Association Between Elevated Lipoprotein(a) and Diastolic Dysfunction: A Retrospective Cohort Study.

IF 2.9 Q2 PERIPHERAL VASCULAR DISEASE

High Blood Pressure & Cardiovascular Prevention Pub Date : 2025-07-01 Epub Date: 2025-07-15 DOI:10.1007/s40292-025-00727-8

Hesham Sheashaa, Kamal Awad, Arshad Mohammed, Juan M Farina, Mohammed Tiseer Abbas, Milagros Pereyra Pietri, Isabel G Scalia, Nima Baba Ali, Nadera N Bismee, Sogol Attaripour Esfahani, Omar Ibrahim, Fatmaelzahraa Abdelfattah, Ahmed K Mahmoud, Steven J Lester, David Simper, Chadi Ayoub, Reza Arsanjani

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引用次数: 0

Abstract

Introduction: Lipoprotein(a) [Lp(a)] has been linked to myocardial fibrosis and endothelial dysfunction, proposed mechanisms for diastolic dysfunction (DD). This study assessed the association between elevated Lp(a) (≥ 50 mg/dL) and DD in patients with preserved ejection fraction (EF).

Aim: We analyzed 1492 adults (median age59) with an Lp(a) measurement and echocardiogram (1997-2024).

Methods: Diastolicdysfunction required ≥ 3 abnormal echo parameters, as per recent guidelines. Logisticregression adjusting for potential confounders was performed.

Results: Seventy-sevenpatients (5.1%) had DD. Lp(a) ≥ 50 mg/dL was not associated with DD [adjusted oddsratio (aOR): 0.89, 95% confidence interval (CI): 0.49-1.54]. However, age (aOR:1.03, p = 0.026), hypertension (aOR: 1.83, p = 0.042), diabetes mellitus (aOR: 2.43, p =0.002), and cardiovascular (CV) diseases (aOR: 1.90, p = 0.043) were associated withDD, while statin therapy was associated with reduced risk (aOR: 0.51, p = 0.016).

Conclusions: In the setting of preserved EF, Lp(a) was not associated with DD,emphasizing management of traditional CV risks.

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脂蛋白升高(a)与舒张功能障碍之间的关系：一项回顾性队列研究。

脂蛋白(a) [Lp(a)]与心肌纤维化和内皮功能障碍有关，这是舒张功能障碍（DD）的潜在机制。本研究评估了保留射血分数（EF）患者Lp(a)升高（≥50 mg/dL）与DD之间的关系。目的：我们分析了1492名成年人（中位年龄59岁）的Lp(a)测量和超声心动图（1997-2024）。方法：舒张功能障碍需要≥3个异常回声参数，根据最近的指南。对潜在混杂因素进行logistic回归调整。结果：77例（5.1%）患者患有DD， Lp(a)≥50 mg/dL与DD无关[调整比值比（aOR）： 0.89, 95%可信区间（CI）： 0.49-1.54]。然而，年龄（aOR:1.03, p = 0.026）、高血压（aOR: 1.83, p = 0.042）、糖尿病（aOR: 2.43, p =0.002）和心血管（CV）疾病（aOR: 1.90, p = 0.043）与dd相关，而他汀类药物治疗与降低风险相关（aOR: 0.51, p = 0.016）。结论：在保留EF的情况下，Lp(a)与DD无关，强调传统心血管风险的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

High Blood Pressure & Cardiovascular Prevention PERIPHERAL VASCULAR DISEASE-

CiteScore

5.70

自引率

3.30%

发文量

期刊介绍： High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes: Invited ''State of the Art'' reviews. Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.