Spontaneous neural activity alterations in medication-naïve primary blepharospasm: a resting-state functional magnetic resonance imaging study.

Abstract

Background: Brain functional reorganization in primary blepharospasm (BSP) remains incompletely understood. This study aimed to add to the increasing knowledge by examining abnormalities in local spontaneous neural activity in this disorder.

Methods: Resting-state functional magnetic resonance imaging data were acquired from 32 medication-naïve patients with BSP and 32 age- and sex-matched healthy controls in this study. The imaging data were analyzed using the amplitude of low frequency fluctuation (ALFF) to measure spontaneous neural activity. Partial correlation analyses between the altered ALFF values and clinical variables (illness duration and Jankovic Rating Scale score) in patients with BSP were further conducted.

Results: Compared to healthy controls, medication-naïve patients with BSP exhibited significantly increased ALFF in the bilateral putamen and left premotor cortex and decreased ALFF in the bilateral thalamus (p < 0.05, threshold-free cluster enhancement with family-wise error correction for multiple comparisons). Furthermore, ALFF values in the left putamen in the patient group were positively correlated with illness duration (r = 0.53, p = 0.002).

Conclusion: Our findings reveal aberrant spontaneous neural activity within key regions of the motor control network in medication-naïve BSP patients. These ALFF alterations, especially the progressive changes observed in the putamen, provide novel insights into BSP neuropathophysiology and highlight the value of studying untreated cohorts to understand the disorder's intrinsic characteristics.