Can an apparent diffusion coefficient of uterine fibroid before uterine artery embolization predict potential fibroid response?

IF 1.2 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Sezgi Güllü Erciyestepe, Ahmet Birtan Boran, Ceyda Turan Bektaş, Özgür Uzun
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引用次数: 0

Abstract

Objectives: ACOG guidance confirms the use of uterine artery embolisation (UAE) as an alternative to hysterectomy or myomectomy. The main objective of this article is to evaluate the ability of preoperative magnetic resonance ımaging (MRI) to study the relationship between uterine fibroid reduction and diffusion coefficient (ADC) value after UAE. This is a relevant topic with the growing interest in using ADC as a noninvasive imaging biomarker for monitoring tissue changes and predicting uterine fibroid response to UAE over the past years.

Material and methods: In this prospective controlled non-randomized trial; uterine fibroid volume, fibroid diameter, uterine volume, fibroid ADC and normal myometrium ADC were recorded before and after UAE. Wilcoxon test was used in the analysis of the dependent quantitative data. Pearson correlation coefficients were calculated between post-UAE uterine volume, fibroid volume, and average fibroid diameter reduction and the patient's age, parity, gravidity, fibroid ADC and myometrial ADC before UAE.

Results: The mean fibroid volume reduction was 36.0% (range between 17.3-77.7%). Mean fibroid diameter, fibroid volume, uterine volume, and myometrium ADC values after UAE were significantly lower than before the procedure (p = 0.002, < 0.001, 0.001, 0.006 respectively), but the decrease in fibroid ADC is not significant. As a result decrease in fibroid volume was greater as pre-UAE fibroid ADC values increased, and that finding may contribute to the selection of the patients for the procedure.

Conclusions: The ADC value before UAE was positively correlated with fibroid volume reduction.

子宫动脉栓塞前子宫肌瘤的表观扩散系数能否预测子宫肌瘤的潜在反应?
目的:ACOG指南确认使用子宫动脉栓塞(UAE)作为子宫切除术或子宫肌瘤切除术的替代方案。本文的主要目的是评价术前磁共振ımaging (MRI)对UAE术后子宫肌瘤缩小与弥散系数(ADC)值关系的研究能力。近年来,越来越多的人将ADC作为一种无创成像生物标志物来监测组织变化和预测子宫肌瘤对UAE的反应,这是一个相关的话题。材料和方法:在这项前瞻性对照非随机试验中;记录UAE前后子宫肌瘤体积、肌瘤直径、子宫体积、肌瘤ADC及正常子宫肌层ADC。相关定量资料的分析采用Wilcoxon检验。计算UAE后子宫体积、肌瘤体积、肌瘤平均直径缩小与患者年龄、胎次、妊娠、子宫肌瘤ADC和子宫肌瘤ADC之间的Pearson相关系数。结果:肌瘤体积平均缩小36.0%(17.3 ~ 77.7%)。术后肌瘤直径、肌瘤体积、子宫体积、肌膜ADC值均显著低于术前(p = 0.002, < 0.001, 0.001, 0.006),但肌瘤ADC值下降不显著。因此,随着uae前肌瘤ADC值的增加,肌瘤体积的减少更大,这一发现可能有助于选择患者进行手术。结论:UAE前的ADC值与肌瘤体积缩小呈正相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Ginekologia polska
Ginekologia polska OBSTETRICS & GYNECOLOGY-
CiteScore
2.00
自引率
15.40%
发文量
317
审稿时长
4-8 weeks
期刊介绍: Ginekologia Polska’ is a monthly medical journal published in Polish and English language. ‘Ginekologia Polska’ will accept submissions relating to any aspect of gynaecology, obstetrics and areas directly related. ‘Ginekologia Polska’ publishes original contributions, comparative works, case studies, letters to the editor and many other categories of articles.
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