Frontiers in Systems Neuroscience最新文献

{"title":"Pharmacologically altered androgens, brain activation and response inhibition in a stop-signal task in male heavy drinkers.","authors":"Marlene Kundlacz, Rafat Boroumand-Jazi, Sabine Hoffmann, Christiane Mühle, Iris Reinhard, Matthias Reichl, Leonard Wenger, Haoye Tan, Patrick Bach, Sabine Vollstädt-Klein, Georg W Alpers, Falk Kiefer, Bernd Lenz, Sarah Gerhardt","doi":"10.3389/fnsys.2026.1907416","DOIUrl":"10.3389/fnsys.2026.1907416","url":null,"abstract":"<p><p>Heavy episodic drinking (HED) is highly prevalent in men and a major risk factor for Alcohol Use Disorder (AUD). Previous studies indicated an influence of testosterone (T) on AUD, and dihydrotestosterone (DHT) was linked to alcohol consumption, impulsivity, and response inhibition. As the role of androgens in AUD and the modulation thereof is not fully understood, this study investigated the effect of a pharmacological reduction in DHT by inhibition of the 5-alpha reductase II with finasteride on brain activation and response inhibition during a stop signal task. Fifty males with HED participated in a randomized, placebo-controlled, double blind, cross-over, functional magnetic resonance imaging (fMRI) study. Participants received either 5 mg finasteride or placebo, resulting in a 9.6% reduction of DHT levels. Full factorial fMRI models and linear mixed models were used to estimate whole-brain effects of DHT and testosterone following finasteride and placebo on neural correlates of behavioral control (<i>N</i> = 47 analyzable participants). While no medication effects were observed on behavioral or neural levels, lower levels of DHT and higher levels of testosterone were related to stronger neural activation in temporal regions during response inhibition for successful or unsuccessful stop-trails, respectively. However, no significant influence of hormone levels on behavioral data of the stop signal task was observed. Although the precise mechanisms underlying the effects of pharmacologically altered DHT levels on neural correlates of response inhibition remain unresolved, both DHT and testosterone appear to be specifically associated with neural activation during response inhibition. These preliminary findings may provide a rational for future studies investigating pharmaceutical modulation of androgens as a potential therapeutic approach for problem drinking, and potentially AUD.</p><p><strong>Clinical trial registration: </strong>https://drks.de/search/de/trial/DRKS00020569, identifier DRKS00020569.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1907416"},"PeriodicalIF":3.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biophysical framework for conscious state transitions based on intrinsic neuronal properties: the dynamic contextual element memory (DCEM) model.","authors":"Takayoshi Tsubo","doi":"10.3389/fnsys.2026.1894336","DOIUrl":"10.3389/fnsys.2026.1894336","url":null,"abstract":"<p><p>Unlike artificial systems that execute externally specified commands, the brain constructs contextual representations to guide behaviors that satisfy innate and learned desires generated by the Affective Valuation System (AVS). However, the neural mechanisms by which contextual representations are formed, selected, maintained, and replaced to generate conscious state transitions remain unknown. Here, we propose the Dynamic Contextual Element Memory (DCEM) model as a biophysical framework within the dorsolateral prefrontal cortex. The DCEM is conceived as a dynamic contextual memory consisting of numerous logical Contextual Elements (CEs), each implemented by multiple physical cortical columns. AVS signals initiate contextual exploration in the DCEM and guide contextual selection, maintenance, and transition. Recurrent interactions between the DCEM and the parietal and temporal association cortices generate γ-band contextual candidates from sensory and memory information. Physical columns of candidates selected by Contextual Element Decision Neurons (CEDeN) in the mediodorsal thalamus receive synchronized feedback and form a coherent β-band Contextual Element Loop (CE Loop) representing a single logical Contextual Element. Outputs from DCEM Layer 5 redistribute the selected context throughout the association cortices, allowing AVS to shape candidates. CE Loops that lose CEDeN support following re-evaluation of behavioral outcomes or new information fail to maintain synchrony and disappear. We therefore propose that conscious state transitions occur through the formation, maintenance, disappearance, and replacement of CE Loops. This model was naturally derived by extending the intrinsic biophysical properties of neurons identified in our studies to cortical networks while integrating accumulated findings from modern observational techniques, neuroanatomy, neurophysiology, and neuroscience.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1894336"},"PeriodicalIF":3.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music-evoked EEG signals for mental health assessment using two- and three-class classification.","authors":"Abdelkader Nasreddine Belkacem, Abdelhadi Hireche, Nour Faris Ali, Mohamed Atef, Abdalla A R M Hamid, Ibrahim M Elfadel, Herbert F Jelinek","doi":"10.3389/fnsys.2026.1886805","DOIUrl":"10.3389/fnsys.2026.1886805","url":null,"abstract":"<p><strong>Introduction: </strong>Electroencephalography (EEG), a non-invasive method of measuring brain activity, has become a valuable tool in mental health research for examining neural activity associated with various psychological disorders and neurofeedback therapies, including music therapy. However, the use of EEG under music and no-music conditions for mental health screening remains insufficiently validated.</p><p><strong>Methods: </strong>In this preliminary study, we implemented an experimental protocol in which 48 participants underwent EEG recordings during both music and no-music sessions with identical relaxation instructions. The Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder 7-item (GAD-7) scale were also included. Five complementary EEG features were extracted for each mental fatigue class: power spectral density (PSD) across different frequency bands, band powers, alpha-theta ratio, theta-beta ratio, and channel coherence. Binary classification (mental fatigue) and multi-output binary classification (anxiety, depression, and stress components) were implemented using a deep residual multi-layer perceptron (MLP), a feedforward neural network with residual skip connections. Leave-Subject-Out cross-validation ensured robust generalization, with all metrics computed at the subject level rather than epoch level.</p><p><strong>Results: </strong>For binary classification, the model achieved 72.92% accuracy in the music condition and 58.33% accuracy in the no-music condition, with notably high recall (96.67%) in the music condition. Multi-output classification in the music condition showed stress with high accuracy (93.75%) but low AUC (35.56%), reflecting the high prevalence of the stressed class (85.7%), while anxiety and depression presented greater challenges (54.17% and 62.50% accuracy, respectively).</p><p><strong>Discussion: </strong>These preliminary results suggest that music may modulate brain activity patterns in ways that enhance the discriminability of mental fatigue states, although the fixed condition order means order and habituation effects cannot be ruled out.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1886805"},"PeriodicalIF":3.6,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct hindlimb motor cortex subregions encode forward and backward hindlimb movements in rats.","authors":"Joey St-Arnault, Andrew R Brown, Marco Bonizzato, Marina Martinez","doi":"10.3389/fnsys.2026.1912148","DOIUrl":"10.3389/fnsys.2026.1912148","url":null,"abstract":"<p><strong>Introduction: </strong>The motor cortex is organized to coordinate voluntary movements through distinct subregions that control different parts of the body. Intracortical microstimulation (ICMS) with long-duration trains (LD-ICMS) can uncover complex, behaviorally relevant movement patterns that differ from the simple, joint-specific responses evoked by conventional short-duration trains (SD-ICMS). While previous studies have primarily examined forelimb representations, the organization of hindlimb movements remains less understood.</p><p><strong>Methods: </strong>Here, we characterized hindlimb movements evoked by LD-ICMS, analyzing their kinematic features, cortical location and functional relevance in rats.</p><p><strong>Results: </strong>Two distinct complex movements, Advance and Elevation, were identified, each with unique kinematic signatures. Principal component analysis revealed that overall movement amplitude and joint flexion patterns underlying movement trajectory systematically distinguished the two movement types. Advance and Elevation movements were spatially segregated within anteromedial and posterolateral cortical subregions, respectively. Phase-coherent stimulation of these subregions during locomotion selectively biased hindlimb trajectories forward or backward in an amplitude-dependent manner.</p><p><strong>Discussion: </strong>These results demonstrate that the rat hindlimb motor cortex contains distinct subregions specialized for directionally specific and functionally relevant movement control.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1912148"},"PeriodicalIF":3.6,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are you afraid? Neurophysiological responses to multidimensional fear in an interactive semi-immersive environment.","authors":"Milton O Candela, J Emiliano Calderón-Gurubel, Alexandro A Ortiz-Espinoza, Josemaria Elizondo-Garcia, Carol S Vélez-Saboyá, Jorge De-J Lozoya-Santos, Ignacio Rodriguez-Sanchez, Manuel Cebral-Loureda, Mauricio A Ramírez-Moreno","doi":"10.3389/fnsys.2026.1908489","DOIUrl":"https://doi.org/10.3389/fnsys.2026.1908489","url":null,"abstract":"<p><strong>Introduction: </strong>Objective fear recognition is crucial for clinical evaluation and understanding emotional processing. This study uses a multi-modal biophysical approach (EEG, HRV, EDA) within an interactive, semi-immersive environment to investigate coordinated brain-body responses across multidimensional fear scenarios.</p><p><strong>Methods: </strong>Ten participants experienced four fear-related scenes mapped to Kantian cognitive dimensions (Embodied, Conceptual, Discursive, Integrative) featuring real-time adaptive audiovisuals. EEG, HRV, and EDA metrics were concurrently recorded and normalized to a resting baseline to evaluate shared signatures, scene-specific modulations, and cross-modal correlations.</p><p><strong>Results: </strong>Neural and autonomic fear markers included frontal and parietal activation, elevated EEG-derived indices (Fatigue, Excitement, Engagement), and increased heart rate and skin conductance. Contextual modulation of fear was characterized by bottom-up and top-down processing during Embodied and Conceptual fear, respectively. Multi-modal clustering showed modality-specific organization overall, with a weak but significant global EEG-autonomic association (Mantel test), and one validated cross-modal link between HRV (LF/HF) and EDA (SCR _<i>P</i> ).</p><p><strong>Conclusion: </strong>Fear manifested through both shared neurophysiological signatures and context-dependent cognitive-embodied variations. Combining immersive technology with multi-modal biophysical sensing presents an exploratory, ecologically-valid framework for emotion research that can inform future closed-loop, adaptive paradigms.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1908489"},"PeriodicalIF":3.6,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Neurobiological foundations of cognition and progress toward artificial general intelligence.","authors":"Yan Yufik, Robert Kozma, James Kroger","doi":"10.3389/fnsys.2026.1967487","DOIUrl":"10.3389/fnsys.2026.1967487","url":null,"abstract":"","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1967487"},"PeriodicalIF":3.6,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral impact of condensed repeated ethanol dosing on withdrawal in adult zebrafish (<i>Danio rerio</i>).","authors":"Rawlie Prince, Tobin Steman, Ethan V Hagen, Andréa L Johnson, Yanbo Zhang, Trevor J Hamilton","doi":"10.3389/fnsys.2026.1924496","DOIUrl":"10.3389/fnsys.2026.1924496","url":null,"abstract":"<p><p>Zebrafish (<i>Danio rerio</i>) are a widely used animal model to study a variety of neuropsychiatric disorders, including drug addiction. Existing paradigms to examine alcohol addiction use repeated daily or continuous ethanol exposures over multiple days. The present study evaluated a condensed repeated dosing paradigm, involving three 1-h ethanol doses (0.8%) per day over 5 days. To examine ethanol withdrawal, locomotor and anxiety-like behavior was assessed at 2, 4, and 8 days following the dosing schedule, using the open field test. There was a significant increase in immobility and angular velocity with ethanol regardless of withdrawal duration. At 8 days of withdrawal, ethanol-treated fish spent significantly less time highly mobile compared to controls. Likewise, there was a change in zone preference at 8 days of withdrawal, with ethanol-treated fish spending significantly more time in the transition zone and less time in the thigmotaxis zone compared to controls. No other significant zone preferences or sex differences were found. These findings suggest that the condensed repeated dosing paradigm produces a measurable behavioral withdrawal phenotype. This dosing schedule is an effective and efficient approach for high-throughput drug addiction research in adult zebrafish and may be useful for evaluating many pharmacological treatments.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1924496"},"PeriodicalIF":3.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13612536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149060124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing late corrections reveals anticipatory motor control.","authors":"Inmaculada Márquez, Luis Lemus, Mario Treviño","doi":"10.3389/fnsys.2026.1892135","DOIUrl":"10.3389/fnsys.2026.1892135","url":null,"abstract":"<p><p>Successful interception requires combining predictive planning with continuous sensory feedback, yet these processes are difficult to dissociate because they operate simultaneously throughout movement. Here, we asked how predictive control is expressed when late online corrections are made ineffective but visual information is left intact. Participants performed a visuomotor interception task in which they moved a horizontal cursor to intercept a falling target at its predicted landing position. On selected trials, the cursor became temporarily unresponsive immediately before interception, preventing late motor corrections while leaving the target continuously visible. Manual and gaze behavior were quantified using two complementary root-mean-square error (RMSE) measures that tracked alignment with either the target's instantaneous position or its landing position. Under normal conditions, manual movements converged on the predicted landing position earlier on successful than on unsuccessful trials; trial-averaged gaze showed no comparable effect. Increasing cursor-freeze durations progressively reduced interception accuracy but shifted manual behavior toward earlier alignment with the landing position before the freeze began, indicating a redistribution of control from late feedback corrections toward earlier predictive planning. These findings show that when late online corrections become ineffective, humans compensate by committing earlier to predicted future states. This redistribution was large and consistent in manual behavior, and considerably harder to detect in trial-averaged gaze.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1892135"},"PeriodicalIF":3.6,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13561802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-scale neuromorphic modeling of cortical networks on FPGA for investigating anesthetic-induced neural dynamics.","authors":"Chuanguang Wang, Xiaotian Pan, Si Chen, Hao Cheng, YuJie Yao, Guodao Zhang, Fang Zheng","doi":"10.3389/fnsys.2026.1866947","DOIUrl":"10.3389/fnsys.2026.1866947","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding the neural mechanisms underlying general anesthesia remains a significant challenge in neuroscience and clinical practice. Traditional software-based simulations of large-scale brain networks are often constrained by high computational costs and fail to achieve real-time performance.</p><p><strong>Methods: </strong>In this paper, we propose a high-performance hardware implementation of large-scale neuromorphic system to investigate anesthetic-induced neural dynamics. The system successfully models a cortical network comprising 10,000 spiking neurons (8,000 excitatory and 2,000 inhibitory) utilizing the biologically plausible Izhikevich neuron model. Deployed on a field-programmable gate array (FPGA), the proposed architecture exploits high parallelism to achieve real-time simulation speeds. By adjusting synaptic weights and network parameters to mimic the pharmacological eects of anesthetic agents, our system can continuously monitor and evaluate state transitions in neural synchronization and firing patterns.</p><p><strong>Results: </strong>The results demonstrate that the hardware-accelerated neuromorphic approach provides an efficient, scalable, and real-time platform for investigating large-scale neural dynamics.</p><p><strong>Discussion: </strong>Pending future validation against empirical clinical EEG data, this foundational framework paves the way for advanced brain-machine interfaces and closed-loop anesthetic delivery systems.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1866947"},"PeriodicalIF":3.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PQ-Neurolink: latency-aware post-quantum-ready secure communication for distributed brain-computer interfaces.","authors":"Tariq Qayyum, Asadullah Tariq, Abdelkader Nasreddine Belkacem","doi":"10.3389/fnsys.2026.1891041","DOIUrl":"10.3389/fnsys.2026.1891041","url":null,"abstract":"<p><strong>Introduction: </strong>Distributed electroencephalography (EEG) brain-computer interface (BCI) systems increasingly transmit neural data and control messages between a head-worn device, a nearby hub, and cloud-assisted services. These links require integrity, authenticity, replay protection, and low latency, while migration to post-quantum cryptography can increase session-establishment cost.</p><p><strong>Methods: </strong>We present PQ-NeuroLink, a latency-aware post-quantum-ready communication framework that separates authenticated session establishment from the symmetric streaming fast path. The design supports classical X25519, post-quantum ML-KEM-768, and hybrid ML-KEM-768 plus X25519 key establishment, with pinned ML-DSA public keys for endpoint identity binding. The prototype was evaluated using EEG-derived traffic from public datasets over BLE-like and Wi-Fi-like link profiles, 1-hop and 2-hop topologies, symmetric key-update and public-key refresh events, active tampering scenarios, and MCU-informed resource and processing-energy projections.</p><p><strong>Results: </strong>Identity pinning and transcript binding prevented successful modeled session-splicing attempts. Post-quantum and hybrid modes primarily increased handshake bytes rather than steady-state streaming latency. In the most constrained BLE 1-hop summary condition, the hybrid M3 mode increased p95 latency by 0.45 ms relative to the unsecured M0 baseline while maintaining 99.0% packet delivery.</p><p><strong>Discussion: </strong>Post-quantum-ready authenticated session establishment can be integrated into distributed EEG communication prototypes when public-key operations are kept off the per-frame path. PQ-NeuroLink provides a reproducible communication-layer basis for secure next-generation BCI deployment studies requiring low-latency operation and long-horizon post-quantum protection.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1891041"},"PeriodicalIF":3.6,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}