Hematology Reports最新文献_第3页

The Many Faces of Philadelphia: A Mature T-Cell Lymphoma with Variant Philadelphia-Translocation and Duplication of the Philadelphia Chromosome. 费城的许多面孔：一个成熟的t细胞淋巴瘤与变异型费城-易位和复制费城染色体。

IF 1.1

Hematology Reports Pub Date : 2025-01-06 DOI: 10.3390/hematolrep17010001

Livia Vida, Bálint Horváth, Miklós Egyed, Béla Kajtár, Hussain Alizadeh

{"title":"The Many Faces of Philadelphia: A Mature T-Cell Lymphoma with Variant Philadelphia-Translocation and Duplication of the Philadelphia Chromosome.","authors":"Livia Vida, Bálint Horváth, Miklós Egyed, Béla Kajtár, Hussain Alizadeh","doi":"10.3390/hematolrep17010001","DOIUrl":"10.3390/hematolrep17010001","url":null,"abstract":"Background: T-cell prolymphocytic leukemia (T-PLL) is a rare mature T-cell lymphoma that is usually associated with poor prognosis and short overall survival. Methods: We present a case of a 61-year-old woman presenting with T-PLL and the leukemic cells harboring BCR::ABL1 (BCR-breakpoint cluster region; ABL1-ABL protooncogene 1) fusion transcripts as the result of a variant of t(9;22)(q34;q11) called Philadelphia translocation: t(9;22;18)(q34;q11;q21). Sequencing revealed a rare BCR transcript with an exon 6 breakpoint corresponding to e6a2 transcripts, which has thus far been reported in only 26 cases of leukemias. Results: After 9 months of follow-up, the disease progressed and required treatment. Following alemtuzumab and chemotherapy, a short course of imatinib therapy stabilized the disease for six months, which was followed by progression and the demise of the patient. Conclusions: To the best of our knowledge, this is the first report of a mature T-cell lymphoma with a variant Philadelphia-translocation and a very rare type of BCR::ABL1 transcript. This case highlights the importance of comprehensive genetic testing of malignancies, as abnormal molecular pathways may be uncovered that may be specifically targeted by drugs.","PeriodicalId":12829,"journal":{"name":"Hematology Reports","volume":"17 1","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alloantibody Identification: The Importance of Temperature, Strength Reaction and Enzymes-A Practical Approach. 同种抗体鉴定：温度、强度、反应和酶的重要性——一种实用的方法。

IF 1.1

Hematology Reports Pub Date : 2024-12-17 DOI: 10.3390/hematolrep16040077

Palma Manduzio

引用次数: 0

Venetoclax Plus Intensified Chemoimmunotherapy as a Bridge to Allogeneic Stem Cell Transplantation in Richter Syndrome: Report of Two Cases. Venetoclax加强化化学免疫治疗作为里氏综合征异基因干细胞移植的桥梁：两例报告

IF 1.1

Hematology Reports Pub Date : 2024-12-13 DOI: 10.3390/hematolrep16040075

Enrico Derenzini, Alessandro Cignetti, Valentina Tabanelli, Daniela Gottardi, Elvira Gerbino, Anna Vanazzi, Simona Sammassimo, Alessio Maria Edoardo Maraglino, Federica Melle, Giovanna Motta, Daniela Malengo, Emanuela Omodeo Salè, Lisa Bonello, Rocco Pastano, Stefano Pileri, Fabrizio Carnevale Schianca, Corrado Tarella

{"title":"Venetoclax Plus Intensified Chemoimmunotherapy as a Bridge to Allogeneic Stem Cell Transplantation in Richter Syndrome: Report of Two Cases.","authors":"Enrico Derenzini, Alessandro Cignetti, Valentina Tabanelli, Daniela Gottardi, Elvira Gerbino, Anna Vanazzi, Simona Sammassimo, Alessio Maria Edoardo Maraglino, Federica Melle, Giovanna Motta, Daniela Malengo, Emanuela Omodeo Salè, Lisa Bonello, Rocco Pastano, Stefano Pileri, Fabrizio Carnevale Schianca, Corrado Tarella","doi":"10.3390/hematolrep16040075","DOIUrl":"10.3390/hematolrep16040075","url":null,"abstract":"Background: Richter syndrome (RS) represents a major unmet need in the lymphoma field, being refractory to chemoimmunotherapy and targeted agents. The BCL-2 inhibitor venetoclax in combination with dose-adjusted EPOCH-R chemoimmunotherapy showed promising efficacy in patients affected by RS. However, responses were not durable, suggesting the need for further treatment optimization. Methods: Here, we report two cases of RS achieving long-term complete remission with intensified chemoimmunotherapy (Rituximab-G-MALL B-ALL/NHL2002 regimen) plus venetoclax induction, followed by haploidentical hematopoietic stem cell transplant (allo-HSCT). Venetoclax was given continuously for 14 consecutive days after every Rituximab-G-MALL cycle in off-label use. An accelerated venetoclax rump-up schedule was used in both patients to reach the maximal dose. Maximal venetoclax dose was 300 mg and 400 mg in patient 1 and patient 2, respectively. Results: The combined treatment was well tolerated, with no major infective complications or non-hematological toxicities. In both patients, immunosuppression was discontinued within day 180 after transplant with no graft-versus-host-disease flares. Both patients are alive and in continuous complete remission after 60 and 72 months following allo-HSCT. Conclusions: This report supports the feasibility of a combination treatment with BCL-2 inhibitors and intensive chemoimmunotherapy as a bridge to allo-HSCT in RS.","PeriodicalId":12829,"journal":{"name":"Hematology Reports","volume":"16 4","pages":"795-803"},"PeriodicalIF":1.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence, Risk Factors, and Outcomes of Thrombocytopenia in Older Medical Inpatients: A Prospective Cohort Study. 老年住院患者血小板减少症的发生率、危险因素和结局：一项前瞻性队列研究

IF 1.1

Hematology Reports Pub Date : 2024-12-13 DOI: 10.3390/hematolrep16040076

Ioanna Papakitsou, Andria Papazachariou, Theodosios D Filippatos, Petros Ioannou

{"title":"Incidence, Risk Factors, and Outcomes of Thrombocytopenia in Older Medical Inpatients: A Prospective Cohort Study.","authors":"Ioanna Papakitsou, Andria Papazachariou, Theodosios D Filippatos, Petros Ioannou","doi":"10.3390/hematolrep16040076","DOIUrl":"10.3390/hematolrep16040076","url":null,"abstract":"Background: Thrombocytopenia, defined as a platelet count of less than 150 × 109/L, is a frequent condition among hospitalized patients and presents unique challenges in diagnosis and management. Despite its commonality, data on incidence and related risk factors in medical inpatients remain limited, especially in older people.Methods: A 2-year prospective cohort study with a 3-year follow-up was conducted on inpatients aged ≥65 years admitted to a medical ward. Clinical data were collected, including demographics, comorbidities, laboratory results, and outcomes. Multivariate logistic regression analysis assessed risk factors associated with non-resolution of thrombocytopenia and mortality.Results: The study included 961 older inpatients with a mean age of 82 years. Thrombocytopenia occurred in 22.6% of the study population. The most common causes were infections (57.4%) and drug-induced thrombocytopenia (25.3%). The non-resolution of thrombocytopenia was noted in 59% of patients. In-hospital and 3-year mortality was significantly higher in this subgroup compared to the rest (24.5% vs. 12.7%, p = 0.015) and (72.4% vs. 59.8%, p = 0.04, respectively). In multivariate analysis, nadir platelet count and hematologic disease were independent factors associated with the non-resolution of thrombocytopenia. Furthermore, in individuals with thrombocytopenia, the administration of norepinephrine (p < 0.001) and a higher clinical frailty score (p < 0.001) were observed as independent mortality predictors.Conclusions: Thrombocytopenia in older medical inpatients is associated with poor prognosis, particularly in those with non-resolution thrombocytopenia. Early identification and targeted management may improve outcomes.","PeriodicalId":12829,"journal":{"name":"Hematology Reports","volume":"16 4","pages":"804-814"},"PeriodicalIF":1.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11675778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incorporation of a Comorbidity Index in Treatment Decisions for Elderly AML Patients Can Lead to Better Disease Management-A Single-Center Experience. 在老年AML患者的治疗决策中纳入合并症指数可导致更好的疾病管理-单中心经验

IF 1.1

Hematology Reports Pub Date : 2024-12-03 DOI: 10.3390/hematolrep16040074

Cristina Negotei, Iuliana Mitu, Silvana Angelescu, Florentina Gradinaru, Cristina Mambet, Oana Stanca, Mihai-Emilian Lapadat, Cristian Barta, Georgian Halcu, Carmen Saguna, Aurora Arghir, Mihaela Sorina Papuc, Andrei Turbatu, Nicoleta Mariana Berbec, Andrei Colita

{"title":"Incorporation of a Comorbidity Index in Treatment Decisions for Elderly AML Patients Can Lead to Better Disease Management-A Single-Center Experience.","authors":"Cristina Negotei, Iuliana Mitu, Silvana Angelescu, Florentina Gradinaru, Cristina Mambet, Oana Stanca, Mihai-Emilian Lapadat, Cristian Barta, Georgian Halcu, Carmen Saguna, Aurora Arghir, Mihaela Sorina Papuc, Andrei Turbatu, Nicoleta Mariana Berbec, Andrei Colita","doi":"10.3390/hematolrep16040074","DOIUrl":"10.3390/hematolrep16040074","url":null,"abstract":"Introduction: Acute myeloid leukemia (AML) is a form of cancer originating from precursor cells within the bone marrow. Elderly patients with acute leukemia require a personalized approach, considering age, performance status, and comorbidities, to determine suitability for intensive treatment. Methods: We studied the results of intense chemotherapy in 46 elderly, fit individuals with AML at a cancer center in Romania from January 2017 to December 2023. Results: The study involved a cohort of 46 patients, including 22 men and 24 women. The research indicated that 89.1% of the patients were diagnosed with de novo acute leukemia. Most patients had an ECOG score of 0-1, with one patient scoring ≥2. HCT-CI > 4 was found in 21 patients (45.7%), while CCI > 4 was present in 38 patients (82.6%). After the induction phase, 25 patients (54.3%) achieved complete remission (CR); the relapse rate was 56.8%. Upon completion of the study, nine individuals (19.6%) were still alive. The overall survival duration ranged from 0 to 33 months, with a median survival time of 8 months (CI 5.0-11.0). Conclusions: When considering treatment options for elderly patients, the Eastern Cooperative Oncology Group (ECOG) Performance Status, as well as comorbidity indices such as the Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) and the Charlson Comorbidity Index (CCI), have shown promising results in the literature, indicating their relevance in the decision-making process.","PeriodicalId":12829,"journal":{"name":"Hematology Reports","volume":"16 4","pages":"781-794"},"PeriodicalIF":1.1,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11727994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Manifestations, Prognostic Factors, and Outcomes of Extranodal Natural Killer T-Cell Lymphoma: A Single-Center Experience in Thailand. 结外自然杀伤t细胞淋巴瘤的临床表现、预后因素和预后：泰国的单中心研究。

IF 1.1

Hematology Reports Pub Date : 2024-11-29 DOI: 10.3390/hematolrep16040073

Wasinee Kaewboot, Lalita Norasetthada, Adisak Tantiworawit, Chatree Chai-Adisaksopha, Sasinee Hantrakool, Thanawat Rattanathammethee, Pokpong Piriyakhuntorn, Nonthakorn Hantrakun, Teerachat Punnachet, Ekarat Rattarittamrong

{"title":"Clinical Manifestations, Prognostic Factors, and Outcomes of Extranodal Natural Killer T-Cell Lymphoma: A Single-Center Experience in Thailand.","authors":"Wasinee Kaewboot, Lalita Norasetthada, Adisak Tantiworawit, Chatree Chai-Adisaksopha, Sasinee Hantrakool, Thanawat Rattanathammethee, Pokpong Piriyakhuntorn, Nonthakorn Hantrakun, Teerachat Punnachet, Ekarat Rattarittamrong","doi":"10.3390/hematolrep16040073","DOIUrl":"10.3390/hematolrep16040073","url":null,"abstract":"Background/Objectives: The primary objective of this study was to investigate clinical manifestations, time to diagnosis, and number of biopsies in patients with extranodal natural killer T-cell lymphoma (ENKTL). The secondary objectives were to determine response rates, survival outcomes, prognostic factor for overall survival (OS), and validation of the Prognostic Index of Natural Killer Lymphoma (PINK), Ann Arbor staging system (AASS), and the CA system. Methods: This retrospective study included data pertaining to patients with newly diagnosed ENKTL in Chiang-Mai University Hospital from 2004 to 2020. Comparisons between the areas under the receiver operating characteristic curve (AUC) of prognostic models (PINK, AASS, and CA system) were made. Results: Sixty patients were enrolled (n = 60) with a mean age of 49.1 ± 13.4 years. The most frequent symptom of ENKTL was nasal obstruction (66%). The median time to diagnosis was 22 days (ranging from 3 to 84 days), with 36.7% requiring more than one biopsy for diagnosis. Most patients presented with limited stage disease (75%). The median OS was 49 months. Factors associated with increased mortality were advanced stage, bone marrow involvement, gastrointestinal tract involvement, and receiving chemotherapy. Following prognostic model validation, the CA system model scored the highest level of accuracy (AUC 0.61), followed by AASS (AUC 0.58) and PINK (AUC 0.54). Conclusions: Patients with ENKTL commonly presented with nasal obstruction, with 36.7% requiring more than one biopsy for diagnosis. An advanced stage, bone marrow involvement, or gastrointestinal tract involvement were associated with poor OS. The CA system model has the highest level of accuracy for prognostic determination.","PeriodicalId":12829,"journal":{"name":"Hematology Reports","volume":"16 4","pages":"769-780"},"PeriodicalIF":1.1,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11727912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of 11C-Methionine PET Imaging for the Evaluation of Lymphomas: A Systematic Review. 11c -蛋氨酸PET成像在淋巴瘤评估中的作用：一项系统综述。

IF 1.1

Hematology Reports Pub Date : 2024-11-27 DOI: 10.3390/hematolrep16040072

Francesco Dondi, Maria Gazzilli, Gian Luca Viganò, Antonio Rosario Pisani, Cristina Ferrari, Giuseppe Rubini, Francesco Bertagna

{"title":"The Role of 11C-Methionine PET Imaging for the Evaluation of Lymphomas: A Systematic Review.","authors":"Francesco Dondi, Maria Gazzilli, Gian Luca Viganò, Antonio Rosario Pisani, Cristina Ferrari, Giuseppe Rubini, Francesco Bertagna","doi":"10.3390/hematolrep16040072","DOIUrl":"10.3390/hematolrep16040072","url":null,"abstract":"Background: In the last years, different evidence has underlined a possible role for [11C]-methionine ([11C]MET) positron emission tomography (PET) imaging for the evaluation of lymphomas. The aim of this paper was, therefore, to review the available scientific literature focusing on this topic. Methods: A wide literature search of the PubMed/MEDLINE, Scopus and Cochrane Library databases was conducted in order to find relevant published articles investigating the role of [11C]MET in the assessment of lymphomas. Results: Eighteen studies were included in the systematic review and the main fields of application of this imaging modality were the evaluation of disease, therapy response assessment, prognostic evaluation and differential diagnosis with other pathological conditions. Conclusion: Even with heterogeneous evidence, a possible role for [11C]MET PET imaging in the assessment of lymphomas affecting both the whole body and the central nervous system was underlined. When compared to [18F]fluorodesoxyglucose ([18F]FDG) imaging, in general, similar results have been reported between the two modalities in these settings.","PeriodicalId":12829,"journal":{"name":"Hematology Reports","volume":"16 4","pages":"752-768"},"PeriodicalIF":1.1,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11675220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142893940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life. 血友病A患儿血清维生素D及其与关节健康和生活质量的关系

IF 1.1

Hematology Reports Pub Date : 2024-11-26 DOI: 10.3390/hematolrep16040071

Aida M S Salem, Takwa Mohamed AbdEltwwab, Hanan Hosni Moawad, Marwa O Elgendy, Reham S Al-Fakharany, Ahmed Khames, Mohamed Hussein Meabed

{"title":"Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life.","authors":"Aida M S Salem, Takwa Mohamed AbdEltwwab, Hanan Hosni Moawad, Marwa O Elgendy, Reham S Al-Fakharany, Ahmed Khames, Mohamed Hussein Meabed","doi":"10.3390/hematolrep16040071","DOIUrl":"10.3390/hematolrep16040071","url":null,"abstract":"Background/Objectives: Hemophilia A is an X-linked recessive illness produced by a deficiency of coagulation factor VIII. This study aimed to evaluate serum vitamin D in hemophilic pediatric patients and its correlation with joint health and quality of life. Methods: This case-control study was performed on ninety children under the age of 18 years old and separated into two groups: study group of 45 children with hemophilia A and control group of 45 healthy children at an outpatient pediatric hematology clinic at the Beni-Suef University hospitals. Results: Serum vitamin D levels were significantly lower in hemophilia A patients than in controls (p < 0.001). The level of serum vitamin D was deficient in 38 (84.4%), insufficient in 4 (8.8%) and sufficient in 3 (6.6%) in the study group while deficient in 8 (17.7%), insufficient in 16 (35.5%) and sufficient in 21 (46.6%) in the control group. Total hemophilia joint health score (HJHS) had a significant negative correlation with serum total calcium (R = -0.31, p = 0.038) and serum vitamin D level (R = -0.974, p < 0.001) while also positively correlated with alkaline phosphatase (R = 0.834, p < 0.001). A quality-of-life index that is specific to total hemophilia (Haemo-Qol/Haem-A-QoL) had a significant positive correlation with total hemophilia joint health score (HJHS) (R = 0.934, p < 0.001) and negatively correlated with serum vitamin D level (R = -0.924, p-value lower than 0.001), alkaline phosphatase (R = 0.842, p < 0.001), and severity of hemophilia (R = 0.67, p < 0.001). Conclusions: patients with hemophilia A had lower vitamin D levels than healthy controls. The severity of vitamin D deficiency is related positively to (HJHS) hemophilia and quality of life hemophilia cases according to Haemo-QoL.","PeriodicalId":12829,"journal":{"name":"Hematology Reports","volume":"16 4","pages":"742-751"},"PeriodicalIF":1.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11727777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal Stem Cells and Reticulated Platelets: New Horizons in Multiple Myeloma. 间充质干细胞和网状血小板：多发性骨髓瘤的新视野。

IF 1.1

Hematology Reports Pub Date : 2024-11-23 DOI: 10.3390/hematolrep16040070

Cristian Alejandro Mera Azaín, Johan Leandro Vargas Pasquel, Sandra Milena Quijano Gómez, Viviana Marcela Rodríguez-Pardo

{"title":"Mesenchymal Stem Cells and Reticulated Platelets: New Horizons in Multiple Myeloma.","authors":"Cristian Alejandro Mera Azaín, Johan Leandro Vargas Pasquel, Sandra Milena Quijano Gómez, Viviana Marcela Rodríguez-Pardo","doi":"10.3390/hematolrep16040070","DOIUrl":"10.3390/hematolrep16040070","url":null,"abstract":"Multiple myeloma (MM) is a malignant plasma cell disorder characterized by the accumulation of abnormal plasma cells in the bone marrow. Mesenchymal stem cells (MSCs) and reticulated platelets (RPs) have been implicated in the pathogenesis of MM. This narrative review aims to explore the role of MSCs and RPs in the pathophysiology of MM, particularly their clinical use as possible variables of prognostic value in this hematologic neoplasia. The interaction between MSCs and MM cells within the bone marrow microenvironment supports MM cell survival, proliferation, and drug resistance. MSCs contribute to the development and maintenance of MM through the secretion of various factors, including cytokines, chemokines, and growth factors. Moreover, RPs, young and highly reactive platelets, have been implicated in promoting angiogenesis, tumor growth, and metastasis in MM. Several studies show that cells such as MSCs and platelets participate actively in the biology of the disease. Still, in clinical practice, they are not considered part of evaluating affected patients. In this review, we explore the possibility of including the evaluation of MSCs and PRs in the clinical practice for patients with MM as part of the strategies to improve the outcomes of this disease.","PeriodicalId":12829,"journal":{"name":"Hematology Reports","volume":"16 4","pages":"732-741"},"PeriodicalIF":1.1,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of B-Cell Lymphoblastic Lymphoma Presenting with an Isolated Epidural Mass Treated Successfully with Radiotherapy Followed by United Kingdom Acute Lymphoblastic Leukemia (UKALL) Chemotherapy Protocol. 英国急性淋巴细胞白血病 (UKALL) 化疗方案成功治疗了一例出现孤立硬膜外肿块的 B 细胞淋巴细胞淋巴瘤患者。

IF 1.1

Hematology Reports Pub Date : 2024-11-23 DOI: 10.3390/hematolrep16040069

Musa Fares Alzahrani

{"title":"A Case of B-Cell Lymphoblastic Lymphoma Presenting with an Isolated Epidural Mass Treated Successfully with Radiotherapy Followed by United Kingdom Acute Lymphoblastic Leukemia (UKALL) Chemotherapy Protocol.","authors":"Musa Fares Alzahrani","doi":"10.3390/hematolrep16040069","DOIUrl":"10.3390/hematolrep16040069","url":null,"abstract":"Background: B-cell lymphoblastic lymphoma (B-LBL) is an aggressive type of non-Hodgkin lymphoma that usually involves lymph nodes, skin and soft tissue. Bone marrow and peripheral blood are normally spared from involvement in the disease. B-LBL typically forms solid masses that have similar pathologic and immunophenotypic features to their liquid counterpart, B-cell acute lymphoblastic leukemia (B-ALL). The presentation of B-LBL with a solitary epidural mass at the cervical spine is very rare and the optimal treatment of such cases is unknown. Most of the literature on the management of B-LBL comes from small case series, pediatric patients, or as part of retrospective data that combine B-LBL with B-ALL cases.Case presentation: The case presented herein is a unique presentation that was treated using three modalities, namely surgical resection, radiotherapy and consolidation with systemic chemotherapy, adopted from the United Kingdom acute lymphoblastic leukemia (UKALL14) protocol.Conclusions: The patient attained complete remission following the planned treatment and is still in remission for more than four and half years from the time of his initial diagnosis.","PeriodicalId":12829,"journal":{"name":"Hematology Reports","volume":"16 4","pages":"724-731"},"PeriodicalIF":1.1,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0