High Blood Pressure & Cardiovascular Prevention最新文献

{"title":"Authors' Response to Comment by Mohammad Jameel Rahmatullah Suhotoo on \"Epistaxis and Clinic Blood Pressure Values: Is There a Relationship?\"","authors":"Claudia Lodovica Modesti, Gabriele Testa, Massimo Salvetti, Davide Lombardi, Cesare Piazza, Maria Lorenza Muiesan","doi":"10.1007/s40292-025-00711-2","DOIUrl":"10.1007/s40292-025-00711-2","url":null,"abstract":"","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"365"},"PeriodicalIF":3.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Carotid Intima-Media Thickness and Novel Lipid Parameters in Hypertensive Patients.","authors":"Martina Morelli, Chiara Tognola, Ilaria Garofani, Marco Le Van, Andrea Tacchetto, Marco Bellomare, Michela Algeri, Atea Shkodra, Cristina Giannattasio, Alessandro Maloberti","doi":"10.1007/s40292-025-00718-9","DOIUrl":"10.1007/s40292-025-00718-9","url":null,"abstract":"<p><strong>Introduction: </strong>Carotid Intima-Media Thickness (IMT) is a marker of subclinical atherosclerosis and cardiovascular risk. Dyslipidemia is a well-established risk factor for atherosclerosis and novel lipid parameters have recently emerged.</p><p><strong>Aim: </strong>The aim of our study was to assess the association between IMT and novel lipid parameters in hypertensive patients.</p><p><strong>Methods: </strong>We analyzed the IMT of 848 hypertensive patients followed at the Hypertension Unit of San Gerardo Hospital (Monza, Italy). Classic (total, HDL, LDL and non-HDL cholesterol and triglycerides) and novel indices (non-HDL/HDL, LDL/HDL, total cholesterol/HDL, log triglycerides/HDL and triglycerides-glycemia index) were measured and calculated.</p><p><strong>Results: </strong>Univariable analyses showed a significant correlation between IMT and most lipid parameters. Multivariable linear regression with IMT as continuous dependent variable revealed a significant association with total cholesterol (β = 0.108, p = 0.001), LDL cholesterol (β = 0.119, p < 0.001), non-HDL cholesterol (β = 0.126, p < 0.001), non-HDL/HDL (β = 0.134, p < 0.001), LDL/HDL (β = 0.140, p < 0.001) and total cholesterol/HDL (β = 0.134, p < 0.001). Logistic multivariable regression with IMT categorized as ≥ or < 0.9 mm demonstrated a significant association with total cholesterol (OR = 1.100 per 10 mg/dL increase, p = 0.003), LDL cholesterol (OR = 1.130 per 10 mg/dL increase, p = 0.001), non-HDL cholesterol (OR = 1.110 per each unit increase, p = 0.001), non-HDL/HDL (OR = 1.368 per each unit increase, p = 0.002), LDL/HDL (OR = 1.583 per each unit increase, p = 0.001) and total cholesterol/HDL (OR = 1.368 per each unit increase, p = 0.002).</p><p><strong>Conclusions: </strong>Carotid IMT is significantly associated with various lipid parameters, with the strongest association observed for non-HDL/HDL, LDL/HDL and total cholesterol/HDL.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"335-341"},"PeriodicalIF":3.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Pre-participation Cardiovascular Evaluation for Paris 2024 Olympic Games in Elite Athletes: The Italian Experience.","authors":"Maria Rosaria Squeo, Armando Ferrera, Giuseppe Di Gioia, Federica Mango, Viviana Maestrini, Sara Monosilio, Erika Lemme, Simone Crotta, Alessandro Spinelli, Andrea Serdoz, Roberto Fiore, Domenico Zampaglione, Cosimo Damiano Daniello, Massimo Volpe, Marco Bernardi, Antonio Pelliccia","doi":"10.1007/s40292-025-00715-y","DOIUrl":"10.1007/s40292-025-00715-y","url":null,"abstract":"","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"367"},"PeriodicalIF":3.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic Remodeling in Patients with Arterial Hypertension: Pathophysiological Mechanisms, Therapeutic Interventions and Preventive Strategies-A Position Paper from the Heart and Hypertension Working Group of the Italian Society of Hypertension.","authors":"Costantino Mancusi, Christian Basile, Ilaria Fucile, Carlo Palombo, Maria Lembo, Giacomo Buso, Claudia Agabiti-Rosei, Valeria Visco, Antonietta Gigante, Giuliano Tocci, Alessandro Maloberti, Chiara Tognola, Giacomo Pucci, Rosa Curcio, Sebastiano Cicco, Federica Piani, Marialuisa Sveva Marozzi, Alberto Milan, Dario Leone, Chiara Cogliati, Riccardo Schiavon, Massimo Salvetti, Michele Ciccarelli, Nicola De Luca, Massimo Volpe, Maria Lorenza Muiesan","doi":"10.1007/s40292-025-00710-3","DOIUrl":"10.1007/s40292-025-00710-3","url":null,"abstract":"<p><p>In patient with arterial hypertension the whole aorta is exposed to increased wall stress due to pressure overload. Different blood pressure (BP) components have been reported as main determinant of aortic remodelling. In particular increased diastolic BP has been associated with aortic dilatation across all its segments with smaller increase in aortic root and ascending aorta related to increased systolic BP and pulse pressure. Optimal BP control is crucial to prevent development of aortic aneurysm and acute aortic disease. Many studies have evaluated the role of different antihypertensive drug classes for prevention of adverse aortic remodelling including beneficial effects of ACEIs, ARBs, dihydropyridinic calcium channel blockers and Beta-blockers. The present review discusses pathophysiological mechanisms, therapeutic interventions and preventive strategies for development of aortic remodeling in patients with arterial hypertension.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"255-273"},"PeriodicalIF":3.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply: \"Epistaxis and Clinic Blood Pressure Values: Is There a Relationship?\"","authors":"Mohammad Jameel Rahmatullah Suhotoo","doi":"10.1007/s40292-025-00712-1","DOIUrl":"10.1007/s40292-025-00712-1","url":null,"abstract":"","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"363-364"},"PeriodicalIF":3.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Resistive Index and 10-Year Risk of Cardiovascular Disease Predicted by Framingham Risk Score and Pooled Cohort Equations: An Observational Study in Hypertensive Individuals Without Cardiovascular Disease.","authors":"Giulio Geraci, Alessandra Sorce, Luca Zanoli, Vincenzo Calabrese, Giuseppe Cuttone, Alessandro Mattina, Pietro Ferrara, Ligia J Dominguez, Riccardo Polosa, Giuseppe Mulè, Caterina Carollo","doi":"10.1007/s40292-025-00714-z","DOIUrl":"10.1007/s40292-025-00714-z","url":null,"abstract":"<p><strong>Introduction: </strong>The renal resistive index (RRI) has been widely shown to be related with subclinical vascular damage in individuals with essential hypertension, as well as in other populations. However, limited data exist regarding the association between RRI and cardiovascular (CV) events in hypertensive individuals. Additionally, it is unclear whether the 10-year risk of CV disease, as predicted by validated score equations, is associated with impaired intrarenal hemodynamics.</p><p><strong>Aim: </strong>The aim of our study was to analyze the relationship between RRI and both the FS and ASCVD in hypertensive individuals with no history of CV events.</p><p><strong>Methods: </strong>A total of 742 individuals with essential hypertension (40-75 years) were enrolled. RRI was assessed in all patients using Duplex-Doppler ultrasonography, and the 10-year risk of cardiovascular disease was calculated using both the Framingham risk score (FS) and atherosclerotic cardiovascular disease risk score (ASCVD) through validated equations.</p><p><strong>Results: </strong>Higher RRI values were observed in patients with calculated CV risk ≥ 20% compared to those with lower risk (all p  <  0.001). RRI was closely associated with both FS and ASCVD scores in the overall cohort (all p < 0.001), with no significantly differences between groups with glomerular filtration rate ≥ or  <  60 mL/min/1.73m². In multivariate analyses, these associations remained significant after adjusting for traditional risk factors included in the FS and ASCVD equations (p = 0.007 and p = 0.047, respectively). Receiver-operating characteristic curves indicated that RRI values >0.67 and >0.65 were associated with a high CV risk (≥ 20%), as calculated through FS and ASCVD equations, respectively.</p><p><strong>Conclusion: </strong>RRI can be considered a marker of overall CV risk in hypertensive patients, independent of renal function.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"311-322"},"PeriodicalIF":3.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring the Effects of Cardiac Rehabilitation Programs in Heart Failure Patients: The Role of Biomarkers.","authors":"Giovanna Gallo, Camillo Autore, Maurizio Volterrani, Emanuele Barbato, Massimo Volpe","doi":"10.1007/s40292-025-00707-y","DOIUrl":"10.1007/s40292-025-00707-y","url":null,"abstract":"<p><p>Heart failure (HF) is characterized by poor exercise tolerance and reduced ability to perform routine daily activities. Cardiac rehabilitation (CR), which includes exercise training, has shown a role in improving cardiac remodeling, functional capacity and HF outcomes as a consequence of its beneficial effects on neurohormonal dysfunction, endothelial function, vascular tone and peripheral oxygen extraction. Although a multiparametric evaluation, including physical examination, blood sampling, echocardiographic and cardiopulmonary exercise testing parameters, is routinely performed during CR programs, the use of cardiac biomarkers, in particular natriuretic peptides (NPs), is still poorly adopted and characterized. In this article we analyze the potential role of biomarkers in monitoring the success of rehabilitation programs and the potential implications of their use in clinical practice. Indeed, NPs measurements might represent an important tool to modulate the rehabilitative interventions with a favorable cost-effectiveness profile.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"287-297"},"PeriodicalIF":3.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension Criteria and the Early Detection of Vascular Aging in Youth.","authors":"Yolandi Breet, Annemarie Wentzel, Wayne Smith, Aletta S Uys, Adriaan Jacobs, Maserame C Mokhaneli, Lebo F Gafane-Matemane, Catharina Mc Mels, Ruan Kruger","doi":"10.1007/s40292-025-00717-w","DOIUrl":"10.1007/s40292-025-00717-w","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension is a leading risk factor of global morbidity and mortality. Reports indicate a rise in mortality linked to blood pressure (BP) levels exceeding 115/75 mmHg. Even with hypertension management based on redefined guidelines, many young individuals with early signs of target organ injury (TOI) may still go undetected AIM : We determined the most accurate diagnostic criteria of hypertension (using the 2017 ACC/AHA and the 2023 ESC/ESH guidelines) for detecting an increased risk of early vascular aging (EVA). We additionally estimated the effects of the guidelines' definitions on the distribution of BP phenotypes and risk of EVA.</p><p><strong>Methods: </strong>A total of 1026 men and women (aged 20-30 years) were included. The primary data collected included office- and ambulatory blood pressure (ABPM) measurement, and carotid-femoral pulse wave velocity (PWV). The upper 25th percentile of PWV was regarded as having an increased risk of EVA. The frequencies of hypertension and BP phenotypes were calculated according to both guidelines and correlated with TOI by multiple linear regression. Receiver operating characteristic (ROC) curves were constructed to determine the best BP threshold for detecting increased risk of EVA.</p><p><strong>Results: </strong>Pulse wave velocity was associated with all pathological BP phenotypes (SHT, WCHT and MHT), based on the ESC/ESH and with SHT and WCHT based on the ACC/AHA criteria (all p<0.024).</p><p><strong>Conclusion: </strong>The ESC/ESH criteria, but not the ACC/AHA criteria, is sensitive to identify all BP phenotypes. The lower thresholds advised by the ACC/AHA guidelines however seem to favour early detection of increased risk for EVA.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"343-351"},"PeriodicalIF":3.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes in patients with cardiorenal multimorbidity: the role of serum uric acid/serum creatinine ratio.","authors":"Antonietta Gigante, Eleonora Assanto, Claudia Brigato, Chiara Pellicano, Francesco Iannazzo, Edoardo Rosato, Maurizio Muscaritoli, Claudio Ferri, Rosario Cianci","doi":"10.1007/s40292-025-00706-z","DOIUrl":"10.1007/s40292-025-00706-z","url":null,"abstract":"<p><strong>Introduction: </strong>Serum uric acid (SUA), the final product of purine metabolism, is an independent risk factor for cardiovascular (CV) disease. Since SUA levels depend on renal function, SUA to serum creatinine ratio (SUA/sCr) is emerging as a more specific biomarker of CV risk.</p><p><strong>Aim: </strong>To evaluate in hospitalized patients with cardiorenal multimorbidity (CRM) if the SUA/sCr ≥ 5.35 is associated with clinical outcomes. The primary outcome was in-hospital mortality. The secondary outcome was the composite of all-cause of mortality and adverse clinical events.</p><p><strong>Methods: </strong>We conducted a retrospective review of medical records from consecutive CRM inpatients admitted to the medical ward. The composite endpoint was calculated as all-cause mortality and adverse clinical events such as acute coronary syndrome, stroke, infections, and renal replacement therapy.</p><p><strong>Results: </strong>In our cohort, 141 patients (mean age of 75.6 ± 10.2 years) were identified with CRM. In-hospital mortality occurred in 17 patients (16%), and 64 patients (60.4%) experienced adverse clinical outcomes. Among the 106 patients, 20 (18.9%) had an SUA/sCr ≥ 5.35, while 86 (81.1%) had an SUA/sCr < 5.35. Male gender was significantly associated with SUA/sCr ≥ 5.35 (p = 0.007). In-hospital mortality was significantly higher in patients with SUA/sCr ≥ 5.35 (p = 0.010), and a positive correlation with adverse clinical outcomes was documented in this subgroup (p = 0.012).</p><p><strong>Conclusion: </strong>in patients with CRM, SUA/sCr ≥ 5.35 is associated with increased in-hospital mortality and worse clinical outcomes. The ratio and related cut-off value of SUA/sCr could represent a useful biomarker to assess in-hospital complications in CRM patients.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"209-216"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Reversible Leukoencephalopathy Syndrome During Hypertensive Crisis in Obstructive Sleep Apnea Syndrome: Searching for a Link.","authors":"Gioia Torin, Laura Schiavon, Marta Milan, Silvia Rizzati, Carla Destro, Stefano Cuppini, Alberto Mazza","doi":"10.1007/s40292-025-00702-3","DOIUrl":"10.1007/s40292-025-00702-3","url":null,"abstract":"<p><p>Posterior reversible encephalopathy syndrome (PRES) may present with different clinical symptoms including visual disturbance, headache, seizures and impaired consciousness. Brain MRI shows oedema, usually involving the posterior subcortical regions. Triggering factors include hypertension and obstructive sleep apnea syndrome. The mechanism underlying PRES is under debate, but endothelial dysfunction is implicated. Treatment goals of PRES are gradual blood pressure (BP) lowering to avoid sudden hypoperfusion of vital organs and prevention and management of seizures. PRES usually has a favorable prognosis, but delayed diagnosis and treatment may lead to cardiovascular morbidity, mortality or irreversible neurological deficits.</p>","PeriodicalId":12890,"journal":{"name":"High Blood Pressure & Cardiovascular Prevention","volume":" ","pages":"223-225"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}