High Blood Pressure & Cardiovascular Prevention最新文献

{"title":"Artificial Intelligence in Cardiovascular Health: Insights into Post-COVID Public Health Challenges.","authors":"Zayera Naushad, Jaya Malik, Abhishek Kumar Mishra, Shilpy Singh, Dharmsheel Shrivastav, Chetan Kumar Sharma, Ved Vrat Verma, Ravi Kant Pal, Biswajit Roy, Varun Kumar Sharma","doi":"10.1007/s40292-025-00738-5","DOIUrl":"10.1007/s40292-025-00738-5","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) continue to be the topmost cause of the worldwide morbidity and mortality. Risk factors such as diabetes, hypertension, obesity and smoking are significantly worsening the situation. The COVID-19 pandemic has powerfully highlighted the undeniable connection between viral infections and cardiovascular health. Current literature highlights that SARS-CoV-2 contributes to myocardial injury, endothelial dysfunction, thrombosis, and systemic inflammation, increasing the severity of CVD outcomes. Long COVID has also been associated with persistent cardiovascular complications, including myocarditis, arrhythmias, thromboembolic events, and accelerated atherosclerosis. Addressing these challenges requires continued research and public health strategies to mitigate long-term risks. Artificial intelligence (AI) is changing cardiovascular medicine and community health through progressive machine learning (ML) and deep learning (DL) applications. AI enhances risk prediction, facilitates biomarker discovery, and improves imaging techniques such as echocardiography, CT, and MRI for detecting coronary artery disease and myocardial injury on time. Remote monitoring and wearable devices powered by AI enable real-time cardiovascular assessment and personalized treatment. In public health, AI optimizes disease surveillance, epidemiological modeling, and healthcare resource allocation. AI-driven clinical decision support systems improve diagnostic accuracy and health equity by enabling targeted interventions. The integration of AI into cardiovascular medicine and public health offers data-driven, efficient, and patient-centered solutions to mitigate post-COVID cardiovascular complications.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"475-494"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three months of bempedoic acid treatment does not affect cystatin C-based estimation of glomerular filtration rate.","authors":"Leandra Serio, Antonella Paolucci, Maria Ester Carugno, Sofia Cappannari, Alessia Cecchini, Marianna Litterio, Rita Del Pinto, Claudio Ferri","doi":"10.1007/s40292-025-00732-x","DOIUrl":"10.1007/s40292-025-00732-x","url":null,"abstract":"<p><strong>Introduction: </strong>Bempedoic acid can interfere with creatinine excretion, thereby potentially altering the calculation of glomerular filtration rate (eGFR), but is not known to have an effect on cystatin C metabolism.</p><p><strong>Aim: </strong>The aim of this pilot observational study was to assess the impact of 3-months bempedoic acid treatment on renal function assessed by serum creatinine and cystatin C.</p><p><strong>Methods: </strong>Consecutive hypercholesterolemic outpatients with indication to be started on bempedoic acid and available serum creatinine and cystatin C levels were enrolled. Follow-up (45-90 days) renal function markers were assessed. Lipid profile, uric acid levels, and CRP levels were also recorded.</p><p><strong>Results: </strong>Bempedoic acid reduced LDL-c and total cholesterol levels by day 45. No changes were observed in HDL-c, triglycerides, Lp(a), serum creatinine, eGFR_cr, BUN, uric acid, or CRP levels throughout the study. The sensitivity analysis on individuals with complete data for cystatin C during follow-up (42%) confirmed the overall observations, while also showing neutral effects of bempedoic acid eGFR_cys and eGFR_cr-cys.</p><p><strong>Conclusions: </strong>Three-months administration of bempedoic acid did not affect cystatin C levels. Adequately powered studies are needed to test these findings and, ultimately, the renal safety of bempedoic acid.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"533-541"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different Polymorphisms of the Renin-Angiotensin-Aldosterone System Genes are Associated with Poorer Blood Pressure Control in Hypertensive Older Adults.","authors":"Ivna Vidal Freire, Icaro J S Ribeiro, Cezar Augusto Casotti, Diego Andrade, Débora Diniz Bezerra, Jules Ramon Brito Teixeira, Ana Angélica Leal Barbosa, Luciene Cristina Gastalho Campos, Rafael Pereira","doi":"10.1007/s40292-025-00725-w","DOIUrl":"10.1007/s40292-025-00725-w","url":null,"abstract":"<p><strong>Introduction: </strong>Adequate blood pressure control (BPC) is crucial for preventing hypertension, as well as for mitigating the risks associated with inadequate control among hypertensive older adults. Identifying modifiable factors (i.e., dietary and biochemical patterns, sociodemographic characteristics, and health habits) and non-modifiable factors (i.e., genetic background) is crucial for improving control rates.</p><p><strong>Aim: </strong>This study aimed to analyze the association between Renin-Angiotensin-Aldosterone System gene polymorphisms, sociodemographic characteristics, health and lifestyle habits, and BPC in older adults.</p><p><strong>Methods: </strong>one hundred and forty-three older adults comprised the study population, and were genotyped for angiotensinogen (AGT) [M235T], renin (REN) [G2646A] angiotensin-converting enzyme (ACE) [InDel], angiotensin II type 1 receptor (AT1R) [A1166C] aldosterone synthase (CYP11B2) [C344T] gene polymorphisms. Sociodemographic characteristics, health, and lifestyle habits were recorded using questionnaires, and blood pressure was measured using standard methods. A Poisson multivariate regression was applied.</p><p><strong>Results: </strong>Our finding indicated that, together, LDL-C, the A allele of the REN gene (G2646A), and genotype II of the ACE gene (InDel) were significantly associated with inadequate BPC in the community-dwelling older adults.</p><p><strong>Conclusions: </strong>Due to its non-modifiable nature, the genetic background has the potential to identify individuals with a greater risk of illness. The knowledge of the genetic profiles prone to impaired BPC and its interaction with modifiable factors could guide more effective behaviors and/or treatments aiming to mitigate the morbidity and mortality related to poor BPC among hypertensive older adults.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"523-532"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the Epigenetic Remodeler GCN5 Prevents Vascular Oxidative Stress and Endothelial Dysfunction in Obesity: Insights in Patients with Cardiometabolic Disease.","authors":"Sarah Costantino, Shafeeq Mohammed, Alessandro Mengozzi, Emiliano Duranti, Valentina Delfine, Martin A Geiger, Nazha Hamdani, Stefano Taddei, Stefano Masi, Agostino Virdis, Francesco Paneni","doi":"10.1007/s40292-025-00739-4","DOIUrl":"10.1007/s40292-025-00739-4","url":null,"abstract":"<p><strong>Introduction: </strong>Epigenetic changes are important modulators of gene expression. The histone acetyltransferase gene non-derepressible 5 (Gcn5) is emerging as a pivotal epigenetic player in metabolism and cancer, yet its role in obesity and cardiovascular disease remains elusive.</p><p><strong>Aims: </strong>To investigate Gcn5 role in obesity-related endothelial dysfunction.</p><p><strong>Methods: </strong>Human aortic endothelial cells (HAECs) were exposed to vehicle or palmitic acid (200 uM) in the presence or in the absence of the Gcn5 pharmacological inhibitor CPTH2 or gene silencing. Ex-vivo inhibition of Gcn5 was performed in aortic rings from diet-induced obese and control mice. Chromatin immunoprecipitation (ChIP) was performed to investigate the epigenetic regulation of Nox2 promoter. In parallel, Gcn5/Nox2 expression was assessed by real-time PCR in vascular specimens isolated from obese patients and age-matched healthy controls. Endothelial-dependent vasodilation was also assessed in human vessels.</p><p><strong>Results: </strong>PA increased Gcn5 gene expression in HAECs. Gcn5 upregulation was associated with increased expression of the pro-oxidant enzyme Nox2. Interestingly, either Gcn5 inhibition or gene silencing prevented PA-induced Nox2 upregulation and oxidative stress accumulation. ChiP assay showed increased Gcn5 occupancy and enhanced histone 3 acetylation of lysine 14 (H3K14ac) on Nox2 promoter. In aortic rings from obese mice, pharmacological inhibition of Gcn5 by CPTH2 rescued endothelial-dependent vasorelaxation as compared to vehicle. Finally, Gcn5 was increased in vessels from obese patients and correlated with Nox2 expression and endothelial dysfunction.</p><p><strong>Conclusions: </strong>Our findings shed light on the importance of epigenetic regulation in obesity and pinpoint Gcn5 as a therapeutic target to prevent endothelial dysfunction in cardiometabolic disease.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"577-589"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Practical Predictor for Identifying Reverse-Dipper Blood Pressure Patterns: Left Atrial Coupling Index.","authors":"Ayca Arslan, Dogan Ilıs, Inanc Artac, Muammer Karakayali, Timor Omar, Zihni Cagin, Zulfiye Kuzu, Yavuz Karabag, Ibrahim Rencuzogullari","doi":"10.1007/s40292-025-00733-w","DOIUrl":"10.1007/s40292-025-00733-w","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension is a common and persistent disorder and mostly causes myocardial structural and functional abnormalities. As a subtype pattern of HT, the reverse-dipper blood pressure (BP) is associated with worse cardiovascular outcomes and early-phase subclinical myocardial damage compared to other patterns. The Left Atrial Coupling Index (LACI) is a novel echocardiographic parameter developed to assess the mechanical function.</p><p><strong>Aim: </strong>The aim of this study was to investigate the role of the LACI in predicting the reverse-dipper BP pattern in patients with hypertension.</p><p><strong>Methods: </strong>A total of 404 hypertensive patients who underwent 24-hour ambulatory blood pressure monitoring were prospectively enrolled. Patients were classified into dipper, non-dipper, and reverse-dipper groups based on their nocturnal BP profiles. Comprehensive echocardiographic evaluations were performed, and LACI was calculated for each patient.</p><p><strong>Results: </strong>A reverse-dipper BP pattern was observed in 26%(n = 105) of the 404 patients. Those with a reverse-dipper BP pattern exhibited higher mitral E/A ratio, E/Em means, left atrial volume index (LAVI), and LACI, along with lower Em septal, Am lateral mitral, and Am septal values. LACI (OR:3.837, 95% CI: 2.620-5.620, p < 0.001), LAVI, and Am lateral mitral value were found to be independent predictors of the reverse-dipper BP pattern. ROC curve comparison demonstrated that LACI was a better predictor of the reverse-dipper BP pattern than LAVI.</p><p><strong>Conclusions: </strong>Our study demonstrates that LACI, an easily accessible echocardiographic parameter, is a more robust predictor of the reverse-dipper BP pattern compared to traditional echocardiographic markers.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"543-552"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Pressure Variability (BPV): What Clinicians Need to Know a 2025 Expert Consensus Report Endorsed by the Egyptian Society of Cardiology.","authors":"Nabil Farag, Ahmed Bendary, Ahmed Shawky Elserafy, Ahmed Tageldien Abdellah, Bassem Zarif, Khaled Y Elnady, Mohamed Seleem Mohamed, Sameh Elkaffas, Marina Tadros, Omar Salem, Sameh Nessim, Sameh M Shaheen","doi":"10.1007/s40292-025-00737-6","DOIUrl":"10.1007/s40292-025-00737-6","url":null,"abstract":"<p><p>Blood pressure variability (BPV), independent of mean BP, is an emerging predictor of cardiovascular risk and hypertension-mediated organ damage. However, its clinical utility remains limited due to the lack of clear guideline recommendations, leading to variability in physician practices. Using the modified Delphi method, this is the first Egyptian consensus to provide expert recommendations for integrating BPV in Egypt's resource-limited settings.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"511-521"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choice of Reference Blood Pressure in the 2023 Guidelines of the European Society of Hypertension.","authors":"Giuseppe Mancia, Massimo Volpe","doi":"10.1007/s40292-025-00736-7","DOIUrl":"10.1007/s40292-025-00736-7","url":null,"abstract":"","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"469-474"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial Stiffness and Cardiovascular Risk Reclassification in Patients with Autoimmune Rheumatic Diseases.","authors":"Albertina M Ghelfi, Rosana Quintana, Lautaro L Velez, Leonel A Berbotto, Romina Nieto, Boris Kisluk, Jorge O Galindez, Guillermo A Berbotto","doi":"10.1007/s40292-025-00728-7","DOIUrl":"10.1007/s40292-025-00728-7","url":null,"abstract":"<p><strong>Introduction: </strong>Autoimmune rheumatic diseases (ARD) increase the risk of early subclinical vascular damage such as arterial stiffness (AS), which is associated with cardiovascular events. It remains unclear whether this also occurs during clinical remission or low disease activity (CR/LDA).</p><p><strong>Aims: </strong>We aimed to evaluate carotid-femoral pulse wave velocity (cf-PWV) in ARD-patients in CR/LDA and to compare them with a control group.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in Argentina (2022-2023). Group 1: ARD subjects in CR/LDA, without systemic organ involvement, office blood pressure (BP) <140/90 mmHg, and low 10-year cardiovascular risk (CVR) <5% according to WHO's calculator. Group 2: healthy controls.</p><p><strong>Exclusion criteria: </strong>associated clinical conditions, evidence of target organ damage, presence of traditional cardiovascular risk factors, and use of antihypertensives, statins, or aspirin. cf-PWV was measured using the Aortic device.</p><p><strong>Results: </strong>A total of 97 subjects were included: 48 ARD and 49 controls. Among those with high-normal BP: Group 1 showed higher cf-PWV (6.81±1.14 vs. 5.98±0.82 m/s, p<0.0001) and more AS (22/48 vs. 2/49, p<0.0001). In a sub-analysis restricted to subjects with normal-BP: Group 1 also showed higher cf-PWV and more AS (6.57±1.09 vs. 5.84±0.65 m/s, p=0.005; 14/36 vs. 0/37, p<0.0001). Among ARD patients the frequency of AS was 45.8% with high-normal BP and 38.8% with normal BP. Multivariate analysis showed that ARD and diastolic BP were independently associated with AS.</p><p><strong>Conclusions: </strong>ARD patients in CR/LDA even with traditional low-CVR showed higher cf-PWV.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"439-450"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of Cardiovascular Modifiable Risk Factors in a Corporate Wellness Program: A Case Study of Occupational Cardiology in the Ferrari Company.","authors":"Stefano Palermi, Marco Vecchiato, Sara Brusiani, Lorena De Martino, Mariarosaria De Luca, Fredrick Fernando, Elena Cavarretta, Josef Niebauer, Massimo Volpe, Alessandro Biffi","doi":"10.1007/s40292-025-00722-z","DOIUrl":"10.1007/s40292-025-00722-z","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiovascular (CV) diseases are the leading cause of mortality worldwide, and preventive strategies are increasingly focusing on early detection and management of risk factors. Corporate Wellness Programs (CWPs) in workplaces play a crucial role in the primary prevention of chronic non-communicable diseases, especially for early CV modifiable risk detection and management in apparently healthy individuals.</p><p><strong>Aim: </strong>This study explores the prevalence and age-related distribution of CV modifiable risk factors in a large cohort of Ferrari car manufacturer employees evaluated through a CWP.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted among 1992 employees participating for the first time in the \"Ferrari Formula Benessere\" CWP in Maranello, Italy, throughout 2023. The program included a comprehensive medical evaluation, personal and family history, anthropometric measurements, blood testing, and blood pressure evaluation. Data on demographic characteristics, health behaviors, and CV modifiable risk factors were collected and analyzed.</p><p><strong>Results: </strong>Most participants were males (82%), with a mean age of 40 ± 9 years. Findings revealed a notable prevalence of CV modifiable risk factors: 17.3% were active smokers, 43.2% reported physical inactivity, 34.8% were classified as overweight (body mass index ≥ 25), and 7.7% as obese. Early screening identified a significant proportion of employees with elevated CV risk according to the SCORE2 algorithm: 39% were categorized as having a high CV risk and 2% at a very high CV risk. In addition, 6.4% had impaired fasting glycemia (100-125 mg/dL), 3.8% had dyslipidemia and 6.8% had high blood pressure (systolic blood pressure 140-159 mmHg): almost none of them (98%) were on treatment.</p><p><strong>Conclusions: </strong>The \"Ferrari Formula Benessere\" identified a wide range of CV modifiable risk factors in a cohort of apparently healthy employees, not routinely screened, highlighting the essential role of CWPs in the early detection and management of CV health risks. These findings underscore the importance of integrating regular health assessments into corporate wellness strategies to mitigate CV risk and promote overall employee well-being.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"397-408"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women HEalth and PREgnancy Complications (HER): a physician-based Survey on Hypertensive Disorders in Pregnancy of the Italian Society of Hypertension (SIIA).","authors":"Federica Piani, Marialuisa Sveva Marozzi, Alessandro Maloberti, Francesco Spannella, Valeria Visco, Lorenzo Annesi, Sebastiano Cicco, Claudio Borghi, Maria Lorenza Muiesan, Agostino Virdis","doi":"10.1007/s40292-025-00729-6","DOIUrl":"10.1007/s40292-025-00729-6","url":null,"abstract":"<p><strong>Introduction: </strong>Management of hypertensive disorders in pregnancy (HDP) remains challenging, with various healthcare providers involved and no uniform approach with variability in medications, monitoring, and intervention timing reflecting gaps in research.</p><p><strong>Aim: </strong>To investigate Italian physicians' knowledge on the topic and examine their clinical practices.</p><p><strong>Methods: </strong>We collected multi-regional data from Italian experts on Hypertension and Gynecologists. The survey consisted of 18 multiple choice questions. Questions involved patient access pathways for suspected HDP, diagnostic assessments, first- and second-line therapies, follow-up visits modalities, and postpartum recommendations.</p><p><strong>Results: </strong>One-hundred and ten experts on hypertension and 31 gynecologists from third-referral centers of 16 over 20 Italian Regions participated in the survey. Only 27.7% of participants were aware of the actual risk of developing preeclampsia in women with chronic hypertension, and only one over two was aware of all long-term risks of cardiovascular disease. Hypertension specialists were in charge of the first antihypertensive prescription in less than 10% of HDP cases. Most common first-line agent was nifedipine and second-line agent nifedipine or methyldopa. Adding a second agent was slightly preferred over the use of maximum dosage of the first agent; 72.6% declared choosing the medication based on maternal hemodynamic profile. Consistent involvement of Hypertension Centers during both pregnancy and postpartum was reported only by 56.7% of physicians.</p><p><strong>Conclusions: </strong>The survey revealed significant gaps in awareness and management practices for women with HDP.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"451-461"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}