Ginekologia polska最新文献_第2页

Endoglin promotes cell migration and invasion in endometriosis by regulating EMT. Endoglin 通过调节 EMT 促进子宫内膜异位症的细胞迁移和侵袭。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2021-09-20 DOI: 10.5603/GP.a2021.0130

Xiutang Chen, Junjian Wang, Feixia Tu, Qing Yang, Dan Wang, Qin Zhu

{"title":"Endoglin promotes cell migration and invasion in endometriosis by regulating EMT.","authors":"Xiutang Chen, Junjian Wang, Feixia Tu, Qing Yang, Dan Wang, Qin Zhu","doi":"10.5603/GP.a2021.0130","DOIUrl":"10.5603/GP.a2021.0130","url":null,"abstract":"Objectives: This study aims to investigate the expression and role of Endoglin (ENG) in endometriosis (EM).Material and methods: In this study, quantitative real-time polymerase chain reaction, western blot and immunohistochemistry were used to examine the expression of ENG in tissues. Cellular experiments were performed to evaluate the effect of ENG on cellular biological function. Western blot was used to examine the expression of epithelial to mesenchymal transition-related proteins.Results: The expression of ENG was significantly higher in the ectopic endometriotic tissues than that in eutopic endometriotic tissues. Knockdown of ENG inhibited cell viability, migration and invasion, and induced cell apoptosis in hEM15A cells. Additionally, silenced ENG caused increased levels of E-cadherin and decreased levels of N-cadherin, vimentin, MMP-2 and MMP-9.Conclusions: These results confirmed that ENG may be involved in the development of endometriosis by promoting EMT process, revealing a new insight into the pathogenesis of endometriosis and contributing to the exploration of molecular therapeutic strategies against endometriosis.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39431986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse pregnancy outcomes for women with endometriosis: a systematic review and meta-analysis. 子宫内膜异位症妇女的不良妊娠结局：系统回顾和荟萃分析。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2021-09-20 DOI: 10.5603/GP.a2021.0081

Jian-Qing Wang, Jia-Miao Zhang, Bin Qian

{"title":"Adverse pregnancy outcomes for women with endometriosis: a systematic review and meta-analysis.","authors":"Jian-Qing Wang, Jia-Miao Zhang, Bin Qian","doi":"10.5603/GP.a2021.0081","DOIUrl":"10.5603/GP.a2021.0081","url":null,"abstract":"Objectives: This study aimed at assessing the adverse outcomes of pregnancy in women with endometriosis.Material and methods: The Cochrane, Embase and PubMed databases were searched for identifying the required studies published before June 2019. Meta-analyses of relative risk (RR) were performed under the random-effects model to estimate the risk of selected adverse outcomes of pregnancy in females with endometriosis.Results: Twenty-eight studies (53,141 women with and 2,355,923 women without endometriosis data) were selected for meta-analysis. Endometriosis bearing females had a significantly higher risk placenta previa (RR 3.92 [95% CI 2.48-6.20]), miscarriage (RR 1.31 [95% CI 1.06-1.61), gestational hypertension (RR 1.30 [95% CI 1.02-1.65]), cesarean section (RR 1.48 [95% CI 1.33-1.65]) and preeclampsia (RR 1.18 [95% CI 1.09-1.28]). The incidence of placental abruption was not statistically significant between the groups (RR 3.62 [95% CI [0.99-13.28]).Conclusions: Women suffering from endometriosis are at higher risks of miscarriage, preterm birth, gestational hypertension, placenta previa, cesarean section, and preeclampsia.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39431891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of CA125, human epididymis protein 4 (HE4), risk of ovarian malignancy algorithm (ROMA), risk of malignancy index (RMI) and subjective assessment (SA) in preoperative diagnosing of ovarian tumors. CA125、人附睾蛋白 4（HE4）、卵巢恶性肿瘤风险算法（ROMA）、恶性肿瘤风险指数（RMI）和主观评估（SA）在卵巢肿瘤术前诊断中的应用。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2023-01-04 DOI: 10.5603/GP.a2022.0144

Lukasz Janas, Grzegorz Stachowiak, Ewa Glowacka, Iwona Piwowarczyk, Magdalena Kajdos, Malwina Soja, Martyna Masternak, Marek Nowak

{"title":"The use of CA125, human epididymis protein 4 (HE4), risk of ovarian malignancy algorithm (ROMA), risk of malignancy index (RMI) and subjective assessment (SA) in preoperative diagnosing of ovarian tumors.","authors":"Lukasz Janas, Grzegorz Stachowiak, Ewa Glowacka, Iwona Piwowarczyk, Magdalena Kajdos, Malwina Soja, Martyna Masternak, Marek Nowak","doi":"10.5603/GP.a2022.0144","DOIUrl":"10.5603/GP.a2022.0144","url":null,"abstract":"Objectives: To compare utility of CA125, human epididymis protein 4 (HE4), risk of ovarian malignancy algorithm (ROMA), risk of malignancy index (RMI) and subjective assessment (SA) in preoperative diagnosis of ovarian tumors.Material and methods: Research was conducted among 456 patients qualified for surgery due to ovarian tumor. Preoperatively, CA125 and HE4 serum levels were estimated, and transvaginal ultrasound was performed. ROMA and RMI values and SA qualifications were obtained. Results were compared with pathomorphological findings.Results: Receiver Operating Characteristic (ROC)-Area Under Curve (AUC) values for CA125, HE4, ROMA, RMI and SA in preoperative diagnosis of malignant lesions were 0.819, 0.909, 0.911, 0.895 and 0.895, respectively. Combinations of biochemical and sonographic methods increased sensitivity in diagnosis of ovarian tumors. Combinations utilizing serum HE4 concentrations were most useful.Conclusions: CA125, HE4, ROMA, RMI and SA proved to be useful in preoperative diagnosis of ovarian tumors. HE4 and ROMA occurred to be the most useful. Ultrasonographic methods are considerably useful in diagnosis of ovarian tumors. RMI and SA present similar overall diagnostic value.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10533203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apical defect - the essence of cystocele pathogenesis? 顶端缺损--膀胱囊肿发病机制的本质？

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2023-03-17 DOI: 10.5603/GP.a2023.0022

Pawel Szymanowski, Wioletta K Szepieniec, Hanna Szweda, Janusz Ligeza, Anna Sadakierska-Chudy

{"title":"Apical defect - the essence of cystocele pathogenesis?","authors":"Pawel Szymanowski, Wioletta K Szepieniec, Hanna Szweda, Janusz Ligeza, Anna Sadakierska-Chudy","doi":"10.5603/GP.a2023.0022","DOIUrl":"10.5603/GP.a2023.0022","url":null,"abstract":"Objectives: Lack of standardization causes misunderstandings in planning of cystocele treatment and the evaluation of surgical method effectiveness. The POP-Q System and DeLancey's three levels of pelvic support do not account for the phenomenon of cystocele caused by an apical defect. We aimed to evaluate the impact of level I defect on the formation of cystocele.Material and methods: Women reporting complaints related to bladder prolapse (cystocele) were subjected to a urogynecological examination. For this purpose, a simple and standardized method was used, based on the POP-Q System and DeLancey's three levels of pelvic support. Furthermore, it was expanded by evaluating the impact of level I defect (apical defect) on prolapse at level II of the anterior compartment.Results: In total, contribution of an apical defect to the pathogenesis of cystocele was founded in 72.2% of 302 female patients included in this study. In 30.8% the cystocele was caused exclusively by an apical defect. In turn, in 41.4% of patients, it resulted from concomitant apical and level II defect of the anterior compartment (lateral or central).Conclusions: The results of this study indicate that an apical defect may play a significant role in the development of a cystocele. Hence, it could be essential to take the influence of an apical defect on level II in anterior compartment into account when planning a surgical procedure. The authors suggest that lack of such procedures potentially exposes some cystocele patients to ineffective treatment.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9121325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using progesterone to follicular index ratio is better correlated with intracytoplasmic sperm injection outcome than using serum progesterone level alone. 与单纯使用血清孕酮水平相比，使用孕酮与卵泡指数比值与卵胞浆内单精子注射结果的相关性更好。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2023-05-30 DOI: 10.5603/GP.a2023.0031

Athba Abid Kadhim, Thuraya Hussamuldeen Abdulla, Ula Mohammad Alkawaz

{"title":"Using progesterone to follicular index ratio is better correlated with intracytoplasmic sperm injection outcome than using serum progesterone level alone.","authors":"Athba Abid Kadhim, Thuraya Hussamuldeen Abdulla, Ula Mohammad Alkawaz","doi":"10.5603/GP.a2023.0031","DOIUrl":"10.5603/GP.a2023.0031","url":null,"abstract":"Objectives: to investigate the possibility of using the ratio of serum progesterone level to the number of follicles, according to ovarian response in the day of human chorionic gonadotrophin trigger, as a predictor of cycle outcome.Material and methods: A prospective intervensional study was conducted at Kamal Al-Samarai Hospital for Infertility Treatment and IVF during the period from December 2020 to September 2021. Ninety infertile women underwent intracytoplasmic sperm injection (ICSI) cycles using antagonist protocol. Moreover, once the patient reached triggering criteria, meticulous recording of follicular index together with serum estrogen level and serum progesterone level are measured. Fresh embryo transfer of cleavage stage embryo is done once serum progesterone level was less than 1.5 ng/mL. A follow-up to confirm pregnancy rate and cycle outcome was done.Results: The study showed a positive pregnancy rate of 28.9%. The relationship between progesterone follicular index (Prog/FI) ratio and (ICSI) outcome was highly significant with a p value of 0.001. Additionally, an inverse relationship, as the ratio was lower the pregnancy rate was improved, was documented. The receiver operating characteristic (ROC) curve for progesterone follicular index ratio was 0.711 with a cut off value of 0.0354 ng/mL in addition to a sensitivity of 65.6 and a specificity of 65.4.Conclusions: The serum progesterone level is an independent factor for the prediction of intracytoplasmic sperm injection (ICSI) outcome, whereas the progesterone follicular index ratio can be used as a potential marker for predicting ICSI outcome in fresh embryo transfer.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9542220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical significance of S100B protein in pregnant woman with early- onset severe preeclampsia. 早发重度子痫前期孕妇体内 S100B 蛋白的临床意义。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2021-06-09 DOI: 10.5603/GP.a2021.0126

Jinxia Wu, Xiaoqi Sheng, Shaoming Zhou, Chaoying Fang, Yulin Song, Hua Wang, Zhengjun Jia, Xiaozhou Jia, Yiping You

{"title":"Clinical significance of S100B protein in pregnant woman with early- onset severe preeclampsia.","authors":"Jinxia Wu, Xiaoqi Sheng, Shaoming Zhou, Chaoying Fang, Yulin Song, Hua Wang, Zhengjun Jia, Xiaozhou Jia, Yiping You","doi":"10.5603/GP.a2021.0126","DOIUrl":"10.5603/GP.a2021.0126","url":null,"abstract":"Objectives: Preeclampsia is one of the most feared complications of pregnancy, which can progress rapidly to serious complications such as death of both mother and fetus. To present, the leading cause of preeclampsia is still debated. The purpose of this article was to explore the clinical significance of S100B protein, a kind of Ca2+ -sensor protein, in the early-onset severe preeclampsia.Material and methods: Nine pregnant women with early-onset severe preeclampsia (the study group) and 13 healthy pregnant women (the control group) were included in this study. The level of S100B in the amniotic fluid, maternal blood, and umbilical cord blood were detected by enzyme-linked immunosorbent assay (ELISA) and surface plasmon resonance imaging (SPRi) methods. Diagnostic values of S100B for early-onset severe preeclampsia were assessed by Receiver Operating Characteristic (ROC) curve analysis.Results: The levels of S100B in maternal blood and amniotic fluid in the study group were higher than those in the control group (p < 0.05). ROC curve analysis showed that S100B detected by SPRi method (SPRi-S100B) showed a cut-off level of 181 ng/mL with sensitivity of 100%, a specificity of 84.6%, and a Youden index of 0.846 in the maternal blood, which had better clinical significance and diagnostic value (at than that detected by ELISA (ELISA-S100B).Conclusions: The levels of S100B detected by SPRi in maternal blood can indicate early-onset severe preeclampsia and perinatal brain injury.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39077413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LncRNA-loc391533 is involved in the progression of preeclampsia through VEGF. LncRNA-loc391533通过血管内皮生长因子参与子痫前期的进展。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2022-08-09 DOI: 10.5603/GP.a2022.0056

Jun Xiong, Xuan Jin, Kangxiang Xu, Bingqi Wu, Yuqi Xu, Dong Ruan, Xiaoju He

{"title":"LncRNA-loc391533 is involved in the progression of preeclampsia through VEGF.","authors":"Jun Xiong, Xuan Jin, Kangxiang Xu, Bingqi Wu, Yuqi Xu, Dong Ruan, Xiaoju He","doi":"10.5603/GP.a2022.0056","DOIUrl":"10.5603/GP.a2022.0056","url":null,"abstract":"Objectives: Preeclampsia (PE) is a leading cause of maternal death worldwide, which is one of the most major pregnancy complications. The effects of vascular endothelial growth factor (VEGF) and lncRNA-loc391533 on PE were evaluated in the present study.Material and methods: Expression of VEGF in pregnant women with PE was determined using immunohistochemical and enzyme linked immunosorbent assay (ELISA). The effects of lncRNA-loc391533 knockdown and overexpression on VEGF expression was detected using quantitative polymerase chain reaction (qPCR) and western blotting. Loss/gain-of-function assays were performed to evaluate the role of lncRNA-loc391533 on proliferation, cell cycle and migration of trophoblasts HTR-8/SVneo cells.Results: We found that VEGF and its receptor VEGFR1/2 were low expressed in PE. Knockdown of lncRNA-loc391533 enhanced VEGF expression, while overexpression of lncRNA-loc391533 downregulated VEGF. Moreover, lncRNA-loc391533 was required for proliferation and migration of HTR-8/SVneo cells.Conclusions: In conclusion, our findings emphasized that lncRNA-loc391533 exhibited a critical role in progression of PE through VEGF, which might as a novel therapeutic target for PE treatment.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40597146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 18-year-old-girl with unicornuate uterus and endometriosis. 患有单角子宫和子宫内膜异位症的 18 岁女孩。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2023-04-12 DOI: 10.5603/GP.a2023.0040

Yana Osnytska, Rafal Stojko, Agnieszka Drosdzol-Cop

引用次数: 0

ICTP concentration in cervical-vaginal fluid as a potential marker of membrane collagen degradation before labor. 宫颈阴道液中的 ICTP 浓度是临产前膜胶原降解的潜在标志物。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2023-03-17 DOI: 10.5603/GP.a2023.0018

Magdalena Kolak, Joanna Gorecka, Malgorzata Radon-Pokracka, Maciej Piasecki, Agnieszka Cierniak, Agnieszka Micek, Anna Horbaczewska, Andrzej Jaworowski, Hubert Huras

{"title":"ICTP concentration in cervical-vaginal fluid as a potential marker of membrane collagen degradation before labor.","authors":"Magdalena Kolak, Joanna Gorecka, Malgorzata Radon-Pokracka, Maciej Piasecki, Agnieszka Cierniak, Agnieszka Micek, Anna Horbaczewska, Andrzej Jaworowski, Hubert Huras","doi":"10.5603/GP.a2023.0018","DOIUrl":"10.5603/GP.a2023.0018","url":null,"abstract":"Objectives: Numerous physical and chemical processes lead to rupture of membranes. Within the fetal membranes there are numerous types of metalloproteinases, which cause collagen type I degradation. The C-terminal telopeptide of colagen type I (ICTP) is the breakdown product of type I collagen. The aim of the study was to determine whether ICTP is secreted into the vaginal-cervical fluid (VCF) in the case of physiological rupture of the membranes of the fetus before delivery.Material and methods: The study was conducted in March 2021 at the Department of Obstetrics and Perinatology of the Jagiellonian University in Cracow, Poland. Twenty-three cases were included in the study. During routine gynecological examination with the use of specula, VCF was collected twice in a volume of 50 µL. The obtained material was then subjected to enzyme immunoassay using the Human C-telopeptide of type I collagen (ICTP) ELISA Kit (Catalog Number. CSB-E10363h). The concentration of ICTP in the sample was calibrated. The concentration range that the device can detect was 25 ng /mL-800 ng/mL.Results: The presence of ICTP in the VCF was confirmed. The minimum concentration was 43.72 ng/mL, the maximum was 762.59, in five cases the concentration was outside the maximum scale of the device.Conclusions: ICTP was confirmed in the VCF of pregnant women before physiological delivery. Further studies are required to accurately evaluate ICTP as a marker of the processes of collagen degradation in fetal membranes in the mechanism of physiological labor and premature rupture of the membranes.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9121332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Squamous cell carcinoma evolving from mature cystic teratoma of the ovary. 从卵巢成熟囊性畸胎瘤演变而来的鳞状细胞癌。

IF 1.2 4区医学

Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2023-09-19 DOI: 10.5603/gpl.96501

Marlena Cwynar, Karolina Kowalczyk, Grzegorz Cwynar, Piotr Ptak, Mykola Chekan

引用次数: 0