Frontiers in Systems Neuroscience最新文献

{"title":"Deciphering the regulatory mechanism of neural behavioral decisions through biogenic amine-mediated modulation of neural circuits in <i>Caenorhabditis elegans</i>.","authors":"Hui Liu, Yunlong Shen, Dejian Peng","doi":"10.3389/fnsys.2026.1727180","DOIUrl":"https://doi.org/10.3389/fnsys.2026.1727180","url":null,"abstract":"<p><p>Brain function is not simply the sum of individual neuronal activities, but rather emerges from functional neural circuits comprising thousands to millions of neurons with specific topological structures and dynamic properties. Investigating the functions and information-processing architectures of these neural circuits is essential for understanding how the brain performs \"computation\" and \"operation.\" Biological neural regulatory networks are captivating due to their extensive utilization of diverse signaling molecules for interneuronal communication. Neurotransmitters, receptors, and neurons together compose neuroregulatory circuits, which act as fundamental functional units in the network for generating behavioral instructions. However, the discovery and decipherment of neural circuits remain challenging, due to the necessity of comprehending the functions of signaling molecules and neuronal cells, as well as their regulatory mechanisms. In this review, we focus on four biogenic amines signals, including dopamine, serotonin, octopamine and tyramine, and discuss their regulatory roles with their receptors in <i>Caenorhabditis elegans</i> neural circuits. In particular, we summarize the functional roles of the biogenic amine neurons and their complex interaction mechanisms in neural circuits. We also provide perspectives on the fine-scale neural connectivity, which will bridge microscopic neuronal activity with macroscopic cognitive behaviors, offering a theoretical framework for further elucidating the neural mechanisms underlying brain adaptation, learning, and memory.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1727180"},"PeriodicalIF":3.5,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying emotion-dependent brain-eye interactions during audiovisual emotional stimulation.","authors":"Feryal A Alskafi, Ahsan H Khandoker, Faezeh Marzbanrad, Herbert F Jelinek","doi":"10.3389/fnsys.2026.1744042","DOIUrl":"https://doi.org/10.3389/fnsys.2026.1744042","url":null,"abstract":"<p><strong>Purpose: </strong>Electrooculography (EOG) provides a noninvasive measure of eye movements linked to affective processing, yet it is mainly used for artifact correction of electroencephalography (EEG) signals rather than analyzed as a physiological signal in its own right. EEG-EOG coupling has therefore not been well-established. This study aimed to determine whether emotion-specific changes in arousal and valence are reflected in directional and frequency-specific interactions between EEG rhythms and EOG signals.</p><p><strong>Methods: </strong>The DEAP dataset with 32 participants, where each viewed 40 1-min music videos and rated their arousal/valence, was used (1,280 samples). EEG from eight electrodes was filtered into theta, alpha, beta, and gamma frequency bands, while horizontal and vertical EOG were also preprocessed. EOG complexity was assessed using sample, fuzzy, and permutation entropy. EEG-EOG coupling was assessed with the controlled time delay stability (CTDS) framework, which evaluates stability of partial cross-correlation delays.</p><p><strong>Results: </strong>Entropy analysis showed emotion-related differences in horizontal and vertical EOG complexity (<i>p</i> < 0.005). EEG-EOG coupling varied with emotion, with the strongest effects at sensorimotor and frontal sites, primarily within the gamma band. Directional EOG-to-EEG coupling predominating at frontal, sensorimotor, and occipital sites. Differences were most pronounced when arousal and valence varied independently or in opposite directions, with fewer effects during parallel shifts.</p><p><strong>Conclusion: </strong>Emotional states are mirrored by frequency- and channel-specific shifts in EEG-EOG interactions, a core component of the affective behavioral network. These results clarify the directional dynamics linking eye movement and cortical activity, revealing a structured, context-sensitive neural architecture for affective processing.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1744042"},"PeriodicalIF":3.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"dCA1 cells encode and update contextual place preference.","authors":"Kwon Choi, Ignitius Ezekiel Lim, Ajn Vats, Sonni Marie Tarver, Tashonda Benoit Vaughn, Olalekan Michael Ogundele","doi":"10.3389/fnsys.2026.1702298","DOIUrl":"https://doi.org/10.3389/fnsys.2026.1702298","url":null,"abstract":"<p><p>Pyramidal cells in the dorsal hippocampus (dCA1) are excitatory neurons modulated by environmental cues. While a population of dCA1 cells encodes spatial location, other groups are activated by reward probability and encounters. <i>Since \"rewards\" are predicted at \"locations,\" we sought to determine how spatiotemporal coding patterns in the dCA1 resolve contextual preference and subsequent change in preference that is driven by reward encounters.</i> Specifically, we examined these encoding patterns in biased place-preference tasks for simple reward acquisition and for complex discrimination of reward magnitudes. Initial behavioral tests for mice without neural implants revealed a higher sensitivity to discriminating between <i>two locations</i> associated with reward magnitude, in comparison to reward detection. Analysis of dCA1 single-unit spatiotemporal activity during pre-conditioning revealed that these cells exhibited peak firing as they approached the less preferred context. Therefore, when the contextual preference is biased toward a reward or a higher-magnitude reward, a change in dCA1 firing rate around context entry events reflects the updated spatial preference. Interestingly, the context of lower preference with no associated reward or a lower-value reward elicits a stronger firing response than the alternative contexts with higher reward values. Together, we conclude that the spatiotemporal firing patterns of dCA1 single units and the threshold of peak FR change encode contextual preference. Ultimately, the spatiotemporal pattern is updated (remapped) when there is a change in the contextual preference driven by reward contingencies.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1702298"},"PeriodicalIF":3.5,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quadrupedal training approaches in post-stroke rehabilitation: a scoping review of evidence, mechanisms, and clinical applications.","authors":"Jan A Kuipers, Frederick R Carrick, Monèm Jemni","doi":"10.3389/fnsys.2026.1773330","DOIUrl":"https://doi.org/10.3389/fnsys.2026.1773330","url":null,"abstract":"<p><strong>Background: </strong>Persistent impairments in trunk control, balance, and mobility are frequently observed after stroke, even after standard task-specific rehabilitation. Quadrupedal-derived training (QT)-which involves four-point support, dynamic contralateral tasks, transitional kneeling, and crawling-has attracted clinical interest because it may activate bilateral and spinal sensorimotor networks. Nonetheless, the evidence supporting QT has not been thoroughly systematically mapped. Objective: To synthesize the extent, characteristics, mechanisms, and clinical applications of quadrupedal-derived training in adult post-stroke rehabilitation.</p><p><strong>Methods: </strong>A scoping review was conducted in accordance with the JBI Manual for Evidence Synthesis and the PRISMA-ScR guidelines. It involved searching five databases and additional sources from 2010 to 2025 to find studies on QT in stroke populations, along with mechanistic and translational evidence. The outcomes were pre-mapped to the International Classification of Functioning (ICF) domains. Data on intervention types, total dosage, supervision, progression criteria, safety, and feasibility were gathered. Stakeholder input from stroke survivors, clinicians, and researchers helped shape implementation considerations.</p><p><strong>Results: </strong>Eighteen studies met the inclusion criteria, including five randomized controlled trials and one case study involving stroke populations, as well as mechanistic and translational research. QT consistently improved trunk control and balance, with effects on functional mobility and certain gait parameters varying depending on the variant and dose. Kneeling-based QT showed greater balance benefits than treadmill-based training in subacute inpatient settings, while static and dynamic four-point variants were mainly used with chronic outpatient groups. No serious adverse events occurred, and adherence was high where recorded. Mechanistic evidence indicates a pathway connecting quadrupedal loading to activation of spinal and interlimb networks, bilateral proximal muscles, and functional improvements.</p><p><strong>Conclusion: </strong>Quadrupedal-based training is a biologically plausible, resource-efficient, and clinically practical method for improving trunk and balance issues after a stroke. More well-designed studies that include standardized progression, dose-response evaluations, and neurophysiological biomarkers are needed.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1773330"},"PeriodicalIF":3.5,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13099906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grand challenges for systems neuroscience: perspectives and opportunities.","authors":"Wen-Jun Gao","doi":"10.3389/fnsys.2026.1818506","DOIUrl":"https://doi.org/10.3389/fnsys.2026.1818506","url":null,"abstract":"<p><p>Systems neuroscience seeks to uncover how diverse neuronal populations and distributed neural types, circuits, and regions in the brain give rise to perception, learning, emotion, cognition, and behavior, and how dysfunction at any of these levels contributes to neurological and psychiatric disorders. The field has rapidly expanded from single-cell studies to large-scale, multimodal interrogation and manipulation of brain-wide activity, creating unprecedented opportunities alongside major conceptual and technical challenges. Systems neuroscience is at a pivotal moment, with advances in basic, translational, and clinical research converging to deepen understanding of how neural activity generates mental life.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1818506"},"PeriodicalIF":3.5,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG biomarkers of the sense of embodiment: methodological gaps and evidence-based recommendations from a systematic review.","authors":"Daniela Esteves, Athanasios Vourvopoulos","doi":"10.3389/fnsys.2026.1756407","DOIUrl":"https://doi.org/10.3389/fnsys.2026.1756407","url":null,"abstract":"<p><strong>Introduction: </strong>The sense of embodiment (SoE), describing the experience of owning, controlling, and being located within a body, underpins virtual reality (VR) interaction, brain-computer interfaces (BCIs), and multisensory body-illusion research. Although SoE is typically assessed through subjective questionnaires, their variability and limited validity have motivated the search for objective neural markers. Electroencephalography (EEG) has become the most widely used technique given its portability and high temporal resolution; however, the existence of a consistent EEG correlate of embodiment remains unclear.</p><p><strong>Methods: </strong>This systematic review summarizes 35 EEG studies (2010-June 2025) identified through structured database searches, examining SoE across immersive and non-immersive VR, augmented reality, and non-VR paradigms. We analyze EEG features including spectral power, event-related desynchronization/synchronization (ERD/ERS), connectivity, and temporal dynamics, and examine methodological variability in illusion induction and SoE assessment.</p><p><strong>Results: </strong>Across studies, the reduction of the alpha-band over central-parietal regions emerges as the most recurrent correlate of embodiment. Beta-band decreases and gamma-band increases appear in several studies but lack consistent replication, while findings in Delta and Theta bands remain sparse and contradictory. Considerable heterogeneity is found in VR paradigms, EEG setups, preprocessing, and psychometric tools, contributing to inconsistent results and limiting cross-study comparability.</p><p><strong>Discussion: </strong>Critically, no EEG feature demonstrates sufficient reproducibility to qualify as a universal biomarker of SoE, and no standardized protocol for EEG-based embodiment assessment currently exists. Overall, this review highlights both the promise and current limitations of EEG-based approaches to measuring embodiment. We conclude by identifying methodological gaps and outlining recommendations to support the development of reliable EEG markers for future applications in VR rehabilitation, MI-BCIs, cognitive neuroscience, and clinical interventions.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1756407"},"PeriodicalIF":3.5,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefinition of EEG frequency bands: a fractal model inspired by Blagg's Titius-Bode law.","authors":"Sultan Tarlacı, Metin Çınaroğlu, Eda Yılmazer, Selami Varol Ülker","doi":"10.3389/fnsys.2026.1736474","DOIUrl":"https://doi.org/10.3389/fnsys.2026.1736474","url":null,"abstract":"<p><p>The canonical frequency bands used to categorize human electroencephalographic (EEG) activity-delta, theta, alpha, beta, and gamma-have historically been defined using pragmatic and variably applied thresholds rather than a unifying mathematical principle. In this theoretical study, we propose a geometric framework for redefining EEG frequency bands based on logarithmic scaling, drawing on the exponential formulation introduced in Mary Blagg's refinement of the Titius-Bode law. Using the mean adult alpha rhythm as a reference frequency and applying a constant scaling ratio (<i>R</i> = 1.7275), we derive a mathematically ordered hierarchy of EEG band centers and boundaries within a continuous log-spaced spectrum. Unlike descriptive models of spectral 1/f scaling, the present framework provides an explicit generative rule for discrete band centers and transition frequencies. The resulting segmentation produces band definitions numerically consistent with commonly reported EEG frequency ranges while offering a fully proportional, non-overlapping structure. The model further introduces principled subdivisions within the alpha and gamma ranges and redefines the beta-gamma transition using geometric rather than conventional criteria. As a descriptive quantitative observation, the model-derived theta-alpha transition (∼7.98 Hz) lies in numerical proximity to the Earth's fundamental Schumann resonance (∼7.83 Hz); this correspondence arises from the predefined geometric rule and does not imply causal interaction. Overall, the proposed framework reframes EEG band organization as a mathematically explicit, scale-invariant system and provides a hypothesis-generating basis for future empirical evaluation of oscillatory structure.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1736474"},"PeriodicalIF":3.5,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13044072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a correlation between functional recovery of manual dexterity after motor cortex lesion and initial motor learning slope in the intact state?","authors":"Eric M Rouiller","doi":"10.3389/fnsys.2026.1754760","DOIUrl":"https://doi.org/10.3389/fnsys.2026.1754760","url":null,"abstract":"<p><p>A cohort of 13 adult macaques offered a unique opportunity to collect over several years manual dexterity data, from an initial learning phase in intact animals to a terminal phase of functional recovery after unilateral lesion of primary motor cortex (M1). Manual dexterity was assessed daily using the modified Brinkman Board task, yielding a total score given by the number of food pellets retrieved by one or the other hand from vertical and horizontal slots. A motor <i>learning curve slope</i> was established during the initial learning phase before reaching a stable performance with the dominant hand. Later, following contralateral M1 lesion, the manual dexterity score dropped to zero, before a progressive spontaneous functional recovery occurred, reaching a unique plateau of usually incomplete recovery. A <i>recovery curve slope</i> was calculated. In six of the 13 monkeys, a treatment aimed at enhancing the functional recovery of manual dexterity was applied, yielding a second plateau of recovery added to the first spontaneous recovery plateau. A <i>recovery curve slope</i> was also calculated for the second plateau. The hypothesis that steep initial motor learning is correlated with rapid and efficient functional recovery after M1 lesion was tested. In contradiction to this hypothesis, the data showed an inverse correlation with decreasing <i>recovery curve slopes</i> as a function of increasing <i>learning curve slopes</i>. This result suggests that the mechanisms underlying initial motor learning may be different from those mobilized for functional recovery after M1 lesion.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1754760"},"PeriodicalIF":3.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural coding in gustatory cortex reflects consumption decisions: evidence from conditioned taste aversion.","authors":"Martin A Raymond, Ian F Chapman, Stephanie M Staszko, Max L Fletcher, John D Boughter","doi":"10.3389/fnsys.2026.1765204","DOIUrl":"https://doi.org/10.3389/fnsys.2026.1765204","url":null,"abstract":"<p><p>Taste-responsive neurons in the gustatory cortex (GC) have been shown to encode multiple properties of stimuli, including whether they are palatable or not. Previous studies have suggested that a form of taste-involved learning, conditioned taste aversion (CTA), may alter the cortical representation of taste stimuli in a number of ways. We used miniscopes to image taste responses from a large population of neurons in the gustatory cortex of mice before and after CTA to NaCl, comparing taste responses in control and conditioned mice. Following conditioning, no significant effects on the number of responsive cells, or the magnitude of response to either NaCl or other taste stimuli were found. However, population-level analyses showed that in mice receiving a CTA, the representation of NaCl diverged from other appetitive stimuli in neural space and moved closer to that of aversive Quinine. We also tracked the extinction of the CTA in a subset of animals and showed that as NaCl became less aversive, the neural pattern reverted to match the behavior. These data suggest that the predominant function of the taste representation in GC is palatability; the neuronal response pattern to stimuli at the population level reflects the decision of the animal to consume or not consume the stimulus, regardless of quality or chemical identity.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1765204"},"PeriodicalIF":3.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the gatekeeper falls: developmental vulnerability of the thalamic reticular nucleus in neonatal and pediatric hypoxic-ischemic brain injury.","authors":"Kuangfu Hsiao","doi":"10.3389/fnsys.2026.1753562","DOIUrl":"10.3389/fnsys.2026.1753562","url":null,"abstract":"<p><p>The thalamic reticular nucleus orchestrates thalamocortical oscillations and sensory gating. Its early development features a unique confluence of depolarizing GABA signaling, immature chloride regulation, and transient electrical coupling via connexin-36 gap junctions. These developmental specializations, essential for synchronizing cortical maturation, also render thalamocortical networks vulnerable to hypoxic-ischemic insults such as perinatal asphyxia or pediatric cardiac arrest. Following cellular ATP depletion, rapid chloride imbalance eliminates fast synaptic inhibition, permitting abnormal network activity to propagate via gap-junction coupling that persists when chemical inhibition collapses. The resulting electrical hypersynchrony, exacerbated by depolarizing GABAergic currents and impaired chloride extrusion, promotes excitotoxicity and thalamocortical dysrhythmia. This review synthesizes recent evidence to establish a framework that accounts for the selective vulnerability of the immature brain. Understanding these mechanisms may inform strategies to preserve developmental integrity and promote circuit resilience after pediatric asphyxial events.</p>","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"20 ","pages":"1753562"},"PeriodicalIF":3.5,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13008923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}