High Blood Pressure & Cardiovascular Prevention最新文献

{"title":"Epicardial Fat Volume as a Good Predictor for Multivessel Coronary Artery Disease.","authors":"Eman S El Shahawy,&nbsp;Asmaa A Hassan,&nbsp;Mohamed S El Shahawy","doi":"10.1007/s40292-023-00590-5","DOIUrl":"10.1007/s40292-023-00590-5","url":null,"abstract":"<p><strong>Introduction: </strong>Epicardial adipose tissue may have an important role in the pathogenesis of coronary artery disease (CAD).</p><p><strong>Aim: </strong>We aimed to study the association between epicardial fat volume (EFV) and presence of obstructive as well as multivessel CAD.</p><p><strong>Methods: </strong>A total of 87 adult subjects with suspected CAD who underwent both quantified by multidetector computerized tomography (MDCT) and Invasive Coronary Angiography (ICA) were enrolled in this observational study. EVF was measured by MDCT by calculating the sum of cross- sectional areas of fat multiplied by slice thickness. EFV measurement and its association with the presence of obstructive CAD (defined as coronary artery stenosis > 70%) was evaluated.</p><p><strong>Results: </strong>Overall, 89.6% patients had obstructive CAD with higher EFV as compared to 10.3% patients with non-obstructive CAD (57 ± 20.14 cm³ vs. 44 ± 7.4 cm³; P < 0.001). Furthermore, EFV was significantly increased in group II as compared with group I (74 ± 24.3 ml vs. 53 ± 16.2 ml; P < 0.003). On the hand, the coronary calcium score (CAC) was insignificantly increased in group II as compared with group I (486.1 vs. 211.2; P = 0.10). Multivariate analysis revealed that, EFV might be an independent risk factor for not only the presence of obstructive CAD (odds ratio [OR], 1.062; 95% CI 1.018- 1.108; P < 0.005) but also in predicting multivessel disease affection.</p><p><strong>Conclusions: </strong>Our results demonstrated that, EFV was significantly increased not only with obstructive CAD, independent of other traditional risk factors and CAC score, but also it can be considered a good predictor of multivessel disease occurrence.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"427-434"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41117285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Clinical Phenotypes of Patients with Acute Decompensated Heart Failure.","authors":"Tanya Mohammadi,&nbsp;Said Tofighi,&nbsp;Babak Mohammadi,&nbsp;Shadi Halimi,&nbsp;Farshad Gharebakhshi","doi":"10.1007/s40292-023-00598-x","DOIUrl":"10.1007/s40292-023-00598-x","url":null,"abstract":"<p><strong>Introduction: </strong>Acute decompensated heart failure (AHF) is a clinical syndrome with a poor prognosis.</p><p><strong>Aim: </strong>This study was conducted to identify clusters of inpatients with acute decompensated heart failure that shared similarities in their clinical features.</p><p><strong>Methods: </strong>We analyzed data from a cohort of patients with acute decompensated heart failure hospitalized between February 2013 and January 2017 in a Department of Cardiology. Patients were clustered using factorial analysis of mixed data. The clusters (phenotypes) were then compared using log-rank tests and profiled using a logistic model. In total, 458 patients (255; 55.7% male) with a mean (SD) age of 72.7 (11.1) years were included in the analytic dataset. The demographic, clinical, and laboratory features were included in the cluster analysis.</p><p><strong>Results: </strong>The two clusters were significantly different in terms of time to mortality and re-hospitalization (all P < 0.001). Cluster profiling yielded an accurate discriminating model (AUC = 0.934). Typically, high-risk patients were elderly females with a lower estimated glomerular filtration rate and hemoglobin on admission compared to the low-risk phenotype. Moreover, the high-risk phenotype had a higher likelihood of diabetes type 2, transient ischemic attack/cerebrovascular accident, previous heart failure or ischemic heart disease, and a higher serum potassium concentration on admission. Patients with the high-risk phenotype were of higher New York Heart Association functional classes and more positive in their medication history.</p><p><strong>Conclusions: </strong>There are two phenotypes among patients with decompensated heart failure, high-risk and low-risk for mortality and re-hospitalization. They can be distinguished by easy-to-measure patients' characteristics.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"457-466"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10154501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Arterial Hypertension After COVID-19 Recovery.","authors":"Tomoyuki Kawada","doi":"10.1007/s40292-023-00597-y","DOIUrl":"10.1007/s40292-023-00597-y","url":null,"abstract":"","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"485"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10083894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Azelnidipine as an Antihypertensive Compared to Amlodipine: A Systematic Review and Meta-analysis.","authors":"Debkumar Pal,&nbsp;Shampa Maji,&nbsp;Rituparna Maiti","doi":"10.1007/s40292-023-00601-5","DOIUrl":"10.1007/s40292-023-00601-5","url":null,"abstract":"<p><strong>Introduction: </strong>Azelnidipine is one of the newer Calcium Channel Blockers (CCB) approved in China, Japan, and India. Some studies have found that the blood pressure-lowering effect of azelnidipine is more than amlodipine, and others found the effect similar.</p><p><strong>Aim: </strong>This meta-analysis was conducted to evaluate the efficacy of azelnidipine in managing hypertensive patients by lowering Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and Heart Rate (HR) as compared to amlodipine.</p><p><strong>Methods: </strong>PubMed/MEDLINE, Google Scholar, PROQUEST, and International Clinical Trial Registry Platform (ICTRP) were searched for published articles to evaluate the clinical efficacy of azelnidipine in the management of hypertension patients. Data were extracted from the selected 11 randomized clinical trials (RCTs). The risk of bias 2 (RoB2) tool was used for the quality assessment of the included studies, and the random-effects model was used to estimate the effect size.</p><p><strong>Results: </strong>There were no statistically significant differences in the reduction of SBP (Mean Difference, MD: - 1.07; 95% CI: - 4.10, 1.95, p-value: 0.49) and DBP (MD: 0.27; 95% CI: - 2.66, 3.20, p-value: 0.86) between both the drugs. In terms of HR reduction, there was a statistically significant difference (MD: - 3.63; 95% CI: - 5.27, - 2.00, p-value: < 0.0001) between both drugs. Egger's test excluded any publication bias for the included studies (p = 0.21). Meta-regression excluded the effect of the duration of treatment on outcome parameters.</p><p><strong>Conclusion: </strong>Though no significant difference between azelnidipine and amlodipine was found, in terms of reduction in SBP and DBP, azelnidipine reduced heart rate significantly compared to amlodipine.</p><p><strong>Prospero registration: </strong>CRD42023390361.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"401-410"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41112951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telemedicine and Digital Medicine in the Clinical Management of Hypertension and Hypertension-Related Cardiovascular Diseases: A Position Paper of the Italian Society of Arterial Hypertension (SIIA).","authors":"Pietro Minuz,&nbsp;Fabio Lucio Albini,&nbsp;Egidio Imbalzano,&nbsp;Raffaele Izzo,&nbsp;Stefano Masi,&nbsp;Martino F Pengo,&nbsp;Giacomo Pucci,&nbsp;Filippo Scalise,&nbsp;Massimo Salvetti,&nbsp;Giuliano Tocci,&nbsp;Arrigo Cicero,&nbsp;Guido Iaccarino,&nbsp;Carmine Savoia,&nbsp;Leonardo Sechi,&nbsp;Gianfranco Parati,&nbsp;Claudio Borghi,&nbsp;Massimo Volpe,&nbsp;Claudio Ferri,&nbsp;Guido Grassi,&nbsp;Maria Lorenza Muiesan","doi":"10.1007/s40292-023-00595-0","DOIUrl":"10.1007/s40292-023-00595-0","url":null,"abstract":"<p><p>High blood pressure is the leading cause of death and disability globally and an important treatable risk factor for cardiovascular, cerebrovascular and chronic kidney diseases. Digital technology, including mobile health solutions and digital therapy, is expanding rapidly in clinical medicine and has the potential to improve the quality of care and effectiveness of drug treatment by making medical interventions timely, tailored to hypertensive patients' needs and by improving treatment adherence. Thus, the systematic application of digital technologies could support diagnosis and awareness of hypertension and its complications, ultimately leading to improved BP control at the population level. The progressive implementation of digital medicine in the national health systems must be accompanied by the supervision and guidance of health authorities and scientific societies to ensure the correct use of these new technologies with consequent maximization of the potential benefits. The role of scientific societies in relation to the rapid adoption of digital technologies, therefore, should encompass the entire spectrum of activities pertaining to their institutional role: information, training, promotion of research, scientific collaboration and advice, evaluation and validation of technological tools, and collaboration with regulatory and health authorities.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"387-399"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/57/95/40292_2023_Article_595.PMC10600275.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10012746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial Stiffness in Overweight and Obesity: Association with Sex, Age, and Blood Pressure.","authors":"John G Eikås,&nbsp;Eva Gerdts,&nbsp;Hilde Halland,&nbsp;Helga Midtbø,&nbsp;Dana Cramariuc,&nbsp;Ester Kringeland","doi":"10.1007/s40292-023-00593-2","DOIUrl":"10.1007/s40292-023-00593-2","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity has been associated with increased arterial stiffness. Sex-differences in arterial stiffness in obesity have been less explored.</p><p><strong>Aim: </strong>To explore sex-differences in arterial stiffness by applanation tonometry in 323 women and 225 with overweight and obesity, free of cardiovascular disease.</p><p><strong>Methods: </strong>Covariables of arterial stiffness were identified in multivariable linear regression analyses in the total cohort and separately in women and men.</p><p><strong>Results: </strong>In the total study cohort, women had higher augmentation pressure (AP) and augmentation index (AIx), and lower carotid-femoral pulse wave velocity (cf-PWV) than men, independent of confounders (all p < 0.001). In sex-specific analyses, higher AP was associated with higher age and 24-hours systolic blood pressure (BP), and with lower heart rate in women (all p < 0.001), and with higher age and BP in men (all p < 0.001). Similarly, higher AIx was associated with higher age and BP, and lower body mass index (BMI) and heart rate in women (all p < 0.05), and with higher age in men (all p < 0.001). Higher cf-PWV correlated with higher age and BP in women (all p < 0.005), and additionally with higher heart rate and non-smoking in men (all p < 0.05). When replacing BMI with waist-hip ratio, higher waist-hip ratio was associated with higher cf-PWV in men only (p < 0.05).</p><p><strong>Conclusions: </strong>Among subjects with overweight and obesity, AP and AIx were higher in women, and cf-PWV was higher in men. Age and 24-hours systolic BP were the main factors associated with arterial stiffness in both sexes, while measures of adiposity had little impact on arterial stiffness.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"435-443"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/67/9c/40292_2023_Article_593.PMC10600283.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10242577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation.","authors":"Alessandro Maloberti,&nbsp;Alessandro Mengozzi,&nbsp;Elisa Russo,&nbsp;Arrigo Francesco Giuseppe Cicero,&nbsp;Fabio Angeli,&nbsp;Enrico Agabiti Rosei,&nbsp;Carlo Maria Barbagallo,&nbsp;Bruno Bernardino,&nbsp;Michele Bombelli,&nbsp;Federica Cappelli,&nbsp;Edoardo Casiglia,&nbsp;Rosario Cianci,&nbsp;Michele Ciccarelli,&nbsp;Massimo Cirillo,&nbsp;Pietro Cirillo,&nbsp;Giovambattista Desideri,&nbsp;Lanfranco D'Elia,&nbsp;Raffaella Dell'Oro,&nbsp;Rita Facchetti,&nbsp;Claudio Ferri,&nbsp;Ferruccio Galletti,&nbsp;Cristina Giannattasio,&nbsp;Loreto Gesualdo,&nbsp;Guido Iaccarino,&nbsp;Luciano Lippa,&nbsp;Francesca Mallamaci,&nbsp;Stefano Masi,&nbsp;Maria Masulli,&nbsp;Alberto Mazza,&nbsp;Maria Lorenza Muiesan,&nbsp;Pietro Nazzaro,&nbsp;Gianfranco Parati,&nbsp;Paolo Palatini,&nbsp;Paolo Pauletto,&nbsp;Roberto Pontremoli,&nbsp;Nicola Riccardo Pugliese,&nbsp;Fosca Quarti-Trevano,&nbsp;Marcello Rattazzi,&nbsp;Gianpaolo Reboldi,&nbsp;Giulia Rivasi,&nbsp;Massimo Salvetti,&nbsp;Valerie Tikhonoff,&nbsp;Giuliano Tocci,&nbsp;Andrea Ungar,&nbsp;Paolo Verdecchia,&nbsp;Francesca Viazzi,&nbsp;Massimo Volpe,&nbsp;Agostino Virdis,&nbsp;Guido Grassi,&nbsp;Claudio Borghi","doi":"10.1007/s40292-023-00602-4","DOIUrl":"10.1007/s40292-023-00602-4","url":null,"abstract":"<p><p>The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. Despite the substantial number of publications on the topic, there are still some elements of doubt: (1) the better cut-off to be used to refine CV risk (also called CV cut-off); (2) the needing for a correction of UA values for kidney function; and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation?. The Uric acid Right for heArt Health (URRAH) project was designed by the Working Group on uric acid and CV risk of the Italian Society of Hypertension to answer the first question. After the first papers that individuates specific cut-off for different CV disease, subsequent articles have been published responding to the other relevant questions. This review will summarise most of the results obtained so far from the URRAH research project.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"411-425"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/6b/40292_2023_Article_602.PMC10600296.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Serum Total Cholesterol and High Total Cholesterol Prevalence Among Royal Thai Army Personnel in Thailand, 2017-2022.","authors":"Boonsub Sakboonyarat,&nbsp;Jaturon Poovieng,&nbsp;Kanlaya Jongcherdchootrakul,&nbsp;Phutsapong Srisawat,&nbsp;Panadda Hatthachote,&nbsp;Mathirut Mungthin,&nbsp;Ram Rangsin","doi":"10.1007/s40292-023-00596-z","DOIUrl":"10.1007/s40292-023-00596-z","url":null,"abstract":"<p><strong>Introduction: </strong>High total cholesterol (TC) is a robust-documented risk factor for atherosclerosis cardiovascular diseases. Approximately one-fourth (23.5%) of Thai civilians had high TC. However, the information on high TC among the Royal Thai Army (RTA) personnel is limited.</p><p><strong>Aim: </strong>The study aimed to identify the trends in serum TC and high TC prevalence among RTA personnel from 2017 to 2022.</p><p><strong>Methods: </strong>A serial cross-sectional study from 2017 to 2022 was conducted. A total of 318,353 active-duty RTA personnel aged 35-60 years were included in the study. High TC was defined as fasting TC ≥ 240 mg/dL. A multivariable log-binomial regression analysis was performed to investigate factors associated with high TC.</p><p><strong>Results: </strong>The overall age- and sex-adjusted high TC prevalence was 26.3% in 2017 and dropped to 22.9% in 2020; then, it increased to 26.4% in 2022 (p for quadratic trend < 0.001). Younger-aged RTA personnel have significantly rising trends in sex-adjusted high TC prevalence over 6 years. In the south, the age- and sex-adjusted high TC prevalence was 24.4% in 2017 and substantially rose to 33.6% in 2022 (p for quadratic trend < 0.001). Meanwhile, in the northeast, it rose by 3.6% over 6 years. High body mass index, high blood pressure, and hyperglycemia were associated with high TC prevalence among this population.</p><p><strong>Conclusion: </strong>High TC was a common essential health issue among RTA personnel. Rising trends in mean serum TC and high TC prevalence from 2017 to 2022 were discovered, especially in younger participants and those residing in the south and northeast.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"445-456"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10039748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Impact of 2021 ESC Guidelines for Cardiovascular Disease Prevention on Hypertensive Patients Risk: Secondary Analysis of Save Your Heart Study.","authors":"Rita Del Pinto,&nbsp;Corrado Giua,&nbsp;Enrico Keber,&nbsp;Eleonora Grippa,&nbsp;Marco Tilotta,&nbsp;Claudio Ferri","doi":"10.1007/s40292-023-00599-w","DOIUrl":"10.1007/s40292-023-00599-w","url":null,"abstract":"","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"487"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/b0/40292_2023_Article_599.PMC10600036.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10573075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropometric Measures of Adiposity as Markers of Kidney Dysfunction: A Cross-Sectional Study.","authors":"Sara Vela-Bernal,&nbsp;Rita Facchetti,&nbsp;Raffaella Dell'Oro,&nbsp;Fosca Quarti-Trevano,&nbsp;Empar Lurbe,&nbsp;Giuseppe Mancia,&nbsp;Guido Grassi","doi":"10.1007/s40292-023-00600-6","DOIUrl":"10.1007/s40292-023-00600-6","url":null,"abstract":"<p><p>The present study was designed to provide information on the ability of several different anthropometric markers to reflect the renal impairment associated with body weight increase and to predict the development of renal alterations linked to overweight and obesity. In 574 subjects representative of the general population of the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study, with an age range between 57 and 73 years, we investigated the association between different anthropometric markers of body fat, as alternative to body mass index, and renal failure, to obtain information useful for determining their potential predictive value. Renal dysfunction was significantly associated with almost all anthropometric markers of adiposity related to body weight and body shape. After adjustment for confounders, such as age, sex, office blood pressure, serum glucose, antihypertensive drugs and smoking habit, association remained significant only for waist-to-hip ratio (WHR), lipid accumulation product (LAP) and visceral adiposity index (VAI). These 3 markers also displayed at the receiver operating curves (ROC) analysis the best ability to detect subjects with or without kidney dysfunction. The results of the present study provide evidence that WHR, LAP and VAI represent the best markers of renal dysfunction associated with visceral body fat accumulation.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"467-474"},"PeriodicalIF":3.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/95/f8/40292_2023_Article_600.PMC10600305.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41120243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}