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Genomics of cardiometabolic disease: contributions of Mexican research groups. 心脏代谢疾病基因组学：墨西哥研究小组的贡献。
IF 0.6 4区 医学
Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.24000415
Mayra Domínguez-Pérez, Leonor Jacobo-Albavera, Samuel Canizales-Quinteros, Ma Teresa Villarreal-Molina
{"title":"Genomics of cardiometabolic disease: contributions of Mexican research groups.","authors":"Mayra Domínguez-Pérez, Leonor Jacobo-Albavera, Samuel Canizales-Quinteros, Ma Teresa Villarreal-Molina","doi":"10.24875/GMM.24000415","DOIUrl":"https://doi.org/10.24875/GMM.24000415","url":null,"abstract":"<p><p>Understanding the genetic architecture of complex disease has helped identify at risk individuals, new pathways involved in pathophysiology, and potential pharmacological targets for prevention and/or treatment. Thus, the identification of susceptibility variants of Native American or Mexican origin can potentially benefit any patient, regardless of ethnic origin. The purpose of this review is to provide an overview of the most relevant contributions of Mexican researchers to knowledge on genomics of cardiometabolic disease in the Mexican population, including ethnic-specific variants and population genomics studies, stressing the importance of evolutionary approaches in understanding complex disease. Collaborative efforts and large long-term cohort studies including genomic, multi-omic, fine phenotyping and environmental exposure data are necessary to identify the clinical relevance of these variants and how they interact with the environment, in order to apply this knowledge to personalized medicine.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 1","pages":"66-74"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High frequency of metabolic syndrome in non-obese Maya children from México: Implications of PPARG, KCNJ1, HHEX, HNF4A, ACE (I/D), FTO and ABCA1 genetics variants. 非肥胖玛雅儿童代谢综合征的高频率：PPARG， KCNJ1， HHEX, HNF4A, ACE (I/D)， FTO和ABCA1遗传变异的意义
IF 0.6 4区 医学
Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.25000022
Barbara Peña-Espinoza, Carlos Juárez-López, Guadalupe Ortiz-López, Angéles Granados-Silvestre, Marta Menjivar
{"title":"High frequency of metabolic syndrome in non-obese Maya children from México: Implications of PPARG, KCNJ1, HHEX, HNF4A, ACE (I/D), FTO and ABCA1 genetics variants.","authors":"Barbara Peña-Espinoza, Carlos Juárez-López, Guadalupe Ortiz-López, Angéles Granados-Silvestre, Marta Menjivar","doi":"10.24875/GMM.25000022","DOIUrl":"https://doi.org/10.24875/GMM.25000022","url":null,"abstract":"<p><strong>Background: </strong>Both environmental and genetic factors determine metabolic syndrome (MetS) and eventually result in metabolic diseases. MetS is a national health problem in adults and children, with a higher incidence in Indigenous than mestizo individuals.</p><p><strong>Objective: </strong>Evaluate the association of PPARG/rs1801282, KCNJ11/rs5219, HHEX/rs1111875, HNF4A/rs1800961, ACE-I/D, FTO/rs9939609 and ABCA1/rs9282541 variants with MetS or its components in the Maya children from Yucatan.</p><p><strong>Material and methods: </strong>A total of 508 Maya children of 9 to 13 years were recruited. We analyze the association of genetic variants with MetS in non-obese Maya children by univariate and multivariate models adjusted by sex, age, and BMI.</p><p><strong>Results: </strong>Interestingly, the frequency of MetS in non-obese Maya children from rural and urban areas was 35% and 39%, respectively. The genotype-phenotype analysis in rural Maya children revealed that rs9282541-ABCA1 was associated with high glucose (p = 0.011); rs9939609-FTO, with high blood pressure (p = 0.048) and rs1800961-HNF4A, with high insulin and HOMA-IR (p = 0.038, p = 0.043). In urban children, I/D-ECA was associated with high blood pressure (p = 0.022); rs1111875-HHEX, with high triglycerides (p = 0.050) and rs1800961-HNF4A, with low HDL-c (p = 0.048).</p><p><strong>Conclusions: </strong>These findings provide strong evidence of the role of the studied variants in conferring genetic susceptibility to develop MetS in non-obese Maya children from Mexico.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 1","pages":"110-118"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The genomics of Mexicans in metabolic diseases. 墨西哥人代谢性疾病的基因组学研究。
IF 0.6 4区 医学
Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25000968
Miguel Cruz, Jaime Berumen
{"title":"The genomics of Mexicans in metabolic diseases.","authors":"Miguel Cruz, Jaime Berumen","doi":"10.24875/GMM.M25000968","DOIUrl":"https://doi.org/10.24875/GMM.M25000968","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 1","pages":"1-2"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Authors' reply to the letter "Guillain-Barré syndrome before and during the COVID-19 pandemic"]. [作者对 "COVID-19 大流行之前和期间的格林-巴利综合征 "一信的回复]。
IF 0.6 4区 医学
Gaceta medica de Mexico Pub Date : 2024-04-08 DOI: 10.24875/GMM.M24000872
Juan C López-Hernández, Javier Galnares-Olalde, Edwin S Vargas-Cañas
{"title":"[Authors' reply to the letter \"Guillain-Barré syndrome before and during the COVID-19 pandemic\"].","authors":"Juan C López-Hernández, Javier Galnares-Olalde, Edwin S Vargas-Cañas","doi":"10.24875/GMM.M24000872","DOIUrl":"10.24875/GMM.M24000872","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 2","pages":"213-214"},"PeriodicalIF":0.6,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Authors' reply to the letter to the editor "Artificial intelligence and screening for visual impairment related to diabetic retinopathy and macular edema"]. [作者对致编辑的信 "人工智能与糖尿病视网膜病变和黄斑水肿相关视力损伤筛查 "的回复]。
IF 0.6 4区 医学
Gaceta medica de Mexico Pub Date : 2024-04-08 DOI: 10.24875/GMM.M24000873
Liliana Pérez-Peralta, David Rivera-De la-Parra, Enrique O Graue-Hernández, Sergio Hernández-Jiménez, Paloma Almeda-Valdés, Héctor Velázquez-Jurado, Aída Jiménez-Corona
{"title":"[Authors' reply to the letter to the editor \"Artificial intelligence and screening for visual impairment related to diabetic retinopathy and macular edema\"].","authors":"Liliana Pérez-Peralta, David Rivera-De la-Parra, Enrique O Graue-Hernández, Sergio Hernández-Jiménez, Paloma Almeda-Valdés, Héctor Velázquez-Jurado, Aída Jiménez-Corona","doi":"10.24875/GMM.M24000873","DOIUrl":"10.24875/GMM.M24000873","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 2","pages":"219-220"},"PeriodicalIF":0.6,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Non-therapeutic hysterectomy in Mexican young females with intellectual disability: a problematized reality]. [墨西哥智障女青年的非治疗性子宫切除术：一个问题化的现实]。
IF 0.6 4区 医学
Gaceta medica de Mexico Pub Date : 2024-04-08 DOI: 10.24875/GMM.M24000879
Edith Valdez-Martínez, Horacio Márquez-González, Miguel Bedolla
{"title":"[Non-therapeutic hysterectomy in Mexican young females with intellectual disability: a problematized reality].","authors":"Edith Valdez-Martínez, Horacio Márquez-González, Miguel Bedolla","doi":"10.24875/GMM.M24000879","DOIUrl":"10.24875/GMM.M24000879","url":null,"abstract":"<p><strong>Background: </strong>Non-therapeutic hysterectomy in girls and adolescents with intellectual disability (ID) is an acceptable practice, even when there is a lack of prescriptive ethical reason.</p><p><strong>Objectives: </strong>To determine the magnitude of the practice of hysterectomy in girls and adolescents with ID, and explore the emic factors associated with this procedure.</p><p><strong>Material and methods: </strong>Multicenter, intersectoral study with a mixed methods design.</p><p><strong>Results: </strong>The quantitative results showed that 50 of 234 reported hysterectomies corresponded to females with ID. Average age at the time of surgery was 15 ± 2.9 years. Prophylactic abdominal hysterectomy was the most common procedure, and the justifications for it were \"fertility control\", \"menstrual hygiene management\", and \"risk of sexual abuse\". A qualitative analysis of 15 focus groups revealed that parents' main concern was how to manage their daughters' index disease and reproductive health; they perceived menstruation positively; they expressed their fear of dying and leaving them without support, and emphasized fertility control; none of them approved hysterectomy.</p><p><strong>Conclusions: </strong>The bodies that define health policies need to create a new philosophy that avoids the reductionist approach of current biomedical model, which separates (in the health-disease process) our interdependence with other humans.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 2","pages":"179-186"},"PeriodicalIF":0.6,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comment on the article "Guillain-Barre syndrome before and during the COVID-19 pandemic in a referral center of Mexico"]. [对 "墨西哥一家转诊中心在 COVID-19 大流行之前和期间发生的格林-巴利综合征 "一文的评论]。
IF 0.6 4区 医学
Gaceta medica de Mexico Pub Date : 2024-04-03 DOI: 10.24875/GMM.M24000880
Ma Eugenia Jiménez-Corona, Luis P Cruz-Hervert, Mauricio Rodríguez-Álvarez, Samuel Ponce-de-León-Rosales
{"title":"[Comment on the article \"Guillain-Barre syndrome before and during the COVID-19 pandemic in a referral center of Mexico\"].","authors":"Ma Eugenia Jiménez-Corona, Luis P Cruz-Hervert, Mauricio Rodríguez-Álvarez, Samuel Ponce-de-León-Rosales","doi":"10.24875/GMM.M24000880","DOIUrl":"10.24875/GMM.M24000880","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 2","pages":"211-212"},"PeriodicalIF":0.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Artificial intelligence and screening for visual impairment related to diabetic retinopathy and macular edema]. [人工智能与糖尿病视网膜病变和黄斑水肿相关视力损伤筛查]。
IF 0.6 4区 医学
Gaceta medica de Mexico Pub Date : 2024-04-03 DOI: 10.24875/GMM.M24000881
Jorge A Castrillón-Lozano, Dayhana Arango-Cárdenas, Daniel E Marulanda-Márquez
{"title":"[Artificial intelligence and screening for visual impairment related to diabetic retinopathy and macular edema].","authors":"Jorge A Castrillón-Lozano, Dayhana Arango-Cárdenas, Daniel E Marulanda-Márquez","doi":"10.24875/GMM.M24000881","DOIUrl":"10.24875/GMM.M24000881","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 2","pages":"217-218"},"PeriodicalIF":0.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Florence: WHO's digital health assistant]. [佛罗伦萨：世卫组织的数字健康助手]。
IF 0.6 4区 医学
Gaceta medica de Mexico Pub Date : 2024-04-03 DOI: 10.24875/GMM.M24000865
Miguel Gallegos
{"title":"[Florence: WHO's digital health assistant].","authors":"Miguel Gallegos","doi":"10.24875/GMM.M24000865","DOIUrl":"https://doi.org/10.24875/GMM.M24000865","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 2","pages":"221-222"},"PeriodicalIF":0.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Preparedness for an upcoming pandemic. Recommendations by the National Academy of Medicine of Mexico]. [为即将到来的大流行病做好准备。墨西哥国家医学院的建议]。
IF 0.6 4区 医学
Gaceta medica de Mexico Pub Date : 2024-04-03 DOI: 10.24875/GMM.M24000871
Alejandro E Macías-Hernández, Elsa J Sarti-Gutiérrez, Germán Fajardo-Dolci, Raúl Carrillo-Esper
{"title":"[Preparedness for an upcoming pandemic. Recommendations by the National Academy of Medicine of Mexico].","authors":"Alejandro E Macías-Hernández, Elsa J Sarti-Gutiérrez, Germán Fajardo-Dolci, Raúl Carrillo-Esper","doi":"10.24875/GMM.M24000871","DOIUrl":"https://doi.org/10.24875/GMM.M24000871","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 2","pages":"117-120"},"PeriodicalIF":0.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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