Christopher A Gutiérrez-García, Martín R Gutiérrez-Jiménez, Roberto de J Sandoval-Muñiz, Raúl C Baptista-Rosas
{"title":"Single nucleotide variants of the SLC2A2 gene in Mexican-origin population.","authors":"Christopher A Gutiérrez-García, Martín R Gutiérrez-Jiménez, Roberto de J Sandoval-Muñiz, Raúl C Baptista-Rosas","doi":"10.24875/GMM.M25000985","DOIUrl":"https://doi.org/10.24875/GMM.M25000985","url":null,"abstract":"<p><strong>Background: </strong>Diabetes, which is caused by environmental and genetic factors, has a high global prevalence (10.5%). Some single nucleotide variants (SNVs) modify the activity of glucose transporters such as GLUT2, which plays a significant role in insulin secretion and glucose metabolism.</p><p><strong>Objective: </strong>To analyze the SNVs associated with type 2 diabetes (T2D) in the Mexican population.</p><p><strong>Material and methods: </strong>Reference databases for SNVs registered for SLC2A2 gen associated with T2DM in the Mexican population.</p><p><strong>Results: </strong>83 SNVs were analyzed, identifying 3 relevant variants in Mexican population associated with T2D: rs5404, rs5406 and rs5398, a pathogenic variant with RM >1.0 and p value < 0.05.</p><p><strong>Conclusions: </strong>Detailed genetic analysis and mapping coupled with functional studies are needed to identify the mechanism by which GLUT2 variants influence diabetes development.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 1","pages":"102-109"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos M Manrique-Rabelo, Magnolia V Aliende-Pinto
{"title":"Myths and beliefs about contraception: the transdermal patch as a practical and effective method.","authors":"Carlos M Manrique-Rabelo, Magnolia V Aliende-Pinto","doi":"10.24875/GMM.M25000997","DOIUrl":"https://doi.org/10.24875/GMM.M25000997","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"217-218"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tonatiuh R Bedolla-Pulido, Diana I Juárez-Luna, Jaime Morales-Romero, Dante D Hernández-Colín, María E Núñez-Núñez, Martín Bedolla-Barajas
{"title":"Prevalence and associated factors of hypersensitivity to tropical fruits among Mexican adults.","authors":"Tonatiuh R Bedolla-Pulido, Diana I Juárez-Luna, Jaime Morales-Romero, Dante D Hernández-Colín, María E Núñez-Núñez, Martín Bedolla-Barajas","doi":"10.24875/GMM.24000380","DOIUrl":"https://doi.org/10.24875/GMM.24000380","url":null,"abstract":"<p><strong>Background: </strong>Although tropical fruits (TF) are an important part of the diet in many regions worldwide, epidemiological data on hypersensitivity to tropical fruits (HSTF) are scarce globally.</p><p><strong>Objectives: </strong>This study aims to determine the prevalence of HSTF in adults, identify the most common symptoms and foods associated with it, and identify factors linked to its occurrence.</p><p><strong>Materials and methods: </strong>A structured questionnaire was administered to a sample of Mexican adults to identify symptoms associated with TF consumption. Two study groups were formed: one without HSTF and another with HSTF.</p><p><strong>Results: </strong>A total of 930 adults participated in the study; 35 had HSTF (prevalence of 3.8%; 95%CI: 2.7%-5.2%). The kiwi (13/930, 1.4%), pineapple (8/930, 0.9%), and avocado (7/930, 0.8%) had the highest prevalence. The main symptoms caused by TF were pharyngeal tightness (15/35, 44.1%), oral itching (12/35, 34.3%), and lip itching (9/35, 25.7%). Multivariate analyses identified asthma (aOR: 3.46, p = 0.014), atopic dermatitis (aOR: 7.08, p = 0.002), and a family history of urticaria (aOR: 8.15, p < 0.001) as factors associated with HSTF.</p><p><strong>Conclusions: </strong>This study indicates that approximately 4% of surveyed adults experience symptoms after consuming TF and identifies asthma, atopic dermatitis, and a family history of urticaria as significant factors associated with HSTF.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"161-167"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María A Perez-Velilla, Paola Toffoletti, Luciana D Garlissi
{"title":"Translational medicine, a new competence of the 21<sup>st</sup> century, and its relationship with medical biophysics.","authors":"María A Perez-Velilla, Paola Toffoletti, Luciana D Garlissi","doi":"10.24875/GMM.M25000993","DOIUrl":"https://doi.org/10.24875/GMM.M25000993","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"208-209"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Robles-Martínez, Carolina Consejo Y Chapela, Víctor M Castaño-Meneses
{"title":"Social responsibility and moral agency: transforming the doctor-patient relationship in medical practice.","authors":"José Robles-Martínez, Carolina Consejo Y Chapela, Víctor M Castaño-Meneses","doi":"10.24875/GMM.M25000992","DOIUrl":"https://doi.org/10.24875/GMM.M25000992","url":null,"abstract":"<p><p>Social responsibility and moral agency in the doctor-patient relationship is a complex issue, but at the same time crucial and it can be guided by bioethical and responsibility principles. This relationship goes beyond simple professional interaction and seeks to ensure a health care model with equity and focused on the comprehensive well-being of the patient and the community. It is essential that health care professionals respect and support the moral agency of the patient, providing them with clear and understandable information, and facilitating ethical decision-making. Empathic communication and empathy are key to establishing a strong therapeutic relationship and helping the patient face difficult decisions with the most autonomy possible, confidence, and security. The intention of this article is to explore how the integration of social responsibility and moral agency can transform the doctor-patient relationship, fostering an environment of trust, mutual respect, and active collaboration in decision-making in health care practice and better decision-making. of decisions to avoid bioethical problems.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"200-204"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nayeli Ortiz-Olvera, Juan P Ochoa-Maya, Marina A González-Martínez
{"title":"Gastroesophageal reflux disease and pregnancy: recommendations for safe treatment.","authors":"Nayeli Ortiz-Olvera, Juan P Ochoa-Maya, Marina A González-Martínez","doi":"10.24875/GMM.M25000986","DOIUrl":"https://doi.org/10.24875/GMM.M25000986","url":null,"abstract":"<p><p>Gastroesophageal reflux disease (GERD) is common during pregnancy, affecting up to 80% of pregnant women. Treatment aims to relieve symptoms and not harm the fetus. Our objective is to provide guidance on the safe treatment of GERD in pregnancy. An electronic search of the English-language literature was performed in MEDLINE, PubMed, and Cochrane, to identify randomized controlled trials, observational studies, management recommendations, and reviews of GERD and its treatment during pregnancy. The search period was defined from 1992 to 2024. Treatment during pregnancy should be gradual, starting with lifestyle changes. If symptoms are severe, calcium-containing antacids or alginates should be started as the first pharmacological measure (grade A recommendation). If symptoms persist, sucralfate may be introduced (grade C recommendation), followed by a histamine-2 receptor antagonist (grade B recommendation). Proton pump inhibitors are reserved for women with intractable symptoms or complicated GERD; all are Food and Drug Administration category B drugs except omeprazole, which is category C (grade C recommendation). There are drugs that are contraindicated during pregnancy, and others that have not been thoroughly studied in this situation.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"119-126"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariana A Martínez-Castillo, María Á Hernández Cueto, Keiko Taniguchi-Ponciano, Mauricio Salcedo
{"title":"RET could act as suppressor tumor gene in cervical cancer cells.","authors":"Mariana A Martínez-Castillo, María Á Hernández Cueto, Keiko Taniguchi-Ponciano, Mauricio Salcedo","doi":"10.24875/GMM.24000379","DOIUrl":"https://doi.org/10.24875/GMM.24000379","url":null,"abstract":"<p><strong>Background: </strong>RET gene is an oncogene for thyroid cancer, in contrast as tumor suppressor gene in colon cancer.</p><p><strong>Objective: </strong>To know the role of RET gene in Cervical Cancer (CC) cells.</p><p><strong>Materials and methods: </strong>Tissue microarray harboring healthy, Low- or High-Squamous Intraepithelial Lesions (LSIL or HSIL), and CC tissues were evaluated by immunohistochemistry. Nuclear cellular membranes were evaluated by an Olympus cellSens Dimension system. DNA from cervical cells and cervical-cell lines were assessed for detecting RET point mutation and methylation promoter status. GraphPad Prism ver. 9.3.1 software was used for the analysis.</p><p><strong>Results: </strong>Healthy cervical samples expressed RET protein, in contrast a quite similar proportion 75-90% of the LSIL or HSIL, or CC samples (squamous or adenocarcinoma) demonstrated a lack of RET expression. Cervical glandular intraepithelial lesions presented a similar expression pattern compared with the control group. The CC cells do not exhibit RET point mutation for exons 10 and 16, but the RET gene promoter was methylated.</p><p><strong>Conclusions: </strong>The lack of RET expression could correlate with the promoter methylated in the transformed cervical epithelial cells. These findings could suggest that RET gene acts as tumor suppressor gene in Cervical cancer.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"132-139"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amado Jiménez-Ruiz, Diego de J Gómez-López, Naomi N Becerra-Aguiar, Alejandra S Hernández-Montoya, Enrique Gómez-Figueroa, José L Ruiz-Sandoval
{"title":"Evolving risk factors and mortality among geriatric patients: a comparison between 2010 and 2022-2023 cohorts.","authors":"Amado Jiménez-Ruiz, Diego de J Gómez-López, Naomi N Becerra-Aguiar, Alejandra S Hernández-Montoya, Enrique Gómez-Figueroa, José L Ruiz-Sandoval","doi":"10.24875/GMM.24000377","DOIUrl":"https://doi.org/10.24875/GMM.24000377","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"205-207"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health personnel live not only on data: on humanism, narrative and poetry in medical practice.","authors":"Patricio Santillán-Doherty","doi":"10.24875/GMM.M25000999","DOIUrl":"https://doi.org/10.24875/GMM.M25000999","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"221-222"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marisol Olivares-Arévalo, Hugo Villamil-Ramírez, Blanca López-Contreras, Paola León-Mimila, Teresa Villarreal-Molina, Samuel Canizales-Quinteros
{"title":"Genetics of metabolic obesity phenotypes.","authors":"Marisol Olivares-Arévalo, Hugo Villamil-Ramírez, Blanca López-Contreras, Paola León-Mimila, Teresa Villarreal-Molina, Samuel Canizales-Quinteros","doi":"10.24875/GMM.M25000970","DOIUrl":"https://doi.org/10.24875/GMM.M25000970","url":null,"abstract":"<p><p>Although obesity is an important risk factor for cardiometabolic diseases, not every individual with obesity shows metabolic complications, this phenotype is called metabolically healthy obesity (MHO). Several studies suggest that the distribution of body fat and its accumulation in ectopic depots, rather than overall adiposity, are important factors in defining the metabolic health of individuals with obesity. The identification of genes involved in fat accumulation, particularly in the expansion of subcutaneous adipose tissue, has contributed to better understanding the physiological mechanisms related to metabolic health. Notably, some Latin American populations have an increased susceptibility to the development of metabolic complications. In this review, we discuss the differences in the prevalence of MHO among populations, including Latin Americans, as well as some of the main genetic findings related to healthy and unhealthy metabolic phenotypes of obesity.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 1","pages":"33-40"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}