霍德兰健康研究：老年女性血压和动脉僵硬的关系比男性强。

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE

High Blood Pressure & Cardiovascular Prevention Pub Date : 2025-05-01 Epub Date: 2025-05-12 DOI:10.1007/s40292-025-00719-8

Annabel Eide Ohldieck, Helga Midtbø, Ester Kringeland, Arleen Aune, Eva Gerdts

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引用次数: 0

摘要

臂膀血压生命历程发展的性别差异（Bi et al.）。中华医学杂志，2014。https://doi.org/10.1056/NEJMoa2412006)以及肱和中央血压之间的关系都有很好的文献记载。目的：探讨老年女性和男性动脉僵硬度升高与肱动脉和中央动脉血压的关系是否存在差异。方法：采用霍德兰健康研究中1135名女性和943名68岁男性的数据。肱血压分为正常（血压< 130/85 mmHg）、高正常（血压130-139/85-89 mmHg）或高血压（血压≥140/90 mmHg）。通过颈-股脉波速度（cfPWV）评估动脉僵硬度，通过肱脉波分析评估中心收缩压。在逻辑回归分析中检验了血压和动脉僵硬度增加（cfPWV >10 m/s）之间的性别特异性关联，并以比值比（OR）和95%置信区间（CI）报告。结果：在多变量分析中，与男性（OR为2.56 [95% CI 1.43-4.56]和OR为2.01 [95% CI 1.22-3.33]）相比，女性（OR为5.81 [95% CI 3.86-8.75]和OR为2.56 [95% CI 1.43-4.56]和OR为2.01 [95% CI 1.22-3.33]）的高血压和高正常血压与动脉僵硬度增加的相关性更强。在68岁的个体中，高正常血压、高血压和高中枢收缩压与女性动脉僵硬增加的关系比男性更强。

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Stronger Association Between Blood Pressure and Arterial Stiffness in Older Women than Men: The Hordaland Health Study.

Introduction: Sex differences in the life course development of brachial blood pressure (Bi et al. N Engl J Med, 2024. https://doi.org/10.1056/NEJMoa2412006 ) and the association between brachial and central BP are well documented.

Aim: To explore if the associations of brachial and central BP with the presence of increased arterial stiffness differ between older women and men.

Methods: Data from 1135 women and 943 men aged 68 in the Hordaland Health Study were used. Brachial BP was categorised as normal (BP< 130/85 mmHg), high-normal (BP 130-139/85-89 mmHg) or hypertension (BP≥140/90 mmHg). Arterial stiffness was assessed from carotid-femoral pulse wave velocity (cfPWV), and central systolic BP from brachial pulse wave analysis. Sex-specific associations between BP and increased arterial stiffness (cfPWV >10 m/s) were tested in logistic regression analyses and reported as odds ratio (OR) and 95% confidence intervals (CI).

Results: In multivariable analyses, both hypertension and high-normal BP were more strongly associated with presence of increased arterial stiffness in women (OR 5.81 [95% CI 3.86-8.75] and OR 2.56 [95% CI 1.43-4.56], respectively) compared to men (OR 2.56 [95% CI 1.43-4.56] and OR 2.01 [95% CI 1.22-3.33], both p for sex-interaction <0.05). Additionally, central systolic BP showed a stronger association with increased arterial stiffness in women (OR 1.06 [95% CI 1.05-1.07]) than in men (OR 1.05 [95% CI 1.04-1.06], p for sex-interaction <0.05).

Conclusions: In 68-year-old individuals, a high normal BP, hypertension and higher central systolic BP were all more strongly associated with the presence of increased arterial stiffness in women than in men.

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来源期刊

High Blood Pressure & Cardiovascular Prevention PERIPHERAL VASCULAR DISEASE-

CiteScore

5.70

自引率

3.30%

发文量

期刊介绍： High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes: Invited ''State of the Art'' reviews. Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.