Christopher A Gutiérrez-García, Martín R Gutiérrez-Jiménez, Roberto de J Sandoval-Muñiz, Raúl C Baptista-Rosas
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引用次数: 0
Abstract
Background: Diabetes, which is caused by environmental and genetic factors, has a high global prevalence (10.5%). Some single nucleotide variants (SNVs) modify the activity of glucose transporters such as GLUT2, which plays a significant role in insulin secretion and glucose metabolism.
Objective: To analyze the SNVs associated with type 2 diabetes (T2D) in the Mexican population.
Material and methods: Reference databases for SNVs registered for SLC2A2 gen associated with T2DM in the Mexican population.
Results: 83 SNVs were analyzed, identifying 3 relevant variants in Mexican population associated with T2D: rs5404, rs5406 and rs5398, a pathogenic variant with RM >1.0 and p value < 0.05.
Conclusions: Detailed genetic analysis and mapping coupled with functional studies are needed to identify the mechanism by which GLUT2 variants influence diabetes development.
期刊介绍：
Gaceta Médica de México México is the official scientific journal of the Academia Nacional de Medicina de México, A.C. Its goal is to contribute to health professionals by publishing the most relevant progress both in research and clinical practice.
Gaceta Médica de México is a bimonthly peer reviewed journal, published both in paper and online in open access, both in Spanish and English. It has a brilliant editorial board formed by national and international experts.
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