High Blood Pressure & Cardiovascular Prevention最新文献

{"title":"The Ratio of Red Blood Cell Distribution Width To Serum Albumin and its Association with Cardiovascular and All-Cause Mortality Risk in Diabetic Patients: A Cohort Study Using NHANES Data from 1999 to 2018.","authors":"Yunzhen Lei, Jiaying Diao, Ming Xu, Nanqu Huang, Qianfeng Jiang","doi":"10.1007/s40292-025-00743-8","DOIUrl":"https://doi.org/10.1007/s40292-025-00743-8","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, Red Blood Cell Distribution Width (RDW) and serum albumin have been recognized as important markers of inflammation and nutritional status. The ratio of RDW to serum albumin (RAR) is considered a comprehensive indicator that combines both inflammatory and nutritional characteristics. However, the potential relationship between RAR and all-cause mortality as well as cardiovascular mortality in diabetic patients has not been fully explored.</p><p><strong>Aim: </strong>To investigate whether RAR is associated with all-cause mortality and cardiovascular mortality in diabetic patients, and to examine the dose-response relationship between them.</p><p><strong>Methods: </strong>This study used data from the NHANES collected between 1999 and 2018, including 4254 participants aged 18 years and older, with RDW and serum albumin levels obtained from laboratory tests. Weighted Cox regression and adjusted models were used to explore the relationship between RAR and specific mortality rates. Stratified analysis was performed to examine the relationship between mortality and specific subgroups, and restricted cubic splines (RCS) were used to explore the dose-response relationship between RAR and specific mortality. Statistical significance was set at a two-tailed p-value < 0.05.</p><p><strong>Results: </strong>Among diabetic patients, higher baseline RAR levels were significantly associated with increased risks of all-cause mortality, heart disease mortality, and cardiovascular disease mortality, even after adjusting for multiple confounding factors. However, no statistically significant association was found between RAR and cerebrovascular disease mortality. Kaplan-Meier survival analysis and RCS analysis revealed a significant dose-response relationship between RAR and all-cause mortality, cardiovascular disease mortality, and heart disease mortality. This relationship showed a nonlinear increasing trend once RAR reached a certain threshold, suggesting that RAR elevation does not simply linearly increase risk, but rather accelerates the pathophysiological imbalance, leading to a sharp increase in mortality risk. Stratified analysis indicated heterogeneity in the association between RAR and heart disease mortality across different subgroups. For example, in diabetic patients not using antidiabetic medications, the predictive value of RAR may be stronger. In addition, the association between RAR and heart disease mortality was stronger in male patients than in female patients. Furthermore, the association between RAR and all-cause mortality, heart disease mortality, and cardiovascular disease mortality was particularly significant in smokers, patients with hypertension, and those with cardiovascular disease.</p><p><strong>Conclusions: </strong>This study found that in diabetic patients, an elevated RAR is significantly associated with increased risks of all-cause mortality, heart disease mortality, and cardiova","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Lorundrostat in Uncontrolled and/or Treatment Resistant Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Manahil Mubeen, Kuldeep Dalpat Rai, Aneesh Kumar Sangtiani, Laiba Shuaib, Ayesha Irfan, Sijan Poudel","doi":"10.1007/s40292-025-00742-9","DOIUrl":"https://doi.org/10.1007/s40292-025-00742-9","url":null,"abstract":"<p><strong>Background: </strong>Resistant hypertension (RH) persists despite use of three different antihypertensive drug classes. Additionally, people with persistent hypertension despite the use of multiple drugs, who do not fit the RH criteria are said to have uncontrolled hypertension. Both these populations have increased risk of cardiovascular, CNS, and renal complications. Aldosterone plays a key role in RH and uncontrolled hypertension. Lorundrostat, a selective aldosterone synthase inhibitor targeting CYP11B2 enzyme, shows promise in improving blood pressure control in these populations.</p><p><strong>Aim: </strong>To evaluate lorundrostat's efficacy and safety in uncontrolled and treatment-resistant hypertension through a meta-analysis of randomized controlled trials.</p><p><strong>Methods: </strong>We searched PubMed, Cochrane, Google Scholar, and clinicaltrials.gov through July 2025. Screening was done via rayyan.ai; data analyzed with Review Manager 5.4. Risk of bias and evidence certainty used Cochrane Risk of Bias 2.0 and GRADE.</p><p><strong>Results: </strong>Three high-quality RCTs with 1426 patients were included. Stable dose lorundrostat significantly reduced mean systolic blood pressure compared to placebo (MD = - 9.81 mmHg; 95% CI [- 12.80, - 6.83]; p < 0.00001) and dose-adjusted lorundrostat also showed reduction (MD= - 7.35; 95% CI [- 10.81, - 3.89]; p < 0.0001). Adverse events; hypotension, hyponatremia, hyperkalemia, and reduced GFR were more frequent with lorundrostat, while hypertension-related events were more common in placebo. Certainty of evidence was high (except for any adverse event), and heterogeneity was low across outcomes (except for any adverse event with dose adjustment).</p><p><strong>Conclusion: </strong>Lorundrostat effectively reduces systolic BP in uncontrolled and resistant hypertension but requires cautious monitoring due to safety concerns.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of the Triglyceride-Glucose Index and Body Fat Composition with Blood Pressure in Children and Adolescents.","authors":"Qingshan Yan, Wenya Cai, Jieling Wu, Yong Guo","doi":"10.1007/s40292-025-00749-2","DOIUrl":"https://doi.org/10.1007/s40292-025-00749-2","url":null,"abstract":"<p><strong>Introduction: </strong>While the triglyceride-glucose (TyG) index is a recognized marker of cardiometabolic risk, its influence on blood pressure through body composition in children has not been fully elucidated.</p><p><strong>Aim: </strong>This study aimed to investigate the associations between the TyG index and blood pressure in children and adolescents, and to examine the mediating role of body composition in this relationship.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted using data from 408 children aged 6-17 years in Guangdong Province, representing a subsample of the National Nutrition and Health Systematic Survey for children aged 0-18 years in China. The participants underwent venous blood tests (TyG index calculation), body composition assessments (InBody 770 bioelectrical impedance analyzer), and blood pressure measurements. Linear/logistic regression and mediation analyses were performed to evaluate associations and mediating effects.</p><p><strong>Results: </strong>The TyG index showed the strongest positive associations with systolic blood pressure (SBP: β = 4.49, 95% CI 2.36-6.61; P<0.001) and diastolic blood pressure (DBP: β = 2.07, 95% CI 0.56-3.58; P=0.007). Elevated blood pressure risk was significantly linked to the TyG index (OR = 2.04, 95% CI 1.29-3.22; P=0.002) and obesity-related parameters, particularly the fat mass index (FMI: OR = 1.50) and waist‒hip ratio (WHR-z: OR = 2.10). Mediation analysis revealed partial indirect effects of body composition on the TyG-SBP association (total effect: 4.49, 95% CI 2.36-6.61) but no mediation effect for the TyG-DBP.</p><p><strong>Conclusions: </strong>Our findings demonstrate that the TyG index is independently associated with elevated blood pressure in children and adolescents. Importantly, obesity-related body fat composition, especially measured by the FMI and WHR, partially mediates the association between TyG index and SBP.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Pre-participation Evaluation of Athletes with an Impairment Recruited for Paris 2024 Paralympic Games.","authors":"Maria Rosaria Squeo, Armando Ferrera, Giuseppe Di Gioia, Cristian Triolo, Andrea Serdoz, Federica Mango, Viviana Maestrini, Sara Monosilio, Giovanni Marco Dutti, Alessandro Spinelli, Roberto Fiore, Domenico Zampaglione, Giulia Paoletti, Simone Crotta, Giuseppe Santoro, Massimo Volpe, Antonio Pelliccia, Marco Bernardi","doi":"10.1007/s40292-025-00740-x","DOIUrl":"https://doi.org/10.1007/s40292-025-00740-x","url":null,"abstract":"<p><strong>Introduction: </strong>Paralympic athletes (PA) represent a special part of the athletic population and deserve a specialized functional and medical care. In view of the 2024 Paris Paralympic Games, a comprehensive sport medical screening was carried out in Italy. This pre-participation medical assessment included clinical, laboratory and instrumental tests including cardiopulmonary exercise test (CPET) and trans thoracic echocardiography (TTE).</p><p><strong>Aim: </strong>To assess prevalence and type of cardiovascular abnormalities in PA candidate to compete in 2024 Paralympic Games.</p><p><strong>Methods: </strong>We enrolled 167 PA, 80 female and 87 male PA. All of them underwent a comprehensive, multidisciplinary evaluation, including a full panel of blood tests, resting ECG, TTE and CPET.</p><p><strong>Results: </strong>74 PA (44%) showed one or more cardiovascular abnormalities. In details, 12 PA showed abnormal basal ECG findings, 7 abnormal TTE results, 1 uncontrolled hypertension, 30 exercise induced arrhythmias, 8 abnormal basal ECG findings in combination with exercise induced arrhythmias and 7 abnormal basal ECG finding and abnormal echocardiographic findings. Furthermore, 9 PA showed exercise test induced arrhythmias with abnormal echocardiographic findings.</p><p><strong>Conclusions: </strong>PA, despite their attitude high levels of performance, are not exempt from cardiovascular and metabolic abnormalities, including a small proportion of cardiac conditions at potential risk of sudden cardiac death. Comprehensive diagnostic tools, including CPET, echocardiography and full blood tests are important to identify hidden cardiovascular abnormalities potentially harmful to the athlete's health.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Morning Hypertension is a Predictor of Cardiovascular Events in Treated and Well Controlled Hypertensive Patients.","authors":"Romina Diaz, Jessica Barochiner, Lucas Aparicio, Rocio Martinez","doi":"10.1007/s40292-025-00746-5","DOIUrl":"https://doi.org/10.1007/s40292-025-00746-5","url":null,"abstract":"<p><strong>Introduction: </strong>The prognostic significance of isolated morning hypertension (IMH) in treated hypertensive patients remains unclear. Although overall blood pressure (BP) control is often considered adequate, morning BP surges may still pose cardiovascular risks.</p><p><strong>Aim: </strong>To determine whether the presence of IMH in treated hypertensive patients with globally controlled BP is associated with an increased risk of cardiovascular events.</p><p><strong>Methods: </strong>This cohort study included hypertensive patients on stable antihypertensive treatment for ≥ 4 weeks who underwent home blood pressure monitoring (HBPM) between September 1, 2008, and December 31, 2015. BP was measured in duplicate over four days (morning, afternoon, and evening) using an OMRON 705 CP device. IMH was defined as an average morning BP > 135 and/or 85 mmHg, despite overall mean BP < 135/85 mmHg. Patients were followed until April 30, 2020, for fatal and non-fatal cardiovascular and cerebrovascular events. Cox proportional hazards models were used to assess the prognostic value of IMH.</p><p><strong>Results: </strong>A total of 925 patients were included, with a prevalence of IMH of 17.4% (95% CI 15.1-20%). During a median follow-up of 6.2 years, 126 cardiovascular events occurred. Compared to well-controlled hypertensive patients without IMH, those with IMH had a significantly higher risk of cardiovascular events after adjusting for sex, age, body mass index, number of antihypertensive drugs, smoking status, diabetes, and office BP (HR 1.6, 95% CI 1.1-2.2; p = 0.02).</p><p><strong>Conclusions: </strong>IMH detected through HBPM was associated with an increased risk of fatal and non-fatal cardiovascular and cerebrovascular events in treated hypertensive patients with otherwise adequate global BP control. Monitoring and addressing IMH may be essential to further reducing cardiovascular risk.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension International Guidelines: Three of a Kind?","authors":"Agostino Virdis, Maria Lorenza Muiesan, Guido Grassi, Massimo Volpe","doi":"10.1007/s40292-025-00748-3","DOIUrl":"https://doi.org/10.1007/s40292-025-00748-3","url":null,"abstract":"","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal Aorta Remodeling in Hypertensive Patients: The Campania Salute Network.","authors":"Costantino Mancusi, Ilaria Fucile, Daniela Pacella, Christian Basile, Maria Virginia Manzi, Maria Lembo, Grazia Canciello, Carmine De Luca, Maddalena Tesone, Stefano Cristiano, Giuseppe Giugliano, Maria Angela Losi, Nicola De Luca, Eduardo Bossone, Raffaele Piccolo, Carmine Morisco, Raffaele Izzo, Giovanni Esposito","doi":"10.1007/s40292-025-00745-6","DOIUrl":"https://doi.org/10.1007/s40292-025-00745-6","url":null,"abstract":"<p><strong>Introduction: </strong>Routine assessment of abdominal aorta (AA) is not currently advised by the available guidelines, although hypertension is a major risk factor for the development of AA aneurysm.</p><p><strong>Aim: </strong>In the present study, we assessed correlations and predictive factors of AA dimension in a cohort of hypertensive patients.</p><p><strong>Methods: </strong>3083 Patients ≥ 18 years old with available AA ultrasound were included. AA dilatation was defined as an AA diameter ≥ 25 mm. Correlations of AA dimension and dilatation with demographics and metabolic profile were explored. Multivariable regression was also used to identify potential confounders influencing univariate correlations. To evaluate the prognostic impact of AA dilatation a propensity score model was implemented, and survival probability curves were constructed using the Kaplan-Meier method.</p><p><strong>Results: </strong>Increased AA diameter was independently associated with older age, male sex, active smoking, higher diastolic and lower systolic blood pressure, higher LV mass index and aortic root dimension and less use of β-blockers at baseline (all p < 0.05). A significant effect of baseline use of β-blockers and calcium channel blockers therapy were found (all p < 0.01). During a mean follow-up of 4.76 ± 2.91 years, 32 MACE occurred. Kaplan-Meier analysis showed that having AA ≥ 25 mm is associated with significant risk of MACE compared to patients with AA < 25 mm.</p><p><strong>Conclusions: </strong>AA remodeling is strongly influenced by the cardiovascular (CV) risk profile and hypertension mediated target organ damage and AA dilatation contributes to increased CV risk in treated hypertensive patients.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Differences in Subclinical Organ Damage and Cardiovascular Risk Stratification Among Patients Classified by the Presence of Coronary Artery Disease and Hypertension.","authors":"Lucyna Woźnicka-Leśkiewicz, Anna Posadzy-Małaczyńska","doi":"10.1007/s40292-025-00744-7","DOIUrl":"https://doi.org/10.1007/s40292-025-00744-7","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiovascular diseases are the leading cause of death. Women are more frequently affected by these diseases than men.</p><p><strong>Aims: </strong>To investigate the relationships between subclinical organ damage markers: ankle-brachial index (ABI), pulse wave velocity (PWV), intima-media thickness (IMT) and cardiovascular risk assessed by SCORE2/SCORE2-OP scales, stratified by sex and the presence or absence of coronary artery disease (CAD) and/or hypertension (HT).</p><p><strong>Methods: </strong>We studied 200 patients divided into groups: CAD + HT+, CAD + HT-, CAD-HT+, and CAD-HT-. Measurements included: ABI, PWV, IMT and cardiovascular risk assessed by SCORE2/SCORE2-OP scales. Statistical analyses were performed using StatSoft Statistica 10.</p><p><strong>Results: </strong>In hypertensive and non-hypertensive groups, cardiovascular risk assessed by SCORE2/SCORE2-OP scales was higher in men than in women. In the group without CAD, women- with and without hypertension- showed a significant correlation between cardiovascular risk and both ABI and IMT. In men without CAD and hypertension, cardiovascular risk correlated significantly with PWV and IMT. In logistic regression models within the primary prevention group (with or without hypertension), significant correlations between ABI and SCORE2/SCORE2-OP were observed only in women, whereas significant correlations between PWV and SCORE2/SCORE2-OP were found only in men.</p><p><strong>Conclusion: </strong>Sex-related differences in cardiovascular risk factor profiles and disease progression highlight the importance of sex-specific approaches in risk stratification and management. Logistic regression models suggest a dependence on patient sex in predictive accuracy and biomarker significance. These findings point to a potential role for sex-specific models in risk assessment, but must be interpreted cautiously as associative, not predictive, consistent with the observational design.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of Cardiovascular Diseases Attributable to Hypertension in Population Aged 60 Years or Older from 1990 to 2040 across BRICS-plus Countries (Egypt, Ethiopia, Iran, Saudi Arabia, United Arab Emirates, Brazil, Russia, India, China, and South Africa).","authors":"Hongrui Zhang, Bin Wang, Jiake Guo, Yichen Liu, Zhuoshuai Liang, Xiaoyang Li, Ruofei Li, Yuyang Tian, Shuan Qiu, Yong Li, Yulu Gu, Huan He, Yichun Qiao, Siyu Liu, Yunkai Liu, Yi Cheng, Yawen Liu","doi":"10.1007/s40292-025-00747-4","DOIUrl":"https://doi.org/10.1007/s40292-025-00747-4","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension, frequently found in the population aged 60 years or older, is associated with multiple cardiovascular diseases (CVDs). BRICS-plus countries (Egypt, Ethiopia, Iran, Saudi Arabia, the United Arab Emirates, Brazil, Russia, India, China, and South Africa) account for over 40% of global population and are undergoing rapid economic development and population growth. The burden of CVDs attributable to hypertension in the elderly population of BRICS-plus remains uncharted.</p><p><strong>Aim: </strong>To Explore the burden of CVDs attributable to hypertension in the elderly population in BRICS-plus.</p><p><strong>Methods: </strong>Deaths and disability adjusted life years (DALYs) were used as indices of the burden of CVDs attributable to hypertension. This burden was investigated using joinpoint regression, age-period-cohort, and Nordpred analysis.</p><p><strong>Results: </strong>Age-standardized DALYs rate and age-standardized mortality rate declined in Russia after 2002, but fluctuating in United Arab Emirates after 2003. The average age-standardized DALYs rate of stroke, ischemic heart disease (IHD), and hypertensive heart disease (HHD) had anisotropic features for nations (China: 58.02%, Russia: 54.64%, and Ethiopia: 37.81%) from 1990 to 2021.</p><p><strong>Conclusion: </strong>The burden of CVDs attributable to hypertension in the elderly population from 1990 to 2021 in aging countries shows different decline trends. Egypt has the highest burden in none-aging countries. The United Arab Emirates remains elusive because the elderly female population has remained at a relatively low level. HHD, IHD, and stroke account for the highest proportion in Ethiopia, Russia, and China.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulse Wave Velocity Progression Determinants: No Significant Association with Novel Lipids Parameter.","authors":"Ilaria Garofani, Chiara Tognola, Martina Morelli, Atea Shkodra, Michela Algeri, Marco Bellomare, Valentina Colombo, Filippo Brucato, Serena Guasti, Andrea Bonelli, Cristina Giannattasio, Alessandro Maloberti","doi":"10.1007/s40292-025-00741-w","DOIUrl":"https://doi.org/10.1007/s40292-025-00741-w","url":null,"abstract":"<p><strong>Introduction: </strong>Whether novel lipid parameters are related to arterial stiffness (pulse wave velocity-PWV), changes during follow-up (i.e ΔPWV) has never been evaluated.</p><p><strong>Aim: </strong>To evaluate the relationship between standard and emerging lipid parameters (non-HDL/HDL, LDL/HDL, total cholesterol/HDL, TG/HDL, Log(TG)/HDL, Log(TG/HDL) and the triglyceride-glucose index [TyG]) and ΔPWV among hypertensive patients.</p><p><strong>Methods: </strong>We included 469 hypertensive patients enrolled from September 2006 to October 2010 from the Hypertension Unit of San Gerardo Hospital (Monza, Italy). PWV was measured at baseline and after a mean follow-up of 3.8 years (I-III quartiles 3.5-4.2 years) and the relative change (ΔPWV) was calculated.</p><p><strong>Results: </strong>The study cohort had a mean age of 53.6 ± 12.9 years and 58.4% were male. PWV significantly increased from baseline to follow-up (8.6 ± 2.1 vs. 9.2 ± 2.4 m/s; p=0.0001), with 51.6% of patients exhibiting a ΔPWV≥0.5 m/s. These patients had a significantly lower HDL cholesterol (51.5 ± 13.5 vs. 54.7 ± 13.3 mg/dL) with higher LDL/HDL ratio (2.5 ± 0.9 vs. 2.3 ± 0.9 p=0.049), non-HDL/HDL ratio (3.0 ± 1.1 vs. 2.8 ± 1.1), total cholesterol/HDL ratio (4.0 ± 1.1 vs. 3.8 ± 1.1), Log(TG)/HDL (0.043 ± 0.015 vs. 0.039 ± 0.014) and Log(TG/HDL) (0.351 ± 0.290 vs. 0.295 ± 0.278, p<0.05 for all comparison). A significant univariate association was found between ΔPWV and ΔPWV≥0.5 and Log(TG)/HDL (r = 0.121, p =  0.009 and r = 0.094, p =  0.042, respectively) but it didn't persist at multivariable analysis adjusted for age, sex, Δ systolic blood pressure, anti-hypertensive therapies and statins, diabetes, and glomerular filtration rate.</p><p><strong>Conclusions: </strong>Our study found no significant associations between emerging lipid parameters and PWV/ΔPWV. Age and blood pressure values remains the main determinants of PWV and its changes over time.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}