Frontiers in Systems Neuroscience最新文献

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Replicability of a resting-state functional connectivity study in profound early blindness. 深度早期失明静息状态功能连接研究的可复制性。
IF 3.1 4区 医学
Frontiers in Systems Neuroscience Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1547276
Negin Nadvar, Corinna Bauer, Zahide Pamir, Lotfi B Merabet, Vincent Koppelmans, James Weiland
{"title":"Replicability of a resting-state functional connectivity study in profound early blindness.","authors":"Negin Nadvar, Corinna Bauer, Zahide Pamir, Lotfi B Merabet, Vincent Koppelmans, James Weiland","doi":"10.3389/fnsys.2025.1547276","DOIUrl":"https://doi.org/10.3389/fnsys.2025.1547276","url":null,"abstract":"<p><p>It has been shown that the choice of preprocessing pipelines to remove contamination from functional magnetic resonance images can significantly impact the results, particularly in resting-state functional connectivity (rsFC) studies. This underscores the critical importance of replication studies with different preprocessing methodologies. In this study, we attempted to reproduce the rsFC results presented in an original study by Bauer et al. in 2017 on a group of sighted control (SC) and early blind (EB) subjects. By using the original dataset, we utilized another widely used software package to investigate how applying different implementations of the original pipeline (RMin model) or a more rigorous and extensive preprocessing stream (RExt model) can alter the whole-brain rsFC results. Our replication study was not able to fully reproduce the findings of the original paper. Overall, RExt shifted the distribution of rsFC values and reduced functional network density more drastically compared with RMin and the original pipeline. Remarkably, the largest rsFC effects appeared to primarily belong to certain connection pairs, irrespective of the pipeline used, likely demonstrating immunity of the larger effects and the true results against suboptimal processing. This may highlight the significance of results verification across different computational streams in pursuit of the true findings.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1547276"},"PeriodicalIF":3.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robustness of brain state identification in synthetic phase-coupled neurodynamics using Hidden Markov Models. 基于隐马尔可夫模型的合成相耦合神经动力学中脑状态识别的鲁棒性。
IF 3.1 4区 医学
Frontiers in Systems Neuroscience Pub Date : 2025-04-24 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1548437
Giulia Pieramico, Saeed Makkinayeri, Roberto Guidotti, Alessio Basti, Domenico Voso, Delia Lucarelli, Antea D'Andrea, Teresa L'Abbate, Gian Luca Romani, Vittorio Pizzella, Laura Marzetti
{"title":"Robustness of brain state identification in synthetic phase-coupled neurodynamics using Hidden Markov Models.","authors":"Giulia Pieramico, Saeed Makkinayeri, Roberto Guidotti, Alessio Basti, Domenico Voso, Delia Lucarelli, Antea D'Andrea, Teresa L'Abbate, Gian Luca Romani, Vittorio Pizzella, Laura Marzetti","doi":"10.3389/fnsys.2025.1548437","DOIUrl":"https://doi.org/10.3389/fnsys.2025.1548437","url":null,"abstract":"<p><p>Hidden Markov Models (HMMs) have emerged as a powerful tool for analyzing time series of neural activity. Gaussian HMMs and their time-resolved extension, Time-Delay Embedded HMMs (TDE-HMMs), have been instrumental in detecting discrete brain states in the form of temporal sequences of large-scale brain networks. To assess the performance of Gaussian HMMs and TDE-HMMs in this context, we conducted simulations that generated synthetic data representing multiple phase-coupled interactions between different cortical regions to mimic real neural data. Our study demonstrates that TDE-HMM performs better than Gaussian HMM in accurately detecting brain states from synthetic phase-coupled interaction data. Finally, for TDE-HMMs, we manipulated key parameters such as phase coupling variability, state duration, and influence of volume conduction effect to evaluate the models' performance under varying conditions.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1548437"},"PeriodicalIF":3.1,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two methodologies for brain signal analysis derived from Freeman Neurodynamics. 两种脑信号分析方法源自Freeman神经动力学。
IF 3.1 4区 医学
Frontiers in Systems Neuroscience Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1570231
Jeffery Jonathan Joshua Davis, Ian J Kirk, Robert Kozma
{"title":"Two methodologies for brain signal analysis derived from Freeman Neurodynamics.","authors":"Jeffery Jonathan Joshua Davis, Ian J Kirk, Robert Kozma","doi":"10.3389/fnsys.2025.1570231","DOIUrl":"https://doi.org/10.3389/fnsys.2025.1570231","url":null,"abstract":"<p><p>Here, Freeman Neurodynamics is explored to introduce the reader to the challenges of analyzing electrocorticogram or electroencephalogram signals to make sense of two things: (a) how the brain participates in the creation of knowledge and meaning and (b) how to differentiate between cognitive states or modalities in brain dynamics. The first (a) is addressed via a Hilbert transform-based methodology and the second (b) via a Fourier transform methodology. These methodologies, it seems to us, conform with the systems' neuroscience views, models, and signal analysis methods that Walter J. Freeman III used and left for us as his legacy.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1570231"},"PeriodicalIF":3.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Women in systems neuroscience. 社论:系统神经科学中的女性。
IF 3.1 4区 医学
Frontiers in Systems Neuroscience Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1576398
Jacqueline K Rose, Susan Shore, Lili Li
{"title":"Editorial: Women in systems neuroscience.","authors":"Jacqueline K Rose, Susan Shore, Lili Li","doi":"10.3389/fnsys.2025.1576398","DOIUrl":"https://doi.org/10.3389/fnsys.2025.1576398","url":null,"abstract":"","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1576398"},"PeriodicalIF":3.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum: Doppler shift compensation performance in Hipposideros pratti across experimental paradigms. 勘误:跨实验范式的多普勒频移补偿性能。
IF 3.1 4区 医学
Frontiers in Systems Neuroscience Pub Date : 2025-04-11 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1595428
Jinhong Luo, Manman Lu, Xindong Wang, Huimin Wang, Cynthia F Moss
{"title":"Corrigendum: Doppler shift compensation performance in <i>Hipposideros pratti</i> across experimental paradigms.","authors":"Jinhong Luo, Manman Lu, Xindong Wang, Huimin Wang, Cynthia F Moss","doi":"10.3389/fnsys.2025.1595428","DOIUrl":"https://doi.org/10.3389/fnsys.2025.1595428","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnsys.2022.920703.].</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1595428"},"PeriodicalIF":3.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining the role of the photopigment melanopsin in the striatal dopamine response to light. 研究光色素黑视素在纹状体多巴胺对光的反应中的作用。
IF 3.1 4区 医学
Frontiers in Systems Neuroscience Pub Date : 2025-04-02 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1568878
L Sofia Gonzalez, Austen A Fisher, Kassidy E Grover, J Elliott Robinson
{"title":"Examining the role of the photopigment melanopsin in the striatal dopamine response to light.","authors":"L Sofia Gonzalez, Austen A Fisher, Kassidy E Grover, J Elliott Robinson","doi":"10.3389/fnsys.2025.1568878","DOIUrl":"https://doi.org/10.3389/fnsys.2025.1568878","url":null,"abstract":"<p><p>The mesolimbic dopamine system is a set of subcortical brain circuits that plays a key role in reward processing, reinforcement, associative learning, and behavioral responses to salient environmental events. In our previous studies of the dopaminergic response to salient visual stimuli, we observed that dopamine release in the lateral nucleus accumbens (LNAc) of mice encoded information about the rate and magnitude of rapid environmental luminance changes from darkness. Light-evoked dopamine responses were rate-dependent, robust to the time of testing or stimulus novelty, and required phototransduction by rod and cone opsins. However, it is unknown if these dopaminergic responses also involve non-visual opsins, such as melanopsin, the primary photopigment expressed by intrinsically photosensitive retinal ganglion cells (ipRGCs). In the current study, we evaluated the role of melanopsin in the dopaminergic response to light in the LNAc using the genetically encoded dopamine sensor dLight1 and fiber photometry. By measuring light-evoked dopamine responses across a broad irradiance and wavelength range in constitutive melanopsin (<i>Opn4</i>) knockout mice, we were able to provide new insights into the ability of non-visual opsins to regulate the mesolimbic dopamine response to visual stimuli.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1568878"},"PeriodicalIF":3.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of ketamine and thiopental anesthesia on ultraweak photon emission and oxidative-nitrosative stress in rat brains. 氯胺酮和硫喷妥钠麻醉对大鼠脑超弱光子发射和氧化-亚硝化应激的影响。
IF 3.1 4区 医学
Frontiers in Systems Neuroscience Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1502589
Mahdi Khorsand Ghaffari, Niloofar Sefati, Tahereh Esmaeilpour, Vahid Salari, Daniel Oblak, Christoph Simon
{"title":"The impact of ketamine and thiopental anesthesia on ultraweak photon emission and oxidative-nitrosative stress in rat brains.","authors":"Mahdi Khorsand Ghaffari, Niloofar Sefati, Tahereh Esmaeilpour, Vahid Salari, Daniel Oblak, Christoph Simon","doi":"10.3389/fnsys.2025.1502589","DOIUrl":"10.3389/fnsys.2025.1502589","url":null,"abstract":"<p><p>Anesthetics such as ketamine and thiopental, commonly used for inducing unconsciousness, have distinct effects on neuronal activity, metabolism, and cardiovascular and respiratory systems. Ketamine increases heart rate and blood pressure while preserving respiratory function, whereas thiopental decreases both and can cause respiratory depression. This study investigates the impact of ketamine (100 mg/kg) and thiopental (45 mg/kg) on ultraweak photon emission (UPE), oxidative-nitrosative stress, and antioxidant capacity in isolated rat brains. To our knowledge, no previous study has investigated and compared UPE in the presence and absence of anesthesia. Here, we compare the effects of ketamine and thiopental anesthetics with each other and with a non-anesthetized control group. Ketamine increased UPE, lipid peroxidation, and antioxidant enzyme activity while reducing thiol levels. Conversely, thiopental decreased UPE, oxidative markers, and antioxidant enzyme activity, while increasing thiol levels. UPE was negatively correlated with thiol levels and positively correlated with oxidative stress markers. These findings suggest that the contrasting effects of ketamine and thiopental on UPE are linked to their differing impacts on brain oxidative stress and antioxidant capacity. This research suggests a potential method to monitor brain oxidative stress via UPE during anesthesia, and opens up new ways for understanding and managing anesthetic effects.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1502589"},"PeriodicalIF":3.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Local connections among excitatory neurons underlie characteristics of enriched environment exposure-induced neuronal response modulation in layers 2/3 of the mouse V1. 兴奋性神经元之间的局部连接是小鼠V1 2/3层富集环境暴露诱导的神经元反应调节特征的基础。
IF 3.1 4区 医学
Frontiers in Systems Neuroscience Pub Date : 2025-02-19 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1525717
Nobuhiko Wagatsuma, Yuka Terada, Hiroyuki Okuno, Natsumi Ageta-Ishihara
{"title":"Local connections among excitatory neurons underlie characteristics of enriched environment exposure-induced neuronal response modulation in layers 2/3 of the mouse V1.","authors":"Nobuhiko Wagatsuma, Yuka Terada, Hiroyuki Okuno, Natsumi Ageta-Ishihara","doi":"10.3389/fnsys.2025.1525717","DOIUrl":"10.3389/fnsys.2025.1525717","url":null,"abstract":"<p><p>Environmental enrichment, an enhancement in the breeding environment of laboratory animals, enhance development of the cortical circuit and suppresses brain dysfunction. We quantitatively investigated the influences of enriched environment (EE) exposure, on responses in layers 2/3 (L2/3) of the primary visual area (V1) of mice. EE modifies visual cortex plasticity by inducing immediate early genes. To detect this, we performed immunostaining for the immediate early gene product c-Fos. EE exposure significantly increased the number of neurons with high c-Fos fluorescence intensity compared with those of mice under standard housing (SH). In contrast, there was no significant difference in the number of neurons exhibiting low c-Fos intensity between the SH and EE exposure groups. To further investigate the mechanism of modulation by EE exposure, we developed a microcircuit model with a biologically plausible L2/3 of V1 that combined excitatory pyramidal (Pyr) neurons and three inhibitory interneuron subclasses. In the model, synaptic strengths between Pyr neurons were determined according to a log-normal distribution. Model simulations with various inputs mimicking physiological conditions for SH and EE exposure quantitatively reproduced the experimentally observed activity modulation induced by EE exposure. These results suggested that synaptic connections among Pyr neurons obeying a log-normal distribution underlie the characteristic EE-exposure-induced modulation of L2/3 in V1.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1525717"},"PeriodicalIF":3.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic changes in large-scale functional connectivity prior to stimulation determine performance in a multisensory task. 刺激前大规模功能连接的动态变化决定了多感官任务的表现。
IF 3.1 4区 医学
Frontiers in Systems Neuroscience Pub Date : 2025-02-12 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1524547
Edgar E Galindo-Leon, Karl J Hollensteiner, Florian Pieper, Gerhard Engler, Guido Nolte, Andreas K Engel
{"title":"Dynamic changes in large-scale functional connectivity prior to stimulation determine performance in a multisensory task.","authors":"Edgar E Galindo-Leon, Karl J Hollensteiner, Florian Pieper, Gerhard Engler, Guido Nolte, Andreas K Engel","doi":"10.3389/fnsys.2025.1524547","DOIUrl":"10.3389/fnsys.2025.1524547","url":null,"abstract":"<p><p>Complex behavior and task execution require fast changes of local activity and functional connectivity in cortical networks at multiple scales. The roles that changes of power and connectivity play during these processes are still not well understood. Here, we study how fluctuations of functional cortical coupling across different brain areas determine performance in an audiovisual, lateralized detection task in the ferret. We hypothesized that dynamic variations in the network's state determine the animals' performance. We evaluated these by quantifying changes of local power and of phase coupling across visual, auditory and parietal regions. While power for hit and miss trials showed significant differences only during stimulus and response onset, phase coupling already differed before stimulus onset. An analysis of principal components in coupling at the single-trial level during this period allowed us to reveal the subnetworks that most strongly determined performance. Whereas higher global phase coupling of visual and auditory regions to parietal cortex was predictive of task performance, a second component revealed a reduction in coupling between subnetworks of different sensory modalities, probably to allow a better detection of the unimodal signals. Furthermore, we observed that long-range coupling became more predominant during the task period compared to the pre-stimulus baseline. Taken together, our results show that fluctuations in the network state, as reflected in large-scale coupling, are key determinants of the animals' behavior.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1524547"},"PeriodicalIF":3.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11860953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Multimodal approaches to investigating neural dynamics in cognition and related clinical conditions: integrating EEG, MEG, and fMRI data. 社论:研究认知和相关临床状况中的神经动力学的多模式方法:整合脑电图、脑磁图和功能磁共振成像数据。
IF 3.1 4区 医学
Frontiers in Systems Neuroscience Pub Date : 2025-02-11 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1495018
Golnaz Baghdadi, Fatemeh Hadaeghi, Chella Kamarajan
{"title":"Editorial: Multimodal approaches to investigating neural dynamics in cognition and related clinical conditions: integrating EEG, MEG, and fMRI data.","authors":"Golnaz Baghdadi, Fatemeh Hadaeghi, Chella Kamarajan","doi":"10.3389/fnsys.2025.1495018","DOIUrl":"10.3389/fnsys.2025.1495018","url":null,"abstract":"","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1495018"},"PeriodicalIF":3.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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