Frontiers in Systems Neuroscience最新文献_第9页

Cerebellar control of fear learning via the cerebellar nuclei-Multiple pathways, multiple mechanisms? 小脑核对恐惧学习的控制——多途径，多机制?

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1176668

Julie D Urrutia Desmaison, Romain W Sala, Ahsan Ayyaz, Pimpimon Nondhalee, Daniela Popa, Clément Léna

引用次数: 2

Role of cerebellum in sleep-dependent memory processes. 小脑在睡眠依赖性记忆过程中的作用。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1154489

Andrew Jackson, Wei Xu

引用次数: 1

Cerebellar contribution to the regulation of defensive states. 小脑对防御状态调节的贡献。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1160083

Gabriela Neubert da Silva, Nina Seiffert, Philip Tovote

{"title":"Cerebellar contribution to the regulation of defensive states.","authors":"Gabriela Neubert da Silva, Nina Seiffert, Philip Tovote","doi":"10.3389/fnsys.2023.1160083","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1160083","url":null,"abstract":"Despite fine tuning voluntary movement as the most prominently studied function of the cerebellum, early human studies suggested cerebellar involvement emotion regulation. Since, the cerebellum has been associated with various mood and anxiety-related conditions. Research in animals provided evidence for cerebellar contributions to fear memory formation and extinction. Fear and anxiety can broadly be referred to as defensive states triggered by threat and characterized by multimodal adaptations such as behavioral and cardiac responses integrated into an intricately orchestrated defense reaction. This is mediated by an evolutionary conserved, highly interconnected network of defense-related structures with functional connections to the cerebellum. Projections from the deep cerebellar nucleus interpositus to the central amygdala interfere with retention of fear memory. Several studies uncovered tight functional connections between cerebellar deep nuclei and pyramis and the midbrain periaqueductal grey. Specifically, the fastigial nucleus sends direct projections to the ventrolateral PAG to mediate fear-evoked innate and learned freezing behavior. The cerebellum also regulates cardiovascular responses such as blood pressure and heart rate-effects dependent on connections with medullary cardiac regulatory structures. Because of the integrated, multimodal nature of defensive states, their adaptive regulation has to be highly dynamic to enable responding to a moving threatening stimulus. In this, predicting threat occurrence are crucial functions of calculating adequate responses. Based on its role in prediction error generation, its connectivity to limbic regions, and previous results on a role in fear learning, this review presents the cerebellum as a regulator of integrated cardio-behavioral defensive states.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"17 ","pages":"1160083"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10102664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9317370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prefrontal modulation of anxiety through a lens of noradrenergic signaling. 通过去甲肾上腺素能信号透镜调节前额叶焦虑。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1173326

Nadia N Bouras, Nancy R Mack, Wen-Jun Gao

{"title":"Prefrontal modulation of anxiety through a lens of noradrenergic signaling.","authors":"Nadia N Bouras, Nancy R Mack, Wen-Jun Gao","doi":"10.3389/fnsys.2023.1173326","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1173326","url":null,"abstract":"Anxiety disorders are the most common class of mental illness in the U.S., affecting 40 million individuals annually. Anxiety is an adaptive response to a stressful or unpredictable life event. Though evolutionarily thought to aid in survival, excess intensity or duration of anxiogenic response can lead to a plethora of adverse symptoms and cognitive dysfunction. A wealth of data has implicated the medial prefrontal cortex (mPFC) in the regulation of anxiety. Norepinephrine (NE) is a crucial neuromodulator of arousal and vigilance believed to be responsible for many of the symptoms of anxiety disorders. NE is synthesized in the locus coeruleus (LC), which sends major noradrenergic inputs to the mPFC. Given the unique properties of LC-mPFC connections and the heterogeneous subpopulation of prefrontal neurons known to be involved in regulating anxiety-like behaviors, NE likely modulates PFC function in a cell-type and circuit-specific manner. In working memory and stress response, NE follows an inverted-U model, where an overly high or low release of NE is associated with sub-optimal neural functioning. In contrast, based on current literature review of the individual contributions of NE and the PFC in anxiety disorders, we propose a model of NE level- and adrenergic receptor-dependent, circuit-specific NE-PFC modulation of anxiety disorders. Further, the advent of new techniques to measure NE in the PFC with unprecedented spatial and temporal resolution will significantly help us understand how NE modulates PFC function in anxiety disorders.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"17 ","pages":"1173326"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9410439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Dynamic causal modeling reveals increased cerebellar- periaqueductal gray communication during fear extinction. 动态因果模型揭示了恐惧消退过程中小脑-导水管周围灰质通讯的增加。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1148604

Elena Paci, Bridget M Lumb, Richard Apps, Charlotte L Lawrenson, Rosalyn J Moran

{"title":"Dynamic causal modeling reveals increased cerebellar- periaqueductal gray communication during fear extinction.","authors":"Elena Paci, Bridget M Lumb, Richard Apps, Charlotte L Lawrenson, Rosalyn J Moran","doi":"10.3389/fnsys.2023.1148604","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1148604","url":null,"abstract":"Introduction: The extinction of fear memories is an important component in regulating defensive behaviors, contributing toward adaptive processes essential for survival. The cerebellar medial nucleus (MCN) has bidirectional connections with the ventrolateral periaqueductal gray (vlPAG) and is implicated in the regulation of multiple aspects of fear, such as conditioned fear learning and the expression of defensive motor outputs. However, it is unclear how communication between the MCN and vlPAG changes during conditioned fear extinction.Methods: We use dynamic causal models (DCMs) to infer effective connectivity between the MCN and vlPAG during auditory cue-conditioned fear retrieval and extinction in the rat. DCMs determine causal relationships between neuronal sources by using neurobiologically motivated models to reproduce the dynamics of post-synaptic potentials generated by synaptic connections within and between brain regions. Auditory event related potentials (ERPs) during the conditioned tone offset were recorded simultaneously from MCN and vlPAG and then modeled to identify changes in the strength of the synaptic inputs between these brain areas and the relationship to freezing behavior across extinction trials. The DCMs were structured to model evoked responses to best represent conditioned tone offset ERPs and were adapted to represent PAG and cerebellar circuitry.Results: With the use of Parametric Empirical Bayesian (PEB) analysis we found that the strength of the information flow, mediated through enhanced synaptic efficacy from MCN to vlPAG was inversely related to freezing during extinction, i.e., communication from MCN to vlPAG increased with extinction.Discussion: The results are consistent with the cerebellum contributing to predictive processes that underpin fear extinction.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"17 ","pages":"1148604"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9568570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Functional columnar organization and long-range circuits in different cortical systems. 编辑:不同皮质系统的功能柱状组织和远程回路。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1168606

Kerstin E Schmidt, Ralf A W Galuske

引用次数: 0

Editorial: Role of brain oscillations in neurocognitive control systems. 社论:脑振荡在神经认知控制系统中的作用。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1182496

Golnaz Baghdadi, Chella Kamarajan, Fatemeh Hadaeghi

引用次数: 0

Basal ganglia for beginners: the basic concepts you need to know and their role in movement control. 初学者的基底神经节:你需要知道的基本概念和它们在运动控制中的作用。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1242929

Gabriel S Rocha, Marco A M Freire, André M Britto, Karina M Paiva, Rodrigo F Oliveira, Ivana A T Fonseca, Dayane P Araújo, Lucidio C Oliveira, Fausto P Guzen, Paulo L A G Morais, José R L P Cavalcanti

引用次数: 2

7,8-dihydroxyflavone enhances long-term spatial memory and alters brain volume in wildtype mice. 7,8-二羟黄酮增强野生型小鼠长期空间记忆并改变脑容量。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1134594

Florence Rawlings-Mortimer, Alberto Lazari, Cristiana Tisca, Mohamed Tachrount, Aurea B Martins-Bach, Karla L Miller, Jason P Lerch, Heidi Johansen-Berg

{"title":"7,8-dihydroxyflavone enhances long-term spatial memory and alters brain volume in wildtype mice.","authors":"Florence Rawlings-Mortimer, Alberto Lazari, Cristiana Tisca, Mohamed Tachrount, Aurea B Martins-Bach, Karla L Miller, Jason P Lerch, Heidi Johansen-Berg","doi":"10.3389/fnsys.2023.1134594","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1134594","url":null,"abstract":"Introduction: 7,8-dihydroxyflavone (7,8-DHF) is a low molecular weight compound that can cross the blood brain barrier and has been implicated in numerous functions and behaviours. It is thought to have neuroprotective capability and has been shown to alleviate symptoms in a wide range of diseases. Methods: 7,8-DHF was administered systemically to wildtype mice during Morris water maze training. Long-term spatial memory was assessed 28 days later. Ex-vivo T2-weighted (T2w) imaging was undertaken on a subset of these mice to assess brain-wide changes in volume. Results: We found that systemic 7,8-DHF administration during the training period enhanced spatial memory 28 days later. Volumetric changes were observed in numerous brain regions associated with a broad range of functions including cognition, sensory, and motor processing. Discussion: Our findings give the first whole brain overview of long-term anatomical changes following 7,8-DHF administration providing valuable information for assessing and understanding the widespread effects this drug has been shown to have in behaviour and disease.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"17 ","pages":"1134594"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9235459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Alterations of PAC-based resting state networks in Parkinson's disease are partially alleviated by levodopa medication. 左旋多巴药物可部分缓解帕金森病中基于pac的静息状态网络的改变。

IF 3 4区医学

Frontiers in Systems Neuroscience Pub Date : 2023-01-01 DOI: 10.3389/fnsys.2023.1219334

Sean Mertiens, Matthias Sure, Alfons Schnitzler, Esther Florin

{"title":"Alterations of PAC-based resting state networks in Parkinson's disease are partially alleviated by levodopa medication.","authors":"Sean Mertiens, Matthias Sure, Alfons Schnitzler, Esther Florin","doi":"10.3389/fnsys.2023.1219334","DOIUrl":"https://doi.org/10.3389/fnsys.2023.1219334","url":null,"abstract":"Introduction: Parkinson's disease (PD) is a neurodegenerative disorder affecting the whole brain, leading to several motor and non-motor symptoms. In the past, it has been shown that PD alters resting state networks (RSN) in the brain. These networks are usually derived from fMRI BOLD signals. This study investigated RSN changes in PD patients based on maximum phase-amplitude coupling (PAC) throughout the cortex. We also tested the hypothesis that levodopa medication shifts network activity back toward a healthy state.Methods: We recorded 23 PD patients and 24 healthy age-matched participants for 30 min at rest with magnetoencephalography (MEG). PD patients were measured once in the dopaminergic medication ON and once in the medication OFF state. A T1-MRI brain scan was acquired from each participant for source reconstruction. After correcting the data for artifacts and performing source reconstruction using a linearly constrained minimum variance beamformer, we extracted visual, sensorimotor (SMN), and frontal RSNs based on PAC.Results: We found significant changes in all networks between healthy participants and PD patients in the medication OFF state. Levodopa had a significant effect on the SMN but not on the other networks. There was no significant change in the optimal PAC coupling frequencies between healthy participants and PD patients.Discussion: Our results suggest that RSNs, based on PAC in different parts of the cortex, are altered in PD patients. Furthermore, levodopa significantly affects the SMN, reflecting the clinical alleviation of motor symptoms and leading to a network normalization compared to healthy controls.","PeriodicalId":12649,"journal":{"name":"Frontiers in Systems Neuroscience","volume":"17 ","pages":"1219334"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10020459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1