{"title":"Challenges for public health regarding diseases among older adults in Mexico.","authors":"José L Rodríguez-Eguizabal","doi":"10.24875/GMM.M25000994","DOIUrl":"https://doi.org/10.24875/GMM.M25000994","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"210-211"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
René C Crocker-Sagastume, José L Vázquez-Castellanos, Emmanuel Zúñiga-Romero
{"title":"The new epidemic in Indigenous peoples: the adiposity syndrome in poverty.","authors":"René C Crocker-Sagastume, José L Vázquez-Castellanos, Emmanuel Zúñiga-Romero","doi":"10.24875/GMM.M25000990","DOIUrl":"10.24875/GMM.M25000990","url":null,"abstract":"<p><strong>Background: </strong>The incorporation of industrial foods in Indigenous peoples has generated health problems in families, related to the excessive accumulation of adipose tissue, Diabetes mellitus type II, metabolic liver disease, defined as \"adiposity in poverty syndrome\".</p><p><strong>Objective: </strong>To analyze the frequency of diseases of the adiposity syndrome in poverty in Indigenous peoples in transition to modernity in the Wixarika region of the state of Jalisco, Mexico.</p><p><strong>Material and methods: </strong>An epidemiological, cross-sectional analytical design with sampling segmented by community size is applied. 238 cases over 30 years old of 221 families from three communities are studied. Statistical analysis is performed by nonparametric tests, with significant p < 0.05.</p><p><strong>Results: </strong>There is a significant difference in the frequencies of adiposity syndrome by community size, by locality and between traditional communities and those in the process of westernization.</p><p><strong>Conclusions: </strong>The study provides a sociohistorical approach to the problems of Indigenous peoples from critical epidemiology. In the Wixaritari populations there are changes in health conditions, determined by the degree of social development and by their incorporation into the processes of Westernization.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"185-191"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetic influence on obesity: beyond bad habits in the Mexican population.","authors":"Ulisses Moreno-Celis, Adriana Aguilar-Galarza, Teresa García-Gasca","doi":"10.24875/GMM.M25000984","DOIUrl":"10.24875/GMM.M25000984","url":null,"abstract":"<p><p>This paper addresses the genetic influence on obesity within the Mexican population, highlighting that this condition is the result of a complex interaction between genetic and environmental factors. Specific genetic variants are identified that not only predispose to obesity but may also offer protection against it. This knowledge is crucial for the development of personalized medicine and nutrition strategies that adapt health interventions to the individual genetic characteristics of patients, thus improving the effectiveness in the prevention and treatment of obesity. Despite the promising potential of personalized medicine and nutrition, the study recognizes significant challenges, such as genetic variability within the Mexican population, the infrastructure necessary to integrate genetic data into clinical practice, and ethical considerations in the management of this information. It is important to highlight the need for future research that delves deeper into the relationship between genetics and obesity, also considering environmental factors. Likewise, it is suggested that the integration of these findings into public health policies could offer more specific and effective approaches to combat obesity in Mexico, contributing significantly to improving health in the population.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 1","pages":"85-93"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complications of twin pregnancy due to assisted reproductive techniques compared with those of spontaneous twin pregnancy.","authors":"Manuel Y Arnao-Villegas","doi":"10.24875/GMM.M25000998","DOIUrl":"https://doi.org/10.24875/GMM.M25000998","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"219-220"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Frailty in the elderly, a reflection.","authors":"Henry C Rivas-Sucari","doi":"10.24875/GMM.M25001001","DOIUrl":"https://doi.org/10.24875/GMM.M25001001","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"224-225"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Héctor García-Hernández, Mario U Pérez-Zepeda, Lorena Parra-Rodríguez, Carmen García-Peña
{"title":"Reply to the letter \"The cascade of access to the public health system in older Mexican adults and associated factors\".","authors":"Héctor García-Hernández, Mario U Pérez-Zepeda, Lorena Parra-Rodríguez, Carmen García-Peña","doi":"10.24875/GMM.M25000996","DOIUrl":"https://doi.org/10.24875/GMM.M25000996","url":null,"abstract":"","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"215-216"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Ochoa-Guzmán, María T Tusié-Luna, Erwin Chiquete, Andrea Medina-García, Alicia Huerta-Chagoya
{"title":"The genetics of the most prevalent metabolic diseases in Mexicans.","authors":"Ana Ochoa-Guzmán, María T Tusié-Luna, Erwin Chiquete, Andrea Medina-García, Alicia Huerta-Chagoya","doi":"10.24875/GMM.M25000983","DOIUrl":"10.24875/GMM.M25000983","url":null,"abstract":"<p><p>The prevalence of metabolic diseases in Mexicans has grown in recent decades, which increases the burden on the health system. The study of the genetics of metabolic diseases is a complex process resulting from an interaction between environmental and genetic factors. Although most genome-wide association studies for these diseases have focused on populations other than the Mexican population, genetic variants almost exclusive to populations with high Native American ancestry have been discovered, or those initially identified in different populations without Amerindian ancestry have been replicated. Therefore, the objective of this review is to present an overview of the genetics of Mexicans and their relationship with some of the most frequent metabolic diseases in this population, such as type 2 diabetes, gestational diabetes, diabetic neuropathy, obesity, and dyslipidemias.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 1","pages":"9-17"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jesús J Rosales-de la Rosa, José B López-Martínez, Andrea Escamilla-López, María A Mier-Prado, Luis A Hernández-Flores, Salma C Hernández-Orona, Claudia G Hernández-Viedas, Paulina E Huchim-Servin, Emmanuel Peña-Gómez-Portugal
{"title":"The Prognostic Nutritional Index predicts poor postoperative outcomes in patients undergoing video-assisted thoracic surgery for an infectious etiology.","authors":"Jesús J Rosales-de la Rosa, José B López-Martínez, Andrea Escamilla-López, María A Mier-Prado, Luis A Hernández-Flores, Salma C Hernández-Orona, Claudia G Hernández-Viedas, Paulina E Huchim-Servin, Emmanuel Peña-Gómez-Portugal","doi":"10.24875/GMM.24000358","DOIUrl":"https://doi.org/10.24875/GMM.24000358","url":null,"abstract":"<p><strong>Background: </strong>The Prognostic Nutritional Index (PNI) as a prognostic tool for the postoperative outcomes in patients undergoing thoracic surgery due to an infectious etiology remains unexplored.</p><p><strong>Objective: </strong>To evaluate the PNI as predictor of poor postoperative outcomes in patients undergoing surgery for a thoracic infection.</p><p><strong>Material and methods: </strong>A retrospective analysis in patients undergoing VATS during January 2019 to December 2023, including 61 patients. We performed a ROC curve analysis to identify the optimal PNI cut-off value to classify the patients into groups: A high (HR) and low-risk (LR) group. Chi-square, Fisher exact, and Mann-Whitney tests were used to compare them. A multivariate analysis with Cox regression was also performed.</p><p><strong>Results: </strong>The optimal PNI cut-off value was 28.69, with AUC 0.860 (p = 0.001), sensitivity 88.9%, specificity 78.8%. 42 patients were low-risk, while 19 high-risk. There was a significant difference in 30-day mortality between groups (HR 42% vs LR 2%, p < 0.001) as well as in 30-day major complications (HR 68% vs LR 16%, p < 0.001). A multivariate analysis revealed that PNI-based risk group was an independent predictor of mortality (p = 0.008) and major complications (p < 0.001).</p><p><strong>Conclusions: </strong>The PNI is a valid predictor of poor postoperative outcomes in patients undergoing VATS for a thoracic infection.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"176-184"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Humberto García-Ortiz, Francisco M Barajas-Olmos, Cecilia Contreras-Cubas, Angélica Martínez-Hernández, Lorena Orozco
{"title":"From genomics to precision medicine in type 2 diabetes.","authors":"Humberto García-Ortiz, Francisco M Barajas-Olmos, Cecilia Contreras-Cubas, Angélica Martínez-Hernández, Lorena Orozco","doi":"10.24875/GMM.M25000969","DOIUrl":"https://doi.org/10.24875/GMM.M25000969","url":null,"abstract":"<p><p>Type 2 diabetes (T2DM) is a public health problem and the second leading cause of death in Mexico. More than 20 years after the human genome project was completed, the development of innovative technologies and methodologies to determine the genetic risk factors that predispose an individual to develop this and other pathologies, have made the implementation of genomic medicine as part of clinical practice become a reality. Although in Mexico genomic studies are still in the beginning, these have generated knowledge about the etiopathogenesis of T2DM. In this review, we will address genomic knowledge applications in clinical practice, as well as the advances in the genomics of T2DM in Mexico.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 1","pages":"3-8"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ricardo Muñoz-Gómez, Eduardo Domínguez-de la Cruz, Rubén Oropeza-Sánchez, Juan E Chacón-Hernández, Normand García-Hernández, Ma de Lourdes Muñoz
{"title":"Relationship of nuclear and mitochondrial variants with type 2 diabetes and its microvascular comorbidities in a population of Mexican origin.","authors":"Ricardo Muñoz-Gómez, Eduardo Domínguez-de la Cruz, Rubén Oropeza-Sánchez, Juan E Chacón-Hernández, Normand García-Hernández, Ma de Lourdes Muñoz","doi":"10.24875/GMM.M25000979","DOIUrl":"https://doi.org/10.24875/GMM.M25000979","url":null,"abstract":"<p><p>Type 2 diabetes mellitus (T2DM), diabetic nephropathy, retinopathy, and neuropathy represent significant public health challenges in Mexico. The multifactorial nature of these conditions, influenced by both environmental and genetic factors, underscores the complexity of their development. Therefore, it is essential to design new preventive strategies to reduce mortality rates and the substantial economic burden they impose. This review examines genetic variants associated with these pathologies, aiming to establish genetic profiles that explain predisposition in the Mexican population. An extensive search of scientific publications was conducted, selecting studies on nuclear DNA and mitochondrial DNA variants associated with these diseases in different global populations, with a focus on Mexico. Among these variants, genes with critical molecular mechanisms for disease development and progression were identified. Additionally, genetic variants unique to the Mexican population were found. Based on this review, we conclude that increasing genetic association studies is crucial to validate previously described variants and identify new ones, which could serve as molecular markers for predisposition and progression in the Mexican population.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 1","pages":"48-65"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}