Arterial Stiffness and Cardiovascular Risk Reclassification in Patients with Autoimmune Rheumatic Diseases.

IF 2.9 Q2 PERIPHERAL VASCULAR DISEASE

High Blood Pressure & Cardiovascular Prevention Pub Date : 2025-07-01 Epub Date: 2025-07-16 DOI:10.1007/s40292-025-00728-7

Albertina M Ghelfi, Rosana Quintana, Lautaro L Velez, Leonel A Berbotto, Romina Nieto, Boris Kisluk, Jorge O Galindez, Guillermo A Berbotto

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引用次数: 0

Abstract

Introduction: Autoimmune rheumatic diseases (ARD) increase the risk of early subclinical vascular damage such as arterial stiffness (AS), which is associated with cardiovascular events. It remains unclear whether this also occurs during clinical remission or low disease activity (CR/LDA).

Aims: We aimed to evaluate carotid-femoral pulse wave velocity (cf-PWV) in ARD-patients in CR/LDA and to compare them with a control group.

Methods: A cross-sectional study was conducted in Argentina (2022-2023). Group 1: ARD subjects in CR/LDA, without systemic organ involvement, office blood pressure (BP) <140/90 mmHg, and low 10-year cardiovascular risk (CVR) <5% according to WHO's calculator. Group 2: healthy controls.

Exclusion criteria: associated clinical conditions, evidence of target organ damage, presence of traditional cardiovascular risk factors, and use of antihypertensives, statins, or aspirin. cf-PWV was measured using the Aortic device.

Results: A total of 97 subjects were included: 48 ARD and 49 controls. Among those with high-normal BP: Group 1 showed higher cf-PWV (6.81±1.14 vs. 5.98±0.82 m/s, p<0.0001) and more AS (22/48 vs. 2/49, p<0.0001). In a sub-analysis restricted to subjects with normal-BP: Group 1 also showed higher cf-PWV and more AS (6.57±1.09 vs. 5.84±0.65 m/s, p=0.005; 14/36 vs. 0/37, p<0.0001). Among ARD patients the frequency of AS was 45.8% with high-normal BP and 38.8% with normal BP. Multivariate analysis showed that ARD and diastolic BP were independently associated with AS.

Conclusions: ARD patients in CR/LDA even with traditional low-CVR showed higher cf-PWV.

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自身免疫性风湿病患者动脉僵硬和心血管风险重分类

自身免疫性风湿性疾病（ARD）增加了早期亚临床血管损伤（如动脉僵硬（as））的风险，这与心血管事件相关。目前尚不清楚这种情况是否也发生在临床缓解期或低疾病活动度（CR/LDA）期间。目的：我们旨在评估CR/LDA患者的颈动脉-股动脉脉波速度（cf-PWV），并与对照组进行比较。方法：在阿根廷（2022-2023）进行横断面研究。第1组：CR/LDA的ARD患者，无全身器官受累，办公室血压（BP）。排除标准：相关临床状况、靶器官损害证据、存在传统心血管危险因素、使用抗高血压药物、他汀类药物或阿司匹林。使用主动脉仪测量cf-PWV。结果：共纳入97例受试者：ARD患者48例，对照组49例。在血压高正常组中：1组的cf-PWV较高（6.81±1.14 vs 5.98±0.82 m/s）。结论：CR/LDA的ARD患者即使采用传统的低cvr，也有较高的cf-PWV。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

High Blood Pressure & Cardiovascular Prevention PERIPHERAL VASCULAR DISEASE-

CiteScore

5.70

自引率

3.30%

发文量

期刊介绍： High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes: Invited ''State of the Art'' reviews. Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.