Georgian medical news最新文献

{"title":"DEVELOPMENT AND EVALUATION OF A NURSE-LED SELF-DIRECTED PEDIATRIC REHABILITATION MODEL: COMPARATIVE ANALYSIS OF INTERNATIONAL PRACTICES.","authors":"A Giniyat, N Slivkina, V Tkachev, G Khussainova, A Baigaliyev, S Kubekova, A Seidakhmetova, Z Mavlyanova, M Aikhozhayeva, R Burumbaeva, L Pavlovets, R Tleulinova, R Baigenzheyeva, M Alaidarova, J Almazan, A Altynbekova, B Zhangabulova, Z Baissova, M Kankina, P Pirmanova, M Shaizadinova, A Utenova, Z Raiymkul","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pediatric rehabilitation has become a global health priority due to increasing survival among children with neurodevelopmental disorders and medical complexity. Although nurse-led rehabilitation models are increasingly recognized as effective approaches for improving continuity of care and rehabilitation outcomes, considerable international variation persists in nursing roles, organizational structures, and integration of digital health strategies, particularly in transitional health systems.</p><p><strong>Aim: </strong>To systematically map and compare international nurse-led pediatric rehabilitation models, focusing on organizational structures, scope of nursing practice, care coordination mechanisms, rehabilitation outcomes, and digital health integration, in order to develop an evidence-informed conceptual framework for a nurse-led self-directed pediatric rehabilitation model adaptable to transitional health systems.</p><p><strong>Methods: </strong>A scoping review was conducted in accordance with the PRISMA-ScR guidelines using the Arksey and O'Malley methodological framework with refinements proposed by Levac et al. electronic searches were performed in PubMed/MEDLINE, Scopus, Web of Science, CINAHL, Embase, and relevant grey literature sources for studies published between January 2015 and March 2026. Eligible studies included empirical investigations of nurse-led, advanced practice nursing, or nurse practitioner-led pediatric rehabilitation models across hospital, outpatient, community, and home-based settings. Data were synthesized using a thematic narrative approach.</p><p><strong>Results: </strong>The search identified 6,842 records, of which 56 studies met the eligibility criteria. Four principal nurse-led pediatric rehabilitation models were identified: nurse practitioner-led clinical care, advanced practice nursing coordination, integrated multidisciplinary nursing models, and physician-led rehabilitation with nursing support. Comparative analysis demonstrated substantially greater nursing autonomy, broader clinical responsibilities, and more mature rehabilitation systems in high-income countries than in transitional health systems. Five core domains of nursing practice were consistently identified: functional assessment, care coordination, rehabilitation intervention support, family-centered education, and multidisciplinary integration. Digital health strategies-including teleconsultation, telerehabilitation, remote monitoring, and self-directed rehabilitation interventions-were consistently associated with improved adherence, continuity of care, caregiver engagement, and health system efficiency. A multidimensional structural gap was identified in transitional health systems, including Kazakhstan, characterized by limited nursing autonomy, fragmented rehabilitation pathways, and insufficient organizational support for advanced nursing practice.</p><p><strong>Conclusion: </strong>International eviden","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"452-465"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DETECTION OF HEPATITIS B AND C VIRAL INFECTION AMONG CHILDREN WITH ACUTE LEUKAEMIA.","authors":"S Hussein, H Ahmed, A Ahmed","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Viral hepatitis, particularly Hepatitis B (HBV) and Hepatitis C (HCV), represents a significant health complication in immunocompromised patients, including children diagnosed with acute leukaemia. These patients are at increased risk of getting infections due to frequent blood transfusions, invasive procedures, and immunosuppressive therapy. The study aimed to evaluate the occurrence of hepatitis B and C virus infection among children with acute leukaemia treated in the pediatric haematology unit at Ibn Al-Ather Teaching Hospital in Mosul city, compare them with a control group and evaluate associated risk factors, including vaccination status.</p><p><strong>Methods: </strong>This study enrolled a total of 180 children attending Ibn-Al-Atheer Teaching Hospital (Mosul City, Iraq), comprising 90 patients diagnosed with Acute Leukemia and 90 age- and sex-matched controls. The control group included children attending the hospital for conditions unrelated to haematological diseases or predisposing factors for Hepatitis B and Hepatitis C, and had no history of chronic illness. Blood samples were collected and tested for HBV surface antigen (HBsAg) and anti-HCV antibodies using enzyme-linked immunosorbent assay (ELISA) kits. Demographic and clinical data, including vaccination history, were reported and statistically analysed.</p><p><strong>Results: </strong>No significant variation was observed between cases and controls in sex, age, or residency (P>0.05). HBsAg positivity was higher in cases (26.7%) than controls (10.0%) (P=0.005). Anti-HCV was also higher in cases (10.0%) vs controls (2.2%) (P=0.035). HBV vaccination was protective (7.4% vs 34.9%, P=0.004). Blood transfusion was strongly associated with infection (60.0% vs 4.4%, P<0.001).</p><p><strong>Conclusion: </strong>HBV and HCV infections were significantly higher in leukemic children. Blood transfusion was a major risk factor, while HBV vaccination had a protective effect. Strengthening screening and vaccination is essential.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"298-302"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPACT OF CLINICAL, ORGANIZATIONAL, AND PSYCHOSOCIAL FACTORS ON THE QUALITY OF LIFE OF PATIENTS WITH DERMATOVENEREOLOGICAL DISEASES.","authors":"B Kenzhebaeva, M Baimuratova, S Kalmakhanov, I Budakoğlu, M Laktionova, D Abdukalikova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Skin diseases substantially impair patients' quality of life and may affect psychological well-being, social functioning, and daily activities. In addition to clinical characteristics, organizational and psychosocial factors may also influence quality-of-life outcomes; however, these associations remain insufficiently investigated in Central Asian countries.</p><p><strong>Aim: </strong>To assess quality of life among patients with skin diseases in Almaty, Kazakhstan, and to identify socio-demographic, clinical, organizational, and psychosocial factors associated with impaired quality of life.</p><p><strong>Material and methods: </strong>A cross-sectional analytical study was conducted between January and May 2026 among adult patients with dermatological diseases attending outpatient dermatovenereological clinics in Almaty, Kazakhstan. Data were collected using an author-developed questionnaire assessing socio-demographic characteristics, clinical features, healthcare accessibility, and psychosocial aspects of disease. Quality of life was assessed using the Dermatology Life Quality Index (DLQI). The internal consistency of the Kazakh-language DLQI version was evaluated using Cronbach's alpha. Statistical analyses included the Mann-Whitney U test, Kruskal-Wallis test with Bonferroni correction, and CHAID decision tree analysis.</p><p><strong>Results: </strong>A total of 417 patients were included in the study. The Kazakh-language version of the DLQI demonstrated high internal consistency (Cronbach's alpha = 0.864). Poorer quality of life was observed among women, rural residents, students, and patients with secondary education (all p<0.05). Significant associations were identified between quality of life and primary diagnosis, disease duration, exacerbation frequency, hospitalization history, self-medication, distrust in physicians, perceived treatment ineffectiveness, use of alternative medicine, and healthcare accessibility indicators (all p<0.05). Patients with visible skin lesions, lack of social support, stigmatization, prolonged waiting times, and high treatment costs reported significantly poorer quality of life (all p<0.001). CHAID analysis identified perceived usefulness of online consultations, difficulties in obtaining medical consultations, use of alternative medicine, visible skin lesions, family support, waiting time for consultation, and diagnosis as the main predictors of extremely impaired quality of life. The model demonstrated an overall classification accuracy of 84.6%.</p><p><strong>Conclusions: </strong>Quality of life in patients with skin diseases is influenced by a complex interplay of socio-demographic, clinical, organizational, and psychosocial factors. Healthcare accessibility, social support, and telemedicine-related factors appear to play an important role and should be considered in comprehensive patient management.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"105-114"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INDICATIONS FOR REMOVAL OF A PORT SYSTEM IN A PATIENT WITH SUSPECTED SEPTICEMIA IN THE ABSENCE OF OTHER LOCAL SOURCES OF INFECTION.","authors":"G Issakova, S Yessentayeva, D Amangaliyev, A Bralov, A Issayeva, Y Abzalbek, M Akhetov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The integrity of the skin is compromised during the placement of various implantable devices (arterial and venous catheters, port systems, tracheostomies, cholangiostomies, nephrostomies). Currently, there are no materials used for these devices that are completely biologically inert. Microorganisms adhere to their surfaces, forming individual colonies that relatively quickly (within 24 hours) develop into a continuous biofilm. Most microorganisms within the biofilm remain in a dormant state; however, localized foci of proliferation periodically arise, leading to the development of an infectious process.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"395-398"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CARDIOPROTECTIVE EFFECTS OF SILYMARIN AND VITAMIN E AGAINST DOXORUBICIN-INDUCED CARDIOTOXICITY IN RATS: EVIDENCE FROM OXIDATIVE STRESS MARKERS AND HISTOPATHOLOGICAL ANALYSIS.","authors":"H Ezzat, I Faisal","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and objectives: </strong>Doxorubicin-Induced Cardiotoxicity (DIC) is a challenge in clinical settings, with limited therapeutic options. This research was designed to investigate the enhanced cardioprotective potential of combined silymarin and vitamin E therapy.</p><p><strong>Methods: </strong>An in vivo approach was used in order to examine the efficacy of silymarin and vitamin E in protecting myocardial tissue from doxorubicin-induced damage. Doxorubicin was given intraperitoneally at a weekly dose of 5 mg/kg. This study analysed changes in body weight, markers of oxidative stress, inflammation and apoptosis, serum activity of lactate dehydrogenase and cardiac Troponin, in addition to the histological examination of heart tissue samples of the treated animals.</p><p><strong>Results: </strong>Doxorubicin administration caused a significant reduction in body weight and elevated serum levels of Lactate Dehydrogenase (LDH) and Troponin I compared to the control group (P<0.05). In cardiac tissue, doxorubicin treatment significantly increased malondialdehyde (MDA), Interleukin-6 (IL-6), Caspase-3, and the Bax/Bcl-2 ratio, while significantly decreasing superoxide dismutase (SOD) activity and Bcl-2 levels (P<0.001). The co-administration of silymarin and vitamin E significantly attenuated these biochemical alterations, maintained body weight, and restored oxidative and inflammatory markers to levels comparable to the control group. Histopathological examination revealed that the combination therapy effectively preserved myocardial architecture and reduced fibrosis and congestion compared to the doxorubicin-only group.</p><p><strong>Conclusion: </strong>The present study confirmed that at the examined doses, silymarin and vitamin E exhibit a protective effect on the heart tissue against doxorubicin-induced toxicity.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"238-245"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTS OF CURCUMIN ON CLINICAL OUTCOMES AND INFLAMMATORY BIOMARKERS IN KNEE OSTEOARTHRITIS: A RANDOMIZED TRIAL.","authors":"A Jumaah, A Younis, S Othman","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Osteoarthritis (OA) is a chronic degenerative disease of the joints in which pain, functional impairment, and low-grade inflammation appear. Curcumin, the active ingredient extracted from Curcuma longa, has biological effects of both anti-inflammatory and antioxidant activity. However, its influence on inflammatory biomarkers in OA is less consistent.</p><p><strong>Objective: </strong>To evaluate the impact of curcumin supplementation on clinical outcomes and inflammatory biomarkers in patients with knee OA.</p><p><strong>Methods: </strong>In this prospective randomised single-blind placebo-controlled trial, patients with knee OA were assigned to curcumin supplementation or a placebo for three months. A total of 125 participants were randomized, and 80 completed the study. Clinical outcomes were measured with the Visual Analogue Scale (VAS) for pain and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). To assess the effects of curcumin on inflammatory biomarkers, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hs-CRP) were measured before and after drug therapy.</p><p><strong>Results: </strong>Compared to placebo, curcumin supplementation significantly reduced VAS and WOMAC scores that were mainly related to clinical outcomes. A significant reduction in TNF-α was seen, showing a potent anti-inflammatory effect. Conversely, levels of IL-6 decreased slightly, and no significant change was noted for hs-CRP.</p><p><strong>Conclusion: </strong>Curcumin supplementation significantly improves pain and functional outcomes in knee OA, exerting selective anti-inflammatory effects, with a pronounced impact on TNF-α compared to IL-6 and hs-CRP. This pattern may be explained by curcumin's modulation of upstream inflammatory pathways via nuclear factor kappa B (NF-κB) inhibition and AMP-activated protein kinase (AMPK) activation, which lead to pathway-dependent effects within the inflammatory cascade. Curcumin may represent a promising adjunct therapy for osteoarthritis, although further studies are needed to clarify its long-term effects and mechanisms.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"132-138"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A NOVEL KCNJ5 GENE MUTATION ASSOCIATED WITH FAMILIAL ALDOSTERONISM TYPE III WITHOUT HYPERTENSION.","authors":"Meng-Yun Zhou, Shi-Qi Yu, Shao-Jie Zhu, Xiang Kong, Xin-Ming Yao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Primary aldosteronism (PA) involves excessive autonomous aldosterone (ALD) secretion by the adrenal cortex, leading to water and sodium retention and renin-angiotensin system inhibition, causing hypertension and K+ imbalance. Familial hyperaldosteronism type III (FH-III) is a rare subtype, characterized by hypokalemia with hypertension and adrenal hyperplasia. Eight associated pathogenic potassium inward rectifying channel protein subfamily J member 5 (KCNJ5) mutations have been reported. This study reports a Chinese family with FH-III associated with a rare KCNJ5 variant (c.536A>G, p.Asn179Ser), which has been previously reported in cardiac genetics databases (rs147070381). Our study expands its phenotypic spectrum to include familial aldosteronism.</p><p><strong>Methods: </strong>A middle-aged female presented with recurrent hypokalemia unresponsive to oral potassium supplementation. She and her family underwent comprehensive clinical examination, biochemical testing, imaging studies, and whole-exome sequencing.</p><p><strong>Results: </strong>She exhibited recurrent hypokalemia without hypertension, with fluctuating ALD, which were controlled with spironolactone. The proband, along with her sister and mother, were found to carry a heterozygous KCNJ5 variant (exon 2: c.536A>G, p.Asn179Ser).</p><p><strong>Conclusion: </strong>FH-III symptoms vary widely, making diagnosis challenging in patients who solely present with recurrent hypokalemia. Early gene sequencing facilitates accurate diagnosis to guide appropriate treatment.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"259-265"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION OF PULMONARY AND CUTANEOUS CHANGES IN COVID-19-RELATED CONDITIONS.","authors":"G Gradil, I Torianyk, K Yurko, D Shiyan, N Merkulova, O Mohylenets, V Tkachenko, I Karmazina, A Lantukh, Y Hryhorov, V Gargin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The study of skin manifestations in COVID-19 is relevant due to the possibility of their appearance before the onset of the typical pattern of respiratory lesions, and the typicality of this pattern has changed noticeably with the emergence of new strains of the virus (nosomorphosis), therefore skin manifestations have both early diagnostic and possible prognostic value.</p><p><strong>Aim: </strong>The aim of our study was to identify the relationship between the course of SARS-CoV-2 and its specific features of skin manifestations during the COVID-19 pandemic.</p><p><strong>Materials and methods: </strong>A retrospective study of data from patients with maculopapular lesions who had COVID-19 was conducted. Among all the skin manifestations of COVID, we selected maculopapular lesions for a more detailed study, as one of the most frequent dermatological pathological processes in this disease. Based on the assessment of the area of the lesion and symptoms (the nature of itching, dryness, pain or other accompanying discomfort that interferes with normal activity, sleep; skin peeling), the degree of the course was assessed as mild, moderate, severe. The severe form of the acute respiratory syndrome of the coronavirus 2 (SARS-CoV-2) was diagnosed based on a complex of clinical and laboratory data obtained from the medical histories of persons undergoing examination. Among the clinical and laboratory data, we selected C-reactive protein (CRP - a blood plasma protein belonging to the group of acute phase proteins, the concentration of which increases during inflammation), D-dimer (a protein fragment that is formed during the dissolution of a blood clot that occurs during blood clotting), procalcitonin (a precursor of calcitonin, which is involved in calcium metabolism and maintains its constant level in the blood) and blood oxygen saturation level.</p><p><strong>Results: </strong>It has been established that moderate and severe SARS-CoV-2 is characterized by skin lesions in the form of maculopapular lesions. Typical are itching, dryness, painful or other accompanying discomfort, skin peeling. In most patients with rash (198 patients (65.8%)) it was a generalized process, more prominent on extremities. Bilateral jawline and periauricular area were affected in 234 (77.7%) patients. In 204 (67.8%) patients, rashes were observed on the abdomen. The average duration of the rash was 10.4±2.21 days.</p><p><strong>Conclusions: </strong>Among the studied signs, a strong correlation was found between the area of alveolar cell desquamation in the lungs and such changes as the area of skin lesions, skin peeling (r=0.73 and r=0.74, respectively), which could be established in deceased individuals. A high dependence of the area of skin lesions on the level of D-dimer (r=0.71) and procalcitonin (r=0.70) was also found.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"93-98"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149107610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVENTING EXERCISE-RELATED SUDDEN CARDIAC DEATH THROUGH SYSTEMATIC PREPARTICIPATION CARDIOVASCULAR SCREENING: A TWO-YEAR REGIONAL COHORT STUDY OF PEDIATRIC ATHLETES IN ADJARA, GEORGIA.","authors":"M Shervashidze, Kh Dolidze, T Bakhtadze, T Shervashidze","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>To determine the prevalence and risk stratification profile of cardiovascular abnormalities identified during a two-year structured preparticipation screening programme among pediatric competitive athletes in Adjara, Georgia, and to evaluate its implications for prevention of exercise-related sudden cardiac death.</p><p><strong>Material and methods: </strong>A cross-sectional cohort study was conducted over two consecutive athletic seasons (2023-2025) in the Autonomous Republic of Adjara, Georgia. A total of 647 competitive athletes aged 5-17 years were enrolled through organized sports institutions. All participants underwent standardized cardiovascular evaluation comprising structured medical history, physical examination, resting 12-lead electrocardiography interpreted according to international athlete-specific criteria, and transthoracic echocardiography. Detected abnormalities were classified into low-, intermediate-, and high-risk categories for sudden cardiac death in accordance with the 2020 ESC Guidelines on Sports Cardiology and Exercise in Patients with Cardiovascular Disease. Exact 95% confidence intervals were calculated using the Wilson Score method.</p><p><strong>Results: </strong>Cardiovascular abnormalities were identified in 73 of 647 athletes (11.3%; 95% CI 9.1-14.0%). High-risk conditions requiring specialist cardiology evaluation and individualized, shared decision-making-based sports eligibility assessment were detected in 4 athletes (0.62%; 95% CI 0.24-1.57%), comprising one case of hypertrophic cardiomyopathy and three cases of clinically significant conduction disorders. All four affected individuals were previously asymptomatic. The most prevalent abnormalities were patent foramen ovale (4.02%), mitral valve disease (3.09%), and mitral valve insufficiency (1.85%). The number needed to screen to identify one high-risk condition was 162 athletes.</p><p><strong>Conclusions: </strong>Structured preparticipation cardiovascular screening in pediatric athletes in Adjara identifies a clinically meaningful burden of previously undetected cardiac pathology, including life-threatening conditions in asymptomatic individuals. The timely detection of high-risk conditions facilitated specialist referral and entry into an individualized, shared decision-making-based sports eligibility process, thereby potentially preventing exercise-related sudden cardiac events in this cohort. These findings provide essential region-specific epidemiological parameters and support the systematic integration of ECG-inclusive cardiovascular screening, aligned with the 2025 AHA/ACC shared decision-making framework, within organized youth sports programmes in Georgia.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"371-380"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149107807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRO-INFLAMMATORY INTERLEUKINS AND OXIDATIVE IMBALANCE IN L-NAME-INDUCED HYPERTENSION: COMPARATIVE EFFECTS OF Β-BLOCKERS.","authors":"N Kajaia, L Gabunia, M Mantskava, S Kalmakhelidze, G Ormotsadze, S Turabelidze-Robaqidze, T Sanikidze","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a multifactorial condition characterized by vascular dysfunction, oxidative stress, and immune activation. Pro-inflammatory cytokines, particularly IL-6, IL-17, and TNF-α, contribute to inflammatory processes in hypertension; therefore, they should be considered together with nitric oxide (NO) deficiency and oxidative imbalance when interpreting arterial pressure changes.</p><p><strong>Objective: </strong>To evaluate the association between pro-inflammatory interleukins, nitric oxide metabolites, oxidative status, and arterial pressure in an experimental model of hypertension, and to compare the effects of β-blockers.</p><p><strong>Methods: </strong>Hypertension was induced in 70 male Wistar rats by chronic administration of Nω-nitro-L-arginine methyl ester (L-NAME, 40 mg/kg/day, intraperitoneally) for 8 weeks. Animals were randomized into seven groups (n = 10/group): intact control, L-NAME for 4 weeks, L-NAME for 8 weeks, and four L-NAME + β-blocker treatment groups receiving nebivolol (0.5 mg/kg/day), propranolol (0.1 mg/kg/day), metoprolol (3 mg/kg/day), or carvedilol (2 mg/kg/day) by oral gavage during weeks 5-8. Arterial pressure was measured using a noninvasive tail-cuff method. Serum IL-6, IL-17, and TNF-α were quantified by ELISA. Nitric oxide metabolites and total antioxidant activity (TAA) were assessed using the Griess reaction and DPPH assay.</p><p><strong>Results: </strong>L-NAME administration resulted in a time-dependent increase in arterial pressure, accompanied by reduced NO metabolites and TAA and increased interleukin levels. β-blockers attenuated these changes to varying degrees. Nebivolol and carvedilol produced greater improvements in arterial pressure, NO metabolites, TAA, and interleukin levels compared with propranolol and metoprolol.</p><p><strong>Conclusion: </strong>Chronic NOS inhibition was associated with hypertension and concurrent alterations in inflammatory and oxidative parameters. β-blockers differ in their modulatory effects, with nebivolol and carvedilol demonstrating greater overall efficacy. These findings reflect associations rather than causal mechanisms and support further investigation into integrated therapeutic strategies.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"323-330"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149107966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}