D Myrzakozha, T Issabekova, N Rakhymbayev, E Karlova, E Nechepurenko
{"title":"COMPARATIVE STUDY OF ANTIBACTERIAL EFFECTS OF MODIFIED PREPARATIONS CONTAINING METAL NANOPARTICLES.","authors":"D Myrzakozha, T Issabekova, N Rakhymbayev, E Karlova, E Nechepurenko","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The study evaluated the inhibitory effects of pharmaceutical formulations enriched with metal-based nanoparticles on Staphylococcus aureus, Escherichia coli, and Salmonella dublin. Transmission electron microscopy revealed agglomerated chain-like structures of nanoparticles measuring 36-122 nm. Most metal components, including cobalt, zinc, manganese, and germanium, significantly reduced bacterial viability, whereas magnesium showed no suppressive effect. Bactericidal efficacy was confirmed both by diffusion assays and morphological disruption observed under high-resolution microscopy. The outcomes suggest the selective potency of certain metal nanoparticles against nosocomial bacteria and support their further consideration in the development of antimicrobial agents.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 363","pages":"150-157"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Georgian medical news","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
The study evaluated the inhibitory effects of pharmaceutical formulations enriched with metal-based nanoparticles on Staphylococcus aureus, Escherichia coli, and Salmonella dublin. Transmission electron microscopy revealed agglomerated chain-like structures of nanoparticles measuring 36-122 nm. Most metal components, including cobalt, zinc, manganese, and germanium, significantly reduced bacterial viability, whereas magnesium showed no suppressive effect. Bactericidal efficacy was confirmed both by diffusion assays and morphological disruption observed under high-resolution microscopy. The outcomes suggest the selective potency of certain metal nanoparticles against nosocomial bacteria and support their further consideration in the development of antimicrobial agents.
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