Sex Differences in Ambulatory Central Blood Pressure and Arterial Stiffness in Hemodialysis Patients.

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE

High Blood Pressure & Cardiovascular Prevention Pub Date : 2025-04-01 DOI:10.1007/s40292-025-00713-0

Artemios G Karagiannidis, Marieta P Theodorakopoulou, Fotini Iatridi, Antonios Karpetas, Areti Georgiou, Sofia Manti, Panagiota Anyfanti, Eleni Gavriilaki, George Giannakoulas, Pantelis Sarafidis

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引用次数: 0

Abstract

Introduction: Sex differences have a significant role on epidemiology of cardiovascular complications in chronic kidney disease. Among hemodialysis patients, central blood pressure (BP) levels and increased arterial stiffness parameters are independent predictors of cardiovascular and all-cause- mortality.

Aim: To examine the potential differences in ambulatory central BP and arterial stiffness parameters between male and female hemodialysis patients.

Methods: A total of 129 male and 91 female hemodialysis patients were included in this analysis. All participants underwent 48-h ambulatory BP monitoring with Mobil-O-Graph-NG; indices of central hemodynamics (SBP, DBP and pulse pressure), wave reflection (augmentation pressure (AP) and augmentation index (AIx)) and pulse wave velocity (PWV) were estimated.

Results: Age, dialysis vintage and history of major comorbidities did not differ between men and women. Male patients had higher 48-h cSBP (124.7±15.7 vs. 119.8±16.7 mmHg, p=0.027) and 48-h DBP (83.7±12.2 vs. 77.5±11.9 mmHg, p<0.001) compared to female patients; relevant differences were also evident during the 44-h (excluding hemodialysis), 1st 24-h and 2nd 24-h periods and the corresponding daytime and nighttime periods of the recording. Central pulse pressure did not differ between groups. Regarding wave reflection parameters, AP, AIx, and AIx(75) were significantly lower in males versus females during the 48-h (AIx, 25.6±8.2 vs. 32.3±8.6 mmHg, p<0.001), 44-h, 1st and 2nd 24-h and also during respective daytime and nighttime periods. The two groups displayed similar PWV during all studied intervals (48-h PWV, 9.6±1.9 vs 9.7±2.1 m/s, p=0.612).

Conclusions: Male hemodialysis patients present with higher levels of ambulatory central BP but significantly lower levels of AP, AIx and AIx(75) than females. PWV does not differ between sexes.

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血液透析患者动态中心血压和动脉僵硬度的性别差异。

性别差异对慢性肾脏疾病心血管并发症的流行病学有重要影响。在血液透析患者中，中心血压（BP）水平和动脉僵硬度升高参数是心血管和全因死亡率的独立预测因子。目的：探讨男性和女性血液透析患者动态中央血压和动脉硬度参数的潜在差异。方法：选取血液透析患者129例，女性91例。所有参与者均采用移动- o - graph - ng进行48小时动态血压监测；测量中心血流动力学指标（收缩压、舒张压和脉压）、波反射指标（增强压（AP）和增强指数（AIx））和脉搏波速（PWV）。结果：年龄、透析时间和主要合并症的历史在男性和女性之间没有差异。男性患者48小时cSBP（124.7±15.7 vs. 119.8±16.7 mmHg, p=0.027）和48小时DBP（83.7±12.2 vs. 77.5±11.9 mmHg）较高。结论：男性血液透析患者的动态中枢血压水平高于女性，AP、AIx和AIx水平显著低于女性（75）。PWV没有性别差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

High Blood Pressure & Cardiovascular Prevention PERIPHERAL VASCULAR DISEASE-

CiteScore

5.70

自引率

3.30%

发文量

期刊介绍： High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes: Invited ''State of the Art'' reviews. Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.