Genes are Associated with Poorer Blood Pressure Control in Hypertensive Older Adults.","authors":"Ivna Vidal Freire, Icaro J S Ribeiro, Cezar Augusto Casotti, Diego Andrade, Débora Diniz Bezerra, Jules Ramon Brito Teixeira, Ana Angélica Leal Barbosa, Luciene Cristina Gastalho Campos, Rafael Pereira","doi":"10.1007/s40292-025-00725-w","DOIUrl":"10.1007/s40292-025-00725-w","url":null,"abstract":"<p><strong>Introduction: </strong>Adequate blood pressure control (BPC) is crucial for preventing hypertension, as well as for mitigating the risks associated with inadequate control among hypertensive older adults. Identifying modifiable factors (i.e., dietary and biochemical patterns, sociodemographic characteristics, and health habits) and non-modifiable factors (i.e., genetic background) is crucial for improving control rates.</p><p><strong>Aim: </strong>This study aimed to analyze the association between Renin-Angiotensin-Aldosterone System gene polymorphisms, sociodemographic characteristics, health and lifestyle habits, and BPC in older adults.</p><p><strong>Methods: </strong>one hundred and forty-three older adults comprised the study population, and were genotyped for angiotensinogen (AGT) [M235T], renin (REN) [G2646A] angiotensin-converting enzyme (ACE) [InDel], angiotensin II type 1 receptor (AT1R) [A1166C] aldosterone synthase (CYP11B2) [C344T] gene polymorphisms. Sociodemographic characteristics, health, and lifestyle habits were recorded using questionnaires, and blood pressure was measured using standard methods. A Poisson multivariate regression was applied.</p><p><strong>Results: </strong>Our finding indicated that, together, LDL-C, the A allele of the REN gene (G2646A), and genotype II of the ACE gene (InDel) were significantly associated with inadequate BPC in the community-dwelling older adults.</p><p><strong>Conclusions: </strong>Due to its non-modifiable nature, the genetic background has the potential to identify individuals with a greater risk of illness. The knowledge of the genetic profiles prone to impaired BPC and its interaction with modifiable factors could guide more effective behaviors and/or treatments aiming to mitigate the morbidity and mortality related to poor BPC among hypertensive older adults.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"523-532"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Practical Predictor for Identifying Reverse-Dipper Blood Pressure Patterns: Left Atrial Coupling Index.","authors":"Ayca Arslan, Dogan Ilıs, Inanc Artac, Muammer Karakayali, Timor Omar, Zihni Cagin, Zulfiye Kuzu, Yavuz Karabag, Ibrahim Rencuzogullari","doi":"10.1007/s40292-025-00733-w","DOIUrl":"10.1007/s40292-025-00733-w","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension is a common and persistent disorder and mostly causes myocardial structural and functional abnormalities. As a subtype pattern of HT, the reverse-dipper blood pressure (BP) is associated with worse cardiovascular outcomes and early-phase subclinical myocardial damage compared to other patterns. The Left Atrial Coupling Index (LACI) is a novel echocardiographic parameter developed to assess the mechanical function.</p><p><strong>Aim: </strong>The aim of this study was to investigate the role of the LACI in predicting the reverse-dipper BP pattern in patients with hypertension.</p><p><strong>Methods: </strong>A total of 404 hypertensive patients who underwent 24-hour ambulatory blood pressure monitoring were prospectively enrolled. Patients were classified into dipper, non-dipper, and reverse-dipper groups based on their nocturnal BP profiles. Comprehensive echocardiographic evaluations were performed, and LACI was calculated for each patient.</p><p><strong>Results: </strong>A reverse-dipper BP pattern was observed in 26%(n = 105) of the 404 patients. Those with a reverse-dipper BP pattern exhibited higher mitral E/A ratio, E/Em means, left atrial volume index (LAVI), and LACI, along with lower Em septal, Am lateral mitral, and Am septal values. LACI (OR:3.837, 95% CI: 2.620-5.620, p < 0.001), LAVI, and Am lateral mitral value were found to be independent predictors of the reverse-dipper BP pattern. ROC curve comparison demonstrated that LACI was a better predictor of the reverse-dipper BP pattern than LAVI.</p><p><strong>Conclusions: </strong>Our study demonstrates that LACI, an easily accessible echocardiographic parameter, is a more robust predictor of the reverse-dipper BP pattern compared to traditional echocardiographic markers.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"543-552"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the Epigenetic Remodeler GCN5 Prevents Vascular Oxidative Stress and Endothelial Dysfunction in Obesity: Insights in Patients with Cardiometabolic Disease.","authors":"Sarah Costantino, Shafeeq Mohammed, Alessandro Mengozzi, Emiliano Duranti, Valentina Delfine, Martin A Geiger, Nazha Hamdani, Stefano Taddei, Stefano Masi, Agostino Virdis, Francesco Paneni","doi":"10.1007/s40292-025-00739-4","DOIUrl":"10.1007/s40292-025-00739-4","url":null,"abstract":"<p><strong>Introduction: </strong>Epigenetic changes are important modulators of gene expression. The histone acetyltransferase gene non-derepressible 5 (Gcn5) is emerging as a pivotal epigenetic player in metabolism and cancer, yet its role in obesity and cardiovascular disease remains elusive.</p><p><strong>Aims: </strong>To investigate Gcn5 role in obesity-related endothelial dysfunction.</p><p><strong>Methods: </strong>Human aortic endothelial cells (HAECs) were exposed to vehicle or palmitic acid (200 uM) in the presence or in the absence of the Gcn5 pharmacological inhibitor CPTH2 or gene silencing. Ex-vivo inhibition of Gcn5 was performed in aortic rings from diet-induced obese and control mice. Chromatin immunoprecipitation (ChIP) was performed to investigate the epigenetic regulation of Nox2 promoter. In parallel, Gcn5/Nox2 expression was assessed by real-time PCR in vascular specimens isolated from obese patients and age-matched healthy controls. Endothelial-dependent vasodilation was also assessed in human vessels.</p><p><strong>Results: </strong>PA increased Gcn5 gene expression in HAECs. Gcn5 upregulation was associated with increased expression of the pro-oxidant enzyme Nox2. Interestingly, either Gcn5 inhibition or gene silencing prevented PA-induced Nox2 upregulation and oxidative stress accumulation. ChiP assay showed increased Gcn5 occupancy and enhanced histone 3 acetylation of lysine 14 (H3K14ac) on Nox2 promoter. In aortic rings from obese mice, pharmacological inhibition of Gcn5 by CPTH2 rescued endothelial-dependent vasorelaxation as compared to vehicle. Finally, Gcn5 was increased in vessels from obese patients and correlated with Nox2 expression and endothelial dysfunction.</p><p><strong>Conclusions: </strong>Our findings shed light on the importance of epigenetic regulation in obesity and pinpoint Gcn5 as a therapeutic target to prevent endothelial dysfunction in cardiometabolic disease.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"577-589"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choice of Reference Blood Pressure in the 2023 Guidelines of the European Society of Hypertension.","authors":"Giuseppe Mancia, Massimo Volpe","doi":"10.1007/s40292-025-00736-7","DOIUrl":"10.1007/s40292-025-00736-7","url":null,"abstract":"","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"469-474"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}