Marcos N Blancarte-Ibarra, Renée Guevara-Olivera, Paloma Siller-García, Marlene Alvarado-Castillejos, Mariana Lechuga-Ordoñez, Valeria E Gómez-Islas, Kevin R García-Fong, Sofía A Méndez-Bribiesca, Iván Pérez-Diaz
{"title":"Evaluation of the quality of medical care in patients with type 2 diabetes mellitus in a National Institute of Health. Clinical results and risk factors.","authors":"Marcos N Blancarte-Ibarra, Renée Guevara-Olivera, Paloma Siller-García, Marlene Alvarado-Castillejos, Mariana Lechuga-Ordoñez, Valeria E Gómez-Islas, Kevin R García-Fong, Sofía A Méndez-Bribiesca, Iván Pérez-Diaz","doi":"10.24875/GMM.24000238","DOIUrl":"https://doi.org/10.24875/GMM.24000238","url":null,"abstract":"<p><strong>Background: </strong>DM2 is a highly prevalent chronic disease.</p><p><strong>Objective: </strong>Evaluate the quality of the medical care provided to patients with DM2 in a National Institute of Health, based on the goals established by the Diabetes Recognition Program (DRP), and identify risk factors for poor glycemic control. Establish a cohort of patients with DM2 for follow-up.</p><p><strong>Material and methods: </strong>This is a descriptive, observational, and retrospective study. We analyzed 7 08 medical charts.</p><p><strong>Results: </strong>According to the National Committee for Quality Assurance (NCQA) parameters, our center obtained the score to be accredited as a center of excellence in the care of patients with DM2 (81/100 points). Patients with poor glycemic control (HbA1c >7%) were younger (62.97 vs 66.06 years, p= 0.0016), their DM2 had been present for a longer period (13.40 vs9.57 years, p= 0.0001), and vitamin D levels were lower (20.49 vs 22.39 ng/ml, p= 0.0021). The risk factors associated with poor glycemic control were younger age, longer course of the disease, and low vitamin D levels.</p><p><strong>Conclusions: </strong>The internal medicine department provides high-quality medical care, and fulfills international standards; however, poor DM2 control, overweight, and obesity are still highly prevalent.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 5","pages":"511-518"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra M Montoya, Joan Grimaldo, Gloria M González
{"title":"Phenotypic and molecular identification of Fusarium spp. clinical and environmental isolates.","authors":"Alexandra M Montoya, Joan Grimaldo, Gloria M González","doi":"10.24875/GMM.M24000943","DOIUrl":"https://doi.org/10.24875/GMM.M24000943","url":null,"abstract":"<p><strong>Background: </strong>Fusarium is a genus of fungi whose identification is based primarily on phenotypic characteristics, although molecular identification procedures have outperformed conventional procedures. In Mexico, there is no information on the species or complexes of the members of this genus.</p><p><strong>Objective: </strong>To identify the species of a collection of 116 Fusarium spp. strains obtained from clinical and environmental samples.</p><p><strong>Material and methods: </strong>Phenotypic identification was carried out by morphology analysis of cultures on the following media: Sabouraud dextrose agar, dextrose potato agar, oat agar, Speziller Nährstoffarmer agar and water agar. Molecular identification was performed by amplification and sequencing of the ITS, TEF1, RPB2 and CL regions.</p><p><strong>Results: </strong>Only 39 Fusarium strains could be identified at the complex level using phenotypic characteristics. The remaining 77 strains were identified using molecular procedures. In addition, molecular confirmation of identification was sought for the 39 strains already mentioned. ITS sequencing was sufficient for the identification of F. oxysporum and F. solani complex species. For the identification of other species, the sequencing of TEF1, RPB2 and/or CL was required.</p><p><strong>Conclusions: </strong>Phenotypic identification was often limited by the lack of fungal structure production when cultured on conventional and some minimal media. Molecular procedures are essential to achieve the precise identification of the species of this genus.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 5","pages":"527-534"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura S Rangel-Cova, Silverio Soto-Álvarez, Enrique Estudillo, Lidia F E Huerta-Núñez
{"title":"Potential protein biomarkers of central nervous system infiltration in childhood acute lymphoblastic leukemia.","authors":"Laura S Rangel-Cova, Silverio Soto-Álvarez, Enrique Estudillo, Lidia F E Huerta-Núñez","doi":"10.24875/GMM.M24000945","DOIUrl":"https://doi.org/10.24875/GMM.M24000945","url":null,"abstract":"<p><p>Acute lymphoblastic leukemia (ALL) is the most common neoplasia among children worldwide, and the main cause of death by cancer in patients with less than 18 years, thus representing a serious health concern. One problem of ALL is the infiltration of leukemic cells in the central nervous system (CNS), which is only detected in the 3-5% of children in their diagnostic due to a lack of sensibility and specificity, which compromises an efficient prognostic and follow-up of the disease. This drawback demands the search of novel biomarkers of infiltration. Therefore, this review focuses on 1) the relevance of cerebrospinal fluid proteomics and protein biomarkers as possible candidates to aim in the diagnostic of pediatric patients with ALL that display CNS infiltration and 2) a general perspective of the methods for analyzing biomarkers in the CSF to further comprehend the leukemia in the CNS.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 5","pages":"465-472"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Posting sensitive personal data in social media: opportunities for improvement.","authors":"Aldo Barajas-Ochoa, César Ramos-Remus","doi":"10.24875/GMM.M24000848","DOIUrl":"10.24875/GMM.M24000848","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 1","pages":"104-106"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New perspectives in the management of SARS-CoV-2 Pirola variants and the development of long COVID syndrome: anti-Ro52/TRIM21 antibodies and qRT-PC.","authors":"César E Rabadán-Martínez","doi":"10.24875/GMM.M24000922","DOIUrl":"https://doi.org/10.24875/GMM.M24000922","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 4","pages":"450-451"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diabetes and economy, a problem for the population.","authors":"Henry C Rivas-Sucari","doi":"10.24875/GMM.M24000929","DOIUrl":"https://doi.org/10.24875/GMM.M24000929","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 4","pages":"463-464"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Virginia Bañares, Javier Martini, Graciela López, Pablo Corral, Laura Schreier
{"title":"Application of the 6-SNP elevated LDL-cholesterol polygenic risk score in individuals with familial hypercholesterolemia phenotype from an Argentine population.","authors":"Virginia Bañares, Javier Martini, Graciela López, Pablo Corral, Laura Schreier","doi":"10.24875/GMM.M24000918","DOIUrl":"https://doi.org/10.24875/GMM.M24000918","url":null,"abstract":"<p><strong>Introduction: </strong>LDL-cholesterol greater than 190 mg/dL indicates severe hypercholesterolemia (HS) of monogenic and/or polygenic origin. Genetic risk scores (GRS) evaluate potential polygenic causes.</p><p><strong>Objective: </strong>we applied a GRS of 6-SNP (GRS-6) in HS individuals.</p><p><strong>Material and methods: </strong>69 subjects from the Familial Hypercholesterolemia (HF) Detection registry in Argentina (Da Vinci).</p><p><strong>Results: </strong>with 44 individuals with HF-phenotype, not carriers of genetic variants that indicate a monogenic origin (HF/M-) and 26 controls, the GRS-6 cut-off value was established, > 0.76, sensitivity 0.59, specificity 0.69. 15/44(34 %) HF/M- presented GRS-6+. The mean GRS-6 values in HF/M-, HF/M+ and controls were 0.72 ± 0.17, 0.66 ± 0.17, and 0.70 ± 0.13 respectively (p = 0.43). There were no significant differences in cholesterol values, or in the clinical score, between cases with positive vs negative GRS-6. The GRS-6 was positive in 32 % of the cases vs 20 % of the previously applied GRS-10 (p = 0.003), significantly increasing the detection of polygenic contribution.</p><p><strong>Conclusions: </strong>We present an estimate of the first cut-off value for the GRS-6 in a Latin American population, and we conclude that the GRS-6 could contribute to the evaluation of the polygenic contribution in cases with severe hypercholesterolemia in our population in a similar way to that of other European populations.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 4","pages":"413-419"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Special issue: aging.","authors":"Carmen García-Peña, Germán E Fajardo-Dolci","doi":"10.24875/GMM.M24000893","DOIUrl":"https://doi.org/10.24875/GMM.M24000893","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 3","pages":"231-232"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amor A Segura-Duarte, Gerardo Méndez-Suárez, Laura P Burgos-Morelos, José J Rivera-Sánchez
{"title":"Concordance of grip strength measurement between a digital handheld dynamometer and a Hydraulic dynamometer.","authors":"Amor A Segura-Duarte, Gerardo Méndez-Suárez, Laura P Burgos-Morelos, José J Rivera-Sánchez","doi":"10.24875/GMM.24000109","DOIUrl":"https://doi.org/10.24875/GMM.24000109","url":null,"abstract":"<p><strong>Background: </strong>Assessment of muscle strength is of great interest for the study of age-associated pathologies, including frailty and sarcopenia. However, the cost of some of the equipment necessary for its evaluation could be prohibitive for its generalized use in some settings.</p><p><strong>Objective: </strong>The purpose of the present study was to compare two handheld dynamometers to evaluate the measure of concordance between the measurements. Material and methods The study was conducted in the outpatient Geriatrics clinics where 120 community-dwelling participants aged 60 years and more were evaluated using two devices: the JAMAR<sup>®</sup> Hydraulic Hand Dynamometer and the digital hand dynamometer CAMRY<sup>®</sup> EH101.</p><p><strong>Results: </strong>We observed a positive correlation between the two devices for dominant hand (DH) Pearson r 0.974 (p < 0.001) and a Spearman ρ 0.973 (p < 0.001) for non-dominant hand (NDH) Lin's coefficient for the DH was 0.98 (p < 0.001) and for the NDH 0.97 (p < 0.001). The intraclass correlation coefficient was 0.971 (95% CI, 0.95-0.97; p < 0.001) for DH and 0.975 (95% CI, 0.96-0.98; p < 0.001) for NDH.</p><p><strong>Conclusions: </strong>In this study, the Camry dynamometer was observed to be reliable for measuring hand grip strength in community-dwelling people 60 years or older.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 3","pages":"308-312"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ChatGPT: opportunities, risks, medical care, teaching, and research.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.24875/GMM.23000497","DOIUrl":"https://doi.org/10.24875/GMM.23000497","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 2","pages":"215-216"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}