Ginekologia polska最新文献_第2页

Effect of tumor type on response to adjuvant platinum-based chemotherapy and prognosis in patients with stage II-IV epithelial ovarian carcinoma. 肿瘤类型对 II-IV 期上皮性卵巢癌患者辅助铂类化疗反应和预后的影响。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2023-09-05 DOI: 10.5603/gpl.94024

Gizem Aktemur, Cigdem Kilic, Fatih Kilic, Mehmet Ünsal, Gunsu Kimyon Comert, Taner Turan

{"title":"Effect of tumor type on response to adjuvant platinum-based chemotherapy and prognosis in patients with stage II-IV epithelial ovarian carcinoma.","authors":"Gizem Aktemur, Cigdem Kilic, Fatih Kilic, Mehmet Ünsal, Gunsu Kimyon Comert, Taner Turan","doi":"10.5603/gpl.94024","DOIUrl":"10.5603/gpl.94024","url":null,"abstract":"Objectives: To evaluate the effect of histological subtype on oncological outcome and adjuvant platinum-based chemotherapy response in patients with epithelial ovarian cancer (EOC).Material and methods: The study group was created with stage II-IV EOC patients. Progression-free survival (PFS) and disease-specific survival (DSS) estimates were determined by using the Kaplan-Meier method. The log-rank test and cox proportional hazards model were performed.Results: A total 396 patients were included the study. Tumor type was serous in 332 (83.8%). Two hundred and thirty-one patients (58.3%) had maximal cytoreduction. Three hundred and twenty-seven (82.6%) patients received complete clinical response. Refractory disease was present in 69 (17.4%) patients. In patients with complete clinical response, 183 (56%) patients recurred. Five-year PFS was 32% in serous group and 31% in non-serous group (p = 0.755). Five-year DSS was 78% in serous group and 87% in non-serous group (p = 0.084). On multivariate analysis, recurrence rates 1.959 times (95% CI: 1.224-3.085; p = 0.004), death rates 2.624 times (95% CI: 1.328-5.185; p = 0.005) higher in patients with optimal cytoreduction than patients with maximal cytoreduction, respectively.Conclusions: Although the rate of maximal cytoreduction was higher in patients with non-serous tumor type, the rate of refractory disease was higher after adjuvant chemotherapy. However, the recurrence rate was higher in serous tumor type. Survival rates were similar in serous and non-serous tumor types. Maximal cytoreduction was an independent predictor factor for survival. Maximal cytoreduction should be the main target in EOC.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"99-107"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10527249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for postpartum hemorrhage after elective cesarean deliveries for twin pregnancies. 双胎妊娠选择剖宫产术后产后出血的风险因素。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2023-08-07 DOI: 10.5603/GP.a2023.0071

Xiaojie Wan, Wei Zhao, Li Zhao, Nan Li, Hong Wen

{"title":"Risk factors for postpartum hemorrhage after elective cesarean deliveries for twin pregnancies.","authors":"Xiaojie Wan, Wei Zhao, Li Zhao, Nan Li, Hong Wen","doi":"10.5603/GP.a2023.0071","DOIUrl":"10.5603/GP.a2023.0071","url":null,"abstract":"Objectives: To identify the high-risk factors associated with postpartum hemorrhage (PPH) after an elective cesarean delivery of twins.Material and methods: This retrospective cohort study included all women with twin gestations who chose to have an elective cesarean delivery after 28 weeks of gestation at at the Women's Hospital, School of Medicine, Zhejiang University between September 2014 and April 2019. Women with an intrauterine fetal demise of one or both twins were excluded. PPH was defined as an estimated blood loss of ≥ 1,000 mL within 24 h of birth. A total of 532 women were analyzed and classified into the PPH group (n = 70) and the no-PPH group (n = 462). Univariate and multivariate logistic regression analyses were performed to assess the independent risk factors.Results: Among the 532 women pregnant with twins, PPH occurred in 13.2% women (n = 70). There were statistically significant differences in preeclampsia (p = 0.005), premature rupture of membrane (PROM, p < 0.001), placenta previa (p < 0.001), anemia [hemoglobin (Hb) < 100 g/L; p = 0.003], and antenatal magnesium sulfate (MgSO₄) use (p < 0.001) between the two groups. However, the following were the independent risk factors for PPH after an elective cesarean delivery for a twin pregnancy: preeclampsia [odds ratio (OR): 2.91; 95% confidence interval (CI): 1.33-6.36], PROM (OR: 8.57; 95% CI: 2.54-28.89), placenta previa (OR: 9.46; 95% CI: 3.59-24.89), antenatal MgSO₄ use (OR: 7.64; 95% CI; 3.18-18.41), and anemia (Hb < 100 g/L; OR: 2.68; 95% CI: 1.42-5.06).Conclusions: Preeclampsia, PROM, placenta previa,and antenatal MgSO₄ use were the risk factors for PPH after an elective cesarean delivery for twin pregnancies. Risk factor identification and prevention should be a priority.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"531-535"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10303557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse pregnancy outcomes for women with endometriosis: a systematic review and meta-analysis. 子宫内膜异位症妇女的不良妊娠结局：系统回顾和荟萃分析。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2021-09-20 DOI: 10.5603/GP.a2021.0081

Jian-Qing Wang, Jia-Miao Zhang, Bin Qian

{"title":"Adverse pregnancy outcomes for women with endometriosis: a systematic review and meta-analysis.","authors":"Jian-Qing Wang, Jia-Miao Zhang, Bin Qian","doi":"10.5603/GP.a2021.0081","DOIUrl":"10.5603/GP.a2021.0081","url":null,"abstract":"Objectives: This study aimed at assessing the adverse outcomes of pregnancy in women with endometriosis.Material and methods: The Cochrane, Embase and PubMed databases were searched for identifying the required studies published before June 2019. Meta-analyses of relative risk (RR) were performed under the random-effects model to estimate the risk of selected adverse outcomes of pregnancy in females with endometriosis.Results: Twenty-eight studies (53,141 women with and 2,355,923 women without endometriosis data) were selected for meta-analysis. Endometriosis bearing females had a significantly higher risk placenta previa (RR 3.92 [95% CI 2.48-6.20]), miscarriage (RR 1.31 [95% CI 1.06-1.61), gestational hypertension (RR 1.30 [95% CI 1.02-1.65]), cesarean section (RR 1.48 [95% CI 1.33-1.65]) and preeclampsia (RR 1.18 [95% CI 1.09-1.28]). The incidence of placental abruption was not statistically significant between the groups (RR 3.62 [95% CI [0.99-13.28]).Conclusions: Women suffering from endometriosis are at higher risks of miscarriage, preterm birth, gestational hypertension, placenta previa, cesarean section, and preeclampsia.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"668-676"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39431891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoglin promotes cell migration and invasion in endometriosis by regulating EMT. Endoglin 通过调节 EMT 促进子宫内膜异位症的细胞迁移和侵袭。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2021-09-20 DOI: 10.5603/GP.a2021.0130

Xiutang Chen, Junjian Wang, Feixia Tu, Qing Yang, Dan Wang, Qin Zhu

{"title":"Endoglin promotes cell migration and invasion in endometriosis by regulating EMT.","authors":"Xiutang Chen, Junjian Wang, Feixia Tu, Qing Yang, Dan Wang, Qin Zhu","doi":"10.5603/GP.a2021.0130","DOIUrl":"10.5603/GP.a2021.0130","url":null,"abstract":"Objectives: This study aims to investigate the expression and role of Endoglin (ENG) in endometriosis (EM).Material and methods: In this study, quantitative real-time polymerase chain reaction, western blot and immunohistochemistry were used to examine the expression of ENG in tissues. Cellular experiments were performed to evaluate the effect of ENG on cellular biological function. Western blot was used to examine the expression of epithelial to mesenchymal transition-related proteins.Results: The expression of ENG was significantly higher in the ectopic endometriotic tissues than that in eutopic endometriotic tissues. Knockdown of ENG inhibited cell viability, migration and invasion, and induced cell apoptosis in hEM15A cells. Additionally, silenced ENG caused increased levels of E-cadherin and decreased levels of N-cadherin, vimentin, MMP-2 and MMP-9.Conclusions: These results confirmed that ENG may be involved in the development of endometriosis by promoting EMT process, revealing a new insight into the pathogenesis of endometriosis and contributing to the exploration of molecular therapeutic strategies against endometriosis.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"661-667"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39431986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using progesterone to follicular index ratio is better correlated with intracytoplasmic sperm injection outcome than using serum progesterone level alone. 与单纯使用血清孕酮水平相比，使用孕酮与卵泡指数比值与卵胞浆内单精子注射结果的相关性更好。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2023-05-30 DOI: 10.5603/GP.a2023.0031

Athba Abid Kadhim, Thuraya Hussamuldeen Abdulla, Ula Mohammad Alkawaz

{"title":"Using progesterone to follicular index ratio is better correlated with intracytoplasmic sperm injection outcome than using serum progesterone level alone.","authors":"Athba Abid Kadhim, Thuraya Hussamuldeen Abdulla, Ula Mohammad Alkawaz","doi":"10.5603/GP.a2023.0031","DOIUrl":"10.5603/GP.a2023.0031","url":null,"abstract":"Objectives: to investigate the possibility of using the ratio of serum progesterone level to the number of follicles, according to ovarian response in the day of human chorionic gonadotrophin trigger, as a predictor of cycle outcome.Material and methods: A prospective intervensional study was conducted at Kamal Al-Samarai Hospital for Infertility Treatment and IVF during the period from December 2020 to September 2021. Ninety infertile women underwent intracytoplasmic sperm injection (ICSI) cycles using antagonist protocol. Moreover, once the patient reached triggering criteria, meticulous recording of follicular index together with serum estrogen level and serum progesterone level are measured. Fresh embryo transfer of cleavage stage embryo is done once serum progesterone level was less than 1.5 ng/mL. A follow-up to confirm pregnancy rate and cycle outcome was done.Results: The study showed a positive pregnancy rate of 28.9%. The relationship between progesterone follicular index (Prog/FI) ratio and (ICSI) outcome was highly significant with a p value of 0.001. Additionally, an inverse relationship, as the ratio was lower the pregnancy rate was improved, was documented. The receiver operating characteristic (ROC) curve for progesterone follicular index ratio was 0.711 with a cut off value of 0.0354 ng/mL in addition to a sensitivity of 65.6 and a specificity of 65.4.Conclusions: The serum progesterone level is an independent factor for the prediction of intracytoplasmic sperm injection (ICSI) outcome, whereas the progesterone follicular index ratio can be used as a potential marker for predicting ICSI outcome in fresh embryo transfer.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"525-530"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9542220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic potential of microRNAs Mi 517 and Mi 526 as biomarkers in the detection of hypertension and preeclampsia in the first trimester. microrna Mi 517和Mi 526作为早期妊娠高血压和子痫前期生物标志物的诊断潜力

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2023-04-12 DOI: 10.5603/GP.a2023.0036

Adrianna Kondracka, Bartosz Kondracki, Ilona Jaszczuk, Jakub Staniczek, Wojciech Kwasniewski, Agata Filip, Anna Kwasniewska

{"title":"Diagnostic potential of microRNAs Mi 517 and Mi 526 as biomarkers in the detection of hypertension and preeclampsia in the first trimester.","authors":"Adrianna Kondracka, Bartosz Kondracki, Ilona Jaszczuk, Jakub Staniczek, Wojciech Kwasniewski, Agata Filip, Anna Kwasniewska","doi":"10.5603/GP.a2023.0036","DOIUrl":"10.5603/GP.a2023.0036","url":null,"abstract":"Objectives: MicroRNAs have been observed to play a major role in various physiological processes, for instance, programmed cell death, cell division, pregnancy development, and proliferation. With the help of profiling of microRNAs in the serum of pregnant women, it is possible to link alterations in their concentration to the emergence of gestational problems. The aim of the study was to evaluate the diagnostic potential of MicroRNAs Mi 517 and Mi 526 as biomarkers in the detection of hypertension and preeclampsia.Material and methods: The study considered 53 patients who are in their first trimester of a singleton pregnancy. Participants have been divided into two study groups, one group with normal pregnancy and another group having the risk of developing preeclampsia or who developed hypertension or preeclampsia during follow-up constitute the study group. In order to collect data associated with circulating miRNAs in serum, blood samples have been collected from the participants of the study.Results: Based on the univariate regression model, increased expression of Mi 517 and 526 and parity status (primapara/multipara) has been obtained. The multivariate logistic analysis shows that independent risk factors for hypertension or preeclampsia are the presence of an R527 and being a primipara.Conclusions: The study's findings have revealed that R517s and R526s act as major indicative biomarkers in the first trimester for the detection of hypertension and preeclampsia. The circulating C19MC MicroRNA was examined as a potential early indicator of preeclampsia and hypertension in pregnant individuals.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"952-958"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9284556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical significance of S100B protein in pregnant woman with early- onset severe preeclampsia. 早发重度子痫前期孕妇体内 S100B 蛋白的临床意义。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2021-06-09 DOI: 10.5603/GP.a2021.0126

Jinxia Wu, Xiaoqi Sheng, Shaoming Zhou, Chaoying Fang, Yulin Song, Hua Wang, Zhengjun Jia, Xiaozhou Jia, Yiping You

{"title":"Clinical significance of S100B protein in pregnant woman with early- onset severe preeclampsia.","authors":"Jinxia Wu, Xiaoqi Sheng, Shaoming Zhou, Chaoying Fang, Yulin Song, Hua Wang, Zhengjun Jia, Xiaozhou Jia, Yiping You","doi":"10.5603/GP.a2021.0126","DOIUrl":"10.5603/GP.a2021.0126","url":null,"abstract":"Objectives: Preeclampsia is one of the most feared complications of pregnancy, which can progress rapidly to serious complications such as death of both mother and fetus. To present, the leading cause of preeclampsia is still debated. The purpose of this article was to explore the clinical significance of S100B protein, a kind of Ca2+ -sensor protein, in the early-onset severe preeclampsia.Material and methods: Nine pregnant women with early-onset severe preeclampsia (the study group) and 13 healthy pregnant women (the control group) were included in this study. The level of S100B in the amniotic fluid, maternal blood, and umbilical cord blood were detected by enzyme-linked immunosorbent assay (ELISA) and surface plasmon resonance imaging (SPRi) methods. Diagnostic values of S100B for early-onset severe preeclampsia were assessed by Receiver Operating Characteristic (ROC) curve analysis.Results: The levels of S100B in maternal blood and amniotic fluid in the study group were higher than those in the control group (p < 0.05). ROC curve analysis showed that S100B detected by SPRi method (SPRi-S100B) showed a cut-off level of 181 ng/mL with sensitivity of 100%, a specificity of 84.6%, and a Youden index of 0.846 in the maternal blood, which had better clinical significance and diagnostic value (at than that detected by ELISA (ELISA-S100B).Conclusions: The levels of S100B detected by SPRi in maternal blood can indicate early-onset severe preeclampsia and perinatal brain injury.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"711-717"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39077413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 18-year-old-girl with unicornuate uterus and endometriosis. 患有单角子宫和子宫内膜异位症的 18 岁女孩。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2023-04-12 DOI: 10.5603/GP.a2023.0040

Yana Osnytska, Rafal Stojko, Agnieszka Drosdzol-Cop

引用次数: 0

Squamous cell carcinoma evolving from mature cystic teratoma of the ovary. 从卵巢成熟囊性畸胎瘤演变而来的鳞状细胞癌。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2023-09-19 DOI: 10.5603/gpl.96501

Marlena Cwynar, Karolina Kowalczyk, Grzegorz Cwynar, Piotr Ptak, Mykola Chekan

引用次数: 0

Clinical significance of bladder training in preoperative localization of high-intensity focused ultrasound ablation of uterine fibroids. 膀胱训练在子宫肌瘤高强度聚焦超声消融术术前定位中的临床意义。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2022-12-08 DOI: 10.5603/GP.a2022.0142

Xiaofei He, Sha Liao

{"title":"Clinical significance of bladder training in preoperative localization of high-intensity focused ultrasound ablation of uterine fibroids.","authors":"Xiaofei He, Sha Liao","doi":"10.5603/GP.a2022.0142","DOIUrl":"10.5603/GP.a2022.0142","url":null,"abstract":"Objectives: High-intensity focused ultrasound (HIFU) is widely used to treat uterine fibroids. HIFU preoperative localization of uterine fibroids can be used to determine whether the patient is a suitable candidate for HIFU treatment. This study investigated the clinical significance of bladder training in improving the success rate of HIFU preoperative localization uterine fibroids.Material and methods: Our sample consists of patients who planned to undergo HIFU treatment in our hospital but who were failed in previous HIFU preoperative localization. They were recruited between July 2021 and April 2022, and randomly divided into experimental and control groups. A total of 150 patients were enrolled. Each group consisted of 75 patients. The patients in the experimental group adopted the procedure of drinking water multiple times and retaining urine. The training program lasted three days. The patients in the control group were required to keep regular drinking and urination habits without any special instructions or requirements.Results: There were no statistically significant differences between the two groups in maximum bladder capacity, residual urine volume of bladder, bladder filling levels, and bladder shape change. After bladder training, the maximum bladder capacity and the degree bladder shape change of the patients in the experimental group were improved significantly. The success rate of HIFU preoperative localization in the patients in the experimental group was significantly higher than that of the control group.Conclusions: Bladder training can effectively improve the success rate of HIFU preoperative localization of uterine fibroids.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"791-795"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10361253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0