Cortex-wide spatiotemporal motifs of theta oscillations are coupled to freely moving behavior.

IF 3.1 4区 医学 Q2 NEUROSCIENCES
Frontiers in Systems Neuroscience Pub Date : 2025-06-19 eCollection Date: 2025-01-01 DOI:10.3389/fnsys.2025.1557096
Nicholas J Sattler, Michael Wehr
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引用次数: 0

Abstract

Multisensory information is combined across the cortex and assimilated into the continuous production of ongoing behavior. In the hippocampus, theta oscillations (4-12 Hz) radiate as large-scale traveling waves, and serve as a scaffold for neuronal ensembles of multisensory information involved in memory and movement-related processing. An extension of such an encoding framework across the neocortex could similarly serve to bind disparate multisensory signals into ongoing, coherent, phase-coded processes. Whether the neocortex exhibits unique large-scale traveling waves distinct from that of the hippocampus, however, remains unknown. Here, using cortex-wide electrocorticography in freely moving mice, we find that theta oscillations are organized into bilaterally-symmetric spatiotemporal "modes" that span virtually the entire neocortex. The dominant mode (Mode 1) is a divergent traveling wave that originates from retrosplenial cortex and whose amplitude correlates with mouse speed. Secondary modes are asynchronous spiral waves centered over primary somatosensory cortex (Modes 2 and 3), which become prominent during rapid drops in amplitude and synchrony (null spikes) and which underlie a phase reset of Mode 1. These structured cortex-wide traveling waves may provide a scaffold for large-scale phase-coding of information across the cortex.

theta振荡的皮质范围的时空基元与自由移动的行为相耦合。
多感官信息在大脑皮层相互结合,并被吸收成持续不断的行为。在海马体中,θ波振荡(4-12 Hz)以大尺度行波的形式辐射,并作为多感觉信息的神经元集合的支架,参与记忆和运动相关的处理。将这种编码框架扩展到整个新皮层,同样可以将不同的多感官信号绑定到持续的、连贯的、阶段编码的过程中。然而,新皮层是否表现出与海马体不同的独特的大规模行波,仍然未知。在这里,我们在自由运动的小鼠身上使用皮质电成像技术,发现θ波振荡被组织成双侧对称的时空“模式”,几乎跨越了整个新皮层。主导模式(模式1)是一种发散行波,起源于脾后皮层,其振幅与小鼠速度相关。次级模式是以初级体感皮层为中心的异步螺旋波(模式2和模式3),在振幅和同步性的快速下降(零尖峰)期间变得突出,并且是模式1相位重置的基础。这些结构化的皮层宽行波可能为跨越皮层的信息的大规模相位编码提供了一个框架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Systems Neuroscience
Frontiers in Systems Neuroscience Neuroscience-Developmental Neuroscience
CiteScore
6.00
自引率
3.30%
发文量
144
审稿时长
14 weeks
期刊介绍: Frontiers in Systems Neuroscience publishes rigorously peer-reviewed research that advances our understanding of whole systems of the brain, including those involved in sensation, movement, learning and memory, attention, reward, decision-making, reasoning, executive functions, and emotions.
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