Gerontology最新文献

{"title":"A 20-s Video-Based Assessment of Cognitive Frailty: Results from a Cohort Study within the Precision Aging Network.","authors":"Bijan Najafi, Myeounggon Lee, Mohammad Dehghan Rouzi, J Ray Runyon, Esther M Sternberg, Bonnie J LaFleur","doi":"10.1159/000546227","DOIUrl":"10.1159/000546227","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive frailty, the concurrent presence of mild cognitive impairment and physical frailty, poses a significant risk for adverse outcomes in older adults. Traditional assessments that rely on extensive walking tests or specialized equipment are impractical for routine or remote evaluations. This study evaluated a 20-s video-based Upper Frailty Meter (vFM) test, incorporating dual-task conditions, as a feasible tool for identifying cognitive frailty.</p><p><strong>Methods: </strong>Data from 413 participants aged 50-79 years in the Healthy Minds for Life cohort were analyzed across four sites: the University of Arizona, Johns Hopkins University, Emory University, and the University of Miami. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA), whereas frailty indices were derived from the vFM test. Participants performed repetitive elbow flexion extension under single-task (physical task only) and dual-task (physical task with concurrent cognitive exercise) conditions. Frailty phenotypes, including slowness, weakness, and exhaustion, were quantified using AI-based video kinematic analysis. Logistic regression and receiver operating characteristic (ROC) analyses evaluated the model's predictive accuracy for cognitive frailty.</p><p><strong>Results: </strong>Participants classified as cognitive frailty group (n = 53, 12.8%) demonstrated significantly higher frailty index scores compared to robust individuals (p < 0.001). Among all vFM-derived parameters, the dual-task slowness phenotype demonstrated the strongest correlation with MoCA scores (r = -0.282, p < 0.001) and emerged as the most predictive single marker for distinguishing the cognitive frailty group, demonstrating high clinical applicability (area under the curve [AUC] = 0.87). Combining single-task and dual-task metrics further enhanced predictive accuracy (AUC = 0.91), achieving sensitivity and specificity rates exceeding 85%. This combined approach significantly differentiated cognitive frailty from robust status, outperforming models based on age alone or single-task metrics.</p><p><strong>Conclusion: </strong>The 20-s vFM test offers a practical, noninvasive, easy-to-implement, and accessible solution for objectively evaluating cognitive frailty, demonstrating high predictive accuracy in distinguishing at-risk individuals. Its integration into telehealth platforms could enhance early detection and enable timely interventions, promoting healthier aging trajectories. Further longitudinal studies are recommended to validate its utility in tracking cognitive and physical decline over time.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"589-600"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Tumor Necrosis Factor-Alpha Inhibitor Use and Dementia Risk in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.","authors":"DaRae Chung, Yoojin Noh, Yun Mi Yu, Young-Mi Ah","doi":"10.1159/000544123","DOIUrl":"10.1159/000544123","url":null,"abstract":"<p><strong>Introduction: </strong>Tumor necrosis factor-alpha inhibitors (TNFi), commonly prescribed for rheumatoid arthritis (RA), have been studied for their potential association with dementia risk. However, previous findings are inconclusive. This study aimed to evaluate the impact of TNFi use on dementia in patients with RA.</p><p><strong>Methods: </strong>A systematical search of MEDLINE, Embase, and CENTRAL databases from inception to October 1, 2023, was conducted. Longitudinal comparative studies investigating the association between TNFi use and risk of dementia in patients with RA were included. Pooled adjusted risks of dementia and meta-analysis were conducted to synthesize relative estimates with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Seven observational studies involving 633,089 patients with RA were included, of which 6 were included in the meta-analysis. The pooled meta-analysis comparing the risk of dementia (hazard ratio [HR] = 0.77, 95% CI: 0.64-0.93) and Alzheimer's disease (AD) (odds ratio = 0.31, 95% CI: 0.23-0.43) between TNFi users and non-users showed a significant association. However, the pooled HR for AD risk was inconsistent. Also, the subgroup analyses indicated that TNFi use was associated with a decreased dementia risk in older adult patients with a mean age of ≥65 years at enrollment (HR = 0.86, 95% CI: 0.80-0.92) and TNFi new users (HR = 0.86, 95% CI: 0.80-0.92).</p><p><strong>Conclusions: </strong>Systematic review and meta-analysis suggest that lowering the level of systemic TNF-alpha by using TNFi could lower the risk of dementia. However, given the retrospective nature of the included studies, further prospective studies are needed to evaluate the role of TNFi in dementia onset.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":"71 4","pages":"308-318"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Falls in the Oldest Old: Role of Gender, Living Situation, and Assistive Devices.","authors":"Katherine A Colcord, Luohua Jiang, Zarui A Melikyan, Zeinah Al-Darsani, Nikki Jagusch Arnold, Hayley B Kristinsson, Claudia H Kawas, María M Corrada","doi":"10.1159/000547067","DOIUrl":"10.1159/000547067","url":null,"abstract":"<p><strong>Introduction: </strong>Falls can have serious health consequences, especially in the oldest old (individuals 90+ years), for whom falls often result in injury or even death. Few studies have examined falls in the oldest old. We aim to assess fall prevalence, fall rate, and rate change over time according to gender, living situation, and assistive device use.</p><p><strong>Methods: </strong>Participants are from the 90+ Study, a longitudinal study of individuals 90 years and older with evaluations every 6 months. Participants, or their informants, were asked how many times they have fallen in the past year (first visit) or since their last visit (follow-up visits). We calculated unadjusted baseline fall prevalence. Using generalized linear mixed regression models, we estimated adjusted baseline fall rate and adjusted change in rate over time by gender, living situation, and assistive device.</p><p><strong>Results: </strong>In 1,672 participants (mean age 93 years, range 90-110 years), unadjusted baseline prevalence of 1+ falls was 47.8% in women and 47.9% in men. Estimated adjusted baseline fall rate was 0.66 falls per person-year in women and 0.71 falls per person-year in men. In women, fall rate did not change significantly over time, whereas in men, fall rate increased by an average of 6% per year. Both men and women in nursing homes had a higher fall rate compared with those in the community. In nursing homes, fall rate remained stable over time in men and decreased over time in women. Fall rate was higher in both men and women using assistive devices. However, walkers were associated with a decrease in fall rate over time in women and in participants in nursing homes. Canes were unexpectedly associated with an increase in fall rate over time.</p><p><strong>Conclusion: </strong>Individuals 90 years and older had a high prevalence of falls overall. The higher and increasing rate of falls over time in men compared to women suggests that efforts should be made to increase the uptake of fall prevention strategies specifically in men in the oldest age categories. The increasing fall rate in participants using canes suggests that referral to a health care provider trained in gait analysis prior to assistive device prescription could assist with fall prevention efforts in the oldest old.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"723-733"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily Fluctuations in Subjective Age among Older Adults: Links with Stressors, Positive Events, and Emotional Reactions.","authors":"Patrick Klaiber, Theresa Pauly","doi":"10.1159/000543805","DOIUrl":"10.1159/000543805","url":null,"abstract":"<p><strong>Introduction: </strong>Subjective age, or felt age, refers to individuals' perception of their age compared to their chronological age. Feeling older than usual has been associated with experiencing more same-day stressors and higher negative affect. Feeling older may indicate depleted psychological resources, increasing the likelihood of interpreting everyday situations as stressful and reacting more intensely to them. Conversely, feeling younger may indicate greater psychosocial resources, enhancing engagement in and responsiveness to positive events.</p><p><strong>Methods: </strong>This study investigated fluctuations in subjective age as a predictor of same-day event occurrence (stressors and positive events) and affective responses to these events using 14-day diary data from a sample of 108 older Swiss adults (aged 65-92).</p><p><strong>Results: </strong>On average, participants felt approximately 8 years younger than their chronological age, with significant day-to-day variability (ICC = 0.69). On days when individuals felt older than usual, they reported more stressors and fewer positive events. Older subjective age was also associated with greater stress reactivity (greater upticks in negative affect and greater dips in positive affect) and more pronounced responses to positive events. Time-ordered effects showed subjective age predicting positive events, but not stressors.</p><p><strong>Conclusion: </strong>These findings underscore the importance of subjective age as a dynamic psychological construct potentially shaping the events people encounter and how they affectively respond to them. In addition, the lagged analyses provide evidence for subjective age as a predictor of daily event processes, but not for daily events as predictors of future subjective age, which contributes to disentangling the direction of association.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":"71 3","pages":"239-251"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Living at Moderate Altitude in the USA: Epidemiology and Key Research Questions.","authors":"Elan Small, Deborah Thomas, Lake Crawford, Isabelle Chatroux, Harrison Steins, Moses Asori, Ben Honigman","doi":"10.1159/000546192","DOIUrl":"10.1159/000546192","url":null,"abstract":"<p><strong>Background: </strong>Over the last 20 years, the USA has seen a significant population migration into moderate elevation locations (defined as elevations 1,800-2,500 m for the purposes of this review). While considerable research has investigated how chronic diseases are impacted on acute ascent to high altitude, little research has examined how residing at high altitude impacts longer term health including risk of various disease states and long-term morbidity, with even fewer studies examining moderate altitude specifically.</p><p><strong>Summary: </strong>This review investigated how living at moderate elevation impacts seven different disease states/health issues pertinent to the aging individual. Overall, this review reveals a limited literature in this field, though with interesting findings that warrant the need for further studies. While limited studies have documented a potential protective effect of moderate altitude on ischemic heart disease and obesity prevalence, current evidence suggests worse outcomes for chronic obstructive pulmonary disease, possibly increased rates of pulmonary hypertension and low birth weight (which increases risk of chronic diseases later in life), negative impacts on sleep, and increased association with risk of mental health issues including suicide.</p><p><strong>Key messages: </strong>Residing at moderate altitude appears to be beneficial for some disease states but detrimental to others. Further research is needed to solidify these associations, particularly for aging populations, and more importantly to understand the mechanisms that might explain these associations. Understanding the role of mild hypoxia in health resulting from living at moderate altitudes guides improved care delivery and the design of public health interventions.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"535-545"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential Role of Mitochondria in Age-Related Health Benefits Conferred by Moderate Hypoxia.","authors":"Johannes Burtscher, Kamilla Woznica Miskowiak, Katharina Hüfner, Hannelore Ehrenreich, Martin Kopp","doi":"10.1159/000546478","DOIUrl":"10.1159/000546478","url":null,"abstract":"<p><strong>Background: </strong>Mitochondrial integrity and efficiency deteriorate with age and are linked to cellular senescence. Mitochondria are highly responsive to reduced oxygen availability (hypoxia), which, e.g., occurs when exposed to altitude. We hypothesize that mitochondria are involved in the observed health benefits at moderate altitude. Because the experimental evidence on mitochondrial changes at moderate altitude is limited, we also evaluate dose-response associations of oxygen transport and mitochondrial functions derived from measurements at normoxia and severe hypoxia.</p><p><strong>Summary: </strong>We summarize the effects of environmental oxygen availability and changes in cellular oxygen demand/supply on mitochondrial functions and assess, how this may influence aging. Hypotheses are presented how mild hypoxia at moderate altitude (1,000-2,500 m) could improve mitochondrial function and possibly explain the reported lower levels of mortality from several age-related diseases.</p><p><strong>Key messages: </strong>It is unknown, whether continuous or intermittent types of hypoxia exposure are more effective in improving mitochondrial functions and promoting healthy aging. The combination of tissue-specific oxygen demand (e.g., during physical exercise) with mild reductions of ambient oxygen availability may enable the reported health benefits associated with moderate altitude residence.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"555-563"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Relationship between Primary Sarcopenia and Intestinal Barrier Dysfunction in Geriatric Patients: Insights from SARC-F, Serum DAO, Zonulin, LPS, and I-FABP Levels.","authors":"Seyda Bilgin, Veysel Suzan, Bahar Bektan Kanat, Gulru Ulugerger Avci, Suna Avci, Hakan Yavuzer, Ibrahim Murat Bolayırlı, Alper Doventas, Deniz Suna Erdincler","doi":"10.1159/000545939","DOIUrl":"10.1159/000545939","url":null,"abstract":"<p><strong>Introduction: </strong>Objectives of this study were to assess the correlation between serum levels of DAO (diamine oxidase), LPS (lipopolysaccharide), I-FABP (intestinal fatty acid binding protein), and zonulin with primary sarcopenia in elderly patients and to compare the diagnostic performance of these biomarkers with the SARC-F score.</p><p><strong>Methods: </strong>The study included 88 patients aged 65 and above. Comorbidities and geriatric syndromes were assessed, and those with secondary sarcopenia were excluded. The EWGSOP2 criteria were applied for diagnosing sarcopenia, while the SARC-F questionnaire was utilized to identify individuals at risk of sarcopenia. Serum levels of DAO, zonulin, LPS, and I-FABP were measured using ELISA.</p><p><strong>Results: </strong>No significant differences were observed between the two groups regarding age and gender. SARC-F, serum DAO, and zonulin concentrations were notably higher in the sarcopenia group than in the non-sarcopenia group (p < 0.001). Statistically significant parameters were analyzed using stepwise multiple regression. In stepwise multivariate logistic regression analysis, both DAO and zonulin scores were found to be associated with sarcopenia (odds ratio [OR] 1.041, 95% confidence interval [CI]: 1.020-1.063, p < 0.001; OR 1.108, 95% CI: 1.018-1.206, p = 0.018, subsequently). ROC curve analysis revealed that the area under the curve for DAO, zonulin, and SARC-F was 0.807 (p < 0.001), 0.723 (p < 0.001), and 0.943 (p < 0.001), subsequently. The Spearman correlation test revealed a significant, low correlation between serum zonulin and the SARC-F score (r = 0.3583, p = 0.0006) and a moderate correlation between serum DAO and the SARC-F score (r = 0.4384, p < 0.0001).</p><p><strong>Conclusion: </strong>This study is the first to show a connection between primary sarcopenia and intestinal barrier dysfunction. While the findings support the use of the SARC-F questionnaire in routine practice, serum levels of DAO and zonulin could serve as an alternative when the SARC-F questionnaire is not applicable.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"513-523"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward Senior-Friendly Hospitals: An Overview of Programs, Their Elements and Effectiveness in Improving Care.","authors":"Kira Scheerman, Julio R Klaverweide, Carel G M Meskers, Andrea B Maier","doi":"10.1159/000540655","DOIUrl":"10.1159/000540655","url":null,"abstract":"<p><strong>Background: </strong>Comprehensive \"senior-friendly hospital\" (SFH)-programs have been developed to counteract negative health outcomes in hospitalized older adults. The aim of this narrative review was to provide an overview of published SFH-programs and their elements and to summarize evidence of their effect on quality of care and patient satisfaction.</p><p><strong>Summary: </strong>A search of the databases Pubmed/Medline from inception to July 2023 and of governmental, regional, and hospital websites was performed. Programs were earmarked as SFH-programs if they primarily focused on the hospital setting, and comprised a hospital wide, multilevel approach and consisted of multiple elements. Articles and reports were included if participants were hospitalized and aged 60 years and older, and described the effect on quality of care or patient satisfaction. Articles focusing on specific patient groups or wards or on a health system or network were excluded. Ten SFH-programs were identified, with mutual elements like \"organizational support,\" \"social climate and services,\" \"processes of care,\" and \"physical environment.\" Only for the \"Acute Care for Elders\" program (USA), evidence was found showing positive effects on functional abilities, falls, delirium, length of stay, and patient satisfaction; effectiveness of other SFH-programs could not be found.</p><p><strong>Key message: </strong>Elements of SFH-programs may improve care for hospitalized older adults, but the evidence of their effectiveness is scarce.</p><p><strong>Background: </strong>Comprehensive \"senior-friendly hospital\" (SFH)-programs have been developed to counteract negative health outcomes in hospitalized older adults. The aim of this narrative review was to provide an overview of published SFH-programs and their elements and to summarize evidence of their effect on quality of care and patient satisfaction.</p><p><strong>Summary: </strong>A search of the databases Pubmed/Medline from inception to July 2023 and of governmental, regional, and hospital websites was performed. Programs were earmarked as SFH-programs if they primarily focused on the hospital setting, and comprised a hospital wide, multilevel approach and consisted of multiple elements. Articles and reports were included if participants were hospitalized and aged 60 years and older, and described the effect on quality of care or patient satisfaction. Articles focusing on specific patient groups or wards or on a health system or network were excluded. Ten SFH-programs were identified, with mutual elements like \"organizational support,\" \"social climate and services,\" \"processes of care,\" and \"physical environment.\" Only for the \"Acute Care for Elders\" program (USA), evidence was found showing positive effects on functional abilities, falls, delirium, length of stay, and patient satisfaction; effectiveness of other SFH-programs could not be found.</p><p><strong>Key message: </strong>Elements of SFH-programs ma","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-12"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11777139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Potential Blood-Based Biomarkers for Frailty by Using an Integrative Approach.","authors":"Shruti Karnik, Anu Gaikwad, Harishchandra Chaudhari, Priyanka Khopkar-Kale","doi":"10.1159/000543970","DOIUrl":"https://doi.org/10.1159/000543970","url":null,"abstract":"","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":"71 4","pages":"319-320"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Physical Activity Type on Serum Remnant Cholesterol Level in Korean Adults: A Nationwide Population-Based Study.","authors":"Hye Jun Lee, Jung-Ha Kim","doi":"10.1159/000545328","DOIUrl":"10.1159/000545328","url":null,"abstract":"<p><strong>Introduction: </strong>Remnant cholesterol (RC) is an important contributor to cardiovascular disease development. We aimed to investigate the effect of physical activity (PA) type on serum RC levels in Korean adults.</p><p><strong>Methods: </strong>We used data from the 2016-2021 Korea National Health and Nutrition Examination Survey, and included 32,877 adults. Serum RC was calculated by subtracting the low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels from the total cholesterol level. Hyper-remnant cholesterolemia was defined as a serum RC level of ≥30 mg/dL. PA was classified into aerobic, resistance, and walking exercises, which involved practicing 150 min of moderate, 75 min of high-intensity PA, or a combination of the 2, per week; doing resistance exercise more than 2 days per week; walking more than 150 min per week, respectively. Multivariate logistic regression analysis was performed to examine the association between serum RC and PA type.</p><p><strong>Results: </strong>Among those aged <65 years, the odds ratio (OR) of hyper-remnant cholesterolemia was 1.23 times higher in the group that did not perform resistance exercise than in the group that performed more than 2 resistance exercises per week (95% confidence interval [CI] 1.12-1.36, p < 0.0001). Among those aged ≥65 years, the OR of hyper-remnant cholesterolemia was 1.31 times higher in the group that did not practice walking exercise than in the group that walked for more than 150 min per week (95% CI: 1.11-1.55, p < 0.01).</p><p><strong>Conclusion: </strong>This study revealed that resistance exercise in those aged <65 years and walking exercise in those aged ≥65 years were significantly associated with low RC levels in Korean adults.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":"71 5","pages":"365-375"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}