Frontiers in Systems Neuroscience最新文献_第2页

Impact of high-altitude exposure on cerebral lobe functions in climbers: insights from the Nepali Himalayas. 高海拔暴露对登山者脑叶功能的影响：来自尼泊尔喜马拉雅山脉的见解。

IF 3.1 4区医学

Frontiers in Systems Neuroscience Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1563398

Sunil Dhungel, Shavana R L Rana, Arun Kumar Neopane, Barun Mahat, Bipin Kumar Shrestha, Yesha Shree Rajaure, Bikalp Thapa, Naveen Phuyal, Naresh Manandhar, Udaya Shrestha, Suraj Parajuli, Taraman Amatya

{"title":"Impact of high-altitude exposure on cerebral lobe functions in climbers: insights from the Nepali Himalayas.","authors":"Sunil Dhungel, Shavana R L Rana, Arun Kumar Neopane, Barun Mahat, Bipin Kumar Shrestha, Yesha Shree Rajaure, Bikalp Thapa, Naveen Phuyal, Naresh Manandhar, Udaya Shrestha, Suraj Parajuli, Taraman Amatya","doi":"10.3389/fnsys.2025.1563398","DOIUrl":"10.3389/fnsys.2025.1563398","url":null,"abstract":"Introduction: High-altitude environments challenge cognitive function due to hypoxia, yet their specific effects on cerebral lobe functions remain unclear. This study examines the impact of high-altitude exposure on frontal, parietal, temporal, and occipital lobes in climbers in the Nepali Himalayas, aiming to enhance understanding of altitude-related cognitive decline.Methods: A cross-sectional cohort study was conducted with 76 participants, including 46 non-selected individuals (NOSCL) and 30 selected climbers divided into Everest (EMCL, n = 12), Kanchanjanga (KMCL, n = 9), and Manaslu (MMCL, n = 9) groups. Cognitive function tests (CFT) assessed cerebral lobe function at altitudes ranging from 800 to 5,500 meters using a non-invasive neuropsychological battery.Results: Significant altitude-related declines were observed in frontal lobe function, particularly in the Visual Stroop test at 800 meters (75%, p < 0.001) and 2,700 meters (86.1%, p < 0.001). Attention scores also decreased at 800 meters (94.4%, p = 0.002). No significant changes were found in parietal, temporal, or occipital lobe functions. The Manaslu climb presented greater cognitive challenges than Everest or Kanchanjanga, with reduced attention and social cognition scores at 4,800 meters (p = 0.145).Discussion: The findings indicate that frontal lobe functions are particularly vulnerable to hypoxia at high altitudes. The results support the necessity of region-specific cognitive testing for high-altitude risk assessments. Further research should explore long-term cognitive effects and mitigation strategies for climbers exposed to extreme altitude conditions.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1563398"},"PeriodicalIF":3.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Head posture control under perturbed conditions in progressive supranuclear palsy patients. 进行性核上性麻痹患者摄动状态下的头部姿势控制。

IF 3.1 4区医学

Frontiers in Systems Neuroscience Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1466809

Vittorio Lippi, Christoph Maurer, Christian Haverkamp, Stefan Kammermeier

{"title":"Head posture control under perturbed conditions in progressive supranuclear palsy patients.","authors":"Vittorio Lippi, Christoph Maurer, Christian Haverkamp, Stefan Kammermeier","doi":"10.3389/fnsys.2025.1466809","DOIUrl":"10.3389/fnsys.2025.1466809","url":null,"abstract":"Introduction: In neurodegenerative brain diseases like Progressive Supranuclear Palsy (PSP), clinical studies underscore the crucial role of head motion deficits. Similarly, advanced stage Idiopathic Parkinson's disease (IPD) is known to display significantly altered posture control and balance patterns involving the head segment.Methods: This study investigates the relative differences in head control during a perturbed upright stance paradigm between patients affected by PSP and IPD, compared to healthy control subjects using dynamic system modeling. The resulting neural model underlines how PSP primarily affects head control, whereas IPD primarily affects the control of the whole body's center of mass. A neck control model, based on the hypothesis of modular posture control, is proposed to emulate the PSP data in particular.Results: A larger passive stiffness was observed for both groups of patients, with eyes closed, suggesting that the head moves together with the trunk. With eyes open, the active proportional gain KP is relatively larger in all cases, indicating that the head is directed closer to the vertical by the visual contribution. Since this was held for all investigated groups, findings support the notion of intact visual contribution to posture control among PSP and IPD despite the impaired supranuclear eye guidance among PSP.Discussion: The proposed neural model's characteristics will aid in future patient data analysis, disease progression monitoring, and possible modulation of disease-specific features through therapeutic intervention. For engineering and robotics implementations, uses for strengthened resilience of head stabilization are discussed.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1466809"},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Replicability of a resting-state functional connectivity study in profound early blindness. 深度早期失明静息状态功能连接研究的可复制性。

IF 3.1 4区医学

Frontiers in Systems Neuroscience Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1547276

Negin Nadvar, Corinna Bauer, Zahide Pamir, Lotfi B Merabet, Vincent Koppelmans, James Weiland

{"title":"Replicability of a resting-state functional connectivity study in profound early blindness.","authors":"Negin Nadvar, Corinna Bauer, Zahide Pamir, Lotfi B Merabet, Vincent Koppelmans, James Weiland","doi":"10.3389/fnsys.2025.1547276","DOIUrl":"10.3389/fnsys.2025.1547276","url":null,"abstract":"It has been shown that the choice of preprocessing pipelines to remove contamination from functional magnetic resonance images can significantly impact the results, particularly in resting-state functional connectivity (rsFC) studies. This underscores the critical importance of replication studies with different preprocessing methodologies. In this study, we attempted to reproduce the rsFC results presented in an original study by Bauer et al. in 2017 on a group of sighted control (SC) and early blind (EB) subjects. By using the original dataset, we utilized another widely used software package to investigate how applying different implementations of the original pipeline (RMin model) or a more rigorous and extensive preprocessing stream (RExt model) can alter the whole-brain rsFC results. Our replication study was not able to fully reproduce the findings of the original paper. Overall, RExt shifted the distribution of rsFC values and reduced functional network density more drastically compared with RMin and the original pipeline. Remarkably, the largest rsFC effects appeared to primarily belong to certain connection pairs, irrespective of the pipeline used, likely demonstrating immunity of the larger effects and the true results against suboptimal processing. This may highlight the significance of results verification across different computational streams in pursuit of the true findings.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1547276"},"PeriodicalIF":3.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robustness of brain state identification in synthetic phase-coupled neurodynamics using Hidden Markov Models. 基于隐马尔可夫模型的合成相耦合神经动力学中脑状态识别的鲁棒性。

IF 3.1 4区医学

Frontiers in Systems Neuroscience Pub Date : 2025-04-24 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1548437

Giulia Pieramico, Saeed Makkinayeri, Roberto Guidotti, Alessio Basti, Domenico Voso, Delia Lucarelli, Antea D'Andrea, Teresa L'Abbate, Gian Luca Romani, Vittorio Pizzella, Laura Marzetti

{"title":"Robustness of brain state identification in synthetic phase-coupled neurodynamics using Hidden Markov Models.","authors":"Giulia Pieramico, Saeed Makkinayeri, Roberto Guidotti, Alessio Basti, Domenico Voso, Delia Lucarelli, Antea D'Andrea, Teresa L'Abbate, Gian Luca Romani, Vittorio Pizzella, Laura Marzetti","doi":"10.3389/fnsys.2025.1548437","DOIUrl":"https://doi.org/10.3389/fnsys.2025.1548437","url":null,"abstract":"Hidden Markov Models (HMMs) have emerged as a powerful tool for analyzing time series of neural activity. Gaussian HMMs and their time-resolved extension, Time-Delay Embedded HMMs (TDE-HMMs), have been instrumental in detecting discrete brain states in the form of temporal sequences of large-scale brain networks. To assess the performance of Gaussian HMMs and TDE-HMMs in this context, we conducted simulations that generated synthetic data representing multiple phase-coupled interactions between different cortical regions to mimic real neural data. Our study demonstrates that TDE-HMM performs better than Gaussian HMM in accurately detecting brain states from synthetic phase-coupled interaction data. Finally, for TDE-HMMs, we manipulated key parameters such as phase coupling variability, state duration, and influence of volume conduction effect to evaluate the models' performance under varying conditions.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1548437"},"PeriodicalIF":3.1,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two methodologies for brain signal analysis derived from Freeman Neurodynamics. 两种脑信号分析方法源自Freeman神经动力学。

IF 3.1 4区医学

Frontiers in Systems Neuroscience Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1570231

Jeffery Jonathan Joshua Davis, Ian J Kirk, Robert Kozma

引用次数: 0

Editorial: Women in systems neuroscience. 社论：系统神经科学中的女性。

IF 3.1 4区医学

Frontiers in Systems Neuroscience Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1576398

Jacqueline K Rose, Susan Shore, Lili Li

引用次数: 0

Corrigendum: Doppler shift compensation performance in Hipposideros pratti across experimental paradigms. 勘误：跨实验范式的多普勒频移补偿性能。

IF 3.1 4区医学

Frontiers in Systems Neuroscience Pub Date : 2025-04-11 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1595428

Jinhong Luo, Manman Lu, Xindong Wang, Huimin Wang, Cynthia F Moss

引用次数: 0

Examining the role of the photopigment melanopsin in the striatal dopamine response to light. 研究光色素黑视素在纹状体多巴胺对光的反应中的作用。

IF 3.1 4区医学

Frontiers in Systems Neuroscience Pub Date : 2025-04-02 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1568878

L Sofia Gonzalez, Austen A Fisher, Kassidy E Grover, J Elliott Robinson

{"title":"Examining the role of the photopigment melanopsin in the striatal dopamine response to light.","authors":"L Sofia Gonzalez, Austen A Fisher, Kassidy E Grover, J Elliott Robinson","doi":"10.3389/fnsys.2025.1568878","DOIUrl":"https://doi.org/10.3389/fnsys.2025.1568878","url":null,"abstract":"The mesolimbic dopamine system is a set of subcortical brain circuits that plays a key role in reward processing, reinforcement, associative learning, and behavioral responses to salient environmental events. In our previous studies of the dopaminergic response to salient visual stimuli, we observed that dopamine release in the lateral nucleus accumbens (LNAc) of mice encoded information about the rate and magnitude of rapid environmental luminance changes from darkness. Light-evoked dopamine responses were rate-dependent, robust to the time of testing or stimulus novelty, and required phototransduction by rod and cone opsins. However, it is unknown if these dopaminergic responses also involve non-visual opsins, such as melanopsin, the primary photopigment expressed by intrinsically photosensitive retinal ganglion cells (ipRGCs). In the current study, we evaluated the role of melanopsin in the dopaminergic response to light in the LNAc using the genetically encoded dopamine sensor dLight1 and fiber photometry. By measuring light-evoked dopamine responses across a broad irradiance and wavelength range in constitutive melanopsin (Opn4) knockout mice, we were able to provide new insights into the ability of non-visual opsins to regulate the mesolimbic dopamine response to visual stimuli.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1568878"},"PeriodicalIF":3.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of ketamine and thiopental anesthesia on ultraweak photon emission and oxidative-nitrosative stress in rat brains. 氯胺酮和硫喷妥钠麻醉对大鼠脑超弱光子发射和氧化-亚硝化应激的影响。

IF 3.1 4区医学

Frontiers in Systems Neuroscience Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1502589

Mahdi Khorsand Ghaffari, Niloofar Sefati, Tahereh Esmaeilpour, Vahid Salari, Daniel Oblak, Christoph Simon

{"title":"The impact of ketamine and thiopental anesthesia on ultraweak photon emission and oxidative-nitrosative stress in rat brains.","authors":"Mahdi Khorsand Ghaffari, Niloofar Sefati, Tahereh Esmaeilpour, Vahid Salari, Daniel Oblak, Christoph Simon","doi":"10.3389/fnsys.2025.1502589","DOIUrl":"10.3389/fnsys.2025.1502589","url":null,"abstract":"Anesthetics such as ketamine and thiopental, commonly used for inducing unconsciousness, have distinct effects on neuronal activity, metabolism, and cardiovascular and respiratory systems. Ketamine increases heart rate and blood pressure while preserving respiratory function, whereas thiopental decreases both and can cause respiratory depression. This study investigates the impact of ketamine (100 mg/kg) and thiopental (45 mg/kg) on ultraweak photon emission (UPE), oxidative-nitrosative stress, and antioxidant capacity in isolated rat brains. To our knowledge, no previous study has investigated and compared UPE in the presence and absence of anesthesia. Here, we compare the effects of ketamine and thiopental anesthetics with each other and with a non-anesthetized control group. Ketamine increased UPE, lipid peroxidation, and antioxidant enzyme activity while reducing thiol levels. Conversely, thiopental decreased UPE, oxidative markers, and antioxidant enzyme activity, while increasing thiol levels. UPE was negatively correlated with thiol levels and positively correlated with oxidative stress markers. These findings suggest that the contrasting effects of ketamine and thiopental on UPE are linked to their differing impacts on brain oxidative stress and antioxidant capacity. This research suggests a potential method to monitor brain oxidative stress via UPE during anesthesia, and opens up new ways for understanding and managing anesthetic effects.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1502589"},"PeriodicalIF":3.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local connections among excitatory neurons underlie characteristics of enriched environment exposure-induced neuronal response modulation in layers 2/3 of the mouse V1. 兴奋性神经元之间的局部连接是小鼠V1 2/3层富集环境暴露诱导的神经元反应调节特征的基础。

IF 3.1 4区医学

Frontiers in Systems Neuroscience Pub Date : 2025-02-19 eCollection Date: 2025-01-01 DOI: 10.3389/fnsys.2025.1525717

Nobuhiko Wagatsuma, Yuka Terada, Hiroyuki Okuno, Natsumi Ageta-Ishihara

{"title":"Local connections among excitatory neurons underlie characteristics of enriched environment exposure-induced neuronal response modulation in layers 2/3 of the mouse V1.","authors":"Nobuhiko Wagatsuma, Yuka Terada, Hiroyuki Okuno, Natsumi Ageta-Ishihara","doi":"10.3389/fnsys.2025.1525717","DOIUrl":"10.3389/fnsys.2025.1525717","url":null,"abstract":"Environmental enrichment, an enhancement in the breeding environment of laboratory animals, enhance development of the cortical circuit and suppresses brain dysfunction. We quantitatively investigated the influences of enriched environment (EE) exposure, on responses in layers 2/3 (L2/3) of the primary visual area (V1) of mice. EE modifies visual cortex plasticity by inducing immediate early genes. To detect this, we performed immunostaining for the immediate early gene product c-Fos. EE exposure significantly increased the number of neurons with high c-Fos fluorescence intensity compared with those of mice under standard housing (SH). In contrast, there was no significant difference in the number of neurons exhibiting low c-Fos intensity between the SH and EE exposure groups. To further investigate the mechanism of modulation by EE exposure, we developed a microcircuit model with a biologically plausible L2/3 of V1 that combined excitatory pyramidal (Pyr) neurons and three inhibitory interneuron subclasses. In the model, synaptic strengths between Pyr neurons were determined according to a log-normal distribution. Model simulations with various inputs mimicking physiological conditions for SH and EE exposure quantitatively reproduced the experimentally observed activity modulation induced by EE exposure. These results suggested that synaptic connections among Pyr neurons obeying a log-normal distribution underlie the characteristic EE-exposure-induced modulation of L2/3 in V1.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"19 ","pages":"1525717"},"PeriodicalIF":3.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0