Gaceta medica de Mexico最新文献_第5页

Drosophila in the study of hTBP protein interactions in the development and modeling of SCA17. 果蝇研究 hTBP 蛋白在 SCA17 发育和建模中的相互作用。

IF 0.6 4区医学

Gaceta medica de Mexico Pub Date : 2024-01-01 DOI: 10.24875/GMM.M24000845

Rubén J Montalvo-Méndez, Marcela Cárdenas-Tueme, Diana Reséndez-Pérez

{"title":"Drosophila in the study of hTBP protein interactions in the development and modeling of SCA17.","authors":"Rubén J Montalvo-Méndez, Marcela Cárdenas-Tueme, Diana Reséndez-Pérez","doi":"10.24875/GMM.M24000845","DOIUrl":"10.24875/GMM.M24000845","url":null,"abstract":"Background: Protein interactions participate in many molecular mechanisms involved in cellular processes. The human TATA box binding protein (hTBP) interacts with Antennapedia (Antp) through its N-terminal region, specifically via its glutamine homopeptides. This PolyQ region acts as a binding site for other transcription factors under normal conditions, but when it expands, it generates spinocerebellar ataxia 17 (SCA17), whose protein aggregates in the brain prevent its correct functioning.Objective: To determine whether the hTBP glutamine-rich region is involved in its interaction with homeoproteins and the role it plays in the formation of protein aggregates in SCA17.Material and methods: We characterized hTBP interaction with other homeoproteins using BiFC, and modeled SCA17 in Drosophila melanogaster by targeting hTBPQ80 to the fly brain using UAS/GAL4.Results: There was hTBP interaction with homeoproteins through its glutamine-rich region, and hTBP protein aggregates with expanded glutamines were found to affect the locomotor capacity of flies.Conclusions: The study of hTBP interactions opens the possibility for the search for new therapeutic strategies in neurodegenerative pathologies such as SCA17.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 1","pages":"1-8"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracorporeal membrane oxygenation. Experience in the treatment of transplanted heart primary failure. 体外膜肺氧合。治疗移植心脏原发性衰竭的经验。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2024-01-01 DOI: 10.24875/GMM.M24000849

Guillermo Careaga-Reyna, Hugo Jesús Zetina-Tun, Luis M Álvarez Sánchez

引用次数: 0

Serum levels of anti-Ro52/TRIM21 antibodies in SARS-CoV-2 genetic variants and long COVID. Beyond their application in autoimmune diseases. SARS-CoV-2基因变种和长COVID血清中的抗Ro52/TRIM21抗体水平。超越其在自身免疫性疾病中的应用。

IF 0.6 4区医学

Gaceta medica de Mexico Pub Date : 2024-01-01 DOI: 10.24875/GMM.M24000851

Jesús Elizarrarás-Rivas, Sergio A Ramirez-Garcia, Luis A Hernández-Osorio, Renato Salas-Alfaro, Jeús D Elizarrarás-Cruz

引用次数: 0

Association between suicidal behavior and symptoms of other mental health problems in Mexican adolescents. 墨西哥青少年自杀行为与其他心理健康问题症状之间的关联。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2024-01-01 DOI: 10.24875/GMM.M24000855

Abigail Casas-Muñoz, Ángel E Velasco-Rojano, Aarón Rodríguez-Caballero, Arturo Loredo-Abdalá, Eva Prado-Solé, Martín G Álvarez

{"title":"Association between suicidal behavior and symptoms of other mental health problems in Mexican adolescents.","authors":"Abigail Casas-Muñoz, Ángel E Velasco-Rojano, Aarón Rodríguez-Caballero, Arturo Loredo-Abdalá, Eva Prado-Solé, Martín G Álvarez","doi":"10.24875/GMM.M24000855","DOIUrl":"https://doi.org/10.24875/GMM.M24000855","url":null,"abstract":"Background: Suicidal behavior in adolescents is a growing public health problem. Knowing its risk factors is key for reducing it.Objective: To identify the relationship between two suicidal behaviors (ideation and attempt) and eight mental health problems (MHPs) in Mexican adolescents.Material and methods: Through an online survey of adolescent students from 20 states, the following information was screened: symptomatology of six MHPs (affective problems/depression, behavioral problems, somatic problems, inattention and hyperactivity problems, oppositional defiant problems and anxiety problems) and suicidal behavior (suicidal ideation and suicide attempts). MHP and suicidal behavior frequencies and percentages were analyzed, and associations were sought using binary logistic regression.Results: Six-thousand seven hundred sixty-six adolescents completed the survey, out of whom 61.02% were females, with ages ranging between 11 and 19 years (16.38 ± 1.33); 10% reported suicidal behavior, and between 3 and 5%, MHPs. The predictors (χ2(8) = 387.13, p < 0.001) of suicidal behavior were affective problems/depression, behavioral problems, somatic problems, oppositional defiant problems and anxiety problems.Conclusion: Five mental health problems increased the risk of reporting suicidal behaviors.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 1","pages":"32-38"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diet and cognition in older people in Mexico City. 墨西哥城老年人的饮食与认知能力。

IF 0.6 4区医学

Gaceta medica de Mexico Pub Date : 2024-01-01 DOI: 10.24875/GMM.M24000914

Arturo F Martínez-Rodríguez, Guillermo Salinas-Escudero, Elsy A García-Villegas, Lorena Parra-Rodríguez, Adrián Martínez-Ruíz, María F Carrillo-Vega

{"title":"Diet and cognition in older people in Mexico City.","authors":"Arturo F Martínez-Rodríguez, Guillermo Salinas-Escudero, Elsy A García-Villegas, Lorena Parra-Rodríguez, Adrián Martínez-Ruíz, María F Carrillo-Vega","doi":"10.24875/GMM.M24000914","DOIUrl":"10.24875/GMM.M24000914","url":null,"abstract":"Background: Specific dietary compounds are essential for cognitive health.Objective: To examine differences in the consumption of macronutrients and inorganic nutrients between people with a higher and lower risk of cognitive impairment.Material and methods: Cross-sectional analysis of the 3Ollin study. Minimal Mental State Examination determined cognitive status. Two groups were obtained from the median of the score: higher and lower risk of cognitive deterioration. Diet was assessed using two 24-hour recalls. Descriptive statistics and comparison analysis of medians using Mann-Whitney U and Spearman correlation analysis were performed between nutrients and MMSE scores. The results were considered statistically significant when p ≤ 0.05.Results: Data from 425 people were analyzed; the median age was 71 years (P25-P75 = 65-77). In the group with a lower risk of cognitive impairment, a higher consumption of calories, protein, carbohydrates, fiber, folate, phosphorus, ascorbic acid, vitamin E, alpha-tocopherol, vitamin B6, vitamin B12, zinc, selenium, and lycopene were observed. Also, a greater consumption of fruits and vegetables (p < 0.005).Conclusions: There are significant differences in diet between groups at risk for cognitive impairment.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 3","pages":"265-273"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of frailty with the use of health services in older adults: a secondary analysis of the Mexican Health and Aging Study. 虚弱与老年人使用医疗服务的关系：对墨西哥健康与老龄化研究的二次分析。

IF 0.6 4区医学

Gaceta medica de Mexico Pub Date : 2024-01-01 DOI: 10.24875/GMM.M24000853

Mario U Pérez-Zepeda

{"title":"Association of frailty with the use of health services in older adults: a secondary analysis of the Mexican Health and Aging Study.","authors":"Mario U Pérez-Zepeda","doi":"10.24875/GMM.M24000853","DOIUrl":"10.24875/GMM.M24000853","url":null,"abstract":"Background: Frailty has been related to adverse outcomes, but evidence on its association with the use of health services is still scarce.Objective: The purpose of this work was to determine the association of frailty with the use of health services in Mexican adults older than 60 years.Material and methods: Analysis of the Mexican Health and Aging Study for the years 2015 (baseline) and 2018 (follow-up). Frailty was defined with the frailty index. The following outcomes were included: hospitalization, medical visits, major surgery, minor surgical procedures, and dental visits. Competing risk and count analyses (negative binomial regression) were performed.Results: A total of 8,526 individuals were included, whose average age was 70.8%; 55.8% corresponded to the female gender. According to the results, hospitalization days and the number of minor procedures were associated with frailty.Conclusions: Frailty could be useful in the planning of health services for older adults. On the other hand, its evaluation would allow prioritizing care for those who are at higher risk of adverse outcomes.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 1","pages":"17-22"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysphagia in Mexican older adults with mild cognitive impairment and dementia. 患有轻度认知障碍和痴呆症的墨西哥老年人的吞咽困难。

IF 0.6 4区医学

Gaceta medica de Mexico Pub Date : 2024-01-01 DOI: 10.24875/GMM.M24000896

Georgina Martínez-Peña, Alberto J Mimenza-Alvarado, Lourdes M Ávila-Escobedo, Antonio R Villa-Romero, Sara G Aguilar-Navarro

{"title":"Dysphagia in Mexican older adults with mild cognitive impairment and dementia.","authors":"Georgina Martínez-Peña, Alberto J Mimenza-Alvarado, Lourdes M Ávila-Escobedo, Antonio R Villa-Romero, Sara G Aguilar-Navarro","doi":"10.24875/GMM.M24000896","DOIUrl":"https://doi.org/10.24875/GMM.M24000896","url":null,"abstract":"Introduction: Dysphagia and cognitive impairment are common in older people. It is linked to alterations in brain areas related to swallowing.Objective: To explore the characteristics of dysphagia using fluoroscopy in patients with mild cognitive impairment (MCI) and dementia.Material and methods: 158 participants from a memory clinic. Specific criteria for MCI and dementia were used. Dysphagia was assessed with EAT-10 (≥ 3). Those who accepted completed a fluoroscopy study with a barium swallow to evaluate the phases of swallowing; the presence of bronchoaspiration supported the diagnosis of dysphagia. A logistic regression analysis was performed to test the probability between dysphagia and MCI.Results: According to EAT-10, 86 (54.4 %) were at risk of dysphagia, confirmed in 84 by fluoroscopy, 53.8 % MCI group and 46.2 % dementia. An inverse association was observed in the MCI oral phase group (OR 0.23, p < 0.025), and a positive association; in protection phase against regurgitation (OR 3.76, p < 0.056) and laryngeal muscle contraction (OR 3.22, p < 0.045) versus dementia group.Conclusions: The study showed a high frequency of dysphagia in patients with MCI, this highlights the importance of its early detection to improve complications associated with dysphagia.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 3","pages":"274-282"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pilot project of pregnancy-associated plasma protein-A as an early screening test for preeclampsia in a Regional Hospital. 某地区医院妊娠相关血浆蛋白A作为子痫前期筛查试验的试点项目

IF 0.6 4区医学

Gaceta medica de Mexico Pub Date : 2024-01-01 DOI: 10.24875/GMM.M24000931

Jennifer Vega-Iglesias, Adriana Tarcila Velázquez-Pérez, Héctor Oviedo-Cruz

引用次数: 0

Analysis of circulating cell-free nuclear and mitochondrial DNA in plasma of Mexican patients with breast cancer. 墨西哥乳腺癌患者血浆循环游离细胞核和线粒体DNA分析。

IF 0.6 4区医学

Gaceta medica de Mexico Pub Date : 2024-01-01 DOI: 10.24875/GMM.M24000917

Dalia E Rodríguez-Torres, Anilu M Saucedo-Sariñana, Alejandra Palacios-Ramírez, Miriam Y Godínez-Rodríguez, Efraín Salas-González, Aldo A Alcaraz-Wong, José E García-Ortiz, Mónica A Rosales-Reynoso

{"title":"Analysis of circulating cell-free nuclear and mitochondrial DNA in plasma of Mexican patients with breast cancer.","authors":"Dalia E Rodríguez-Torres, Anilu M Saucedo-Sariñana, Alejandra Palacios-Ramírez, Miriam Y Godínez-Rodríguez, Efraín Salas-González, Aldo A Alcaraz-Wong, José E García-Ortiz, Mónica A Rosales-Reynoso","doi":"10.24875/GMM.M24000917","DOIUrl":"https://doi.org/10.24875/GMM.M24000917","url":null,"abstract":"Background: The usefulness of circulating free DNA (cfDNA), nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) as potential biomarkers in cancer remains controversial.Objective: To determine the concentration of cfDNA and plasma nDNA and mtDNA levels in breast cancer (BC) patients.Material and methods: This study included a total of 86 women (69 patients with BC and 17 women as a control group). The cfDNA was determined using fluorometry, and the levels of mtDNA and nDNA were quantified using real-time polymerase chain reaction (qPCR).Results: The concentration of cfDNA was higher in patients with BC compared to the control group (p = 0.001). A higher concentration of cfDNA was also associated with patients over 50 years old (p = 0.001). The level of nDNA was higher in patients with CM compared to the control group (p = 0.004). Levels of mtDNA did not show significant differences (p > 0.005). The concentration of cfDNA and nDNA showed significant discriminatory power (AUC = 0.968, CI = 0.93-1.00, p = 0.001; and AUC = 0.724, CI = 0.59-0.85, p = 0.004, respectively.Conclusions: The concentration of cfDNA and the combination of cfDNA and nDNA are useful biomarkers for diagnosing patients with BC.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 4","pages":"404-412"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contribution of memory T cells to the generation of long-lasting immunity against COVID-19. 记忆 T 细胞有助于产生针对 COVID-19 的持久免疫力。

IF 0.6 4区医学

Gaceta medica de Mexico Pub Date : 2024-01-01 DOI: 10.24875/GMM.M24000878

Alejandro Torres-Flores, Isabel Wong-Baeza, Constantino López-Macías

引用次数: 0