Georgian medical news最新文献

{"title":"PREVALENCE AND SOCIO-DEMOGRAPHIC RISK FACTORS OF EMOTIONAL BURNOUT AMONG PSYCHIATRISTS AND NURSING STAFF IN PSYCHIATRIC SERVICES IN KAZAKHSTAN.","authors":"A Ibrayeva, D Ospanova, K Saduakasova, S Sklyar, A Grjibovski, Sh Tanabayeva, I Fakhradiyev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To date, there are no studies examining the degree of emotional burnout among psychiatrists and nursing staff working in psychiatric hospitals in Kazakhstan. The aim of this study was to assess the prevalence and risk factors of emotional burnout among psychiatrists and nurses working in mental health services in the Republic of Kazakhstan. A cross-sectional survey was conducted using the Maslach Burnout Inventory (MBI) questionnaire among psychiatrists and nurses in psychiatric hospitals across Kazakhstan. According to the MBI questionnaire, metrics such as Emotional Exhaustion (EE), Personal Achievement (PA), and Depersonalization (DP) were measured to assess burnout. Socio-demographic indicators of the participants were recorded. Of the 1015 participants, 29.0% were psychiatrists and 71.0% were nurses. Moderate Emotional Exhaustion (EE) were observed in both groups, with scores of 21.2±8.3 for psychiatrists and 20.5±8.0 for nurses (p=0.345). Depersonalization (DP) scores were 9.0±5.8 for psychiatrists and 9.0±5.4 for nurses (p=0.37). Regression analysis identified various risk factors for EE among psychiatrists including age groups 25-30, 36-40 years (OR1.7 and OR1.8, respectively), work schedule (Flextime OR1.4, Part-Time OR1.5), and job tenure (3-5 years, ≥20 years, OR1.7). Factors associated with the progression of DP in psychiatrists were Part-Time work schedule (OR1.5) and smoking (OR1.5), p<0.05. For nurses, age groups 25-30 and 36-40, job tenure ≥3 years, Part-Time work, and workload were identified as risk factors for EE, p<0.05. Housing conditions were identified as a risk factor for burnout across all measurements in both groups (p<0.05). Smoking was a factor in all three dimensions for psychiatrists, and for EE and DP in nurses, p<0.05. The study reveals a moderate level of emotional burnout among psychiatrists and nurses in Kazakhstan's psychiatric services. Given the unique challenges and vulnerabilities of personnel in psychiatric services, these findings necessitate the implementation of coping strategies and preventative measures to mitigate professional burnout.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 359","pages":"108-115"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENHANCING OPHTHALMIC NURSING EDUCATION: A COMPREHENSIVE APPROACH TO CLINICAL TEACHING AND TRAINING.","authors":"Li-Bo Wang, Chun-Miao Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the current healthcare context, ophthalmic nursing education confronts a complex array of challenges and opportunities. This paper undertakes a methodical and in-depth analysis of these challenges, concurrently exploring innovative strategies designed to optimize clinical teaching models, particularly for novice nurses. In strict accordance with the guiding principles set by the National Health Commission (NHC) and in consonance with broader educational reform initiatives, this study places significant emphasis on the seamless integration of standardized training protocols. It also delves into the cultivation of advanced clinical competencies and the establishment of robust evidence - based evaluation systems. Through the meticulous construction of a structured framework that effectively bridges the divide between theoretical knowledge and practical application, the overarching goal of this research is to substantially elevate the proficiency levels of ophthalmic nurses. This, in turn, is anticipated to enhance patient safety outcomes within the intricate and specialized environment of ophthalmic care.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 359","pages":"120-122"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WHOLE TRANSCRIPTOME SEQUENCING AND CIRC_HSA_0001847 ON PROLIFERATION AND INVASION OF ORAL SQUAMOUS CELL CARCINOMA.","authors":"Liu-Xia Shi, Xiao-Ya Peng, Xiao-Xu Ruan, Rui Li, Wen-Jie Wen, Chao Deng","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) accounts for approximately 90% of malignant epithelial tumors in the oral and maxillofacial region, which is characterized by a high metastatic potential and an unfavorable prognosis. The specific process of oral mucosal carcinogenesis and progression is very complicated.</p><p><strong>Methods: </strong>Five OSCC patients' cancer tissues and paracancerous tissues were collected for whole transcriptome sequencing analysis to screen differentially expressed mRNA, long-stranded noncoding RNA (lncRNA), and circular RNA (circRNA) and bioinformatics [gene ontology (GO) enrichment analysis with genomic database (KEGG) pathway analysis and transcript enrichment analysis, etc.]. Target molecules closely associated with oral squamous cell carcinogenesis, migration, and invasion were identified using a miRNA-circRNA association network.</p><p><strong>Results: </strong>We screened 2310 mRNAs differentially expressed in cancer and paraneoplastic tissues, of which 1019 were upregulated and 1291 were downregulated; 14216 differentially expressed lncRNAs, of which 8829 were upregulated and 5387 were downregulated; and 167 differentially expressed circRNAs, of which 18 were upregulated and 149 were downregulated. Oral squamous cell carcinoma cells had a higher level of hsa_circ_0001847 expression than hok cells (P<0.05). Reduced hsa_circ_0001847 expression inhibited oral squamous cell carcinoma cell proliferation, migration, and invasiveness (P<0.05).</p><p><strong>Conclusion: </strong>Oral tissues contain differentially expressed mRNAs, lncRNAs, and circRNAs, and these differentially expressed mRNAs, lncRNAs, and circRNAs may be involved in the development of OSCC.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 359","pages":"143-155"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE SOCIODEMOGRAPHICAL AND MORPHOLOGICAL CHARACTERISTICS OF PRESCHOOL CHILDREN WITH SIDEROPENIC ANEMIA IN THE KOSOVO SAMPLE.","authors":"V Uka, A Uka, L Isufi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although anemia remains a widespread public health problem in most developing and developed countries, there are very few studies on the prevalence and severity of anemia among school-age children. In this research we examined the socio-demographic and morphometric characteristics of Kosovar preschool children with sideropenic anemia. The prospective study was carried out at the Department of Hemato-Oncology, Pediatric Clinic, University Clinical Center of Kosovo. The study included 244 children with sideropenic anemia and 99 non-anemic controls, ranging in age from one to 72 months. Children with sideropenic anemia had a higher prevalence of positive history of mothers with anemia, had a lower RBC, HGB, HTC, MCV and Iron values compared to children without anemia (p<0.05). Children with sideropenic anemia who had hypotrophic body structure had a lighter body weight at birth, also a lower prevalence of underweight and premature birth (p<0.05). There was no statistical difference between males and females of children with sideropenic anemia on RBC count, MCV, HCT, Le, platelet, reticulocytes, and serum ferritin (p>0.05). In conclusion, we can say that almost half of the children with sideropenic anemia had their mothers with a positive history of anemia. However, there are no differences in gender base on morphologic and hematological parameters among children with sideropenic anemia.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 359","pages":"116-119"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STATISTICAL TEACHING ON BUILDING STROKE PREDICTION MODELS.","authors":"Xin-Juan Wang, Lian-Ping He","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper comprehensively elaborates on a statistical teaching design that is intricately centered around the construction of stroke prediction models. Stroke, being one of the foremost causes of death and disability on a global scale, necessitates the development of accurate prediction models, which carry substantial clinical value. This teaching design is meticulously crafted to not only endow students with practical statistical skills but also to deepen their comprehension of the medical applications of statistics. By doing so, it aims to cultivate cross - disciplinary talents who are proficient in both statistical and medical knowledge, equipping them to contribute effectively to the field of medical data analysis and stroke prevention.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 359","pages":"72-75"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PIRACETAM HELPS RESTORE VISION AFTER CRANIOCEREBRAL TRAUMA.","authors":"M Saidulaev, N Osipova, A Gurtskaya, N Semov, R Khusainov, E Khabarov, D Lech, P Stotland, V Eloeva, A Syromyatnikova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article examines the effect of piracetam on visual function after brain injury. This drug may be useful in restoring ophthalmoscopic changes after craniocerebral trauma, contributing to improved brain activity and neuroplasticity. It is important to note that the efficacy of piracetam may depend on the severity of the injury as well as the general condition of the patient. The object of the study was patients treated at NWSMU named after I.I.Mechnikova for traumatic brain injury over the last three years, who received piracetam for 4 weeks. Depending on the severity of craniocerebral trauma, which was determined using the Glasgow Coma Scale, the subjects were divided into three groups: group №1, who had previously suffered a mild concussion, rated 13-15 points (n=20), group № 2, who had a moderate degree of severity of traumatic brain injury, 9-12 points (n=20) and group № 3, which was a placebo control (n=20). Prior to the study, all participants had their luminance sensitivity threshold (LST) and visual-motor reaction time (VMRT) assessed at specified points in the visual field. These parameters were assessed using colour campimetry, which allowed us to consider these parameters both in general (0-21o) and separately in the macular (0-5o) and peripheral (5-21o) retinal zones. The results were subjected to statistical processing (Student's and sign criteria). At the end of the course of piracetam administration, the visual functions were reassessed, namely, the functional capacity of the retina was determined by the magnitude of LST and VMRT.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 359","pages":"87-88"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WORKSHOP AS A PRACTICE-ORIENTED METHOD OF TEACHING DENTISTS: INTRODUCTION TO EDUCATIONAL PROGRAMS FOR WORKING WITH CHILDREN WITH AUTISM SPECTRUM DISORDERS.","authors":"D Abdukalikova, A Auezova, M Baymuratova, S Yessembayeva, G Yermukhanova, Z Yerkibayeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article addresses the pressing issue of providing dental care to children with Autism Spectrum Disorder (ASD) and emphasizes the need for an innovative approach in the training of dental professionals. The intensive course we have developed for practical training, based on the use of clinical cases and patient management algorithms for ASD, represents an important step toward improving the quality of dental care. During their education in medical universities, students master various types of simulations, which allow them to integrate theoretical knowledge with practical skills. However, given the dynamic nature of medical practice and societal needs, continuous updating of this knowledge is essential. We present a \"portrait\" of a dentist working with children with ASD, which includes a list of criteria in line with current medical standards and innovations. The key aspects of our approach include adherence to WHO standards and the \"Health for All\" principle, highlighting the dentist's responsibility to society; the development of communication skills necessary for effective interaction with children facing communication challenges; the use of clinical cases in the educational process, which promotes the formation of a comprehensive approach to organizing patient appointments and treatment based on successful interactions with patients.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 359","pages":"126-132"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES OF VASOMOTOR RHINITIS IN PATIENTS WITH A HISTORY OF COVID-19 INFECTION.","authors":"N Nakudashvili, L Ratiani, T Megrelishvili, E Sarbekovi, M Tsabadze, N Kipiani, N Intskirveli, M Tortladze, T Gabunia, Sh Tsiklauri, Z Nakudashvili, G Ormotsadze, T Sanikidze","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>to determine some aspects of the pathogenesis of VMR in patients with a history of COVID-19 infection and to evaluate the therapeutic efficacy of a local antihistamine drug.</p><p><strong>Design: </strong>Data was collected from patients diagnosed with Vasomotor rhinitis (VMR) (who had COVID-19 more than 6 months ago, group I) and those without COVID-19 (group II). These patients were filtered to seasonal allergens, a history of bronchial asthma and/or bronchial hypersensitivity, chronic rhinosinusitis, nasal polyposis or sensitivity to aspirin, pregnancy, acute phase of COVID-19 infection, and use of anti-inflammatory drugs within the last 6 weeks.</p><p><strong>Setting: </strong>First University Clinics of Tbilisi State Medical University and the National Centre of Otorhinolaryngology (Tbilisi, Georgia).</p><p><strong>Participants: </strong>Patients diagnosed with VMR for 6 weeks or more were selected.</p><p><strong>Methods: </strong>All patients underwent the instrumental (anterior and posterior rhinoscopy, endoscopy, rhinomanometry) examination, the cytological (eosinophils, neutrophils, and leukocytes count), and biochemical investigations of nasal smear (the content of nitric oxide (NO)) and blood serum total antioxidant activity. Patients were treated with intranasal antihistamine spray - 2 sprays 2 times a day for 10 days. All studies were performed on patients before and after treatment.</p><p><strong>Results: </strong>No statistically reliable difference in the initial insights of the objective and subjective indicators for groups I and II were detected; the cytological examination of nasal smears showed that in patients from group I eosinophils, lymphocytes, an increased number of neutrophils and low-level of NO were revealed compared to corresponding indicators in patients from group II. The level of TAA in the blood serum of patients with VMR was lower than in healthy volunteers (especially in patients of group I).</p><p><strong>Conclusions: </strong>In patients with VMR previously exposed to COVID-19 infection, the intensity of the oxidative stress and depletion of nasal NO were especially high, causing the abolishment of protective ability, chronic eosinophilic inflammation, and airway hyperresponsiveness. Antihistamine spray is effective for VMR treatment in groups I and II; in patients with VMR who previously had a COVID-19 infection, it is necessary to increase the treatment course duration.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 359","pages":"23-31"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RISK PREDICTION MODEL FOR ACUTE KIDNEY INJURY IN PATIENTS WITH SEVERE ACUTE PANCREATITIS.","authors":"Li-Juan Ru, Qian-Qian Yao, Ming Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This research is dedicated to pinpointing the risk factors associated with acute kidney injury (AKI) in patients diagnosed with severe acute pancreatitis (SAP). Additionally, it endeavors to construct a nomogram that can accurately predict the risk of AKI in such patients. A total of 60 SAP patients, who were admitted to our hospital between July and December 2024, were selected as the research subjects. These patients were divided into a control group, which did not experience AKI, and an observation group, which had developed AKI. Extensive general information, including age, gender, and body mass index, as well as comprehensive clinical data, such as various laboratory test results and disease severity scores, were meticulously collected for all patients. Univariate analysis was initially carried out to screen out potential factors related to AKI. Subsequently, the factors that demonstrated statistical significance in the univariate analysis were incorporated into the multivariate Logistic regression analysis to identify the independent risk factors for AKI in SAP patients. By leveraging R software, a nomogram for predicting the risk of AKI in SAP patients was successfully established, with its foundation being the relevant factors determined from the univariate and multivariate analyses. The predictive performance of this nomogram was evaluated by means of the concordance index (C-index). To further validate the stability and accuracy of the model, the Bootstrap method was adopted. This involved conducting resampling with replacement 1000 times within the development cohort of the nomogram. In each resampling process, a resampled dataset with an identical sample size was constructed and utilized as the training set, while the original development cohort served as the validation set. Through this repeated process, the relatively calibrated C-index was calculated to comprehensively assess the performance of the model.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 359","pages":"133-135"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GENETIC ALTERATIONS IN TUBO-OVARIAN EPITHELIUM DURING OVARIAN NEOPLASIA.","authors":"T Dzotsenidze, A Gvenetadze, G Burkadze, E Isakidi, M Shulaia","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Ovarian serous carcinomas are a significant cause of female cancer mortality. Emerging evidence suggests a crucial role for the fallopian tube epithelium in the development of high-grade serous ovarian carcinomas (HGSOC), supported by shared molecular alterations like TP53 mutations. However, the precise pathogenetic mechanisms, hormonal influences, and the impact of cancer stem cells and intra-tumoral heterogeneity remain incompletely understood.</p><p><strong>Methods: </strong>This review synthesizes existing literature, including clinical investigations, epidemiological studies, and molecular analyses, to examine the origins and development of ovarian serous carcinomas. Methodological approaches reviewed include immunohistochemistry, genetic sequencing (e.g., next-generation sequencing), RT-PCR, laser microdissection, and analysis of prophylactic salpingo-oophorectomy specimens.</p><p><strong>Results: </strong>The review highlights the growing evidence supporting the fallopian tube origin of HGSOC, with frequent co-occurrence of serous tubal intraepithelial carcinomas (STIC) and shared TP53 mutations. Genetic mutations in BRCA1/2, BRAF, KRAS, and PTEN contribute to tumor development. Hormonal influences, particularly estrogen and progesterone receptor expression, and the roles of cancer stem cells (CD117, CD133, CD44) and intra-tumoral heterogeneity are crucial for tumor progression and treatment response.</p><p><strong>Conclusion: </strong>The fallopian tube epithelium plays a significant role in HGSOC pathogenesis. Further research is needed to elucidate the pathogenetic mechanisms, hormonal influences, and the impact of cancer stem cells and intra-tumoral heterogeneity. A comprehensive understanding of these factors will improve prevention, prognosis, and the development of tailored treatment strategies, including refined classification systems that account for tumor heterogeneity.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 359","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}