{"title":"Clinical significance of S100B protein in pregnant woman with early- onset severe preeclampsia.","authors":"Jinxia Wu, Xiaoqi Sheng, Shaoming Zhou, Chaoying Fang, Yulin Song, Hua Wang, Zhengjun Jia, Xiaozhou Jia, Yiping You","doi":"10.5603/GP.a2021.0126","DOIUrl":"10.5603/GP.a2021.0126","url":null,"abstract":"<p><strong>Objectives: </strong>Preeclampsia is one of the most feared complications of pregnancy, which can progress rapidly to serious complications such as death of both mother and fetus. To present, the leading cause of preeclampsia is still debated. The purpose of this article was to explore the clinical significance of S100B protein, a kind of Ca2+ -sensor protein, in the early-onset severe preeclampsia.</p><p><strong>Material and methods: </strong>Nine pregnant women with early-onset severe preeclampsia (the study group) and 13 healthy pregnant women (the control group) were included in this study. The level of S100B in the amniotic fluid, maternal blood, and umbilical cord blood were detected by enzyme-linked immunosorbent assay (ELISA) and surface plasmon resonance imaging (SPRi) methods. Diagnostic values of S100B for early-onset severe preeclampsia were assessed by Receiver Operating Characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>The levels of S100B in maternal blood and amniotic fluid in the study group were higher than those in the control group (p < 0.05). ROC curve analysis showed that S100B detected by SPRi method (SPRi-S100B) showed a cut-off level of 181 ng/mL with sensitivity of 100%, a specificity of 84.6%, and a Youden index of 0.846 in the maternal blood, which had better clinical significance and diagnostic value (at than that detected by ELISA (ELISA-S100B).</p><p><strong>Conclusions: </strong>The levels of S100B detected by SPRi in maternal blood can indicate early-onset severe preeclampsia and perinatal brain injury.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"711-717"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39077413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ginekologia polskaPub Date : 2024-01-01Epub Date: 2023-09-05DOI: 10.5603/gpl.95227
Sezgi Güllü Erciyestepe, Ahmet Birtan Boran, Ceyda Turan Bektaş, Özgür Uzun
{"title":"Can an apparent diffusion coefficient of uterine fibroid before uterine artery embolization predict potential fibroid response?","authors":"Sezgi Güllü Erciyestepe, Ahmet Birtan Boran, Ceyda Turan Bektaş, Özgür Uzun","doi":"10.5603/gpl.95227","DOIUrl":"10.5603/gpl.95227","url":null,"abstract":"<p><strong>Objectives: </strong>ACOG guidance confirms the use of uterine artery embolisation (UAE) as an alternative to hysterectomy or myomectomy. The main objective of this article is to evaluate the ability of preoperative magnetic resonance ımaging (MRI) to study the relationship between uterine fibroid reduction and diffusion coefficient (ADC) value after UAE. This is a relevant topic with the growing interest in using ADC as a noninvasive imaging biomarker for monitoring tissue changes and predicting uterine fibroid response to UAE over the past years.</p><p><strong>Material and methods: </strong>In this prospective controlled non-randomized trial; uterine fibroid volume, fibroid diameter, uterine volume, fibroid ADC and normal myometrium ADC were recorded before and after UAE. Wilcoxon test was used in the analysis of the dependent quantitative data. Pearson correlation coefficients were calculated between post-UAE uterine volume, fibroid volume, and average fibroid diameter reduction and the patient's age, parity, gravidity, fibroid ADC and myometrial ADC before UAE.</p><p><strong>Results: </strong>The mean fibroid volume reduction was 36.0% (range between 17.3-77.7%). Mean fibroid diameter, fibroid volume, uterine volume, and myometrium ADC values after UAE were significantly lower than before the procedure (p = 0.002, < 0.001, 0.001, 0.006 respectively), but the decrease in fibroid ADC is not significant. As a result decrease in fibroid volume was greater as pre-UAE fibroid ADC values increased, and that finding may contribute to the selection of the patients for the procedure.</p><p><strong>Conclusions: </strong>The ADC value before UAE was positively correlated with fibroid volume reduction.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"195-199"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10153995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ginekologia polskaPub Date : 2024-01-01Epub Date: 2023-09-19DOI: 10.5603/gpl.96501
Marlena Cwynar, Karolina Kowalczyk, Grzegorz Cwynar, Piotr Ptak, Mykola Chekan
{"title":"Squamous cell carcinoma evolving from mature cystic teratoma of the ovary.","authors":"Marlena Cwynar, Karolina Kowalczyk, Grzegorz Cwynar, Piotr Ptak, Mykola Chekan","doi":"10.5603/gpl.96501","DOIUrl":"10.5603/gpl.96501","url":null,"abstract":"","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"414-415"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10303017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ginekologia polskaPub Date : 2024-01-01Epub Date: 2023-03-17DOI: 10.5603/GP.a2023.0018
Magdalena Kolak, Joanna Gorecka, Malgorzata Radon-Pokracka, Maciej Piasecki, Agnieszka Cierniak, Agnieszka Micek, Anna Horbaczewska, Andrzej Jaworowski, Hubert Huras
{"title":"ICTP concentration in cervical-vaginal fluid as a potential marker of membrane collagen degradation before labor.","authors":"Magdalena Kolak, Joanna Gorecka, Malgorzata Radon-Pokracka, Maciej Piasecki, Agnieszka Cierniak, Agnieszka Micek, Anna Horbaczewska, Andrzej Jaworowski, Hubert Huras","doi":"10.5603/GP.a2023.0018","DOIUrl":"10.5603/GP.a2023.0018","url":null,"abstract":"<p><strong>Objectives: </strong>Numerous physical and chemical processes lead to rupture of membranes. Within the fetal membranes there are numerous types of metalloproteinases, which cause collagen type I degradation. The C-terminal telopeptide of colagen type I (ICTP) is the breakdown product of type I collagen. The aim of the study was to determine whether ICTP is secreted into the vaginal-cervical fluid (VCF) in the case of physiological rupture of the membranes of the fetus before delivery.</p><p><strong>Material and methods: </strong>The study was conducted in March 2021 at the Department of Obstetrics and Perinatology of the Jagiellonian University in Cracow, Poland. Twenty-three cases were included in the study. During routine gynecological examination with the use of specula, VCF was collected twice in a volume of 50 µL. The obtained material was then subjected to enzyme immunoassay using the Human C-telopeptide of type I collagen (ICTP) ELISA Kit (Catalog Number. CSB-E10363h). The concentration of ICTP in the sample was calibrated. The concentration range that the device can detect was 25 ng /mL-800 ng/mL.</p><p><strong>Results: </strong>The presence of ICTP in the VCF was confirmed. The minimum concentration was 43.72 ng/mL, the maximum was 762.59, in five cases the concentration was outside the maximum scale of the device.</p><p><strong>Conclusions: </strong>ICTP was confirmed in the VCF of pregnant women before physiological delivery. Further studies are required to accurately evaluate ICTP as a marker of the processes of collagen degradation in fetal membranes in the mechanism of physiological labor and premature rupture of the membranes.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"518-524"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9121332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ginekologia polskaPub Date : 2024-01-01Epub Date: 2022-12-08DOI: 10.5603/GP.a2022.0142
Xiaofei He, Sha Liao
{"title":"Clinical significance of bladder training in preoperative localization of high-intensity focused ultrasound ablation of uterine fibroids.","authors":"Xiaofei He, Sha Liao","doi":"10.5603/GP.a2022.0142","DOIUrl":"10.5603/GP.a2022.0142","url":null,"abstract":"<p><strong>Objectives: </strong>High-intensity focused ultrasound (HIFU) is widely used to treat uterine fibroids. HIFU preoperative localization of uterine fibroids can be used to determine whether the patient is a suitable candidate for HIFU treatment. This study investigated the clinical significance of bladder training in improving the success rate of HIFU preoperative localization uterine fibroids.</p><p><strong>Material and methods: </strong>Our sample consists of patients who planned to undergo HIFU treatment in our hospital but who were failed in previous HIFU preoperative localization. They were recruited between July 2021 and April 2022, and randomly divided into experimental and control groups. A total of 150 patients were enrolled. Each group consisted of 75 patients. The patients in the experimental group adopted the procedure of drinking water multiple times and retaining urine. The training program lasted three days. The patients in the control group were required to keep regular drinking and urination habits without any special instructions or requirements.</p><p><strong>Results: </strong>There were no statistically significant differences between the two groups in maximum bladder capacity, residual urine volume of bladder, bladder filling levels, and bladder shape change. After bladder training, the maximum bladder capacity and the degree bladder shape change of the patients in the experimental group were improved significantly. The success rate of HIFU preoperative localization in the patients in the experimental group was significantly higher than that of the control group.</p><p><strong>Conclusions: </strong>Bladder training can effectively improve the success rate of HIFU preoperative localization of uterine fibroids.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"791-795"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10361253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ginekologia polskaPub Date : 2024-01-01Epub Date: 2023-08-07DOI: 10.5603/GP.a2023.0072
Metin Kaba
{"title":"Invasion anomaly or neovascularization? A new surgical approach for cesarean delivery in pregnant women with invasive placenta accreta spectrum disorder accompanied by placenta previa.","authors":"Metin Kaba","doi":"10.5603/GP.a2023.0072","DOIUrl":"10.5603/GP.a2023.0072","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of study is to describe a new surgical approach to cesarean delivery in women with invasive placenta accreta spectrum (PAS) accompanied by placenta previa.</p><p><strong>Material and methods: </strong>Cesarean delivery was initiated with a transverse abdominal (Pfannenstiel) incision. A transverse incision was made above the vascular area in the lower uterine segment, and the fetus was delivered. The uterine fundus was removed from the abdomen and wrapped. Placental removal was started at posteriorly, continuing toward the anterior region. If dense adhesions were encountered, dissection was performed by inserting a finger between the adhesions to carefully separate them. It was recognized that two types of vessels develop to supply blood to the placenta. First, a perforating vessel emerges from adjacent tissues, entering the placental bed by perforating the uterine wall. Second, a superficial vessel runs along the uterine wall to enter the placental bed. The new emerging vessels were identified and ligated. Uterine sparing surgery was performed if the hemorrhage ceased. A cesarean hysterectomy was performed if hemorrhage did not cease.</p><p><strong>Results: </strong>Eight cesarean deliveries were performed using this new surgical approach. Cesarean hysterectomy was performed in three patients in who want to sterilization diser and don't mind fertility preservation. Severe maternal morbidity, invasive procedures, intensive care unit admission, and relaparotomy were not required.</p><p><strong>Conclusions: </strong>The described new surgical approach provide surgeon to perform cesarean delivery without causing increase maternal morbidity and mortality. Although the approach is new and the study population is small, the results have acceptable rationality and applicability.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"114-122"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10319616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ginekologia polskaPub Date : 2024-01-01Epub Date: 2023-08-07DOI: 10.5603/GP.a2023.0065
Bin Meng, Ning Liu, Xiaotao Wang, Zhe Geng, Qian Li, Mingmin Xu
{"title":"Current status and outlook of minimally invasive treatment for leiomyomas.","authors":"Bin Meng, Ning Liu, Xiaotao Wang, Zhe Geng, Qian Li, Mingmin Xu","doi":"10.5603/GP.a2023.0065","DOIUrl":"10.5603/GP.a2023.0065","url":null,"abstract":"<p><strong>Objectives: </strong>Leiomyomas are benign, highly prevalent gynecologic conditions that can cause abnormal uterine bleeding, pelvic pain, urinary difficulties, and/or bladder or rectal obstruction. With advances in medical technology, women are increasingly interested in treatments that avoid surgery and/or preserve the uterus, which has undoubtedly contributed to the development of minimally invasive approaches. This article reviews the literature and evaluates the effectiveness and safety of minimally invasive approaches for the treatment of leiomyomas and describes the current state of development of minimally invasive treatment modalities for leiomyomas.</p><p><strong>Material and methods: </strong>Web of Science and PubMed were systematically evaluated using the following keywords: uterine artery embolization, high-intensity focused ultrasound, microwave ablation, radiofrequency ablation, myomectomy, hysterectomy, leiomyomas, fertility. English abstracts relevant to the topic were selected and full-text articles were carefully analyzed.</p><p><strong>Results: </strong>Uterine artery embolization is an effective treatment modality that has been widely validated, and the remaining means each have their distinct advantages in clinical practice, but more practical and comparative studies are needed. Minimally invasive myomectomy and minimally invasive hysterectomy are technically advanced compared to classical open surgery and are widely used due to the completion of practical experience, but a continuous interest in non-invasive minimally invasive treatment modalities is retained.</p><p><strong>Conclusions: </strong>Minimally invasive treatment modalities for leiomyomas have emerged as an important treatment option when considering patient requirements, and further research and practice are needed to support their development into a mainstream modality for the treatment of leiomyomas.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"212-217"},"PeriodicalIF":1.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10319619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}