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Author's Reply to "Painting a Clearer Picture by Measuring the Quadriceps Muscle with Ultrasound". 作者对 "用超声波测量股四头肌,让图像更清晰 "的回复
IF 3.1 3区 医学
Gerontology Pub Date : 2024-01-01 Epub Date: 2024-08-27 DOI: 10.1159/000540996
Byung Chan Lee
{"title":"Author's Reply to \"Painting a Clearer Picture by Measuring the Quadriceps Muscle with Ultrasound\".","authors":"Byung Chan Lee","doi":"10.1159/000540996","DOIUrl":"10.1159/000540996","url":null,"abstract":"","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1150-1151"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11548892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Potential Predicting Value of D-Dimer to Fibrinogen Ratio on Functional Outcome at 1 Year after Acute Ischemic Stroke: A Longitudinal Study. D-二聚体与纤维蛋白原比值对急性缺血性卒中后1年功能转归的潜在预测价值:一项纵向研究。
IF 3.1 3区 医学
Gerontology Pub Date : 2024-01-01 Epub Date: 2023-11-03 DOI: 10.1159/000534768
Qingxia Lin, Dongdong Zhou, Yifan Cheng, Chunxue Wu, Binbin Deng
{"title":"The Potential Predicting Value of D-Dimer to Fibrinogen Ratio on Functional Outcome at 1 Year after Acute Ischemic Stroke: A Longitudinal Study.","authors":"Qingxia Lin, Dongdong Zhou, Yifan Cheng, Chunxue Wu, Binbin Deng","doi":"10.1159/000534768","DOIUrl":"10.1159/000534768","url":null,"abstract":"<p><strong>Introduction: </strong>Previous studies have suggested that the D-dimer to fibrinogen ratio (DD/Fg) could be a potential predictor for deep vein thrombosis, pulmonary embolism, and stroke severity. However, the association between plasma DD/Fg and functional outcome following acute ischemic stroke (AIS) has been unclear.</p><p><strong>Methods: </strong>Our study followed the STROBE guideline and used a prospective cohort design to investigate this association. A total of 454 patients with AIS were enrolled consecutively in our study, and the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) were assessed for stroke severity and functional outcome, respectively.</p><p><strong>Results: </strong>We found a significant difference in DD/Fg values between the three groups based on NIHSS scores at admission. Specifically, the DD/Fg values were higher in the poor functional outcome group (mRS score of 2-6) compared to the favorable functional outcome group (mRS score of 0-1) at the 1-year follow-up (p &lt; 0.001). Additionally, the DD/Fg values were independently associated with poor functional prognosis at 1 year following the onset of stroke, even after adjusting for potential confounders (OR 9.21, 95% CI, 3.68-23.02, p &lt; 0.001).</p><p><strong>Conclusions: </strong>Our findings suggest that DD/Fg values at admission may serve as risk predictors for poor functional outcomes in patients with AIS 1 year after the stroke.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"115-124"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71480702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urgent Endoscopic Retrograde Cholangiopancreatography Treatment Useful for Acute Cholangitis Caused by Bile Duct Stones in Patients Aged 90 Years and Older. 紧急内镜逆行胰胆管造影术有助于治疗 90 岁及以上患者因胆管结石引起的急性胆管炎。
IF 3.1 3区 医学
Gerontology Pub Date : 2024-01-01 Epub Date: 2024-09-30 DOI: 10.1159/000541636
Hideaki Kazumori, Kousuke Fukuda, Koji Onishi, Yasuhiko Ohno
{"title":"Urgent Endoscopic Retrograde Cholangiopancreatography Treatment Useful for Acute Cholangitis Caused by Bile Duct Stones in Patients Aged 90 Years and Older.","authors":"Hideaki Kazumori, Kousuke Fukuda, Koji Onishi, Yasuhiko Ohno","doi":"10.1159/000541636","DOIUrl":"10.1159/000541636","url":null,"abstract":"<p><strong>Background: </strong>Recently, the incidence of acute obstructive cholangitis caused by bile duct stones in patients aged 90 years and older (super-old) has been increasing, for which urgent endoscopic retrograde cholangiopancreatography (ERCP) treatment may be required. The aim of this study was to evaluate the efficacy and safety of urgent ERCP in super-old patients with acute cholangitis caused by bile duct stones.</p><p><strong>Methods: </strong>A total 147 consecutive patients aged between 75 and 99 years who underwent urgent ERCP for acute cholangitis caused by bile duct stones were analyzed in a retrospective manner. They were divided into the old (age 75-89 years, control) and super-old (age 90-99 years) groups. Urgent ERCP efficacy and safety, including general status, ERCP-related findings and outcomes, cardiopulmonary monitoring during ERCP, and mortality, were compared between the groups.</p><p><strong>Results: </strong>The physical status of the super-old group was worse than that of the old group. The success rates for biliary drainage and complete clearance of bile duct stones at the first attempt in the super-old group were lower as compared to the old group, while those after two attempts increased in the super-old group and were nearly the same as in the old group. No fatal cardiopulmonary complications during ERCP were observed in either group. Mortality rate within 2 months was higher in the super-old group, though recovered to the same level as in the old group after 2 months.</p><p><strong>Conclusions: </strong>Efficacy and safety of urgent ERCP treatment in super-old patients were comparable to those seen in old patients, though the overall trend indicated greater difficulty. Urgent ERCP treatment can be useful for acute cholangitis caused by bile duct stones in super-old patients.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1258-1266"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of Geriatric Rehabilitation Inpatients with Nocturia: RESORT. 有夜尿症的老年康复住院病人的特征:RESORT.
IF 3.1 3区 医学
Gerontology Pub Date : 2024-01-01 Epub Date: 2024-10-21 DOI: 10.1159/000542056
Wendy F Bower, Lisa Lau, D Michael Whishaw, Esmee M Reijnierse, Andrea B Maier
{"title":"Characteristics of Geriatric Rehabilitation Inpatients with Nocturia: RESORT.","authors":"Wendy F Bower, Lisa Lau, D Michael Whishaw, Esmee M Reijnierse, Andrea B Maier","doi":"10.1159/000542056","DOIUrl":"10.1159/000542056","url":null,"abstract":"<p><strong>Introduction: </strong>Nocturnal lower urinary tract symptoms are common in geriatric rehabilitation inpatients but have not been well described. The aim of this study was to compare patient characteristics stratified by self-reported nocturia severity in geriatric rehabilitation inpatients.</p><p><strong>Methods: </strong>The REStORing health of acutely unwell adulTs (RESORT) is an observational, longitudinal, prospective inception cohort of geriatric rehabilitation inpatients who underwent a Comprehensive Geriatric Assessment (CGA) at admission and discharge. Nocturia was captured by item 7 of the American Urology Association Symptom Score (AUASS) and dichotomised as ≤1 void and >1 void at night as per the International Continence Society definition. Differences in demographic, functional, and medical characteristics of the inpatients with and without nocturia >1 were compared.</p><p><strong>Results: </strong>Overall, 641 inpatients completed the nocturia item (mean age 82.6 [SD 7.7] years, 59.9% female). Nocturia occurred >once per night in 57.4%; mean number of episodes was 1.96 (SD 1.38), ranging from 0 to 5. There was no change in nocturia severity between admission and discharge. Daily urinary incontinence, urinary urgency, and comorbid illness were independently associated with multiple nocturia episodes. A history of falls within the last year, difficulty climbing stairs pre-admission, higher faecal incontinence score, impaired quality of life domains, higher levels of anxiety and depression were significantly more common in inpatients with multiple episodes of nocturia compared to no or only one episode of nocturia.</p><p><strong>Conclusion: </strong>Lower urinary tract symptoms, poor functional status and frailty markers were associated with repeated episodes of nocturia. Targeted intervention may reduce the severity of nocturia, with potential to improve sleep quality, impact therapeutic gains and influence discharge destination.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1284-1293"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142463159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinimetric Properties of the "FIND-NEEDS" to Screen Geriatric Conditions. 用于筛查老年病的 "FIND-NEEDS "的临床测量特性。
IF 3.1 3区 医学
Gerontology Pub Date : 2024-01-01 Epub Date: 2024-05-15 DOI: 10.1159/000539261
Chia-Ming Chang, Chung-Ying Lin, Fang-Wen -Hu, Ying-Wei Wang, Chi-Chang Huang, Yu-Tai Lo, Chien-Yuan Wu, Yuan-Fang Chung, Chiu-Chen Kang, Yi-Jung Chen, Yi-Ching Yang, Li-Fan Liu, Mark D Griffiths, Dai-Chan Lin, Meng-Ru Shen
{"title":"Clinimetric Properties of the \"FIND-NEEDS\" to Screen Geriatric Conditions.","authors":"Chia-Ming Chang, Chung-Ying Lin, Fang-Wen -Hu, Ying-Wei Wang, Chi-Chang Huang, Yu-Tai Lo, Chien-Yuan Wu, Yuan-Fang Chung, Chiu-Chen Kang, Yi-Jung Chen, Yi-Ching Yang, Li-Fan Liu, Mark D Griffiths, Dai-Chan Lin, Meng-Ru Shen","doi":"10.1159/000539261","DOIUrl":"10.1159/000539261","url":null,"abstract":"<p><strong>Introduction: </strong>Comprehensive geriatric assessment (CGA) is used to thoroughly assess and identify complex healthcare problems among older adults. However, administration of CGA is time-consuming and labor intensive. A simple screening tool with the mnemonic \"FIND-NEEDS\" was developed to quickly identify common geriatric conditions. The present study was to evaluate the clinimetric properties of the FIND-NEEDS.</p><p><strong>Methods: </strong>The participants comprised first-visiting older adults aged 65 years and above (and who were able to communicate by themselves or with the help of a caregiver) who were assessed (October to December, 2021) using the FIND-NEEDS and CGA at geriatric outpatient clinics of a tertiary, referred medical center. The FIND-NEEDS was examined for its criterion-related validity and compared with the CGA results. Two types of scoring (summed score and binary score) of FIND-NEEDS and CGA were analyzed using Spearman correlation, sensitivity and specificity, and area under receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>The mean age of the 114 outpatients was 78.3 ± 7.6 years, and 79 (69.3%) were female. The internal consistency was excellent when using all FIND-NEEDS items, and was acceptable when using domain scores. Exploratory factor analysis showed that most of the FIND-NEEDS domain scores had factor loadings higher than 0.3. Intercorrelations of binary scores between domains of FIND-NEEDS and CGA showed most domains were moderately correlated. The overall correlation of summed scores between FIND-NEEDS and CGA was high. The FIND-NEEDS summed score was moderately correlated with CGA score (r = 0.494; p &lt; 0.001), and the binary score showed excellent correlation (r = 0.944; p &lt; 0.001). When using the CGA score as the gold standard, the FIND-NEEDS showed excellent AUC (0.950), sensitivity (1.00), and specificity (0.90).</p><p><strong>Discussion/conclusion: </strong>The present study demonstrated that the FIND-NEEDS had acceptable clinimetric properties to screen for geriatric problems among older adults. Further in-depth assessment and care plan can then be conducted afterwards.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"893-902"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Test-Retest Reliability of Movement Displacement during a 20-s Stepping-in-Place Test in Community-Dwelling Older Adults with and without Supportive Care. 社区老年人在接受和未接受支持性护理的情况下进行 20 秒钟原地踏步测试时运动位移的测试-重测可靠性。
IF 3.1 3区 医学
Gerontology Pub Date : 2024-01-01 Epub Date: 2024-07-17 DOI: 10.1159/000539748
Eiji Fujita, Nobuo Takeshima, Hideto Sato, Takeshi Kohama, Masanobu Kusunoki, Yukiya Oba, William F Brechue
{"title":"Test-Retest Reliability of Movement Displacement during a 20-s Stepping-in-Place Test in Community-Dwelling Older Adults with and without Supportive Care.","authors":"Eiji Fujita, Nobuo Takeshima, Hideto Sato, Takeshi Kohama, Masanobu Kusunoki, Yukiya Oba, William F Brechue","doi":"10.1159/000539748","DOIUrl":"10.1159/000539748","url":null,"abstract":"<p><strong>Introduction: </strong>Our recent reports have shown that movement pattern and displacement assessed with an infrared depth sensor during a 20-s stepping-in-place test (ST) correlates with measures of balance and need for assistance in older individuals. This study investigated ST test-retest reliability in community-dwelling older adults with and without supportive care.</p><p><strong>Methods: </strong>Two groups were included: those not participating (HO: n = 25, 74.7 ± 5.2 years) and those participating (DSU: n = 41, 78.8 ± 5.8 years) in regular senior day services (supportive care). HO completed three ST trials, separated by 1 week, while DSU completed two ST trials during the same half-day supportive care visit. Testing was conducted with eyes open. ST measures included head movement path distance (TMD), maximum movement displacement (MMD), knee movement path length (KMD), and stepping rate (STEP). TMD×KMD-1 ratio indicated upper-body sway relative to lower-body. Test-retest reliability (intra-class correlation coefficients, ICCs) and between-trial and between group differences (ANCOVA, adjusting for age) were assessed.</p><p><strong>Results: </strong>After adjusting for age, TMD, KMD, TMD×KMD-1 were lesser and STEP was greater in HO than DUS. HO ST variables did not differ across testing days. HO ICC (1, 3) for TMD (0.911 [95% confidence interval: 0.827-0.958]), MMD (0.918 [0.814-0.961]), KMD (0.838 [0.685-0.923]), and TMD×KMD-1 (0.940 [0.884-0.872]) showed strong to very strong reliability. Similarly, DSU ST variables did not differ across same day trials and ICC (1, 2) for TMD, KMD, and TMD×KMD-1 displayed very strong reliability.</p><p><strong>Conclusion: </strong>These ST variables exhibited excellent test-retest reliability of discriminating between community-dwelling older adults with and without supportive care.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"970-977"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying the Number of Steps Required for Familiarisation to Athletic Footwear in Healthy Older Adults. 确定健康老年人熟悉运动鞋所需的步数。
IF 3.1 3区 医学
Gerontology Pub Date : 2024-01-01 Epub Date: 2024-07-24 DOI: 10.1159/000540022
Diana Soares, Iain Fletcher, Andrew Mitchell, Laura Charalambous
{"title":"Identifying the Number of Steps Required for Familiarisation to Athletic Footwear in Healthy Older Adults.","authors":"Diana Soares, Iain Fletcher, Andrew Mitchell, Laura Charalambous","doi":"10.1159/000540022","DOIUrl":"10.1159/000540022","url":null,"abstract":"<p><strong>Introduction: </strong>Research on athletic footwear familiarisation within an older population is sparse. This is problematic because unfamiliar footwear may act as a new perturbation and modify older adults' walking gait and stability. In addition, while athletic footwear has been suggested to enhance older adults' comfort and support during activities of daily living, the necessary period for familiarisation with athletic footwear is unknown. Therefore, this study aimed to identify the number of steps required for older adults to be familiarised with athletic footwear of different midsole thicknesses.</p><p><strong>Methods: </strong>Twenty-six healthy and physically active community-dwelling older adults, 21 females (71.1 ± 4.5 years; 164.5 ± 5.3 cm; 68.4 ± 11.4 kg) and five males (70.6 ± 2.3 years; 175.2 ± 7.8 cm; 72.8 ± 9.7 kg), completed a walking-based protocol. Participants walked two trials of 200 steps at their habitual speed on a 10-m track of an optical measurement system in three footwear conditions: (1) New Balance® REVlite 890v6 (thick midsole); (2) New Balance® REVlite 1400v5 (moderate midsole); and (3) New Balance® Minimus 20v7 (thin midsole). Gait speed (m.s-1) and walking time (min) were analysed for each participant over the 400 steps. Number of required familiarisation steps were established over three analysis phases, consisting of steady-state gait assessment, averaging and analysis of blocks of 40 steps, and sequentially comparing these steps with a predetermined threshold. Footwear familiarisation was assumed when the mean gait speed fell within an acceptable level (±2 SD from 320 to 360 step values) and subsequently maintained.</p><p><strong>Results: </strong>Most participants were familiarised with all three footwear conditions (thick n = 18; moderate and thin n = 20) after walking 80 steps. For all participants, the moderate midsole had the shortest familiarisation period (160 steps). The highest number of familiarisation steps was found in the thick (320 steps) and thin midsoles (240 steps) for some participants.</p><p><strong>Conclusion: </strong>A minimum of 320 familiarisation steps is recommended to account for both individual differences and midsole thicknesses. Implementing this walking-based footwear familiarisation protocol would improve validity of future studies, ensuring they analyse footwear effects rather than familiarisation with the footwear.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1055-1062"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LncRNA SOX21-AS1 Promotes Activation of BV2 Cells via Epigenetical Silencing of SOCS3 and Aggravates Parkinson's Disease. lncRNA SOX21-AS1通过表观遗传沉默SOCS3促进BV2细胞的激活并加重帕金森病的病情
IF 3.1 3区 医学
Gerontology Pub Date : 2024-01-01 Epub Date: 2024-07-24 DOI: 10.1159/000539784
Dan Feng, Yun Liu, Fangya Zuo, Fenfen Liu, Yuqi Liu, Yujie Wang, Lanlan Chen, Xiuhong Guo, Jinyong Tian
{"title":"LncRNA SOX21-AS1 Promotes Activation of BV2 Cells via Epigenetical Silencing of SOCS3 and Aggravates Parkinson's Disease.","authors":"Dan Feng, Yun Liu, Fangya Zuo, Fenfen Liu, Yuqi Liu, Yujie Wang, Lanlan Chen, Xiuhong Guo, Jinyong Tian","doi":"10.1159/000539784","DOIUrl":"10.1159/000539784","url":null,"abstract":"<p><strong>Background: </strong>LncRNAs perform a crucial impact on microglia's activation in Parkinson's disease (PD). Here, our purpose was to probe the function and involved mechanism of lncRNA SOX21-AS1 on microglial activation in PD.</p><p><strong>Methods: </strong>Mice were treated with MPTP, and BV2 cells were treated with LPS/ATP to build PD animal and cell models. Genes' expression was measured using RT-qPCR, immunoblotting, and IHC stain. ELISA was applied for testing inflammatory factors' levels. Cell viability and apoptosis were tested using kits. RIP and RNA pull-down assay were utilized for monitoring the bond of SOX21-AS1 to EZH2, and ChIP was applied for affirming the bond between EZH2 and SOCS3's promoter.</p><p><strong>Results: </strong>The expression of SOX21-AS1 and SOCS3 was abnormal in PD cell and animal models. Inhibition of SOX21-AS1 repressed LPS/ATP-induced activation in BV2 cells and nerve damage caused by activated BV2 cells, alleviating the pathological features of PD mice. Further studies found that SOX21-AS1 epigenetically inhibited SOCS3 by recruiting EZH2 to SOCS3 promoter. SOX21-AS1 overexpression partially offset the repressive impact of SOCS3 enhancement on BV2 cell activation and the protective effect on nerve cells.</p><p><strong>Conclusion: </strong>SOX21-AS1 enhances LPS/ATP-induced activation of BV2 cells and nerve damage caused by activated BV2 cells though recruiting EZH2 to SOCS3's promoter, thereby alleviating PD progression. Our research supplies new potential target for curing PD.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1063-1073"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary Patterns and Healthy or Unhealthy Aging. 饮食模式与健康或不健康的衰老。
IF 3.1 3区 医学
Gerontology Pub Date : 2024-01-01 Epub Date: 2023-10-26 DOI: 10.1159/000534679
Ligia J Dominguez, Nicola Veronese, Mario Barbagallo
{"title":"Dietary Patterns and Healthy or Unhealthy Aging.","authors":"Ligia J Dominguez, Nicola Veronese, Mario Barbagallo","doi":"10.1159/000534679","DOIUrl":"10.1159/000534679","url":null,"abstract":"<p><strong>Background: </strong>The aging process is complex, comprising various contributing factors influencing late-life conditions and eventual occurrence of chronic diseases that generate high financial and human costs. These factors include genetic proneness, lifestyle conducted throughout life, environmental conditions, as well as dietary aspects, among others, all together modulating precise pathways linked to aging, making longevity a multidimensional event.</p><p><strong>Summary: </strong>Compelling evidence support the concept that nutritional determinants have major impact on the risk of age-associated non-communicable diseases as well as mortality. Nutrition research has turned in recent years from considering isolated nutrients or foods to focusing on combinations of foods in dietary patterns in relation to their associations with health outcomes. This narrative review focuses attention on dietary patterns that may contribute to healthy or unhealthy aging and longevity with examples of traditional dietary patterns associated with healthy longevity and reviewing the association of healthy plant-based and unhealthy ultra-processed diets with frailty, a condition that may be considered a hallmark of unhealthy aging.</p><p><strong>Key message: </strong>There is currently accumulated evidence confirming the key role that dietary patterns mainly of plant origin may exert in modifying the risk of age-associated chronic diseases and healthy longevity. These types of dietary models, unlike those in which the use of ultra-processed food is frequent, are associated with a reduced risk of frailty and, consequently, with healthy aging.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"15-36"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10794975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54228752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Scoping Review of Fall-Risk Screening Tools in the Emergency Department for Future Falls in Older Adults. 对急诊科中针对老年人未来跌倒的跌倒风险筛查工具进行范围审查。
IF 3.1 3区 医学
Gerontology Pub Date : 2024-01-01 Epub Date: 2024-09-27 DOI: 10.1159/000541238
Daniel Wickins, Jack Roberts, Steven M McPhail, Nicole M White
{"title":"A Scoping Review of Fall-Risk Screening Tools in the Emergency Department for Future Falls in Older Adults.","authors":"Daniel Wickins, Jack Roberts, Steven M McPhail, Nicole M White","doi":"10.1159/000541238","DOIUrl":"10.1159/000541238","url":null,"abstract":"<p><strong>Background: </strong>Approximately one-third of adults over the age of 65 experience falls annually, with half resulting in injury. Peak bodies have recommended the use of fall-risk screening tools in the emergency department (ED) to identify patients requiring in-depth assessment and potential fall-prevention intervention. This study aimed to examine the scope of published studies on fall-risk screening tools used in the ED and evidence of associations between screening and future falls.</p><p><strong>Summary: </strong>PubMed, Embase and CINAHL were searched for peer-reviewed journal articles published since 2012 that examined one or more screening tools to identify patient-level fall risk. Eligible studies described fall-risk tools applied in the ED. Data extracted included sample information, variables measured, and statistical analysis. Sixteen studies published since 2012 were included after full-text review. Fourteen unique screening tools were found. Eight tools were fall-risk screening tools, one tool was a functional screening tool, one tool was a frailty-screening tool, two tools were rapid physical tests, one tool was a trauma triage tool, and one tool was a component of a health-related quality-of-life measure. Studies that evaluated prognostic performance (n = 11) generally reported sensitivity higher than specificity. Previous falls (n = 10) and high-risk medications (n = 6) were consistently associated with future falls. Augmentation with additional variables from the electronic medical record (EMR) improved screening tool prognostic performance in one study.</p><p><strong>Key messages: </strong>Current evidence on the association between the use of fall-risk screening tools in the ED for future falls consistently identifies previous falls and high-risk medications as associated with future falls. Comparison between tools is difficult due to different evaluation methods and different covariates measured. Augmentation of fall-risk screening using the EMR in the ED requires further investigation.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1227-1240"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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