Georgian medical news最新文献

{"title":"CARDIOMETABOLIC RISK PROFILES IN ADULTS WITH DIABETES: ASSOCIATIONS WITH GLYCEMIC CONTROL, DIABETES TYPE, AND DEMOGRAPHIC CHARACTERISTICS.","authors":"F Althoini, E Almogbel","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Background: Even though diabetes is a major risk factor for ischemic heart disease, modifiable risk factors like hypertension, dyslipidemia, and obesity remain significant factors in the morbidity and mortality associated with this disease in diabetic patients. The data available for the region is still scarce, particularly in the Qassim region. This research aimed to evaluate the prevalence of cardiovascular risk factors among diabetics and their association with glycemic control, diabetes type, and demographic data in the Qassim region.</p><p><strong>Methods: </strong>Methods: A retrospective cross-sectional study was conducted of the electronic medical records (EMR) of patients with diabetes at the Diabetes and Endocrine Center in Qassim, Saudi Arabia, on 1st December 2024 until 15th May 2025. Clinical and laboratory data and demographic and anthropometric data were obtained from medical records.</p><p><strong>Results: </strong>Results: A high prevalence of obesity (56.6 %), physical inactivity (76.3 %), and low levels of high-density lipoprotein (HDL) cholesterol (50.6 %) were noted. There was a significant association between poor glycemic control (HbA1c > 8%) and abnormal levels of LDL and total cholesterol, with 30.95% of patients in the poor control group having high LDL and total cholesterol levels (p < 0.001). Type-2 diabetes mellitus (T2DM) was strongly associated with hypertension, obesity, physical inactivity, low HDL, and high triglycerides compared to type 1 diabetes mellitus (T1DM), which was associated with total cholesterol and LDL abnormalities. Male participants had a higher prevalence of dyslipidemia and smoking; female participants had a higher prevalence of obesity and physical inactivity. In addition, central adiposity and hypertension were related to age.</p><p><strong>Conclusions: </strong>Conclusions: Cardiovascular risk factors were highly prevalent among adults with diabetes in the Qassim region, associated with obesity, physical inactivity, low HDL, and hypertension. The findings emphasize the critical importance of implementing routine screening protocols and customized preventive strategies, with particular focus on the elderly and individuals with T2DM, to mitigate cardiovascular disease burden in this population.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"64-77"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHRONIC URTICARIA AND LEAD EXPOSURE: EVALUATION OF IMMUNOLOGICAL MARKERS.","authors":"N Shavlakadze, I Phkhakadze, A Silagadze, D Kobuladze, A Pakhuridze","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Chronic urticaria (CU) is a mast-cell-driven disorder involving inflammatory and autoimmune mechanisms. Lead can affect immune function, but its relationship with CU has been little studied.</p><p><strong>Objective: </strong>To examine the association of blood lead levels (BLLs) with CU, active wheals at blood sampling, and selected immunological markers.</p><p><strong>Methods: </strong>This single-center case-control study included 303 participants from Western Georgia: 211 patients with CU and 92 healthy controls. BLLs were measured by inductively coupled plasma mass spectrometry. Eosinophils, total IgE, histamine, anti-IgE autoantibodies, and FcεRIα autoantibodies were assessed. BLL ≥10 µg/dL was used as the predefined analytical threshold for higher lead exposure. Associations were evaluated using group comparisons, Spearman correlation, and age-adjusted regression analyses.</p><p><strong>Results: </strong>BLLs were higher in patients with CU than in healthy controls. BLL ≥10 µg/dL was present in 66.8% of patients and 33.7% of controls (OR 3.96; 95% CI 2.36-6.66; p<0.001), and the association remained significant after adjustment for age (aOR 4.07; 95% CI 2.38-6.96; p<0.001). Within the CU group, higher BLLs were associated with eosinophilia and higher histamine, anti-IgE, and FcεRIα autoantibody levels, but not with total IgE. BLL ≥10 µg/dL was also associated with active wheals at blood sampling after adjustment for age (aOR 3.36; 95% CI 1.75-6.45; p<0.001). In an exploratory analysis, the dual-positive anti-IgE/FcεRIα group had the highest frequencies of BLL ≥10 µg/dL (83.3%) and active wheals (92.4%). Compared with patients in whom neither autoantibody was elevated, the dual-positive group had the strongest age-adjusted association with BLL ≥10 µg/dL (aOR 5.49; 95% CI 2.38-12.70; p<0.001).</p><p><strong>Conclusions: </strong>Patients with CU had higher BLLs than healthy controls. Within the CU group, higher BLLs were associated with eosinophilia, histamine, anti-IgE and FcεRIα autoantibodies, and active wheals, but not with total IgE. These associations require confirmation in prospective studies.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"6-16"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SOME HEREDITARY DISEASES PREVALENT IN THE REPUBLIC OF AZERBAIJAN.","authors":"T Asgarova, K Rahimli, G Valiyeva, Sh Hasanova, F Guliyeva, Kh R Mammadova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article presents the results of a study conducted to investigate the prevalence of certain hereditary diseases-hereditary hemochromatosis, hereditary collagenopathies, and hemoglobin-enzymopathies-among the population of the Republic of Azerbaijan. A total of 2,881 individuals of Azerbaijani ethnicity, differing in age and sex, were examined. The phenotypic frequencies of the investigated hereditary diseases were determined. The phenotypic prevalence of hereditary hemochromatosis among the population of the Republic of Azerbaijan was 12.3%, with a gene frequency of 0.1865. The highest phenotypic prevalence was observed among adults (21.2%), the lowest among newborns (6.7%), while among children it was 9.0%. The prevalence of hereditary collagenopathies was highest in the southern regions (12.2%) and lowest among migrants and isolated populations (1.1%). The prevalence of hemoglobin-enzymopathies were 14.3%, with the highest frequency observed in homozygous β-thalassemia (51.9%). Thus, the conducted studies allowed us to genetically characterize the population of Azerbaijan.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"316-319"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRITICAL VALUES OF HEMOSTASIS PARAMETERS IN AN ONCOLOGY CENTER: A RETROSPECTIVE REGISTRY-BASED STUDY.","authors":"Z Kozhakhmetova, N Yelemessova, D Syzdykova, S Abdullina, N Issatayeva, A Turgambayeva, G Kamalbekova, D Zhumagaleyeva, A Mussakhanova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and objectives: </strong>Patients with cancer are at high risk of hemostatic disorders due to tumor-related mechanisms, antineoplastic therapy, and surgical interventions. Critical laboratory values (CVs) represent life-threatening conditions requiring immediate clinical response and are essential indicators of laboratory quality and patient safety.</p><p><strong>Objective: </strong>To analyze the frequency, structure, and distribution of critical values of hemostasis parameters (APTT and fibrinogen) in the clinical diagnostic laboratory of an oncology center.</p><p><strong>Materials and methods: </strong>A retrospective study of the electronic CV registry was conducted for the period January-December 2025. Critical thresholds were defined according to SOPs and international recommendations. Data were analyzed by month, clinical ward, and type of hemostatic disorder. Comparative statistical analysis using the χ² test was performed. During the study period, a total of 48,326 coagulation tests were performed, including 27,418 APTT assays and 20,908 fibrinogen measurements. The overall frequency of critical values was 27.5 per 1,000 coagulation tests.</p><p><strong>Results: </strong>A total of 1,328 CVs were registered. The most frequent abnormalities were hypofibrinogenemia (<1.5 g/L) (60%), prolonged APTT (>78 s) (23%), and absent clot formation by APTT (10%). The distribution of CVs differed significantly across clinical departments (χ²(13)=726.51, p<0.001), with the highest burden observed in the hematobiochemistry department, ICU, and hematology wards. Extreme hypocoagulatory states (absence of clot formation by APTT or fibrinogen assays) accounted for 12% of all registered critical events, indicating a substantial proportion of patients at immediate risk of life-threatening hemorrhagic complications. Seasonal variation was statistically significant (χ²(10)=72.80, p<0.001), with peaks in March, July, and October.</p><p><strong>Conclusions: </strong>Critical hemostasis abnormalities are highly prevalent in oncology patients and are predominantly associated with hypocoagulatory states. Implementation of a structured electronic CV reporting system enables rapid clinician notification, optimization of laboratory workflow, and improved patient safety in high-risk oncology settings.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"85-92"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE IN-VITRO QUALITY EVALUATION OF COMMERCIALLY AVAILABLE DICLOFENAC SODIUM TABLETS.","authors":"R Alkhalify, L Almutairi, F Alghofaili, W Alhowaish, T Alhumidi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Diclofenac Sodium is a widely used non-steroidal anti-inflammatory drug (NSAID) indicated for the management of various inflammatory and painful conditions. Multiple generic brands are available in the Saudi Arabian market, highlighting the importance of evaluating their pharmaceutical quality characteristics.</p><p><strong>Objective: </strong>This study aimed to compare four commercially available brands of Diclofenac Sodium 50 mg enteric-coated tablets using standard in-vitro quality control tests.</p><p><strong>Methods: </strong>Four brands of Diclofenac Sodium enteric-coated tablets were evaluated for weight variation, hardness, friability, disintegration, and dissolution characteristics using established pharmaceutical quality-control procedures. The obtained results were compared with relevant pharmacopeial specifications and commonly accepted quality criteria.</p><p><strong>Results: </strong>All tested brands met the specified acceptance criteria for weight variation and friability. Hardness values varied among brands, with one product exhibiting higher crushing strength than the others. Disintegration testing demonstrated resistance in acidic medium followed by disintegration in phosphate buffer medium. Dissolution testing showed progressive drug release in phosphate buffer, with cumulative drug release exceeding 90% after 60 minutes for all brands.</p><p><strong>Conclusion: </strong>The evaluated Diclofenac Sodium tablet brands demonstrated acceptable in-vitro quality characteristics across the tested parameters. While variations were observed among products, all brands exhibited satisfactory physical performance and drug-release behavior under the study conditions. Further investigations, including content uniformity testing, similarity factor analysis, and in-vivo bioequivalence studies, are recommended to provide a more comprehensive assessment of product equivalence and therapeutic interchangeability.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"123-131"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROLE OF NEOADJUVANT THERAPY FOR PATIENTS WITH GASTRIC CANCER: MULTIDISCIPLINARY HOSPITAL WITH ONCOLOGY CENTER.","authors":"A Saburov, K Kemelbekov, D Arybzhanov, B Abdurakhmanov, Z Huseinov, S Saburova, S Tuktibayeva, A Yernazarov, S Alipbekova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the efficacy and safety of doublet (capecitabine + cisplatin) and triplet (capecitabine + cisplatin + docetaxel) neoadjuvant chemotherapy (NACT) regimens in patients with locally advanced gastric cancer at a regional oncology center in Kazakhstan.</p><p><strong>Methods: </strong>A prospective stratified randomized study included 107 patients with locally advanced gastric cancer. Patients were stratified by age, tumor location, and histological type/differentiation grade and then randomized in a 1:1 ratio to receive either capecitabine plus cisplatin or capecitabine plus cisplatin plus docetaxel. Tumor response was assessed using RECIST 1.1, pathological response was assessed in resected specimens, and toxicity was graded according to CTCAE v5.0.</p><p><strong>Results: </strong>The triplet regimen was associated with numerically higher rates of radiological partial response according to RECIST 1.1 (68.0% vs. 59.3%, p=0.423) and radical surgery among patients with partial response (91.7% vs. 78.1%, p=0.172). Pathological response was assessed in 58 patients who underwent radical gastrectomy. Pathological complete response (ypT0N0/TRG 1a) was observed in 2 patients in the triplet group and in none of the patients in the doublet group (0% vs. 6.1%, p=0.501). Favorable pathological regression (TRG 1a-1b) was more frequent after triplet therapy than after doublet therapy (24.2% vs. 12.0%, p=0.320). Grade III-IV neutropenia was more frequent in the triplet group (24.5% vs. 9.3%, p=0.041).</p><p><strong>Conclusions: </strong>The triplet regimen showed a numerical efficacy advantage but was associated with increased hematologic toxicity, requiring careful monitoring. Treatment personalization based on histology and comorbidities is critical.</p><p><strong>Limitations: </strong>Small sample size, lack of survival data, and the need for multicenter validation.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"32-37"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SELECTED LABORATORY PARAMETERS IN PEDIATRIC PATIENTS WITH COVID-19 STRATIFIED BY WHITE BLOOD CELL AND PLATELET PROFILES.","authors":"D Kobuladze, Ahishtan Nishanthan, N Kedelidze, R Vadatchkoria, M Davitashvili, L Zuroshvili, D Margalitashvili, N Gvarishvili, N Turmanidze, T Peshkova, N Chauhan, T Gogitidze, N Shaikh, A Shaikh, Abeshana Nishanthan, I Nakashidze","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Pediatric COVID-19 generally has a milder clinical course than adult disease, although hematological, inflammatory, hepatic, coagulation-related, and renal laboratory abnormalities may accompany infection. White blood cell (WBC) and platelet (PLT) counts are routinely available hematological measures; however, the relationship between combined WBC/PLT profiles and broader laboratory patterns in pediatric COVID-19 remains incompletely characterized. This study aimed to compare selected laboratory parameters among pediatric patients with COVID-19, stratified according to predefined WBC and platelet profiles.</p><p><strong>Methods: </strong>This retrospective, laboratory-based comparative study included 142 pediatric patients with RT-PCR-confirmed COVID-19 from the Adjara region of Georgia between 2020 and 2021. Patients were classified as WBC+PLT-N/CT (reference; n=94), WBC+PLT-H (n=16), WBC-H (n=3), or PLT-H (n=29). Alanine aminotransferase (ALT), aspartate aminotransferase (AST), C-reactive protein (CRP), D-dimer, ferritin, and creatinine were evaluated. The WBC+PLT-H and PLT-H groups were compared separately with the reference group using two-sided independent-samples Welch's t-tests. The WBC-H subgroup was analyzed descriptively because of its very small size. Analyses were exploratory and were not adjusted for age or multiple comparisons.</p><p><strong>Results: </strong>The overall mean age was 5.71±5.36 years, with both platelet-elevated groups being younger on average than the reference group. Compared with the reference group, the WBC+PLT-H group had higher CRP (16.71±9.17 vs 11.38±6.98 mg/L; p=0.0396) and lower creatinine (58.93±10.20 vs 68.09±15.91 µmol/L; p=0.0052). The PLT-H group had higher ALT (27.29±22.37 vs 18.60±6.65 U/L; p=0.0479). No other comparison met the nominal p<0.05 threshold.</p><p><strong>Conclusion: </strong>Combined WBC/platelet profiles were associated with different laboratory patterns in pediatric COVID-19. These exploratory findings warrant confirmation in larger pediatric cohorts using appropriately age-adjusted analyses.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"303-309"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MINIMALLY INVASIVE FAT TRANSPOSITION IN LOWER BLEPHAROPLASTY.","authors":"A Alfarhan, B Allawi, M Aljodah, A Jawad","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Lower blepharoplasty is a surgical procedure intended to rejuvenate the lower eyelid area by removing excess skin, fat, or muscle. There are many techniques used to correct this ageing process in the lower eyelid, with many modifications. The present prospective case series study aimed at evaluating feasibility, preliminary outcomes, patient satisfaction, and complications.</p><p><strong>Methods: </strong>The present study was conducted as a prospective study at a private clinic, spanning from December 2025 to June 2026. A cohort of 17 individuals enrolled in the study, encompassing 15 females and 2 males. Fat transposition was done through a small transcutaneous incision with or without a CO2 laser for skin rejuvenation.</p><p><strong>Results: </strong>Regardless of sex and age, 10 patients had \"Mild\" skin laxity, while 7 had \"Moderate\" skin laxity. The average satisfaction score indicates that most patients experienced improvement after the procedure. 64.7% of the patients reported experiencing \"very much improvement\", 29.4% reported they were \"much improved\", 5.8% reported they were \"improved\", and 0.0% observed \"no change\" post-procedure.</p><p><strong>Conclusion: </strong>Transcutaneous fat pad transposition, with or without CO2 laser, emerges as an alternative to traditional lower eyelid blepharoplasty.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"423-427"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATIONS OF CYTOKINE PROFILE AND EXOCRINE PANCREATIC FUNCTION WITH A SYMPTOM-BASED DEHYDRATION CATEGORY AND SEASON OF PRESENTATION IN CHRONIC PANCREATITIS: A RETROSPECTIVE STUDY.","authors":"M Umbarov, M Shamsutdinova, R Abdullayev, R Mengliyeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the associations of C-reactive protein (CRP), fecal elastase-1 (FE-1), interleukin-2 receptor (IL-2R), interleukin-6 (IL-6), and transforming growth factor-beta 1 (TGF-β1) with the symptom-based dehydration category and season of presentation in chronic pancreatitis; clinical-group comparisons were secondary.</p><p><strong>Materials and methods: </strong>Of 132 consecutive inpatient records screened in 2023-2025, 80 with complete results for the five laboratory outcomes were analyzed and 52 incomplete records were excluded; each patient contributed one observation. Unadjusted Kruskal-Wallis, Mann-Whitney U, and Spearman analyses used Holm correction. Five linear models with HC3 robust standard errors simultaneously adjusted for dehydration category, summer presentation, clinical group, age, sex, and disease duration.</p><p><strong>Results: </strong>Unadjusted analyses associated higher dehydration category with higher CRP and IL-6 and lower FE-1. After mutual adjustment, only IL-6 remained associated with each one-category increase in dehydration (+36.94 pg/mL; 95% CI, 17.98-55.90; Holm-adjusted p=0.0011). Summer presentation was independently associated with higher CRP (+8.46 mg/L) and IL-6 (+44.23 pg/mL), lower FE-1 (-22.89 µg/g), and lower TGF-β1 (-61.12 pg/mL) (all Holm-adjusted p<0.05), but not IL-2R. The five outcomes did not differ across clinical groups.</p><p><strong>Conclusion: </strong>After adjustment, dehydration category remained independently associated only with IL-6, whereas summer presentation retained associations with CRP, IL-6, FE-1, and TGF-β1. The retrospective observational design precludes causal attribution to heat or dehydration.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"289-297"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149107577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CALCULATED WHOLE BLOOD VISCOSITY IS SPECIFICALLY ASSOCIATED WITH ABDOMINAL OBESITY, BUT NOT WITH OTHER COMPONENTS OF METABOLIC SYNDROME: A CROSS-SECTIONAL STUDY IN A CENTRAL ASIAN ADULT COHORT.","authors":"E Eibov, S Khavaskhonova, K Taubay, K Sadykova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Metabolic syndrome (MetS) is a heterogeneous condition, and its individual components may reflect haemorheological disturbances to differing degrees. Estimated whole blood viscosity (WBV), computed from haematocrit and total protein using the de Simone formulas, is a non-invasive marker of potential microcirculatory disturbance. Existing data on the relationship between WBV and MetS in Central Asian populations remain limited and conflicting.</p><p><strong>Aim: </strong>To evaluate the associations between estimated WBV and abdominal obesity as the leading anthropometric component of MetS, as well as its associations with the remaining components and the composite diagnosis of MetS, in an adult Central Asian population.</p><p><strong>Material and methods: </strong>This cross-sectional study enrolled 359 adults (18-65 years) from Turkestan, Kazakhstan. WBV was calculated at two shear rates (208 s-1 and 0.5 s-1) using the de Simone formulas. MetS components were defined according to the IDF 2006 criteria. The Mann-Whitney U test and the χ² test (or Fisher's exact test) were used for bivariate comparisons; multivariable logistic regression was performed with WBV quartiles as predictors; models were adjusted for age, sex, ethnicity, smoking and alcohol consumption; BMI was added to all models except the one for abdominal obesity (because of collinearity with waist circumference).</p><p><strong>Results: </strong>Abdominal obesity showed a strong dose-dependent association with WBV: the adjusted odds ratio (aOR) for the highest vs. lowest WBV quartile was 5.03 (95% CI 1.62-15.60; p=0.005) at 208 s-1 and 4.38 (1.45-13.22; p=0.009) at 0.5 s-1. The effect persisted with WBV as a continuous variable (aOR 3.04 per 1 cP at 208 s-1; p<0.001). The remaining components - elevated blood pressure, hypertriglyceridemia, low HDL-C and impaired glucose metabolism - showed no significant association with WBV quartiles after adjustment. The composite MetS was likewise not significantly associated with WBV after adjustment (aOR Q4 vs. Q1=1.20, p=0.52).</p><p><strong>Conclusion: </strong>Estimated WBV is specifically associated with abdominal obesity, but not with the metabolic or hypertensive components of MetS after multivariable adjustment. This finding is consistent with the biological role of haemoconcentration and plasma volume as the leading determinants of the de Simone formula parameters. Estimated WBV may represent a marker of anthropometric rather than metabolic disturbance in the Central Asian population and should not be regarded as an independent predictor of composite MetS in such cohorts.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"200-208"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}