墨西哥裔人群SLC2A2基因的单核苷酸变异。

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI:10.24875/GMM.M25000985

Christopher A Gutiérrez-García, Martín R Gutiérrez-Jiménez, Roberto de J Sandoval-Muñiz, Raúl C Baptista-Rosas

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引用次数: 0

摘要

背景：糖尿病是由环境和遗传因素引起的，全球患病率很高（10.5%）。一些单核苷酸变异（SNVs）可以改变葡萄糖转运体如GLUT2的活性，GLUT2在胰岛素分泌和葡萄糖代谢中起重要作用。目的：分析墨西哥人群与2型糖尿病（T2D）相关的snv。材料和方法：墨西哥人群中与T2DM相关的SLC2A2基因snv的参考数据库。结果：分析83个snv，在墨西哥人群中发现3个与T2D相关的变异：rs5404、rs5406和rs5398，其中致病变异RM >1.0， p值< 0.05。结论：需要详细的遗传分析和定位以及功能研究来确定GLUT2变异影响糖尿病发展的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Single nucleotide variants of the SLC2A2 gene in Mexican-origin population.

Background: Diabetes, which is caused by environmental and genetic factors, has a high global prevalence (10.5%). Some single nucleotide variants (SNVs) modify the activity of glucose transporters such as GLUT2, which plays a significant role in insulin secretion and glucose metabolism.

Objective: To analyze the SNVs associated with type 2 diabetes (T2D) in the Mexican population.

Material and methods: Reference databases for SNVs registered for SLC2A2 gen associated with T2DM in the Mexican population.

Results: 83 SNVs were analyzed, identifying 3 relevant variants in Mexican population associated with T2D: rs5404, rs5406 and rs5398, a pathogenic variant with RM >1.0 and p value < 0.05.

Conclusions: Detailed genetic analysis and mapping coupled with functional studies are needed to identify the mechanism by which GLUT2 variants influence diabetes development.

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来源期刊

Gaceta medica de Mexico 医学-医学：内科

CiteScore

1.00

自引率

0.00%

发文量

216

审稿时长

6-12 weeks

期刊介绍： Gaceta Médica de México México is the official scientific journal of the Academia Nacional de Medicina de México, A.C. Its goal is to contribute to health professionals by publishing the most relevant progress both in research and clinical practice. Gaceta Médica de México is a bimonthly peer reviewed journal, published both in paper and online in open access, both in Spanish and English. It has a brilliant editorial board formed by national and international experts.