Georgian medical news最新文献

{"title":"FEATURES OF DISTRIBUTION OF INTRATUMORAL LYMPHOCYTES IN OVARIAN EPITHELIAL TUMOURS OF DIFFERENT HISTOLOGICAL TYPES AND DEGREE OF MALIGNANCY.","authors":"R Devadze, A Gvenetadze, Sh Kepuladze, G Burkadze","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ovarian cancer is the leading cause of death from gynaecological cancers worldwide. In Georgia, ovarian cancer ranks fourth in terms of prevalence, and third in terms of mortality rate. According to the latest epidemiological data, there will be 21,421 new cases of ovarian cancer and 13,770 deaths from ovarian cancer in the United States in 2021. Due to the lack of early screening methods and asymptomatic clinical courses, most ovarian cancer is diagnosed at an advanced stage, when the prognosis of the disease is already poor. Despite the advances in modern medical treatment and surgery, ovarian carcinoma remains the most lethal gynaecological cancer. The 5-year survival rate is 46% for all stages combined. The microenvironment of ovarian carcinomas is mainly represented by macrophages, dendritic cells, neutrophils and lymphocytes. Epithelial ovarian carcinoma-infiltrating lymphocytes (TIL) have attracted much interest in the last five years. Ovarian cancer is a heterogeneous disease concerning tumour-infiltrating lymphocytes and TILs. In terms of histological subtypes, most studies include only high-grade serous carcinomas of the ovary, and studies on other histological types are scarce. The results of our study show that the quantitative evaluation of T lymphocytes and their subpopulations does not show a statistically reliable correlation between different histological types of tumours, which may be due to the intratumoral heterogeneity and individual specificity of tumours.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"154-158"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QUALITY OF LIFE IN INDIVIDUALS WITH VARYING LEVELS OF TRAIT AND STATE ANXIETY.","authors":"H Galstyan, A Sargsyan, A Sahakyan, R Dunamalyan, S Mkrtchyan, G Sakanyan, R Matevosyan, L Danielyan, M Mardiyan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The association between specific domains of quality of life (QOL), viewed as an integral characteristic of an individual's physical, emotional, and social functioning, and anxiety as a distinct psychological trait, has not been thoroughly investigated. The aim of this study is to explore the association between specific domains of quality of life and levels of trait and state anxiety, focusing on uncovering the nature of the relationships between these indicators.</p><p><strong>Materials and methods: </strong>In the study conducted as part of a scientific project, 180 male and female respondents aged 16-60 were involved. Quality of life was assessed using a modified version of the SF-36 questionnaire, and anxiety was evaluated using the Spielberger scale. Statistical processing and data analysis were carried out using the SPSS 22.0 software package, The correlation between the examined indicators were determined using Spearmen's method.</p><p><strong>Results: </strong>The values of the respondents' quality of life scores in specific domains, as measured by the SF-36 questionnaire, ranged from 59.5 to 84.3 points. For MH and RP scales the scores were 43.4 and 49.9 points, respectively, while the scores for trait and state anxiety were 46.1 and 43.6 points, respectively. The observed pattern of relationships between the studied indicators in individuals with varying levels of anxiety shows a decrease in the values of specific QOL domains with an increase in levels of state and trait anxiety. An inverse relationship was found in the anxiety-psychological health component complex (r=-0.602 to -0.697, p<0.001). Weak negative correlations were obtained for the anxiety-physical health component ratio (r=-0.236 to -0.266, p<0.001). No significant relationship was found between PH and MH (r=-0.011, p=0.885). A direct relationship between state and trait anxiety was indicated by the correlation coefficient between these variables (r=0.602 to 0.697, p<0.001).</p><p><strong>Conclusion: </strong>The study of the correlations between specific domains of QOL and anxiety indicates that there are relationships between the variables examined. Notably, significant anxiety considerably reduces QOL, particularly affecting its psychological component.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"27-33"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ARTHROSCOPIC TREATMENT OF POSTERIOR ANKLE IMPINGEMENT SYNDROME - SYSTEMATIC SURGICAL APPROACH AND CASE REPORT.","authors":"I Kolev, A Andreev, I Zazirnyi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Tenosynovitis caused by impingement syndrome of the flexor hallucis longus tendon is a condition that can often be encountered in professional athletes such as football players, ballet dancers, etc. This report aims to familiarize the reader with methods for recognizing impingement syndrome of the dorsal part of the ankle joint, methods for its treatment and to present a case report with such a pathology.</p><p><strong>Materials and method: </strong>Pain in tenosynovitis of the flexor hallucis longus tendon can be provoked by placing the foot and first finger in maximal dorsiflexion, where the pain is localized in the area dorsal to the medial malleolus. A professional soccer player patient underwent arthroscopic excision of os trigonum and release of the synovial sheath of the flexor hallucis longus tendon. The follow-up period was 12 months. Foot and Ankle Outcome Score and American Orthopedic Foot & Ankle Society self-report scales were completed preoperatively and after the first month postoperatively. Time to return to sports activity was also calculated, as the time from the date of surgery to the time to participation in sports activities at levels similar to those before the pathology.</p><p><strong>Results: </strong>The completed Foot and Ankle Outcome Score preoperatively was a total of 80, divided by category (symptoms and stiffness - 75, pain - 75, daily functionality - 93, sports activity - 65, quality of life - 69). The postoperative Foot and Ankle Outcome Score was 99, with the only category scoring 95 being sports activity. American Orthopedic Foot & Ankle Society completed scale scores were 67 preoperatively and increased to 100 postoperatively. The time to return to training with the team was 4 weeks, and the time to start playing with the team at a level similar to that before the onset of the pathology was 7 weeks.</p><p><strong>Conclusion: </strong>Arthroscopic treatment of dorsal ankle impingement syndrome is a safe and effective method that allows patients rapid return to sports activity.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"148-153"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION BETWEEN GLYCATED HEMOGLOBIN AND ELEVATED THYROID HORMONES LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.","authors":"S Hussein, A Alsubhi, A Abdelmola, S Mustafa, P Kandakurti, A Algarni, E Ali, A Abukanna, H Osman, A Alfeel","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction and objective: </strong>Hyperthyroidism is more common in patients with type 2 diabetes mellitus (T2DM) than in those without diabetes. Excess circulating thyroid hormones in hyperthyroidism are associated with poor glycemic control, including hyperglycemia and insulinopenia. This study aimed to determine the association between the serum glycated hemoglobin (HbA1c) and thyroid hormonal profile (FT3, FT4, TSH) in Type 2 diabetic patients.</p><p><strong>Methodology: </strong>A cross-sectional and case control study examined HbA1c, FT3, FT4 and TSH in 189 Type 2 diabetic patients with good and poor glycemic status, analyzed the associations of these biomarkers for predicting hyperthyroidism using Cox proportional hazard and support vector machine analyses. The methods are conducted following the manufacturer's instructions, spectrophotometric assays are used to measure HbA1c and FBG, while electro chemiluminescent assays are used to measure TSH, FT3, and FT4.</p><p><strong>Results: </strong>This study was conducted on 97 Type 2 diabetic patients with poor glycemic status compared to 92 good glycemic status patients. The age range of participants is between 21 to 72 years and classified according to WHO age group classification into three age categories, young adults (21-30), middle-aged adults (31-45), old-aged adults (>45) and the duration of the disease is between (4-15) years. FBG (p=0.001), HbA1c (p=0.016), TSH (p=0.009), FT3 (p=0.048), and FT4 (p=0.038) results among Type 2 diabetic patients revealed significant differences between the means of good and poor glycemic state (P<0.05). The correlation between thyroid markers, glycemic parameters and the diabetes duration, revealed significant moderate a negative correlation between TSH and FBG (R=-0.34, p=0.001), HbA1c (R=-0.27, p=0.02), and diabetes duration (R=-0.21, p=0.036), The scatter matrix plot showed strong a positive correlation between FT3 and FBG (R=0.54, p=0.03), HbA1c (R=0.36, p=0.004), and the diabetes duration (R=0.41, p=0.05), FT4 was also strong positively correlated with FBG (R=0.46, p=0.029), HbA1c (R=0.33, p=0.028), and the diabetes duration (R=0.39, p=0.048), indicated that increased FT3 and FT4 levels are associated with poor glycemic status and longer diabetes duration.</p><p><strong>Conclusion: </strong>Concluded from this study, well-controlled Type 2 Diabetes reduced the risk of hyperthyroidism, relatively high HbA1c and low TSH levels may increase the risk of hyperthyroidism; therefore, the combination of these indicators can serve as a biomarker for identifying healthy individuals from those who would later develop hyperthyroidism.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"168-172"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WAYS TO IMPROVE THE RESULTS OF SURGICAL TREATMENT OF DIFFUSE TOXIC GOITER.","authors":"Y Mukash, N Omarov, M Aimagambetov, A Dyussupov, T Bulegenov, S Abdrakhmanov, M Auyenov, M Kuderbayev, A Masalov","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;This article discusses the prevention of intraoperative complications in the surgical treatment of diffuse toxic goiter. The above complications push surgeons to find a more optimal method of surgical treatment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;Development of new methods to reduce the risk of intraoperative complications in the surgical treatment of patients with diffuse toxic goiter. Materials and methods of research: From 2017 to September 2020, 85 patients with diffuse toxic goiter were operated in the surgical department of the University Hospital NСJSC «Semey Medical University». The age of the patients ranged from 21 to 68 years. The average age of the patients was 36±2. All patients were divided into 2 groups: I - the main group, which included 39 patients operated using the \"method for the prevention of postoperative laryngeal paresis after thyroidectomy\" and \"instrument for the removal of the recurrent laryngeal nerve\", as well as using the technique of thyroid embolization and II- control, in which 46 patients underwent traditional surgical intervention without the use of these techniques.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;According to the safety drainage, hemorrhagic discharge was noted in all patients after surgery on the same day. In the main group - in the amount of 16.4±7.4 ml, in the control group - 36.1±8.4 ml (p&gt; 0.05). On the 1st day in the main group of patients, the amount of discharge was scarce or zero, drainage was removed. In the control group, this manipulation was most often performed only for 2 days. All patients were examined by an ENT (ears, nose and throat) doctor on the 3rd day to assess the condition of the vocal cords. 2 patients (4.3%) with unilateral transient paresis of the vocal cords were identified in the control group, while no such problems were found in the main group. A complication in 2 patients in the control group was transient unilateral laryngeal paresis. It was completely medically stopped during the next 4-6 months. Hypoparathyroidism in the main group was registered in 1 (2.5%) cases, while in the control group 4 (8.6%) cases of hypoparathyroidism were observed. Postoperative bleeding was noted in 2 (4.3%) cases in the control group, while in the main group this complication was not noted. The duration of inpatient treatment after thyroid surgery using new techniques ranged from 3 to 8 days, averaging 4.2±0.6 days. In the control group, the same indicator ranged from 5 to 10 days (On average - 6.1±0.8 days). There were no fatal outcomes among the patients of both the main and control groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The complex use of a method for the prevention of postoperative laryngeal paresis after thyroidectomy, and the use of a tool for the removal of the recurrent laryngeal nerve during surgery, and preoperative X-ray endovascular embolization of the thyroid arteries in patients with DTG (diffuse toxic goiter) can reduce the risk of intraoperative com","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"18-26"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVENTION AND TREATMENT OF PANCREATITIS AFTER ENDOSCOPIC SURGERY ON THE BILE DUCT.","authors":"I Shkvarkovskyj, O Moskaliuk, I Kozlovska, O Kolotylo, O Rusak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Up-to-date endoscopic correction methods for obstructive diseases of the pancreatic-biliary system occupy a leading position among the arsenal of methods to treat mechanical jaundice. The purpose of the paper is to verify the mechanisms and factors promoting pancreatitis development after endoscopic retrograde cholangiopancreatography (ERCP) and to summarize the efforts to prevent and treat this complication. Materials and methods. A detailed analysis of the structure of nosological units resulting in frequent development of mechanical jaundice was made by the results of treatment of 1214 patients. Results and discussion. The role and place of possible factors promoting development of post-ERCP pancreatitis are determined. The causes of development of intra- and post-ERCP complications are studied. Attention is focused on finding ways to prevent the development of post-ERCP pancreatitis. The therapeutic tactics of management of patients with post-ERCP pancreatitis were carried out according to the recommendations of the European Association of Endoscopic Surgeons (EAES). It should be noted that the algorithm of patient management who during surgery presented technical preconditions of development of post-ERCP pancreatitis is not finally formulated. The experience of administration of pharmacological prevention found in literature is indicative of the fact that it does not provide favorable course of the postoperative period in all cases. First of all, it refers to the patients with high risks who develop severe development followed by unfavorable results. Despite a recognized effectiveness of non-steroidal anti-inflammatory drugs, 2% patients develop severe post-ERCP pancreatitis.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"104-107"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVENTION OF COMPLICATIONS OF SURGICAL TREATMENT OF PATIENTS WITH OCCLUSION OF THE AORTOILIAC SEGMENT.","authors":"M Imanbayev, A Dyussupov, Y Sabitov, N Omarov, Y Kazymov, Zh Kozhakhmetov, D Toleutayeva, S Abdrakhmanov, M Akkaliyev, A Masalov","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The relevance of studying this topic is confirmed not only by the high incidence of aortoiliac segment occlusions, but also by the difficulty of preventing complications after surgical treatment. These complications can range from local infectious processes to serious systemic disorders such as renal failure, cardiovascular complications, and even death.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;to study the influence of concomitant pathologies on the outcome of surgical treatment with occlusion of the aortoiliac segment. Materias and methods. The study was conducted at the Semey Medical University. It was aimed at analyzing methods for minimizing complications in surgical treatment of patients suffering from aortoiliac segment occlusion. The study covered a wide range of aspects, from diagnostics to postoperative rehabilitation, and was implemented through a retrospective analysis of medical records of 300 patients who underwent open surgical treatment of this disease between September 2018 and September 2023.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;As part of a large clinical study, two groups of patients, each comprising 150 people, were compared. One group underwent preoperative drug correction of diabetes mellitus and chronic obstructive pulmonary disease (COPD), while the other group continued to receive standard treatment without additional corrections. During the analysis of postoperative complications, it was found that in the group of patients who underwent preoperative correction of comorbidities, complications were observed in 27 patients, which accounted for 18% of the total number. In contrast, in the group without such correction, postoperative complications were recorded in 51 patients, which is equal to 34%. Statistical analysis revealed a significant difference in the incidence of complications between the two groups (p=0.005, t=2.82), confirming the importance of preoperative optimization in reducing the risk of postoperative complications. Complications that arose after surgery included infectious manifestations such as wound infections and pneumonia, cardiovascular problems including myocardial infarction and cardiac arrhythmias, and thrombotic complications including deep vein thrombosis and pulmonary embolism (PE). For example, wound infections were observed in 13 cases among patients without correction and only in 6 cases among those who underwent correction. Pneumonia occurred in 19 cases in the non-corrected group and in 10 cases in the corrected group. These data indicate that preoperative optimization significantly reduces the risk of infectious complications after surgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The study provided valuable data on the impact of preoperative preparation, including medical management of diabetes mellitus and COPD, on surgical outcomes in patients with aortoiliac occlusion. Based on the results, it can be concluded that careful preoperative assessment and preparation play a key r","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"159-167"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVALENCE AND RISK FACTORS OF UROLITHIASIS AMONG THE POPULATION OF AL-BAHA REGION, SAUDI ARABIA.","authors":"Abdulmajeed Alghamdi, Hashim Alghamdi, Adel Alghamdi, Adham Alghamdi, Anmar Alghamdi, Abdulaziz Alkhathami, Abdullah Al-Mimoni, Muhannad Alghamdi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Urolithiasis, a common and painful condition, is influenced by various risk factors and can be mitigated through preventive measures. This study aims to assess the prevalence and risk factors of Urolithiasis among adults in Al-Baha region, Saudi Arabia, and to evaluate the public's knowledge and attitudes toward its prevention and management.</p><p><strong>Methodology: </strong>Researchers conducted a cross-sectional study using electronic questionnaires distributed via social media platforms. The researchers collected data on demographics, BMI, smoking status, chronic diseases, and family history of Urolithiasis. Additionally, the researchers asked participants about their knowledge and attitudes regarding risk factors and preventive measures for Urolithiasis. Researchers performed statistical analyses using SPSS version 26, employing Chi-square and t-tests to assess associations, with significance set at p<0.05.</p><p><strong>Results: </strong>The study included 633 participants where 377 males (59.6%) and 256 females (40.4%). The age distribution ranged from 18 to 60 years older, with the majority aged 18-29 (38.5%). The prevalence of Urolithiasis was 13.6%, with 41.1% of participants reporting a family history of the condition. The researchers found significant associations between Urolithiasis and age (p<0.001), employment status (p<0.001), smoking (p<0.001), and the presence of chronic diseases (p<0.001). Knowledge about Urolithiasis was significantly associated with age (p=0.014) and employment status (p=0.001). Most participants (94.0%) thought that eating habits affect the occurrence of stones, and 75.8% believed that holding urine frequently causes stone disease. Additionally, 84.0% believed there are non-surgical treatments for stones, and 61.9% thought consuming 2.5 liters of fluid daily reduces stone formation.</p><p><strong>Conclusion: </strong>The study highlights the significant prevalence of Urolithiasis in the Al-Baha region and underscores the importance of public education on risk factors and preventive measures. Age, employment status, smoking, and chronic diseases were significantly associated with Urolithiasis, emphasizing the need for targeted interventions.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"34-41"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES OF THYROID DYSFUNCTION IN PATIENTS WITH ATRIAL FIBRILLATION.","authors":"A Abbasova, V Mirzazade, I Mustafayev, N Ismayilova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study explores the prevalence and clinical significance of thyroid dysfunction in patients diagnosed with atrial fibrillation (AF). A total of 134 AF patients (72 males and 62 females) were evaluated using clinical assessments, anthropometric measurements, electrocardiography, Doppler echocardiography, thyroid ultrasound, and thyroid hormone testing (TSH, free T3, free T4, anti-TPO). Participants were grouped according to thyroid gland functional, structural, and autoimmune status. Results indicated that 61.9% had normal thyroid function, whereas 38.1% demonstrated dysthyroidism (subclinical/overt hypothyroidism, subclinical/overt hyperthyroidism, or \"pseudo-dysthyroidism\"). Notably, hypothyroidism was associated with a higher frequency of severe AF symptoms (EHRA class IV). However, it did not significantly influence AF type (bradysystolic, normosystolic, tachysystolic), AF form (paroxysmal, persistent, permanent), or disease duration. Hyperthyroidism also showed no statistically significant effect on AF type, form, or duration, though there was a trend toward more severe symptoms (EHRA III-IV). The study emphasizes the importance of \"pseudo-dysthyroidism,\" a condition marked by secondary alterations in thyroid hormone levels due to other comorbid illnesses. Recognizing such cases is critical to prevent unnecessary thyroid-directed interventions. Overall, the findings suggest that thyroid dysfunction-particularly hypothyroidism-may exacerbate symptom severity in AF without necessarily altering the arrhythmia's fundamental characteristics. Comprehensive thyroid evaluation, including hormone measurements and ultrasound, is recommended for all AF patients to detect both overt and subclinical thyroid disorders and guide appropriate management.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"95-98"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANALYSIS OF ANTIBIOTIC CONSUMPTION IN MULTIDISCIPLINARY HOSPITALS IN ALMATY PERSPECTIVES ON AWARE AND ABC ECONOMIC ANALYSIS.","authors":"B Yeralieva, M Paizova, G Yerkinbekova, R Shlymova, G Nurgazieva, G Rakhmanova, M Nuralim","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Research objectives: </strong>to investigate possible links between antibiotic consumption levels, with subsequent improvement of approaches to enhance antibiotic use effectiveness and curb antibiotic resistance growth.</p><p><strong>Inclusion criteria: </strong>the inclusion criteria were antibacterial drugs for systemic use.</p><p><strong>Materials and methods: </strong>In this study, we selected 2 multidisciplinary hospitals in Almaty. Financial statements for antibacterial drugs from the last two years (2021-2022) were received. The distribution of antibiotics was analyzed using ABC analysis, antibiotic consumption was assessed, and the AWARE classification proposed by WHO was investigated. In modern medicine, antibiotic resistance is becoming a serious problem. Medical hospitals face the challenge of using antibiotics effectively. The study of strategies such as the AWARE Classification (ACCESS, WATCH, RESERVE) and ABC Analysis helps to optimize the use of antibiotics, curb resistance and save resources of medical organizations, ensuring long-term treatment effectiveness and patient satisfaction. Presented by the World Health Organization, the AWARE classification has been in place since 2019. Many countries, including Kazakhstan, have not yet implemented AWaRe. This article highlights the need for an AWaRe tool to ensure optimal antibiotic use and reduce antibiotic resistance.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"75-77"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}