实体肿瘤,液体挑战:凝血障碍的影响。

IF 1.1 Q4 HEMATOLOGY
Nidha Shapoo, Noella Boma, Shobhana Chaudhari, Vladimir Gotlieb
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引用次数: 0

摘要

凝血功能障碍越来越被认为是实体瘤患者的重要并发症,影响着发病率和死亡率。实体瘤可通过释放促凝因子、内皮细胞活化和炎症引起高凝状态,从而增加凝血障碍的风险。这些凝血障碍可能表现为静脉血栓栓塞、动脉血栓栓塞、血栓性微血管病或弥散性血管内凝血。这些疾病可使手术干预复杂化并影响治疗,包括化疗和免疫治疗的疗效,导致预后不良。了解实体肿瘤中凝血功能障碍的影响对于优化患者管理至关重要,包括识别高危患者,实施预防措施,阐明临床结果的生物标志物,以及探索新的治疗药物。这篇综述的目的是提供有关凝血障碍在实体肿瘤及其临床意义的当前知识的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Solid Tumors, Liquid Challenges: The Impact of Coagulation Disorders.

Coagulation disorders are increasingly recognized as significant complications in patients with solid tumors, affecting morbidity and mortality outcomes. Solid tumors can provoke a hypercoagulable state through the release of pro-coagulant factors, endothelial activation, and inflammation, leading to a heightened risk of coagulation disorders. These coagulation disorders may manifest as venous thromboembolism, arterial thromboembolism, thrombotic microangiopathy, or disseminated intravascular coagulation. These disorders can complicate surgical interventions and impact treatments, including chemotherapy and immunotherapy efficacy, leading to poor outcomes. Understanding the implications of coagulation disorders in solid tumors is essential for optimizing patient management, including identifying high-risk patients, implementing prophylactic measures, elucidating biomarkers for clinical outcomes, and exploring novel therapeutic agents. This review aims to provide insights into the current knowledge surrounding coagulation disorders in solid tumors and their clinical implications.

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来源期刊
Hematology Reports
Hematology Reports HEMATOLOGY-
CiteScore
0.90
自引率
0.00%
发文量
47
审稿时长
10 weeks
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