Georgian medical news最新文献

{"title":"PROPORTION OF HEART FAILURE PATIENTS RECEIVING GUIDELINE RECOMMENDED DOSES OF BETA BLOCKERS IN GEORGIA: A STUDY ON TITRATION AND TOLERABILITY.","authors":"G Shaburishvili, N Shaburishvili, S Zeikidze","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and aims: </strong>Beta blockers are an essential part of the treatment and management of heart failure. Unfortunately, due to contraindications and side effects, it is impossible to titrate the medication to the recommended dose by available guidelines in all patients. The aim of this study was to determine the proportion of patients in Georgia receiving the maximum recommended dose of beta blockers and the proportion who could be titrated to a higher dose.</p><p><strong>Methods: </strong>The conducted study focused on the proportion of patients in Georgia receiving the maximum recommended dose of beta blockers and the patient's receiving maximum tolerated dose of beta blockers. 300 patients with heart failure with reduced ejection fraction participated in the study. Patients were divided into 3 groups, depending on which beta blocker they were taking - bisoprolol, carvedilol or metoprolol. In patients who could not take the maximum recommended dose, an attempt was made to titrate to a higher dose.</p><p><strong>Results: </strong>A total of 25.67% (n=77) of the 300 patients were able to reach the target dose and 223 patients were unable to reach the target dose of the medication due to various side effects. In the bisoprolol group, 19.7% reached the target dose, in the carvedilol group - 30.2% and in the metoprolol group - 31.6%. It was also noteworthy that 24.17% of patients (n=58) were able to titrate the prescribed medication to a higher dose. At the end of the study, of the 223 patients who were unable to titrate to the recommended dose of beta-blocker, 64.1% experienced bradycardia, 54.2% experienced hypotension, 32.7% experienced dyspnea, 41.3% experienced fatigue, and 38.1% experienced dizziness.</p><p><strong>Conclusion: </strong>The inability to use beta-blockers, one of the most important medications for heart failure, is a major problem in Georgia, as only 25.67% of patients were able to take the recommended dose of the medication. Since 24.17% of patients were able to titrate to a higher dose of beta blockers, we can conclude that with long-term and careful control of heart failure some patients may be able to titrate to a higher dose of beta blockers through adaptation to the medication and to the cardiac function. It is also possible that patients were not receiving optimal medication treatment at the time of medication initiation and the medication could actually have been titrated to a higher dose. This fact highlights the importance of attempting to titrate to a higher dose of beta blockers, as 24.17% of patients saw improvement in their prescribed medication over the course of the study.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"70-77"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMMUNE RESPONSE OF CULTURED MONOCYTES OF ATHEROSCLEROTIC PATIENTS RECEIVING STATIN THERAPY.","authors":"T Kirichenko, I Yudina, M Lukina, T Andrushchishina, N Elizova, A Markin, Yu Markina","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>The current study was aimed to evaluate the immune response of monocytes/macrophages derived from atherosclerotic patients receiving hydrophilic and lipophilic statins and without lipid-lowering therapy, in order to evaluate the effect of statins on the inflammatory status of circulating monocytes.</p><p><strong>Materials and methods: </strong>Three groups of 20 patients with atherosclerosis of the coronary arteries were included in the study: patients receiving atorvastatin or rosuvastatin therapy for at least 12 months before inclusion in the study and participants without statin therapy within a year before the inclusion in the study. CD14+ monocytes were derived from the whole blood of study participants by immunomagnetic separation. The isolated cells were cultured for 7 days under inflammatory stimulation with LPS and without stimulation. The level of basal, LPS-stimulated and re-stimulated secretion of inflammatory cytokines TNF-α and IL-1β was determined by ELISA.</p><p><strong>Results: </strong>The significantly lower basal secretion of TNF-α was revealed in atorvastatin and rosuvastatin groups in comparison with statin-free group (p=0.003; p<0.001); the basal secretion of IL-1β was lower only in rosuvastatin recipients (p=0.020). LPS-stimulated secretion of TNF-α wasn't significantly different in all groups while secretion of IL-1β was significantly reduced in both atorvastatin and rosuvastatin groups (p=0.002; p=0.001). The re-stimulated secretion of TNF-α was significantly lower in rosuvastatin recipients (p=0.031); the effect of statins on re-stimulated secretion IL-1β wasn't revealed. The correlation analysis revealed the association of total cholesterol and LDL serum levels with basal secretion of TNF-α and IL-1β.</p><p><strong>Conclusions: </strong>Thus, the study demonstrated the significant decrease of inflammatory cytokines secretion by cultured monocytes of patients with coronary atherosclerosis receiving statin therapy. The most prominent effect was observed in rosuvastatin recipients. The reduction of the TNF-α and IL-1β secretion by monocytes correlated with low levels of total cholesterol and LDL.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"123-128"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"SCREAM\" OF CYSTOLITHOTOMY IN HISTORY OF ART: PATIENT PERSPECTIVE.","authors":"A Verit, F Verit","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Duality of \"cutting and pain\" for the bladder stones had even reported in the written material of Hippocrates. \"Art\" and \"Surgical pain\" has been very rarely appeared in the medical literature especially from the patient perspective. The pain perception can be regarded as subjective and the author defined it as in own words; \"Pain is whatever the experiencing person says it is\". Operation for bladder stone, which should be considered as the pioneer complex surgical intervention of mankind and had been performed without anesthesia till the mid-19th CC, and it was a more common surgery than today's practice. The scream of Urological patient expressed in the music nota by great French composer Marin Marais (1656-1728), for his own bladder stone surgery. We aimed to review the reported written feelings and their own art of the patients who underwent surgical operations mainly for the bladder stones before the anesthesia era.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"151-153"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FORMATION OF ARTIFICIAL BURNS IN WISTAR RATS TO EVALUATE THE EFFECTS OF DIFFERENT DRUGS.","authors":"D Kubaevskaya, P Olennikov, S Ishmaev, E Balakireva, D Labazanov, S Boguslavets, V Beskadarov, S Zhidkov, I Budeykina, D Komolov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Burns are a common problem faced by mankind, which in turn affects function and quality of life. Over the centuries, many anti-burn drugs have been developed. In this article the effect of different preparations: Agrosulfan-anti-burn preparation, Shostakovsky's Balsam-anti-burn preparation, Alfazox-esophagoprotector, on artificially formed burns with the help of electrocoagulator on Wistar rats is considered. The rats were kept in standard vivarium conditions in cages under natural light regime and on normal diet with free access to water and food. Comparison of preparations was carried out, the indication of which is treatment of burns. But in comparison with other preparations «Alfazox» is an esophagoprotector, on the basis of its properties (promotes healing of gastric mucosa erosions) and composition (Chondroitin sulfate + hyaluronic acid + poloxamer 407), this preparation can be prescribed for burns off-label. By means of daily measurement of the burn surface area and estimation of tissue repair rate. preparations showed the following results: Agrosulfan - complete epithelization of the wound occurred on the 11th day, showed the best result, «Alfazox» - 13 days, belonging to esophagoprotectors, in contrast to the control group (16 days), which makes it possible to prescribe it off-label. The period of complete epithelialisation of Shostakovsky's Balsam was 14 days. The terms of the control group were 16 days.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"121-122"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POLYPHARMACY, DRUG RELATED NITROSAMINE CONTAMINATION (BISOPROLOL/PROPAFENONE) AND THE LINK TO LICHEN PLANUS/SUBSEQUENT DEVELOPMENT OF KERATINOCYTE AND MUCOSAL CANCER/ORAL LEUKOPLAKIA: PRESENTATION OF THE FIRST CASE AND UPDATE ON THE NEW PATHOGENETIC VISION.","authors":"G Tchernev, V Broshtilova, S Kordeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The association between drug-induced lichen planus - whether oral/mucosal or solely cutaneous - involves a diverse range of drugs, including ACE inhibitors, diuretics, and beta blockers, as well as quinidine, NSAIDs, hydroxychloroquine, antiretroviral medications for HIV, penicillamine, TNF inhibitors, and certain medications for type 2 diabetes. The natural course of lichen planus has been also linked in certain cases to the development of squamous cell carcinoma, affecting both mucous membranes and skin, as extensively documented in the literature. However, little attention has been given to the fact that many of the medications associated with lichen planus - such as ACE inhibitors, diuretics, and beta blockers - are listed by the FDA as contaminated with carcinogenic and mutagenic nitrosamines. These compounds exhibit photocarcinogenic, carcinogenic and mutagenic properties. Their potential role in the progression of lichenoid lesions to oral leukoplakia, oral carcinomas and squamous cell carcinoma, but also strictly cutaneous located tumour has not been previously explored, yet it appears both plausible and significant. We present for the first time in the medical literature, a case of a 91-year-old patient with a 2-year history of oral lichen planus and subsequent oral leukoplakia following 2-year beta-blocker (bisoprolol) and/or anti-arrhythmic (propafenone) administration, with no history of smoking and alcohol consumption, and discuss the possible role of nitrosamines as a cofactor in the malignant transformation of ulcerative lichenoid lesions to oral leukoplakia/mucosal carcinoma. The adverse effects of these medications may be categorized into those related to 1) the active substance - potentially triggering lichen planus and those 2) linked to contaminants/carcinogens/mutagens, such as nitrosamines, which may act as primary or contributory factors in skin carcinogenesis in direction development of oral leukoplakia and oral/cutaneous carcinomas.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"143-150"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVALENCE, PATTERN, RISK FACTORS, AND MANAGEMENT OF ABDOMINAL AND INGUINAL HERNIAS IN KING FAHAD HOSPITAL AT AL-BAHA CITY, SAUDI ARABIA 2024.","authors":"T Alghamdi, A Khallufah, A Alghamdi, M Al Shareef, Alaa Alzahrani, F Alzahrani, K Alghamdi, Anmar Alghamdi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Abdominal hernia is common among genders and all ages. However, information about the prevalence and risk factors of abdominal hernia is still limited in Saudi Arabia. The aim of the study is to assess the Prevalence, Pattern, Risk Factors, and management of abdominal and inguinal hernias.</p><p><strong>Method: </strong>This is an observational study set in King Fahad Hospital (KFH- Al-Baha) in the Al-Baha region of Saudi Arabia, with an inclusion of patients aged 18-80 years old who presented with abdominal or inguinal hernias between January 2022 and January 2024, excluding pediatric patients, patients above 80 & and patients with deficient data.</p><p><strong>Results: </strong>The study included 219 patients, and the most reported type of hernia was indirect inguinal (37.9%). The most common risk factor was a history of previous abdominal surgery (26%), followed by comorbidities like diabetes mellitus (15%) and hypertension (13%). Seventeen percent suffered from hernia recurrence. Most of the hernia cases were reducible (96%). Strangulation features (pain and tenderness) were noted in 3.2% of patients. Ninety-two percent of the patients underwent elective surgical management, with open hernioplasty being the most common (42%). The analysis of hernia types in relation to demographic and clinical characteristics revealed that only gender was a significant finding. Males had significantly higher odds of developing indirect inguinal hernia (OR=35.7, 95% CI: 11.6-165, p<0.001) and direct inguinal hernia (OR=8.15, 95% CI: 2.27-52.2, p=0.006). Conversely, male gender was a protective factor against umbilical (OR=0.23, 95% CI: 0.09-0.58, p=0.002), paraumbilical (OR=0.13, 95% CI: 0.07-0.26, p<0.001), and incisional hernias (OR=0.30, 95% CI: 0.09-0.92, p=0.040).</p><p><strong>Conclusion: </strong>The study concluded that the most common type of hernia was indirect inguinal hernia. Most of the patients underwent elective surgical management, with open hernioplasty being the most common.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDY OF THE ASSOCIATION BETWEEN ASTHMA, WEIGHT STATUS AND NUTRITIONAL INTAKE: RESULTS OF A TUNISIAN PILOT SURVEY.","authors":"Ch Jemai, H Zaibi, T Farhat, N Dhieb, A Mehrez, M Djebbi, Z Ali, Y Htira, F Mami","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to assess asthma characteristics in adults based on weight status and nutritional intake.</p><p><strong>Materials and methods: </strong>This was a cross-sectional study conducted among asthmatic patients aged over 18 years. We collected epidemiological characteristics, asthma characteristics (duration, etiology, severity, disease control (GINA), exacerbations frequency, treatment regimen and adherence (MMA Scale), physical activity level (Ricci and Gagnon questionnaire), basic metabolism (Black & al. formula), energy expenditure, and body composition (bioelectrical impedance). Nutritional intake was assessed (dietary survey was analyzed using Bilnut software). Statistical tests were performed using SPSS 23.</p><p><strong>Results: </strong>The mean age was 46.15±14.13 years, and the sex ratio was 0.25. Of the population, 75% were overweight. With an average body fat of 34.96%. A total of 67.5% had an excessive caloric intake, and micronutrient intake was insufficient for the majority of the population. No significant association was found between asthma characteristics and either weight status or nutritional intake (p=NS).</p><p><strong>Conclusion: </strong>Obesity and dietary errors were common, with no significant association with asthma characteristics.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"78-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OCULAR MANIFESTATIONS IN A PATIENT WITH HIDRADENITIS SUPPURATIVA: A CASE STUDY.","authors":"H Al Dhaheri, M Khan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Patients with chronic inflammatory skin disease called hidradenitis suppurativa (HS), which can also produce systemic comorbidities, show ocular symptoms. Although HS has dermatological roots, if left untreated it can cause major ocular issues like dry eye syndrome and corneal neovascularization, therefore affecting eyesight.</p><p><strong>Case description: </strong>Our patient, a 19-year-old man with corneal neovascularization, scarring, bilateral dry eye disease, uncontrolled HS, and other medical disorders, after a year of therapy with adalimumab failed to sufficiently control the illness, secukinumab (300 mg monthly) and concomitant oral doxycycline (100 mg twice daily) were prescribed to reduce inflammation and prevent subsequent infections. As shown by ophthalmologic findings, bilateral corneal neovascularization, stromal infiltrates, and chronic inflammation helped to explain ocular discomfort and reduced quality of life. Both eyes maintained visual acuity at 6/6 even though corneal scarring could cause future damage. Management and treatment: A multidisciplinary team under management of the patient comprised ophthalmology and dermatology doctors. Using continuous systemic treatment, management of HS flares and ocular inflammation is the ocular treatment included Tobradex, Lumify, artificial tears; more modern treatments like anti-VEGF therapy were under consideration for cases of progressive neovascularization.</p><p><strong>Conclusion: </strong>As this case shows, a multidisciplinary approach is absolutely essential when tackling HS including the eyes. Early diagnosis and tailored treatment plans allow one to improve patient outcomes, maintain visual function, and minimize repercussions. More study is needed to better grasp the pathophysiology of HS-related ocular problems and create more sensible treatment plans.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"31-34"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANALYSIS OF ENAMEL SURFACE WEAR INDUCED BY TWO CONCENTRATIONS OF ZIRCONIA PARTICLE TOOTHPASTE UNDER TWO ELECTRIC TOOTHBRUSHING MODALITIES.","authors":"Z Lila, S Krasniqi, A Gjelaj, J Veronneau","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Dental enamel, the outermost layer of human teeth, is a mineralized tissue that must endure repetitive forces, wear, and corrosion resulting from everyday oral activities like chewing. Its high mineral content provides the strength and hardness necessary for proper tooth function. However, over time, wear, fractures, or cavities often lead to the need for dental repairs. Additionally, unlike other human tissues, dental enamel lacks significant regenerative or self-repair capabilities, making tooth restorations more essential.</p><p><strong>Objective: </strong>To evaluate the effects of two electric toothbrush modalities and two different concentrations of zirconia-containing whitening toothpaste on enamel surface roughness.</p><p><strong>Materials and methods: </strong>Forty extracted lower third molars were divided into four groups based on toothpaste concentration (3% and 4% zirconia) and brushing mode (active and soft). Each tooth was brushed for 5 minutes using an oscillating electric toothbrush. Enamel surface roughness was measured before and after brushing using a contact profilometer.</p><p><strong>Results: </strong>Brushing with 4% zirconia toothpaste in active mode resulted in the highest increase in enamel surface roughness, particularly in Rz and Rq values. Conversely, the soft mode, especially with 4% zirconia toothpaste, demonstrated a protective trend, where post-brushing roughness values decreased in some metrics. However, these changes did not reach statistical significance across any group (p>0.05).</p><p><strong>Conclusion: </strong>While higher concentrations of zirconia in whitening toothpaste and increased brushing force may influence enamel surface roughness, the observed changes were not statistically significant. Further research is needed to determine safe concentrations and brushing techniques to minimize enamel wear.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"50-56"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPLORING THE ROLE OF C-REACTIVE PROTEIN IN PREECLAMPSIA AMONG HYPERTENSIVE PREGNANT WOMEN.","authors":"H Mohamed, A Abdelgadir, A Ismail, O Elsadig, K Gopinath, M Omer, A Alfeel, E Ali, M Almaki, A Abdelmola, H Osman, H Al-Obaidi, A Eltom, M Ismail","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Preeclampsia (PE), a major cause of maternal and fatal morbidity and mortality, affects 4-5% of human pregnancies, characterized by elevated blood pressure and proteinuria after 20 weeks.</p><p><strong>Objective: </strong>The current study sought to investigate a potential link between high CRP levels and the probability of pregnant women to develop PE.</p><p><strong>Methods: </strong>The study involved 50 pregnant women with PE symptoms and 30 control women without symptoms, collecting serum samples and data via questionnaire.</p><p><strong>Results: </strong>The most common age group for this study was 31 to 40 years. The majority of the studied women belong to ethnic groups of Northern Sudan ancestry (52%). The majority of women in the pre-eclampsia group were in their third trimester (54%). Among the fifty women with PE, 35 (70%) tested positive for CRP, while 15 (30%) tested negative. Four (13.3%) participants in the control group tested positive for CRP, while 26 (86.6%) were negative.</p><p><strong>Conclusion: </strong>This study concluded that C-reactive protein (CRP) serves as a valuable predictive marker for the onset of PE. The strong correlation between CRP levels and the incidence of PE suggests that monitoring CRP could help identify women at higher risk for this condition. Additionally, the link between CRP presence and the number of prior PE cases indicates that women who have experienced PE in previous pregnancies may be more susceptible to recurrence, with CRP potentially aiding in early detection. The study discovered no significant effect of ethnic group on the development of pre-eclampsia.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"101-105"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}