Ginekologia polska最新文献

{"title":"The role of PET/CT with fluorine-18-deoxyglucose in the detection of relapsed serous ovarian cancer in patients with normal serum CA125 levels.","authors":"Malgorzata Kosinska,&nbsp;Jacek Fijuth,&nbsp;Piotr Misiewicz,&nbsp;Katarzyna Kalita,&nbsp;Maciej Foks,&nbsp;Lukasz Kuncman,&nbsp;Leszek Gottwald","doi":"10.5603/gpl.94994","DOIUrl":"https://doi.org/10.5603/gpl.94994","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the role of the positron emission tomography with fluorine-18-deoxyglucose (PET/CT) in the detection of recurrent serous ovarian cancer in patients with normal serum CA125 level.</p><p><strong>Material and methods: </strong>Thirty-one patients with suspected recurrent serous ovarian cancer with normal (< 35 IU/mL) serum CA125 level and no prior recurrence underwent PET/CT imaging. The results of the PET/CT were analyzed considering clinical data of the patients, histological diagnosis and 6 months follow-up.</p><p><strong>Results: </strong>The patients were referred to the PET/CT due to suspected relapse in imaging tests (CT - 11 cases, US - 3 cases, MRI - 2 cases; n = 16; 51.6%), clinical examination (n = 4; 12.9%) and clinical symptoms (n = 11; 35.5%). The recurrent serous ovarian cancer was present in 16 patients (51.6%). In 9 these cases (56.3%) the recurrences were diagnosed in patients aged 51-70 years. In 15 cases (93.8%) the recurrences were diagnosed within 24 months after treatment. There were 15 true positive (48.4%), 12 true negative (38.7%), 3 false positive (9.7%) and 1 false negative (3.2%) PET/CT results. Sensitivity, specificity, positive and negative predictive value of the PET/CT were calculated as 93.8% (95% CI, 86.1-97.4%), 80.0% (95% CI, 69.7-88.9%), 83.3% (95% CI, 74.3-90.4%) and 92.3% (95% CI, 84.2-98.3%), respectively.</p><p><strong>Conclusions: </strong>In patients with a diagnosis of complete remission after treatment for serous ovarian cancer, even a multifocal recurrence may occur during follow up despite normal serum CA125 levels. Our results showed a usefulness of the PET/CT in detecting and differentiating malignant from benign lesions in patients with normal serum CA125 levels but inconclusive results in other imaging tests. We observed false results of the PET/CT for lesions in parotid gland, mesorectal adipose tissue and mediastinal lymph nodes.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10154001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effect of the temperature-controlled radio frequency technology in female sexual dysfunction.","authors":"Nan Wang,&nbsp;Huan Li","doi":"10.5603/gpl.94788","DOIUrl":"https://doi.org/10.5603/gpl.94788","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the therapeutic effect of the temperature-controlled radiofrequency technology in female sexual dysfunction (FSD).</p><p><strong>Material and methods: </strong>From July 2020 to June 2021, patients with FSD who visited the Gynecology Clinic of Peking University Shenzhen Hospital were treated with the temperature-controlled radiofrequency technology once every two weeks, for a total of five times. The therapeutic effect was objectively evaluated with pelvic floor dysfunction (PFD) indicators (FSFI score, pelvic floor muscles surface electromyography, sexual function test). The pre- and post-treatment (2 weeks)/follow-up (3 months) results were compared to evaluate the feasibility of this technology for treating FSD, as well as using PFD-related indicators in objective evaluation of FSD patients.</p><p><strong>Results: </strong>Fifty patients completed treatment; 31 patients completed follow-up. The mean FSFI score for post-treatment/follow-up was significantly higher than pre-treatment (p < 0.05). There were no significant changes in the mean pelvic floor resting surface myoelectric potential and its variability and mean myoelectric potential of sexual function test between pre- and post-treatment/follow-up. The mean surface myoelectric potential of the patients' type I and II muscle fibers of the pelvic floor for post-treatment/follow-up was significantly higher than pre-treatment (p < 0.05). The mean peak myoelectric potential for post-treatment was significantly higher than pre-treatment (p < 0.05).</p><p><strong>Conclusions: </strong>Temperature-controlled radiofrequency technology has a certain therapeutic effect on FSD. Pelvic floor surface electromyography and sexual function test can be used as an objective indicator for PFD in FSD patients. Subsequent studies may involve a larger size sample and evaluate the effect over a consecutive time-point, to develop a better therapeutic approach.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10109380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhabdomyosarcoma of the genitourinary system in girls - the role of magnetic resonance imagining in diagnosis, treatment monitoring, and follow-up.","authors":"Paulina Sobieraj,&nbsp;Zofia Malas,&nbsp;Tadeusz Issat,&nbsp;Anna Raciborska,&nbsp;Monika Bekiesinska-Figatowska","doi":"10.5603/gpl.95047","DOIUrl":"https://doi.org/10.5603/gpl.95047","url":null,"abstract":"<p><strong>Objectives: </strong>Rhabdomyosarcoma of the genitourinary system in girls is a rare neoplasm, especially in non-dedicated centers. Our work aimed to sum up and present genitourinary rhabdomyosarcomas in girls from the radiological point of view.</p><p><strong>Material and methods: </strong>We retrospectively reviewed all girls with genitourinary RMS who underwent treatment at the Institute of Mother and Child in Warsaw between 2009 and 2022. We evaluated the demographic, clinical, and pathological patient data and imaging studies.</p><p><strong>Results: </strong>During the study period, ten patients presented with genitourinary RMS and underwent magnetic resonance imaging (MRI). The median age at the time of diagnosis was 2.8 years, six patients were younger than three years, and four patients were older than ten years. The most common clinical symptoms were tumor fragments protruding from the vagina/falling out of the vagina and vaginal bleeding or discharge, and the most common original location was the vagina. One hundred percent of patients had the embryonal subtype of RMS, and 100% of cases where molecular tests for PAX3/FOXO1 fusion gen status were performed had negative status. At presentation, the median tumor volume was 114 cm³. Eight patients (80%) were classified as clinical group III according to the IRS Group, and most patients (70%) were in a standard-risk group. All patients received multimodal treatment, including surgery and chemotherapy; 60% received radiotherapy. Neoadjuvant chemotherapy was the primary treatment for all our patients. In six patients (60%) with a measurable tumor mass after a biopsy, a gradual tumor volume reduction was observed after induction chemotherapy (approximately ten weeks of treatment) - all of which had a partial response (PR). All our patients (100%) responded completely to treatment.</p><p><strong>Conclusions: </strong>MRI was performed at every stage of diagnosis and treatment as well as during follow-up. It allowed for staging, monitoring of chemotherapy, and guided surgery.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10109385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accidentally discovered adolescent botryoid rhabdomyosarcoma.","authors":"Ainur Donayeva,&nbsp;Ainur Amanzholkyzy,&nbsp;Zaituna Khamidullina,&nbsp;Ibrahim A Abdelazim,&nbsp;Gulnara Gubasheva,&nbsp;Dinmukhamed Ayaganov,&nbsp;Ihab I Samaha","doi":"10.5603/gpl.94615","DOIUrl":"https://doi.org/10.5603/gpl.94615","url":null,"abstract":"","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10031963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the COVID-19 pandemic on the course of miscarriages.","authors":"Marta Kacprzak,&nbsp;Hanna Moczulska,&nbsp;Katarzyna Ploszka,&nbsp;Marta Chrzanowska,&nbsp;Piotr Sieroszewski","doi":"10.5603/gpl.94772","DOIUrl":"https://doi.org/10.5603/gpl.94772","url":null,"abstract":"<p><strong>Objectives: </strong>Miscarriage is the most common complication of pregnancy. Infections are well-known causes of pregnancy loss. It has been suggested that infection with SARS-CoV-2 virus may also have an adverse effect on the course of early pregnancy, causing miscarriage.</p><p><strong>Aim: </strong>To assess the impact of the COVID-19 pandemic on pregnancy loss during the first half of pregnancy.</p><p><strong>Material and methods: </strong>The clinical records of patients hospitalized at the Department of Fetal Medicine and Gynecology; Medical University of Lodz were retrospectively reviewed. The study was done during the pandemic (March 2020 to the end of March 2022) and the previous 2 years due to missed abortion, indicated by no fetal heartbeat and spontaneous (complete or incomplete) abortion with vaginal bleeding.</p><p><strong>Results: </strong>While 682 women were hospitalized due to miscarriage in the first half of pregnancy in the period 2018-2020, there were 516 hospitalized during the pandemic. No differences in the proportion of missed and spontaneous abortions with bleeding were found between the group of patients before and during the epidemic SARS CoV-2. COVID-19 exposure appears to have an impact on earlier pregnancy loss.</p><p><strong>Conclusions: </strong>There is no evidence that the COVID-19 pandemic predisposes to the abnormal course of pregnancy in its first half.</p><p><strong>Objectives: </strong>Miscarriage is the most common complication of pregnancy. Infections are well-known causes of pregnancy loss. It has been suggested that infection with SARS-CoV-2 virus may also have an adverse effect on the course of early pregnancy, causing miscarriage.</p><p><strong>Aim: </strong>To assess the impact of the COVID-19 pandemic on pregnancy loss during the first half of pregnancy.</p><p><strong>Material and methods: </strong>The clinical records of patients hospitalized at the Department of Fetal Medicine and Gynecology; Medical University of Lodz were retrospectively reviewed. The study was done during the pandemic (March 2020 to the end of March 2022) and the previous 2 years due to missed abortion, indicated by no fetal heartbeat and spontaneous (complete or incomplete) abortion with vaginal bleeding.</p><p><strong>Results: </strong>While 682 women were hospitalized due to miscarriage in the first half of pregnancy in the period 2018-2020, there were 516 hospitalized during the pandemic. No differences in the proportion of missed and spontaneous abortions with bleeding were found between the group of patients before and during the epidemic SARS CoV-2. COVID-19 exposure appears to have an impact on earlier pregnancy loss.</p><p><strong>Conclusions: </strong>There is no evidence that the COVID-19 pandemic predisposes to the abnormal course of pregnancy in its first half.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10031966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of microRNA (miR126*, miR155, miR21, miR29a) in breast milk cell fraction in women with hypertension: a comparative analysis with women without hypertension.","authors":"Adrianna Kondracka,&nbsp;Paulina Gil-Kulik,&nbsp;Monika Wojtowicz-Marzec,&nbsp;Alicja Petniak,&nbsp;Bartosz Kondracki,&nbsp;Anna Kwasniewska,&nbsp;Janusz Kocki","doi":"10.5603/GP.a2023.0073","DOIUrl":"https://doi.org/10.5603/GP.a2023.0073","url":null,"abstract":"<p><strong>Objectives: </strong>The ideal option of food for a newborn's nourishment has traditionally been human breast milk (HBM). Previous studies have demonstrated a connection between the length of exclusively breastfeeding and its preventive effects on several conditions in neonates. Considering the significance of HBM, the study aimed at detecting the expression of microRNA (miR126*, miR155, miR21, and miR29a) in the breast milk cell fraction of women with hypertension. This was a cohort study of 35 postpartum women.</p><p><strong>Material and methods: </strong>Five ml of milk was collected into a sterile container from patients in the morning on the second and third days after the labor. The collected milk has been centrifuged, total cellular RNA has been isolated from cell fraction from the collected milk, isolated RNA has been subject to qualitative and quantitative analysis, next reverse transcription has been conducted, followed by that, evaluation of the expression of the selected microRNA has been conducted using the synthesized cDNA. Finally, the tested microRNA's relative expression level has been calculated.</p><p><strong>Results: </strong>Among patients with hypertension, the analysis of cell fraction of breast milk reported lower mean expression of miR126*, miR155, miR21, and miR29a as compared to patients without hypertension. Strong and very strong positive correlation between the expression of miR126* and miR155, miR126* and miR21, miR155 and miR21, miR 155 and miR29a, and miR 21 and miR29a have been noted.</p><p><strong>Conclusions: </strong>Comparing patients with and without hypertension, it has been noted that patients with hypertension had lower mean expression of miR126*, miR155, miR21, and miR29a.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10000659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of effectiveness of pharmacological treatment in pelvic congestion syndrome.","authors":"Karolina B Gora,&nbsp;Slawomir Wozniak","doi":"10.5603/GP.a2023.0078","DOIUrl":"https://doi.org/10.5603/GP.a2023.0078","url":null,"abstract":"<p><p>Pelvic congestion syndrome (PCS) is a pain syndrome characterized by positional pelvic pain and is associated with pelvic and vulvar varicosities as well as symptoms of dyspareunia and postcoital pain. Since the etiology of PCS is complex, the treatment should be individualized. Despite both pharmacological and interventional methods being used, there is significant predominance of minimally invasive therapies e.g. embolization. The study considers the answer to the question of whether pharmacological therapy is altogether effective. Using a combination of keywords, a PubMed search was performed for the years 1987-2022. The relevant articles were appointed and included in this narrative review. Despite the multitude of alternatives for pharmacological treatment, the systemic side effects of the medications used, as well as the interactions between drugs, affect patients' compliance and persistence. Furthermore, the quality of the currently existing evidence, considering the efficacy of the given substances, is low. Because of the adverse effects and thus the limited drug administration period, there is currently insufficient research on long-term effectiveness of the PCS pharmacological treatment. Therefore, prospective, comparative studies with larger patient population sizes are necessary to provide the possibility of efficient pharmacological therapy.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10303554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent cervical adenofibroma progressing to adenosarcoma: a rare case report.","authors":"Li Chen,&nbsp;Yugang Chi,&nbsp;Yanlin Chen","doi":"10.5603/GP.a2023.0069","DOIUrl":"https://doi.org/10.5603/GP.a2023.0069","url":null,"abstract":"<p><strong>Objectives: </strong>Cervical adenofibroma is a rare form of mixed mesodermal tumor that can present as cervical polyps with a tendency for local recurrence and progression. Few cases progressing to adenosarcoma have previously been reported. We report a case of cervical adenofibroma progressing to adenosarcoma, and we seek to remind clinicians of the method and importance of the differential diagnosis of this disease. A fertile woman was admitted in our department for the eighth recurrence of a cervical polypoidal mass which for the past 10 years. Recurrence of cervical adenofibroma was confirmed by ultrasound and MRI. A wide local excision under hysteroscopy was performed due to her strong desire to preserve the uterus. Surgical pathology and immunohistochemical interpretation revealed cervical adenosarcoma. A hysterectomy with conservation of the ovaries was recommended, with regular follow-ups for evidence of disease recurrence.</p><p><strong>Conclusions: </strong>Differential diagnoses of cervical adenofibroma are hard to prove. Adenosarcoma should be ruled out, especially in women presenting with recurrent cervical polypoidal masses. A combined histological/immunohistochemical investigation is mandatory.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9771427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple gasless single-port laparoscopy suitable for use in middle- and low-income countries or primary hospitals.","authors":"Xiaoying Wang,&nbsp;Yan Li","doi":"10.5603/GP.a2023.0059","DOIUrl":"https://doi.org/10.5603/GP.a2023.0059","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of the present study is to explore the effectiveness of a modified suspension method combined with gasless single-port laparoscopy (MS-GSPL) for the treatment of benign ovarian tumors. The aim of this approach is to provide a convenient, economical, and minimally invasive method that is suitable for widespread use, even in middle- and low-income countries or primary hospitals.</p><p><strong>Material and methods: </strong>Retrospective analysis of patients who underwent laparoscopic unilateral ovarian cystectomy due to benign ovarian tumors from January 2019 to December 2019.Thirty-six cases were treated with MS-GSPL, and 36 cases were treated with single-port laparoscopy (SPL). The patients' medical records, perioperative surgical outcomes, postoperative pain scores and complications were reviewed and compared.</p><p><strong>Results: </strong>There are no significant differences in age, body mass index, previous pelvic surgery, tumor diameter, and tumor pathologic outcomes between MS-GSPL group and SPL group. The median operation times were 50 (Q1~Q3, 44~62.25) min in the MS-GSPL group and 60.5 (Q1~Q3, 57.25~78) min in the SPL group with a significant difference. The median estimated blood loss was 40 (Q1~Q3, 30~50) mL in the MS-GSPL group and 50(Q1~Q3, 30~60) mL in the SPL group with no significant difference. Compared with SPL group, patients in MS-GSPL group had earlier postoperative exhaust times, shorter hospital stays and lower costs, and all these differences were statistically significant (p < 0.05). There was a strong positive correlation between operation time and BMI in the MS-GSPL groups.</p><p><strong>Conclusions: </strong>The patients receiving MS-GSPL treatment have quick postoperative recoveries. MS-GSPL is a novel, safe and economical surgical method that is suitable for extensive clinical development in middle- and low-income countries or primary hospitals.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9761739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of serum levels of soluble (s)L- and (s)P-selectins in endometrial cancer.","authors":"Dominika Majchrzak-Baczmanska,&nbsp;Krzysztof Pogoda,&nbsp;Anna Oblekowska,&nbsp;Dariusz Owczarek,&nbsp;Beata Antosiak,&nbsp;Michal Wojciechowski,&nbsp;Agnieszka Wosiak,&nbsp;Andrzej Malinowski","doi":"10.5603/GP.a2023.0056","DOIUrl":"https://doi.org/10.5603/GP.a2023.0056","url":null,"abstract":"<p><strong>Objectives: </strong>A number of reports on the role of selectin in the process of carcinogenesis, at the stage of proliferation and metastasis, have been available. The aim of the study was to analyze (s)P- and (s)L-selectin serum concentrations in women with EC and to compare these concentrations to clinical/pathological parameters and disease progression using surgical-pathological staging data.</p><p><strong>Material and methods: </strong>A total of 46 patients with EC and 50 healthy controls were included in the study. Serum concentrations of sL- and sP-selectins were measured in all participants. The oncologic protocol was implemented in all women from the study group.</p><p><strong>Results: </strong>Significantly higher serum concentrations were found in EC women as compared to controls. No statistically significant differences were found between the concentrations of the soluble forms of selectins and the following parameters: histologic type of EC, histologic tumor differentiation, depth of myometrial infiltration, cervical involvement, distant metastases, vascular space invasion, and disease advancement. Slightly higher (s)P-selectin concentrations were observed in serous carcinoma, in women with cervical involvement, in the sera of women with vascular space invasion and with advanced stages of the disease. Slightly higher mean (s)P-selectin concentrations correlated with lower differentiation of the tumor. Slightly higher mean (s)P-selectin concentration was detected in the sera of women with lymph node metastases and with the serosal and/or adnexal involvement. The results were statistically insignificant, but they almost reached statistical significance.</p><p><strong>Conclusions: </strong>L- and P-selectins play a role in the biology of EC. The absence of an unambiguous relationship between differences in (s)L- and (s)P-selectin levels and disease advancement suggests that they do not play a vital role in tumor progression in endometrial cancer.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9755821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}