Frontiers in Systems Neuroscience最新文献_第8页

Editorial: The role of brain oscillatory activity in human sensorimotor control and learning: bridging theory and practice. 社论:大脑振荡活动在人类感觉运动控制和学习中的作用:衔接理论与实践。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1211763

Elisa Tatti, Alberto Cacciola

引用次数: 0

The influence of action on perception spans different effectors. 动作对知觉的影响涉及不同的效应体。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1145643

Annalisa Bosco, Pablo Sanz Diez, Matteo Filippini, Patrizia Fattori

{"title":"The influence of action on perception spans different effectors.","authors":"Annalisa Bosco, Pablo Sanz Diez, Matteo Filippini, Patrizia Fattori","doi":"10.3389/fnsys.2023.1145643","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1145643","url":null,"abstract":"Perception and action are fundamental processes that characterize our life and our possibility to modify the world around us. Several pieces of evidence have shown an intimate and reciprocal interaction between perception and action, leading us to believe that these processes rely on a common set of representations. The present review focuses on one particular aspect of this interaction: the influence of action on perception from a motor effector perspective during two phases, action planning and the phase following execution of the action. The movements performed by eyes, hands, and legs have a different impact on object and space perception; studies that use different approaches and paradigms have formed an interesting general picture that demonstrates the existence of an action effect on perception, before as well as after its execution. Although the mechanisms of this effect are still being debated, different studies have demonstrated that most of the time this effect pragmatically shapes and primes perception of relevant features of the object or environment which calls for action; at other times it improves our perception through motor experience and learning. Finally, a future perspective is provided, in which we suggest that these mechanisms can be exploited to increase trust in artificial intelligence systems that are able to interact with humans.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"17 ","pages":"1145643"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9496882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Putting forward a model for the role of the cerebellum in cocaine-induced pavlovian memory. 提出了小脑在可卡因诱发的巴甫洛夫记忆中的作用模型。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1154014

Ignasi Melchor-Eixea, Julian Guarque-Chabrera, Aitor Sanchez-Hernandez, Patricia Ibáñez-Marín, Raúl Pastor, Marta Miquel

{"title":"Putting forward a model for the role of the cerebellum in cocaine-induced pavlovian memory.","authors":"Ignasi Melchor-Eixea, Julian Guarque-Chabrera, Aitor Sanchez-Hernandez, Patricia Ibáñez-Marín, Raúl Pastor, Marta Miquel","doi":"10.3389/fnsys.2023.1154014","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1154014","url":null,"abstract":"Substance Use Disorder (SUD) involves emotional, cognitive, and motivational dysfunction. Long-lasting molecular and structural changes in brain regions functionally and anatomically linked to the cerebellum, such as the prefrontal cortex, amygdala, hippocampus, basal ganglia, and ventral tegmental area, are characteristic of SUD. Direct and indirect reciprocal connectivity between the cerebellum and these brain regions can explain cerebellar roles in Pavlovian and reinforcement learning, fear memory, and executive functions. It is increasingly clear that the cerebellum modulates brain functions altered in SUD and other neuropsychiatric disorders that exhibit comorbidity with SUD. In the present manuscript, we review and discuss this evidence and present new research exploring the role of the cerebellum in cocaine-induced conditioned memory using chemogenetic tools (designer receptor exclusively activated by designer drug, DREADDs). Our preliminary data showed that inactivation of a region that includes the interposed and lateral deep cerebellar nuclei reduces the facilitating effect of a posterior vermis lesion on cocaine-induced preference conditioning. These findings support our previous research and suggest that posterior vermis damage may increase drug impact on the addiction circuitry by regulating activity in the DCN. However, they raise further questions that will also be discussed.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"17 ","pages":"1154014"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9794591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebellar control of fear learning via the cerebellar nuclei-Multiple pathways, multiple mechanisms? 小脑核对恐惧学习的控制——多途径，多机制?

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1176668

Julie D Urrutia Desmaison, Romain W Sala, Ahsan Ayyaz, Pimpimon Nondhalee, Daniela Popa, Clément Léna

引用次数: 2

Role of cerebellum in sleep-dependent memory processes. 小脑在睡眠依赖性记忆过程中的作用。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1154489

Andrew Jackson, Wei Xu

引用次数: 1

Cerebellar contribution to the regulation of defensive states. 小脑对防御状态调节的贡献。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1160083

Gabriela Neubert da Silva, Nina Seiffert, Philip Tovote

{"title":"Cerebellar contribution to the regulation of defensive states.","authors":"Gabriela Neubert da Silva, Nina Seiffert, Philip Tovote","doi":"10.3389/fnsys.2023.1160083","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1160083","url":null,"abstract":"Despite fine tuning voluntary movement as the most prominently studied function of the cerebellum, early human studies suggested cerebellar involvement emotion regulation. Since, the cerebellum has been associated with various mood and anxiety-related conditions. Research in animals provided evidence for cerebellar contributions to fear memory formation and extinction. Fear and anxiety can broadly be referred to as defensive states triggered by threat and characterized by multimodal adaptations such as behavioral and cardiac responses integrated into an intricately orchestrated defense reaction. This is mediated by an evolutionary conserved, highly interconnected network of defense-related structures with functional connections to the cerebellum. Projections from the deep cerebellar nucleus interpositus to the central amygdala interfere with retention of fear memory. Several studies uncovered tight functional connections between cerebellar deep nuclei and pyramis and the midbrain periaqueductal grey. Specifically, the fastigial nucleus sends direct projections to the ventrolateral PAG to mediate fear-evoked innate and learned freezing behavior. The cerebellum also regulates cardiovascular responses such as blood pressure and heart rate-effects dependent on connections with medullary cardiac regulatory structures. Because of the integrated, multimodal nature of defensive states, their adaptive regulation has to be highly dynamic to enable responding to a moving threatening stimulus. In this, predicting threat occurrence are crucial functions of calculating adequate responses. Based on its role in prediction error generation, its connectivity to limbic regions, and previous results on a role in fear learning, this review presents the cerebellum as a regulator of integrated cardio-behavioral defensive states.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"17 ","pages":"1160083"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9317370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prefrontal modulation of anxiety through a lens of noradrenergic signaling. 通过去甲肾上腺素能信号透镜调节前额叶焦虑。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1173326

Nadia N Bouras, Nancy R Mack, Wen-Jun Gao

{"title":"Prefrontal modulation of anxiety through a lens of noradrenergic signaling.","authors":"Nadia N Bouras, Nancy R Mack, Wen-Jun Gao","doi":"10.3389/fnsys.2023.1173326","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1173326","url":null,"abstract":"Anxiety disorders are the most common class of mental illness in the U.S., affecting 40 million individuals annually. Anxiety is an adaptive response to a stressful or unpredictable life event. Though evolutionarily thought to aid in survival, excess intensity or duration of anxiogenic response can lead to a plethora of adverse symptoms and cognitive dysfunction. A wealth of data has implicated the medial prefrontal cortex (mPFC) in the regulation of anxiety. Norepinephrine (NE) is a crucial neuromodulator of arousal and vigilance believed to be responsible for many of the symptoms of anxiety disorders. NE is synthesized in the locus coeruleus (LC), which sends major noradrenergic inputs to the mPFC. Given the unique properties of LC-mPFC connections and the heterogeneous subpopulation of prefrontal neurons known to be involved in regulating anxiety-like behaviors, NE likely modulates PFC function in a cell-type and circuit-specific manner. In working memory and stress response, NE follows an inverted-U model, where an overly high or low release of NE is associated with sub-optimal neural functioning. In contrast, based on current literature review of the individual contributions of NE and the PFC in anxiety disorders, we propose a model of NE level- and adrenergic receptor-dependent, circuit-specific NE-PFC modulation of anxiety disorders. Further, the advent of new techniques to measure NE in the PFC with unprecedented spatial and temporal resolution will significantly help us understand how NE modulates PFC function in anxiety disorders.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"17 ","pages":"1173326"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9410439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Dynamic causal modeling reveals increased cerebellar- periaqueductal gray communication during fear extinction. 动态因果模型揭示了恐惧消退过程中小脑-导水管周围灰质通讯的增加。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1148604

Elena Paci, Bridget M Lumb, Richard Apps, Charlotte L Lawrenson, Rosalyn J Moran

{"title":"Dynamic causal modeling reveals increased cerebellar- periaqueductal gray communication during fear extinction.","authors":"Elena Paci, Bridget M Lumb, Richard Apps, Charlotte L Lawrenson, Rosalyn J Moran","doi":"10.3389/fnsys.2023.1148604","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1148604","url":null,"abstract":"Introduction: The extinction of fear memories is an important component in regulating defensive behaviors, contributing toward adaptive processes essential for survival. The cerebellar medial nucleus (MCN) has bidirectional connections with the ventrolateral periaqueductal gray (vlPAG) and is implicated in the regulation of multiple aspects of fear, such as conditioned fear learning and the expression of defensive motor outputs. However, it is unclear how communication between the MCN and vlPAG changes during conditioned fear extinction.Methods: We use dynamic causal models (DCMs) to infer effective connectivity between the MCN and vlPAG during auditory cue-conditioned fear retrieval and extinction in the rat. DCMs determine causal relationships between neuronal sources by using neurobiologically motivated models to reproduce the dynamics of post-synaptic potentials generated by synaptic connections within and between brain regions. Auditory event related potentials (ERPs) during the conditioned tone offset were recorded simultaneously from MCN and vlPAG and then modeled to identify changes in the strength of the synaptic inputs between these brain areas and the relationship to freezing behavior across extinction trials. The DCMs were structured to model evoked responses to best represent conditioned tone offset ERPs and were adapted to represent PAG and cerebellar circuitry.Results: With the use of Parametric Empirical Bayesian (PEB) analysis we found that the strength of the information flow, mediated through enhanced synaptic efficacy from MCN to vlPAG was inversely related to freezing during extinction, i.e., communication from MCN to vlPAG increased with extinction.Discussion: The results are consistent with the cerebellum contributing to predictive processes that underpin fear extinction.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"17 ","pages":"1148604"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9568570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Functional columnar organization and long-range circuits in different cortical systems. 编辑:不同皮质系统的功能柱状组织和远程回路。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1168606

Kerstin E Schmidt, Ralf A W Galuske

引用次数: 0

Editorial: Role of brain oscillations in neurocognitive control systems. 社论:脑振荡在神经认知控制系统中的作用。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1182496

Golnaz Baghdadi, Chella Kamarajan, Fatemeh Hadaeghi

引用次数: 0