Gaceta medica de Mexico最新文献_第5页

Challenges for public health regarding diseases among older adults in Mexico. 墨西哥老年人疾病方面的公共卫生挑战。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25000994

José L Rodríguez-Eguizabal

引用次数: 0

Complex relationship between Amerindian ancestry and obesity in the Mexican population. 美洲印第安人血统与墨西哥人口肥胖之间的复杂关系。

IF 0.6 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25000971

Paulina Baca, Elizabeth Barrera, Pablo A Kuri, Jason Torres, Carlos González-Carballo, Alberto Zarza, Fernando Rivas, Georgina Del Vecchyo, Oscar Pérez-Flores, Carlos A Pantoja, Jonathan Emberson, Jesús Alegre-Díaz, Roberto Tapia-Conyer, Jaime Berumen

{"title":"Complex relationship between Amerindian ancestry and obesity in the Mexican population.","authors":"Paulina Baca, Elizabeth Barrera, Pablo A Kuri, Jason Torres, Carlos González-Carballo, Alberto Zarza, Fernando Rivas, Georgina Del Vecchyo, Oscar Pérez-Flores, Carlos A Pantoja, Jonathan Emberson, Jesús Alegre-Díaz, Roberto Tapia-Conyer, Jaime Berumen","doi":"10.24875/GMM.M25000971","DOIUrl":"10.24875/GMM.M25000971","url":null,"abstract":"The high prevalence of obesity in Mexican-American populations in the United States has suggested that the different genetic composition of the Mexican population may be related to the high prevalence of obesity in Mexico. Recently, the genome of 140,000 individuals in the Mexico City Prospective Study (MCPS) cohort was explored, and it was found that the average Amerindian ancestry (AMR) was 66.2%, followed by European (29.2%), African (3.7%), and Asian (0.8%) ancestries. However, the proportions of ancestry vary by geographic region of the country, with an increasing gradient of AMR from north to south. Despite the importance of this relationship, there are few studies that have analyzed the relationship between obesity and AMR, and the results are controversial. The relationship between AMR and central obesity has been more consistent, especially in women. Few genetic variants associated with obesity have been found in Mexico, due to the small number of individuals analyzed. Future analysis of the MCPS cohort will likely clarify the relationship between AMR and obesity, and identify genetic variations and genes associated with obesity and other metabolic diseases, specific to the Amerindian genome.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 1","pages":"41-47"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mx BIOBANKS: a strategic pillar for national science to impact the health of Mexicans. Mx biobank：国家科学影响墨西哥人健康的战略支柱。

IF 1.3 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25001089

Hugo A Barrera-Saldaña, Alfredo Ulloa-Aguirre, Juan P Reyes, Berenice Illiades, Sofía Bernal, Celia Alpuche, Claudia M Luna, Karen Moreno, Karla Estrada, Martín Lajous, Ruy López-Ridaura, Miguel A Campomanes

{"title":"Mx BIOBANKS: a strategic pillar for national science to impact the health of Mexicans.","authors":"Hugo A Barrera-Saldaña, Alfredo Ulloa-Aguirre, Juan P Reyes, Berenice Illiades, Sofía Bernal, Celia Alpuche, Claudia M Luna, Karen Moreno, Karla Estrada, Martín Lajous, Ruy López-Ridaura, Miguel A Campomanes","doi":"10.24875/GMM.M25001089","DOIUrl":"10.24875/GMM.M25001089","url":null,"abstract":"The development of biobanks in Mexico has emerged as an essential strategic initiative to advance scientific research and its translation, to improve public health. This paper highlights the role of biospecimens, including surgical and liquid biopsies, in promoting diagnostic and therapeutic innovations. It underscores the importance of high-quality biobanking for translational research and the challenges faced due to insufficient infrastructure and professionalized services in Mexico. Through a historical overview, the paper describes the origin and initial evolution of biobanking efforts in Mexico, from establishing the first institutional biobanks to creating the National Biobank Laboratory (LANBIOBAN) network. The collaboration between national and international entities has allowed Mexico to engage in global biobanking networks, furthering precision medicine. Despite limited resources, these biobanks are fostering significant progress in translational research, improving diagnostic and therapeutic practices, and bridging the gap between research and clinical application.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 5","pages":"456-464"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Against COVID-19 vaccination: influence of social barriers and personal perceptions. 预防COVID-19疫苗接种：社会障碍和个人观念的影响

IF 1.3 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25001098

Manuel Y Arnao-Villegas

引用次数: 0

Clinical and molecular characterization of six Mexican patients with FGFR2-related syndromic craniosynostosis. 6例墨西哥fgfr2相关综合征性颅缝闭闭患者的临床和分子特征

IF 1.3 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.25000135

Angel R González-Cuevas, Eugenia D Ruiz-Cruz, Grecia C Olivera-Bernal, Laura Santana-Díaz, Juan C Huicochea-Montiel, Juan Carlos Zenteno

引用次数: 0

Thanatophoric dysplasia: prevalence, clinical characteristics, and molecular findings in a public hospital from Western Mexico. 嗜盐性发育不良：墨西哥西部一家公立医院的患病率、临床特征和分子特征。

IF 1.3 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M26001074

Jessica P Cruz-Cruz, Kiabeth Robles-Espinoza, María T Magaña-Torres, Christian Peña-Padilla, Felipe J Bustos-Rodríguez, Ernesto Barrios-Prieto, Lucina Bobadilla-Morales, Alfredo Corona-Rivera, Jorge R Corona-Rivera

{"title":"Thanatophoric dysplasia: prevalence, clinical characteristics, and molecular findings in a public hospital from Western Mexico.","authors":"Jessica P Cruz-Cruz, Kiabeth Robles-Espinoza, María T Magaña-Torres, Christian Peña-Padilla, Felipe J Bustos-Rodríguez, Ernesto Barrios-Prieto, Lucina Bobadilla-Morales, Alfredo Corona-Rivera, Jorge R Corona-Rivera","doi":"10.24875/GMM.M26001074","DOIUrl":"10.24875/GMM.M26001074","url":null,"abstract":"Background: Thanatophoric dysplasia (TD) is a lethal FGFR3 chondrodysplasia characterized by micromelia and bowed femurs (TD1), or straight femurs and cloverleaf skull (TD2).Objective: To determine the prevalence and clinical and molecular characteristics of patients with TD in a public hospital in Western Mexico.Materials and methods: Observational, retrospective and descriptive study. Ten live births with TD were included from a total of 118,154 births between 2009 and 2024 at the Hospital Civil de Guadalajara Dr. Juan I. Menchaca (Mexico). The FGFR3 gene was analyzed by PCR, followed by direct sequencing of exons 4-6 and 8.Results: The prevalence of TD was 0.85 per 10,000 births (95% CI: 0.32-1.37). All presented TD1 (4 men and 6 women), sporadic occurrence and 4/10 advanced paternal age. Phenotype: short stature, macrocephaly, hypotonia, distinctive facial features, narrow thorax, prominent abdomen, micromelia, redundant skinfolds, trident hand, short ribs, rhizomelic shortening, irregular metaphyses, platyspondyly and bowed femurs. In seven, pathogenic variants in FGFR3 were identified: p.Arg248Cys (n = 3), p.Ser371Cys (n = 2), p.Gly370Cys (n = 1) and p.Try373Cys (n = 1).Conclusions: One in 11,815 infants was born with T1D. Molecular analysis allows to distinguish it from other lethal chondrodysplasias and to provide appropriate genetic counseling.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 6","pages":"599-606"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioethics with a philosophical and literary perspective: a view from latin america. 哲学与文学视角下的生命伦理学：来自拉丁美洲的观点。

IF 1.3 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25001053

Henry C Rivas-Sucari, Carlos M Manrique-Rabelo, Sandra A Rivas-Sucari, Ana M Flores-Núñez

引用次数: 0

Baseline brain magnetic resonance imaging findings as predictors of dementia progression: insights from a Mexican memory clinic. 基线脑磁共振成像结果作为痴呆进展的预测因素：来自墨西哥记忆诊所的见解。

IF 1.3 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.25000064

Luis E Martínez-Bravo, Sara G Aguilar-Navarro, Mauricio Vazquez-Guajardo, Lidia A Gutiérrez-Gutiérrez, Teresa Juarez-Cedillo, Alberto J Mimenza-Alvarado

{"title":"Baseline brain magnetic resonance imaging findings as predictors of dementia progression: insights from a Mexican memory clinic.","authors":"Luis E Martínez-Bravo, Sara G Aguilar-Navarro, Mauricio Vazquez-Guajardo, Lidia A Gutiérrez-Gutiérrez, Teresa Juarez-Cedillo, Alberto J Mimenza-Alvarado","doi":"10.24875/GMM.25000064","DOIUrl":"10.24875/GMM.25000064","url":null,"abstract":"Background: Dementia is a progressive syndrome characterized by cognitive decline. Brain atrophy has been associated with disease progression, but its predictive value in Latin American populations remains underexplored.Objective: To assess whether brain atrophy, evaluated through visual rating scales, predicts progression from mild to moderate dementia over one year, using the Clinical Dementia Rating-Sum of Boxes.Materials and methods: A retrospective cohort study was conducted in a memory clinic with 73 participants aged ≥65 years with mild dementia and baseline brain magnetic resonance imaging. Temporal and parietal atrophy were assessed using Scheltens and Koedam scales, and white matter hyperintensities were evaluated with Fazekas. Logistic regression models adjusted for age, education, depression, and vitamin D/B12 deficiencies were used to estimate the risk of progression.Results: Fifteen participants (21%) progressed to moderate dementia. Moderate-to-severe atrophy in the parietal (OR: 6.84; 95%CI: 1.29-36.2; p = 0.024) and temporal lobes (OR: 6.33; 95%CI: 1.23-32.43; p = 0.027) significantly increased the odds of progression.Conclusions: At one-year follow-up, moderate-to-severe atrophy in the parietal and temporal lobes was associated with dementia progression, supporting the potential clinical utility of visual rating scales for monitoring disease progression.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 4","pages":"385-392"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost-effectiveness of dual treatment with metformin-sitagliptin versus metformindapagliflozin in patients with type 2 diabetes. 二甲双胍西格列汀与二甲双胍阿格列净对2型糖尿病患者双重治疗的成本-效果

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25001022

Linda A Cruz-Gallegos, Enrique Villarreal-Ríos, Leticia Blanco-Castillo, Liliana Galicia-Rodríguez

{"title":"Cost-effectiveness of dual treatment with metformin-sitagliptin versus metformindapagliflozin in patients with type 2 diabetes.","authors":"Linda A Cruz-Gallegos, Enrique Villarreal-Ríos, Leticia Blanco-Castillo, Liliana Galicia-Rodríguez","doi":"10.24875/GMM.M25001022","DOIUrl":"https://doi.org/10.24875/GMM.M25001022","url":null,"abstract":"Background: And new high-cost antihyperglycemic agents have been introduced into the basic medical at primary care level for its management. The cost-effectiveness evaluation allows the economic and epidemiological components to be analysed together.Objective: To determine the cost-effectiveness of dual therapy with metformin + sitagliptin versus metformin + dapagliflozin in patients with type 2 diabetes.Material and methods: Economic cost-effectiveness study with two groups of patients with type 2 diabetes aged 30 to 64 years in dual treatment, metformin + sitagliptin versus metformin + dapagliflozin. The fixed and variable unit costs were examined; the average variable cost was estimated using the microcost technique, and the average fixed cost was estimated using the time and motion technique. The average annual cost was integrated with the average variable and fixed costs. The cost-effectiveness ratio was estimated at $4000 and cost-effectiveness projections were made.Results: Glycaemic control (efficacy) was 42.10% for metformin + dapagliflozin and 26.50% for metformin + sitagliptin. In the intermediate scenario, average annual costs were $3598.52 for metformin + dapagliflozin and $5,746.82 for metformin + sitagliptin. For an investment of $4000, the effectiveness of the metformin + dapagliflozin group was 46.80%, and the effectiveness of the metformin + sitagliptin group was 18.44%.Conclusions: In patients with type 2 diabetes, metformin + dapagliflozin achieves the best cost-effectiveness ratio.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 3","pages":"267-273"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunogenicity and safety of tetravalent dengue vaccines: a systematic review of clinical trials. 四价登革热疫苗的免疫原性和安全性：临床试验的系统回顾。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25001007

Lenyn D Montes-Sevilla, Paul E Hernández-Montes, Erick Ramírez-García, Edgar D Guzmán-Ríos, Marco F Flores-Reyes, Gilberto H Acosta-Gutiérrez, Osmara Morales-Hernández, Manuel I Girón-Pérez

{"title":"Immunogenicity and safety of tetravalent dengue vaccines: a systematic review of clinical trials.","authors":"Lenyn D Montes-Sevilla, Paul E Hernández-Montes, Erick Ramírez-García, Edgar D Guzmán-Ríos, Marco F Flores-Reyes, Gilberto H Acosta-Gutiérrez, Osmara Morales-Hernández, Manuel I Girón-Pérez","doi":"10.24875/GMM.M25001007","DOIUrl":"https://doi.org/10.24875/GMM.M25001007","url":null,"abstract":"Tetravalent dengue vaccines have been the subject of study, particularly in the prevention of severe cases of the disease. However, the variability in results and the methodological quality of existing studies raise questions about their effectiveness. The objective is to evaluate the immunogenicity and safety of tetravalent vaccines compared to placebo in the prevention of severe dengue cases through a systematic review of randomized clinical trials. A systematic search was conducted in databases PubMed, Scopus, and Web of Science, including randomized clinical trials published between 2019 and 2024. Inclusion and exclusion criteria were applied to select relevant studies, and methodological quality was assessed using the level of evidence from the Oxford Centre for Evidence-Based Medicine (OCEBM). Six randomized clinical trials were included, with a total of 24,249 participants. The studies evaluated outcomes such as the incidence of severe dengue, seropositivity, and immune response to the vaccines TV003 and TV005. Tetravalent vaccines show a promising outlook in reducing the incidence of severe dengue, although limitations were identified in study designs and heterogeneity in the studied populations. Further research is needed to confirm efficacy and safety in diverse populations.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 3","pages":"227-236"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0