Georgian medical news最新文献

{"title":"DESIGN, MOLECULAR DOCKING, MOLECULAR DYNAMICS, AND EVALUATION OF NOVEL LIGANDS TARGETING BETA-2 ADRENERGIC RECEPTOR FOR ASTHMA THERAPEUTICS.","authors":"N Mousa, A Attia, K Ali","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study investigates the design and molecular docking of novel ligands targeting the beta-2 adrenergic receptor [β2AR], a critical protein involved in bronchoconstriction and asthma regulation. Utilizing molecular docking simulations, we evaluated the binding affinities of synthesized compounds, including compound 1, compound 5, and the reference drug salbutamol, against β2AR. The docking studies were conducted using GOLD software, and binding interactions were analyzed to identify key residues responsible for ligand binding and receptor activation. The results revealed that all tested compounds, particularly compound 1 and compound 5, demonstrated strong binding to the β2AR, with binding energies comparable to salbutamol. Key residues such as SER 207, PHE 289, LYS 305, and ASP 192 played significant roles in stabilizing the receptor-ligand interactions. The presence of functional groups like NO2 and NC in the synthesized compounds enhanced their affinity, suggesting that structural modifications could optimize β2AR binding. These findings provide valuable insights into the molecular mechanisms underlying β2AR-ligand interactions and highlight the potential of compounds 1 and 5 as promising candidates for further development into β2 agonists for asthma treatment. Salbutamol, as a well-established β2 agonist, served as a benchmark for evaluating the efficacy of the novel ligands, confirming the feasibility of designing β2AR-targeting therapeutics with improved potency and selectivity.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"138-147"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A STUDY ON THE RELATIONSHIP BETWEEN TYPE A PERSONALITY, EMPLOYMENT STRESS, AND MENTAL HEALTH OF RESIDENT PHYSICIANS IN TERTIARY HOSPITALS IN NANCHONG, CHINA.","authors":"J Liu, A Hu, Y Xie","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>to explore the relationship between Type A personality, employment stress, and mental health among resident physicians in tertiary hospitals in Nanchong, providing a research foundation for future targeted interventions to regulate employment stress and improve their mental health.</p><p><strong>Methods: </strong>A total of 65 resident physicians from tertiary hospitals in Nanchong, Sichuan, were recruited for this study. The General Health Questionnaire-20 (GHQ-20), Type A Behavior Pattern (TABP), University Student Employment Stress Scale, Medical Student Employment Stress Questionnaire, and Employment Intentions Survey for Medical University Students were used to assess the participants. Based on the GHQ-20 scores, the residents were divided into a positive group and a negative group to analyze the relationship between Type A personality, employment stress, and mental health.</p><p><strong>Results: </strong>The results of this study did not show a significant correlation between Type A personality, employment stress, and mental health among resident physicians in tertiary hospitals in Nanchong (P>0.05).</p><p><strong>Conclusion: </strong>This study did not confirm a significant relationship between Type A personality, employment stress, and mental health among resident physicians in tertiary hospitals in Nanchong. This may be due to the small sample size and insufficient assessment methods. Future research should consider increasing the sample size and designing more comprehensive and detailed assessment systems to further explore the factors influencing the mental health of resident physicians.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"125-131"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSMENT OF THE RELATIONSHIP BETWEEN OVERACTIVE BLADDER AND FUNCTIONAL CONSTIPATION, IN QASSIM REGION, SAUDI ARABIA.","authors":"E ALwashmi, B Alqefari, S Alsenidi, E Alwasidi, Y Alhujaylan, A Alsabhawi, M Almeshigeh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Urinary urgency that is abrupt and uncontrollable, sometimes accompanied by increased frequency of voiding during the day and nocturia, is a set of symptoms known as an overactive bladder (OAB). An increasing number of people are concerned about the health effects of overactive bladder and symptoms of functional constipation, such as straining and painful, irregular bowl movements.</p><p><strong>Methods: </strong>A sample of 556 members of the general population of the Qassim region of Saudi Arabia were used in this randomized descriptive cross-sectional survey study. Online surveys were filled out by the participants, who were guaranteed anonymity.</p><p><strong>Results: </strong>The incidence of functional constipation was 25.2%, and the prevalence of overactive bladder (OAB) was 34.4%. There was a statistically significant correlation (p=0.025) between the OAB and functional constipation. A history of pelvic surgery (OR=1.80, p=0.047), diabetes mellitus (OR=1.52, p=0.021), female gender (OR=1.84, p=0.003), smoking (OR=2.31, p=0.001), and an overactive bladder (OR=2.81, p<0.001) were all significant predictors of functional constipation. Female gender [AOR=1.722; 95% CI=1.149-2.580; p=0.008], having colorectal surgery [AOR=5.461; 95% CI=1.094-27.253; p=0.038], and having hypertension [AOR=0.458; 95% CI=0.219-0.955; p=0.037] were all substantially linked to the prevalence of overactive bladder (OAB). Furthermore, there was a significant correlation between a greater incidence of OAB and being a student [AOR=0.611; 95% CI=0.405-0.924; p=0.019] or unemployed [AOR=0.515; 95% CI=0.267-0.993; p=0.048].</p><p><strong>Conclusion: </strong>Overactive bladder (OAB) is linked to functional constipation, and smoking, being a woman, having diabetes, and having had pelvic surgery are common risk factors for functional constipation. Additionally, there was a strong correlation found between a higher prevalence of OAB and female gender, colorectal surgery, hypertension, and being a student or unemployed person. The substantial prevalence of these illnesses among the people living in Saudi Arabia's Qassim region is demonstrated by these data, underscoring the urgent need for education and awareness campaigns.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"68-74"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A NEW COMBINATION OF KNOWN AGENTS FOR TREATMENT OF ALOPECIA AREATA: A CASE-SERIES STUDY.","authors":"M Al-Zobaidy, Sh Sabri, A Barrak, N Salim, S Sabri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Alopecia Areata is an autoimmune disorder that affects hair follicles and results in non-scarring circumscribed areas of baldness that may be localised or widespread. Actually, we came across many cases with different patterns of hair loss that showed significant improvement after three months duration of treatment with a topical preparation (Freezia cream). The latter was prepared by specialized doctors and pharmacists, and obtained approval from the Iraqi Ministry of Health. Therefore, the current study is a case-series one that showed the presentations of some of these cases and the improvement achieved following treatment with the preparation in question.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"78-82"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NURSES' KNOWLEDGE WITH REGARD PAIN AS A PART OF A VITAL SIGNS.","authors":"M Natheer, M Tariq, T Thamir, R Ramadhan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pain is the fundamental symptoms joined with various disorders which are handled daily by nurses. Although it is a compensatory mechanism that makes patients acquire healthcare help. This study aimed to assess the nurse's knowledge of pain assessment and management as the fifth part of vital signs.</p><p><strong>Methods: </strong>A descriptive study design was utilized from the first of November 2024 till the 30 of December 2024, the study samples were (100) nurses who are working at different medical wards, and a questionnaire was used to collect data structured and self-administered.</p><p><strong>Results: </strong>Only 67% of the nurses knew that pain assessment was a part of the vital signs, however, 74% of the sample believed that pain assessment may affect the patient's prognosis of health.</p><p><strong>Conclusion: </strong>The study concluded that there is a statistical relationship between the advancement of years of experience and academic level, with the development of nurses' knowledge regarding pain assessment and considering it an important part of the process of measuring patient's vital signs.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"115-118"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE IMPORTANCE OF ONE HEALTH IN PREVENTING THE SPREAD OF HIGHLY PATHOGENIC AVIAN INFLUENZA/H5N1.","authors":"T Hayashi, K Acharya, S Phuyal, I Konishi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Infections with H5N1, a type of pathogenic avian influenza (HPAI) virus, are spreading among livestock farmers, particularly among dairy cows in the United States. Until now, HPAI/H5N1 has rarely infected humans, but transmission from H5N1-infected dairy cows to dairy workers has been reported. Additionally, cases of human-to-human transmission of H5N1 have been reported. It is thought that perhaps during the process of repeated amplification and replication of H5N1 viral genes in the mammary tissue of dairy cows, genetic mutations occurred that make H5N1 more susceptible to human infection. As more human spillover events are identified, there is pressing need to apply a one health approach to better characterize circulating highly pathogenic avian influenza (HPAI) viruses in wild migratory birds globally. It is important to develop a comprehensive international strategy for surveillance and monitoring systems in wild birds so the epidemiology of HPAI can be compared between countries and regions. In this review, we discuss the importance of One Health in preventing the spread of highly pathogenic avian influenza/H5N1.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"187-189"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIAGNOSTIC OF PANCREATIC INJURY USING INFRARED THERMOMETRY.","authors":"O Babkina, S Danylchenko, I Korobko, V Zozuliak, V Kucher","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>the study of the dynamics of changes in the temperature indicators of the injured pancreatic tissues in various types of mechanical trauma, depending on the time elapsed since the injury and the time of death.</p><p><strong>Material and methods: </strong>The material of the study was the pancreatic tissue of 256 individuals, both male and female, aged 20 to 60, who died with a known time of injury and time of death, with or without the presence of alcohol in the blood.</p><p><strong>Results: </strong>The article analyzes the issue of diagnostics, determining the time of injury and time of death. In the course of the conducted studies, statistically reliable dynamics of temperature decrease was revealed in both injured and intact pancreatic tissues in individuals who died from injuries, which can be used as one of the criteria for determining the time of injury. The study revealed that higher quantitative temperature indicators are observed directly in the area of pancreatic damage in comparison with uninjured pancreatic tissues with an average difference of 1.5-3ºC (±0.17). It was established that the sex of a person (male or female) does not significantly influence the temperature indicators of the pancreas.</p><p><strong>Conclusions: </strong>Based on the results of the study, a regression model was proposed for using to determine the time of death. This model takes into account the temperature indicators of the parenchymal organs of the abdominal cavity and retroperitoneal space in combination (liver, pancreas, spleen, kidneys) in dynamics at both positive and negative temperatures, using a modern method of infrared thermometry.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"181-186"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTS OF SESAMUM INDICUM (SESAME) OIL IN REMINERALIZING OF WHITE SPOT LESIONS INDUCED AFTER BRACKET DEBONDING: AN IN VITRO STUDY.","authors":"N Agha, A Qasim, A Al-Khatib","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Potential damage to dental enamel associated with orthodontic treatment especially enamel demineralization or white spot lesions formation are encountered as a common and undesirable complication of fixed orthodontic treatment.</p><p><strong>Aims of study: </strong>estimation the remineralization potential of paste prepared from Sesamum indicum oil in different concentrations and compare with casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) paste on artificial enamel caries produced in bracket debonded tooth surface.</p><p><strong>Materials and methods: </strong>Fifty-five sound permanent premolars were collected for this study. After mounting, bracket bonding and bracket debonding, the teeth were randomly divided into five groups. Artificial enamel caries was created by immersion of the samples in the demineralization solution. The enamel surface treated as following: Group A (n=11): Baseline (no demineralization and no treatment). Group B (n=11): Control negative (artificial saliva only), Group C (n=11): CPP-ACFP paste, Group D (n=11): 5% Sesamum indicum oil (paste 1). Group E (n=11): 10% Sesamum indicum oil (paste 2). Eight samples from each group were subjected to a surface microhardness test (SMH) and three samples from each group were subjected to scanning electron microscope (SEM) with energy dispersive X-ray spectroscopy (EDX) after 30 days of treatment. One-way analysis of variance (ANOVA), and Kruskal-wills tests were used to determine the significant differences between the groups. The statistical outcomes were considered significant at p<0.05.</p><p><strong>Results: </strong>ANOVA results of SMH revealed a statistically significant difference in surface micro hardness after treatment among the study groups and the greatest mean value of surface microhardness was seen in 5% Sesamum indicum oil (paste1) after the baseline group. Kruskal-wills test outcomes of EDX showed no significant difference after treatment among the treatment groups. SEM observations showed occlusion the craters of enamel rods and well-sealed interprismatic cavities of enamel after treatment.</p><p><strong>Conclusion: </strong>The Sesamum indicum oil used in this study exhibited potential remineralization in subsurface enamel lesions when compared with CPP-ACFP.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INTERMITTENT FASTING (5:2) VS. NON-FASTING: A COMPARATIVE ANALYSIS OF ANTHROPOMETRIC PARAMETERS, DEPRESSION, AND STRESS IN HEALTHY ADULTS - A CROSS-SECTIONAL STUDY.","authors":"R Othman, I Karmous, R Mizouri, O Berriche, A Bornaz, I Mannai, F Mahjoub, F Slama, H Jamoussi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intermittent fasting, particularly the 5:2 diet, has emerged as a popular dietary strategy for weight loss and metabolic health improvement.</p><p><strong>Objective: </strong>to compare the anthropometric and nutritional profiles among individuals adhering to the 5:2 intermittent fasting diet (IF 5:2) and non-fasting individuals.</p><p><strong>Methods: </strong>A cross-sectional study was conducted between December and June 2023. The study included 71 fasting and non-fasting patients who attended a private general medical practice. Among them, 35 were regular fast IF 5:2, consisted of two days per week fasting (Monday and Thursday) and five days per week of habitual intake, and 36 were non-fasting individuals. The two groups were matched for age and gender. Data were collected through a pre-established questionnaire, anthropometric measurements, and a dietary survey (24-hour recall and dietary habit). Depressive symptoms using the Hospital Anxiety and Depression scale and stress levels using the Perceived Stress Scale 4 were performed Results. Both groups had an average age of 55 years. None of the fasting group had a history of diabetes or dyslipidemia. There were no significant differences in weight and BMI between the two groups. The diet of fasters contained lower levels of proteins, lipids, and carbohydrates, while non-fasting individuals had a diet richer in potassium, phosphor and sugars. According to the HAD (Hospital Anxiety and Depression) score, the fasting group had fewer depressive symptoms (p=0.04). However, the level of stress was found to be similar between the two groups (p=0.19).</p><p><strong>Conclusion: </strong>This study suggested that there is a difference in the nutritional profiles of fasting and non-fasting subjects.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"132-137"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METHOD FOR PREVENTION OF COAGULOPATHIC BLEEDING DURING SURGERY FOR MECHANICAL JAUNDICE.","authors":"M Orazgalieva, M Aimagambetov, S Abdrakhmanov, N Omarov, M Auyenov, M Akkaliyev, A Orazalina, A Masalov, D Bokin, J Omarova, A Ulbauova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Violation of hemostasis directly depends on the severity of hepatocyte dysfunction. Such patients may develop disseminated intravascular coagulation (DIC syndrome) and bleeding during and after surgery.</p><p><strong>Objectives: </strong>to improve the results of treatment of coagulopathic bleeding during surgery for mechanical jaundice, through proactive therapy.</p><p><strong>Methods: </strong>A prospective randomized clinical-controlled research was conducted according to the study protocol, which was based on the purpose of the study and objectives. The state of hemostasis was studied depending on the duration of jaundice in 79 patients with mechanical jaundice treated at the Semey Medical University Hospital, Non-Commercial Joint-Stock Company (NCJSC) at the age of 18 to 85 years, the average age was 62 years. (95% confidence interval (CI) 59.2/64.6 for average 61.9). The patients were distributed by gender in the following order: males - 30 patients (38%), females - 49 patients (62%).</p><p><strong>Inclusion criteria: </strong>all patients aged 18 and older with mechanical jaundice requiring surgical treatment.</p><p><strong>Exclusion criteria: </strong>includes children and adolescents under 18 years of age, patients who do not agree to participate, incapacitated, pregnant women are excluded from the study. The total number of the sample was n=79 (100%) patients for the study, the patients were divided into 2 groups: the main group n = 35 (44.3%), patients who were treated with L-carnitine and the control group n=44 (55.7%). The prevention was based on a previously developed method of treating coagulopathies during surgery for mechanical jaundice, which includes a systemic effect on hemostasis and low invasiveness: treatment with levocarnitine at a dose of 5 ml intravenously slowly for 2-3 minutes, or drip in 100-200 ml of 0.9% sodium chloride.</p><p><strong>Results: </strong>Changes in blood clotting parameters in patients with mechanical jaundice upon admission and on the 1st, 3rd and 5th days after treatment with the proposed method noticeably improve, so there is a shift in the indications APTT, Claus fibrinogen, INR and PT towards hypercoagulation already on day 1 (because they are specific markers of prolonged bleeding).</p><p><strong>Conclusion: </strong>The proposed improved method of preventing coagulopathic bleeding during surgery for mechanical jaundice allowed to significantly reduce the incidence of coagulopathy in these patients, which is especially important, the frequency of their clinical manifestation, so Klausfibrinogen in the blood on the 5th day was 3.8 g/l, which turned out to be statistically significant U-412.500 (P=0.05) and improved PT by the 5th day was 12.3 seconds, the statistical significance of U was 208.500 (P=0.05).</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"108-114"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}