Gaceta medica de Mexico最新文献_第3页

Efficacy comparison of single-dose thoracic epidural analgesia with morphine and erector spinae plane block for open thoracotomy analgesia. 吗啡单剂量硬膜外镇痛与竖脊肌平面阻滞用于开胸镇痛的疗效比较。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.24000404

Fatma Acil, Andaç Dedeoğlu, Okan Andıç, Zeki Korhan, Ahmet Sızlanan, Atilla Durkan, Hülya Tosun-Söner, Osman Uzundere, Sedat Kaya, Cem Kıvılcım-Kaçar, Erhan Gökçek

{"title":"Efficacy comparison of single-dose thoracic epidural analgesia with morphine and erector spinae plane block for open thoracotomy analgesia.","authors":"Fatma Acil, Andaç Dedeoğlu, Okan Andıç, Zeki Korhan, Ahmet Sızlanan, Atilla Durkan, Hülya Tosun-Söner, Osman Uzundere, Sedat Kaya, Cem Kıvılcım-Kaçar, Erhan Gökçek","doi":"10.24875/GMM.24000404","DOIUrl":"https://doi.org/10.24875/GMM.24000404","url":null,"abstract":"Backgound: Postoperative pain after thoracotomy can be severe.Objective: To assess whether low-dose morphine-assisted thoracic epidural analgesia (TEA) reduces pain (as measured by the visual analogue scale - VAS) and opioid consumption more than erector spinae plane block (ESP) in patients after thoracotomy.Material and methods: 140 patients scheduled for elective thoracotomy (69 with TEA and 71 with ESP) were evaluated. VAS scores, respiratory capacity, nausea, vomiting, pruritus and opioid consumption were recorded at different intervals after the operation (30 min, 2, 6, 12 and 24 hours).Results: Patients with TEA had significantly lower VAS scores in all postoperative measurements compared to the ESP group (p < 0.001). Respiratory capacity was also higher in the TEA group (p < 0.001). Postoperative opioid consumption was lower in the TEA group (p < 0.001), although there were no differences in intraoperative consumption (p = 1).Conclusion: Thoracic epidural analgesia with low-dose morphine improves long-term postoperative pain control compared with ESP block.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"168-175"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-care and quality of life of medical students. 医学生的自我照顾与生活质量。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25001005

José L Rodríguez-Eguizabal

引用次数: 0

Contributions of pharmacogenetics to personalized precision therapy of diabetes and hypercholesterolemia. 药物遗传学对糖尿病和高胆固醇血症个体化精准治疗的贡献。

IF 0.6 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25000975

Hugo A Barrera-Saldaña, Rafael B R León-Cachón, Vanessa González-Covarrubias, Héctor E Sánchez-Ibarra, Fernando Lavalle-González

{"title":"Contributions of pharmacogenetics to personalized precision therapy of diabetes and hypercholesterolemia.","authors":"Hugo A Barrera-Saldaña, Rafael B R León-Cachón, Vanessa González-Covarrubias, Héctor E Sánchez-Ibarra, Fernando Lavalle-González","doi":"10.24875/GMM.M25000975","DOIUrl":"https://doi.org/10.24875/GMM.M25000975","url":null,"abstract":"Background: Personalized medicine allows the selection of the drug and dose based on the patient's genetic information, which is imperative in the treatment of diabetes and hypercholesterolemia, diseases with high prevalence in Mexico.Objective: To integrate pharmacogenetic and genomic research on antidiabetic and antihypercholesterolemic drugs in Mexican patients.Material and methods: We integrated our research, relating it with similar research from national and foreign laboratories.Results: For antidiabetic pharmacological treatments, variants in the ABCC8 and KCNJ11 genes were consistently associated with the response to sulfonylureas, while variants in the SLC47A1, SLC28A1 and ABCG2 genes explained up to 55% of the variability in the response to metformin. Regarding hypercholesterolemia, atorvastatin treatment is influenced by variants in the genes MTHFR, DRD3, GSTM3, TNFα MDR1, SLCO1BI, ABCB1, CYP2D6, CYP2B6, NAT2 and COMT.Conclusion: Our findings highlight the need to integrate pharmacogenetics into clinical practice to achieve greater therapeu tic success in diabetes and hypercholesterolemia.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 1","pages":"94-101"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional genomics in the Mexican population. An approach to prevent the development of obesity-associated metabolic diseases. 墨西哥人口的营养基因组学。预防肥胖相关代谢疾病发展的方法。

IF 0.6 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25000973

Augusto Aguilar-Salazar, Génesis K González-Quijano, M Elizabeth Tejero, Guadalupe León-Reyes

{"title":"Nutritional genomics in the Mexican population. An approach to prevent the development of obesity-associated metabolic diseases.","authors":"Augusto Aguilar-Salazar, Génesis K González-Quijano, M Elizabeth Tejero, Guadalupe León-Reyes","doi":"10.24875/GMM.M25000973","DOIUrl":"https://doi.org/10.24875/GMM.M25000973","url":null,"abstract":"Obesity is characterized by excess body fat, metabolic dysfunction, and an increased risk of developing other chronic diseases. This review aims to describe the main molecular mechanisms involved in metabolic diseases associated with obesity and to highlight the most recent studies on Nutritional Genomics in the Mexican population. The findings show that in Mexico, multiple observational and experimental investigations have been carried out on the gene-nutrient interaction, and its effect on human health. Changes in the eating pattern towards obesogenic diets and the presence of certain genetic variants can predispose to developing obesity and other disorders. These genetic variants could have a differential impact on each ethnicity; some of them have been identified in Caucasian populations, and they have subsequently been analyzed in the Mexican population (e.g., CAPN10, apolipoproteins, and PPARs). On the contrary, there are genetic variants that are more frequent (almost exclusive) to the Mexican population, and that have been consistently associated with metabolic alterations. For example, the rs9282541-ABCA1 variant associated with lower HDL-C concentrations. These findings highlight the importance of studying these genetic variants in different populations, to establish better strategies for the prevention, prognosis and treatment of metabolic diseases.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 1","pages":"18-27"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of bioethical competencies in clinical simulation scenarios. 临床模拟情景中生物伦理能力的发展。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25001004

María E de Los Ríos-Uriarte, Ariana Cerón-Apipilhuasco

{"title":"Development of bioethical competencies in clinical simulation scenarios.","authors":"María E de Los Ríos-Uriarte, Ariana Cerón-Apipilhuasco","doi":"10.24875/GMM.M25001004","DOIUrl":"10.24875/GMM.M25001004","url":null,"abstract":"Background: Based on the challenge of training competent professionals in complex clinical environments and the fundamental role that simulation plays in the education of both physicians and bioethicists, simulation emerges as an effective and evolving method for acquiring bioethical skills and competencies.Objective: This article proposes the implementation of bioethical scenarios through simulation as a teaching-learning method of identification, analysis and resolving bioethical dilemmas.Material and methods: A bibliographic review was conducted on the use of simulation to develop bioethical competencies, following the framework proposed by the American Society for Bioethics and Humanities.Results: Simulation, particularly debriefing, was found to provide an effective space for learning and developing skills in bioethical analysis and discernment. Additionally, challenges were identified in using clinical simulation to develop bioethical competencies in students.Conclusions: The clinical simulation method facilitates the learning and development of bioethical skills and competencies in students, both in medicine and bioethics, and requires further implementations to identify areas for improvement and optimize competency acquisition.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"127-131"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical and medical complications associated with mucormycosis in a tertiary hospital. 三级医院毛霉菌病的外科和内科并发症。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25000988

Francisco J Barrera-López, Maura E Noyola-García, Natalia G Barrera-López, Alejandra Albarrán-Sánchez

{"title":"Surgical and medical complications associated with mucormycosis in a tertiary hospital.","authors":"Francisco J Barrera-López, Maura E Noyola-García, Natalia G Barrera-López, Alejandra Albarrán-Sánchez","doi":"10.24875/GMM.M25000988","DOIUrl":"https://doi.org/10.24875/GMM.M25000988","url":null,"abstract":"Background: Mucormycosis is an infection caused by Mucorales. Management includes surgical treatment and antifungals.Objective: To describe the surgical and medical complications associated with mucormycosis in a third-level hospital.Material and methods: Records of patients with mucormycosis treated between 2019 and 2022 were collected.Results: A total of 25 patients were obtained, 17 (68%) men and 8 (32%) women. Surgical complications occurred on admission in 16% and early in 4% of cases. The most frequent medical complications were soft tissue infection on admission (84%) and late sepsis (52%). Amphotericin B deoxycholate was used in all cases, finding hypokalemia in 20 (80%), hypomagnesemia in 18 (72%), and acute kidney injury in 15 (60%).Conclusions: The most commonly performed surgery was surgical debridement on admission (76%). Surgical complications occurred mainly on admission (16%). The most frequent medical complications were soft tissue infection on admission (84%) and late sepsis (52%). Due to the high cost of the liposomal and lipid forms of amphotericin, the use of amphotericin B deoxycholate continues to persist in our setting, which leads to a high degree of renal toxicity and hydroelectrolytic alterations.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"148-153"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical student barriers to mental healthcare. 医学生心理保健障碍。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25000991

Roberto C Quiñones-Robles, Cristina Almeida-Perales, Dellanira Ruiz de Chávez-Ramírez, Carolina Díaz-Flores, Pascual G García-Zamora

{"title":"Medical student barriers to mental healthcare.","authors":"Roberto C Quiñones-Robles, Cristina Almeida-Perales, Dellanira Ruiz de Chávez-Ramírez, Carolina Díaz-Flores, Pascual G García-Zamora","doi":"10.24875/GMM.M25000991","DOIUrl":"10.24875/GMM.M25000991","url":null,"abstract":"Background: Medical education is associated with different mental disorders, a growing concern. Additionally, several barriers have been reported that hinder the use of mental health care services among physicians in training.Objective: To identify the main barriers faced by medical students in seeking professional help and care the mental health.Material and methods: Cross-sectional observational study of descriptive and analytical type, in medical students (n = 305), in whom the BACE (Barriers to Care Evaluation) instrument was applied and Pearson's correlation coefficient was applied.Results: Based on mean subscale values of the instrument, the barriers from highest to lowest were: stigma (x- = 0.69, SD = 0.264), attitudinal (x- = 0.67, SD = 0.472) and structural (x- = 0.63, SD = 0.396). The characteristics most correlated with barriers included female gender, identification with gender and sexual diversity, having a mental health disorder, and exhibiting suicidal behavior (p < 0.05).Conclusions: These findings are key in the creation of approaches to mitigate the impact these barriers have on the mental health care of medical students.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"192-199"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetics of the premature coronary artery disease in Mexicans. 墨西哥人过早冠状动脉疾病的遗传学。

IF 0.6 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25000972

Rosalinda Posadas-Sánchez, Giovanny Fuentevilla-Álvarez, Gilberto Vargas-Alarcón

引用次数: 0

Reply to the letter "Self-care and quality of life of medical students". 答复“医学生自我照顾与生活质量”信函。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25000995

Iván J Canales-Gómez, Blanca M Torres-Mendoza

引用次数: 0

Seroprevalence of infectious agents in blood donors from a hospital on the Southern border of Mexico. 墨西哥南部边境一家医院献血者感染因子的血清流行率。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25000989

Óscar M Delgado-Cuellar, Clemente Mosso-González, Jorge M Castañeda-Gómez, Aldo S de la Rosa-Cruz, María C Jiménez-González

{"title":"Seroprevalence of infectious agents in blood donors from a hospital on the Southern border of Mexico.","authors":"Óscar M Delgado-Cuellar, Clemente Mosso-González, Jorge M Castañeda-Gómez, Aldo S de la Rosa-Cruz, María C Jiménez-González","doi":"10.24875/GMM.M25000989","DOIUrl":"10.24875/GMM.M25000989","url":null,"abstract":"Background: Blood transfusion and its derivatives are an essential therapeutic action in the different hospital services. Despite the strict haemovigilance carried out in blood banks, there is still a residual risk of contracting infectious diseases through blood transfusion.Objective: To determine the seroprevalence of infectious agents in blood donors.Material and methods: Retrospective and observational study. The detections were made in blood donors who came to the blood bank of the General Hospital Zone No. 1 of Tapachula, Chiapas, Mexico, during the period from August 2020 to December 2023.Results: The general seroprevalence was 3.94%, with syphilis being most frequently found (1.37%), followed by brucellosis (1.17%), human immunodeficiency virus (0.55%), hepatitis C (0.34%), hepatitis B (0.19%), and Chagas disease (0.19%), with 0.10% of co-infection cases.Conclusions: The seroprevalence of infectious agents in blood donors described in this study allows us to know an epidemiological overview of what happened in a city on the Southern border of Mexico, reaffirming syphilis as a re-emerging disease in this zone, with high prevalences of brucellosis and human immunodeficiency virus.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"154-160"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0