Georgian medical news最新文献

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CONGENITAL HYPOTHYROIDISM: FROM THEORY TO PRACTICE - A CLINICAL CASE.
Georgian medical news Pub Date : 2025-01-01
Y Boldyreva, I Lebedev, E Zakharchuk, E Babakin, I Aptekar
{"title":"CONGENITAL HYPOTHYROIDISM: FROM THEORY TO PRACTICE - A CLINICAL CASE.","authors":"Y Boldyreva, I Lebedev, E Zakharchuk, E Babakin, I Aptekar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hypothyroidism (HT) is one of the common diseases in endocrinology, caused by a long-term, persistent deficiency of thyroid hormones or a deficiency of their effect on tissues. The deficiency of these hormones leads not only to a slowdown in the biochemical processes of growth and development of the child's body, disruption of metabolic processes, including lipid peroxidation and the blood clotting mechanism, but also to a delay in intellectual development and inhibition of the formation of personality structure and thinking. In this regard, early diagnosis, as well as timely and adequate therapy are very important.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"47-49"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PRETERM BIRTH PREVENTION IN MULTIFETAL PREGNANCIES: A RETROSPECTIVE STUDY ON CERVICAL PESSARY EFFICACY.
Georgian medical news Pub Date : 2025-01-01
L Melia, R Sulukhia, N Jojua, T Gognadze, N Davidova
{"title":"PRETERM BIRTH PREVENTION IN MULTIFETAL PREGNANCIES: A RETROSPECTIVE STUDY ON CERVICAL PESSARY EFFICACY.","authors":"L Melia, R Sulukhia, N Jojua, T Gognadze, N Davidova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim of the study: </strong>the assessment of the efficacy of pessary in Preterm Birth (PB) prevention in patients with multifetal pregnancies.</p><p><strong>Material and methods: </strong>The retrospective cohort study was conducted in the Perinatal Department of Gudushauri National Medical Center from 2020 to 2024 and included 226 women only with multifetal pregnancies and threatened PB. The patients were divided into three groups: group I - 68 patients who conceived naturally and a pessary was used to prevent the preterm delivery; group II - 84 pregnant women after assistive reproductive technologies (ART) and the treatment of premature birth was also provided using a pessary; and group III - 74 women with threatened preterm delivery in whom a pessary was not used for the prevention. In all cases the pessaries were inserted between 14-24 weeks of gestation. The difference was statistically significant if P<0.05.</p><p><strong>Results: </strong>In group I, the frequency of late preterm delivery - n=35 (51.47%) was statistically significantly higher compared to moderate - n=24 (35.29%), very preterm - n=7 (10.29%) and extremely preterm - n=2 (2.94%) delivery rates (P<0.001). The same tendency was revealed as in patients after IVF and pessary insertion, so in patients without pessary (P<0.001). However, a statistically significant difference was not found when comparing rates between groups (P>0.05).</p><p><strong>Conclusion: </strong>The use of pessary in multifetal pregnancies must be regarded as supportive therapy as it may prolong the pregnancy, however, it does not prevent the preterm delivery.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"6-10"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TRANSMISSION OF RABIES VIRUS THROUGH A CONTACT LENS CONTAMINATED WITH SALIVA FROM AN INFECTED DOG (CASE REPORT).
Georgian medical news Pub Date : 2025-01-01
M Samsonia, M Kandelaki, T Giorgadze
{"title":"TRANSMISSION OF RABIES VIRUS THROUGH A CONTACT LENS CONTAMINATED WITH SALIVA FROM AN INFECTED DOG (CASE REPORT).","authors":"M Samsonia, M Kandelaki, T Giorgadze","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;p&gt;The aim of the present work was to describe the clinical course of rabies in a 9-year-old boy with progressive rabies symptoms and fatal outcome after atypical exposure to the virus through a contact lens contaminated with saliva from an infected dog. Epidanamnesis data. The patient is a third-grade elementary school student, was admitted to the emergency department of Kutaisi Infectious Diseases Hospital, with fever, periodic dyspnea, malaise, headache, lacrimation, nasal congestion, sore throat, lack of appetite and insomnia. The boy became acutely ill three days before hospitalization, complaining of chills (fever up to 38.5°C), pain in the area of the right eyebrow, redness of the right eye, lacrimation and nasal congestion. In the following days, against the background of persisting symptoms, appetite decreased, and sleep was disturbed. Short attacks of dyspnea, unexplained anxiety and fear of suffocation arose intermittently, mainly when drinking water. On objective physical examination: the medical condition is moderate severity. Fever of 37.8°C. There is no evidence of skin discoloration or rash. The mucous membrane of the oropharynx is slightly hyperemic, tonsils are not enlarged, except for single enlarged but painless lymph nodes palpated in the submandibular and cervical regions. Redness of the right eye, lacrimation and photophobia are noted. The cardiac silhouette is not enlarged, heart sounds and cardiac rhythm are normal, HR 70/min, BP 100/75 mm Hg. Chest is clear to auscultation, no wheezing, respiratory rate 17/min, oxygen saturation index is within normal limits (SpO2 ≥ 98% on room air). The tongue is moist, covered with white plaque. The abdomen is soft and painless on palpation without organomegaly. A full blood count (FBC) test reveals mildly elevated leukocytes of 15.0 x 109/L, immature neutrophils count greater than 10%, urinalysis shows albuminuria, cylindroid and leukocyturia (12-15 WBCs/hpf). Neurological status: the patient is conscious, with no meningeal or focal symptoms. Gait is stable and smooth. Cranial nerves are intact. In the following days, the boy's condition began to gradually deteriorate. Clinical manifestations include pronounced signs: weakness, headache, insomnia, constant fear, lack of appetite, decreased mood, periodic feeling of \"breathlessness\", keratoconjunctivitis of the right eye, photophobia, lachrymation, salivation and hyperhidrosis. When the patient drinks water in small sips, he develops a feeling of fear and fear of choking. Brief attacks of convulsive respiratory movements occur periodically at rest. Visual and tactile hallucinations are also noted. The attacks of aerophobia are inconstant. Based on the dynamics of clinical features of the disease, the diagnosis of \"rabies\" was established. When delving into the exposure history, important information was obtained from the patient's classmate. It was found that 15 days before hospitalization, a stray dog had attacked the child (near t","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"22-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VALID AND INFORMED CONSENT IN ORTHOPAEDIC SURGERY: A MULTICENTRE, REGIONAL SERVICE EVALUATION OF CURRENT UK PRACTICE.
Georgian medical news Pub Date : 2025-01-01
R Mills, M Sohail, H Sadique, O Adebayo, K Shanmuganathan, G Mamarelis, S Ali, A Sanalla, F Acquaah, A Ali, S Subhash, M Archunan, S Janjua, O Toma, V Matera, A Al-Sukaini, G Hourston, J Barwell, A Adeyeye, A Genena, M Lebe, S Towell, Ch Chan, A MacDowell, P Novak, W Khan, F Bhatti, A Iqbal, H Fawi, J Patel, M Begum, I Marciulynaite, N De Reock, R Tansey, S Hussein, Z Elgheriany, R Munni, T Sandhu, J Rahman, M Popescu, M Loeffler
{"title":"VALID AND INFORMED CONSENT IN ORTHOPAEDIC SURGERY: A MULTICENTRE, REGIONAL SERVICE EVALUATION OF CURRENT UK PRACTICE.","authors":"R Mills, M Sohail, H Sadique, O Adebayo, K Shanmuganathan, G Mamarelis, S Ali, A Sanalla, F Acquaah, A Ali, S Subhash, M Archunan, S Janjua, O Toma, V Matera, A Al-Sukaini, G Hourston, J Barwell, A Adeyeye, A Genena, M Lebe, S Towell, Ch Chan, A MacDowell, P Novak, W Khan, F Bhatti, A Iqbal, H Fawi, J Patel, M Begum, I Marciulynaite, N De Reock, R Tansey, S Hussein, Z Elgheriany, R Munni, T Sandhu, J Rahman, M Popescu, M Loeffler","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>In recent years, there has been increasing focus upon tailoring the consent process to reflect patients' individual needs and concerns. Meanwhile, clinical litigation costs for 'failure to warn' as part of 'informed consent' remain staggeringly high. We aimed to investigate the validity of the patient consent process in elective lower limb arthroplasty surgery regionally, with a view to ascertaining how it could be improved.</p><p><strong>Methods: </strong>Regional data across the East of England was collected retrospectively from seven hospital trusts (fifty data sets per hospital) in 2021 and analyzed against predetermined criteria. Data analyzed included operation notes, patient records and clinic letters.</p><p><strong>Results: </strong>A total of 165 elective knee and 173 elective hip replacement cases were included in the final analysis. Capacity criteria (defined as the ability to understand, retain, weigh up and communicate a decision) were fulfilled in 11.6% of hip and 13.9% of knee replacement surgeries, despite Consent Form 1 (a form commonly used in England to consent adults, deemed to have capacity, for surgical procedures) being completed in 94.8% and 88.5% of these same cases. Procedure-specific consent was obtained in 74.0% and 72.1% of cases, respectively, whilst 'Type' and 'Brand' of implant were rarely consented for. Alternative treatment options were offered in 67.1% of hips and 62.1% of knee cases. Separate consent clinics were offered in 55.5% of hip and 57.6% of knee cases.</p><p><strong>Conclusions: </strong>This study demonstrates that there is room for improvement within the current consent process. We propose digitalization, utilizing interactive multimedia and audio-visual demonstrations to explain surgical procedures, as a dynamic and versatile adjunct to the consent process.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"57-69"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VARIATION OF ASTIGMATISM BETWEEN TEMPORAL AND SUPERIOR APPROACH IN PHACO SURGERY.
Georgian medical news Pub Date : 2025-01-01
A Abdulameer, M Abdulzahra, Z Hashim
{"title":"VARIATION OF ASTIGMATISM BETWEEN TEMPORAL AND SUPERIOR APPROACH IN PHACO SURGERY.","authors":"A Abdulameer, M Abdulzahra, Z Hashim","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Advances of phacoemulsification techniques and surgical equipment, patients satisfaction becomes more difficult to gain because they are expecting perfect results and ideal visual outcome, thus perfection of surgical procedures settled mandatory.</p><p><strong>Aim: </strong>This research deals with comparison between two incision sites in phacoemulsification surgery and check which of them has more visual outcomes which are temporal and superior entrance sites of the phaco probe.</p><p><strong>Methods: </strong>Total of 68 eyes from 59 patients were studied, they grouped into 2 groups; group A (36 eyes temporal style) and group B (32 eyes superior style).</p><p><strong>Results: </strong>After group B has undergone surgical procedure, the percentage against the rule (ATR) has increased 91% compared to 44% preoperatively compared to reduction to 33% of ATR in group A postoperatively compared to 45%.</p><p><strong>Conclusion: </strong>Phacoemulsion surgery has provided good approach for healing eyes in astigmatism patients. Temporal clear corneal incision has more feasibility and produces less surgically induced astigmatism in comparison to superior corneal scratch.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"134-137"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFICIENT RECONSTRUCTION METHOD SELECTION IN LOWER LIP CANCER.
Georgian medical news Pub Date : 2025-01-01
M Rustamzade, N Amiraliyev, K Amiraliyev
{"title":"EFFICIENT RECONSTRUCTION METHOD SELECTION IN LOWER LIP CANCER.","authors":"M Rustamzade, N Amiraliyev, K Amiraliyev","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The primary treatment method for lower lip cancer is surgery. The defects that occur after resections are restored using various methods depending on their localization and size.</p><p><strong>Aim: </strong>The aim of the study is to estimate the effectiveness of the reconstruction for defects formed after radical resections performed due to lower lip cancer.</p><p><strong>Materials and methods: </strong>The clinical outcomes after various reconstruction methods were studied in 102 patients with lower lip cancer who underwent radical resections. The selection of reconstruction methods was based on the size and localization of the resulting defects.</p><p><strong>Results: </strong>Among the patients included in the study group, the degree of spread of the primary tumor was as follows: T1 - 35 (34.34 %), T2 - 30 (29.5 %), T3 - 27 (26.4%), T4 - 10 (9.8 %).</p><p><strong>Conclusion: </strong>The effective selection of a reconstruction method for defects following radical resection of lower lip cancer should provide satisfactory functional and aesthetic outcomes in the treatment process.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"154-157"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
INNOVATIONS IN DERMATOLOGIC SURGERY AND MELANOMA PATHOGENESIS: FROM THE PERSONALISED SURGERY TO THE CONCEPT OF GENOMIC MAPPING/TARGETING VIA NITROSAMINES IN DRUGS: SPOTLIGHT ON CONTAMINATION OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND ANGIOTENSIN RECEPTOR BLOCKERS.
Georgian medical news Pub Date : 2025-01-01
G Tchernev, V Broshtilova, S Kordeva
{"title":"INNOVATIONS IN DERMATOLOGIC SURGERY AND MELANOMA PATHOGENESIS: FROM THE PERSONALISED SURGERY TO THE CONCEPT OF GENOMIC MAPPING/TARGETING VIA NITROSAMINES IN DRUGS: SPOTLIGHT ON CONTAMINATION OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND ANGIOTENSIN RECEPTOR BLOCKERS.","authors":"G Tchernev, V Broshtilova, S Kordeva","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;p&gt;The pathogenesis and successful surgical treatment of cutaneous melanoma remain a mystery to this day, the unraveling of which has excited clinicians and research teams worldwide. The breakthrough regarding the interpretation of the pathogenesis of skin cancer and melanoma in particular in all likelihood concerns phototoxicity and photocarcinogenesis as some of the major factors associated with its occurrence. Extremely interesting and revealing are two types of observations/indisputable facts that definitely change completely the current vision of melanoma occurrence and progression: 1) The presence of carcinogens, photocarcinogens and mutagens in more than 95% of the most widely distributed drugs worldwide. On the one hand, they are inducers of heterogeneous types of mutations and, on the other hand, potentiate phototoxicity, and 2) clinicopathological correlations demonstrating a pathogenetic link between the intake of actual/potential photocarcinogen/mutagen contaminated products and the subsequent or concurrent development of melanomas. The categorical refusal of regulators (so far) to oblige manufacturers to officially declare the presence of photocarcinogens/mutagens/genome modifiers in medicines , remains puzzling and disturbing to say the least. This is what makes it difficult to make an accurate judgement on the specific risk of a particular nitrosamine present as a contaminant in a particular drug in a particular geographical area. The regulation of the distribution and concealment of carcinogens in medicines correlates with the occurrence of heterogeneous forms of it in the geographical regions concerned. This is a strong reason to formalize carcinogens in medicines. Conflicting evidence on the risk of developing melanomas in one latitude/continent or another is likely to correlate with the type of photo/nitroso/contaminant involved and the concentration in which it is present in a given drug. The official data of the regulatory authorities in America and Australia, for example, do not correspond with each other and show the different availability in different preparations with different photocarcinogens/mutagens/genome modifiers or so-called nitrosamines. For other continents, there are no epidemiological data on the subject. It remains an open and speculative question whether genetic targeting based on so-called genetic mapping is involved in these cases in order to maximize future benefits. The issue of genetic profiling of a nation, a geographical region or a particular collective is a matter of national but also global security for every country. In recent times, it is precisely this 'policy of nation preservation' that has led to a ban on the use of US genetic databases, with the 2024 ban targeting the world's strongest export economies: that of China. We present a patient, who developed thick nodular melanoma within a long-term treatment with sartan/valsartan and ACE inhibitor/ Enalapril. We comment on the possibility of ","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"40-46"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OBESITY AND THYROID FUNCTION IN OBESE WOMEN: A PILOT STUDY.
Georgian medical news Pub Date : 2025-01-01
C Jemai, R Gharbi, H Kandara, I Kammoun, M Jemel, O Berriche, F Mahjoub, H Jamoussi
{"title":"OBESITY AND THYROID FUNCTION IN OBESE WOMEN: A PILOT STUDY.","authors":"C Jemai, R Gharbi, H Kandara, I Kammoun, M Jemel, O Berriche, F Mahjoub, H Jamoussi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Obesity is an expanding pathology in the world and in Tunisia. We conducted this study to assess the thyroid function in a population of obese women and to investigate the relationship of thyroid status parameters with clinical and metabolic parameters.</p><p><strong>Methods: </strong>This was a cross-sectional retrospective study about 50 obese women. We collected body mass index (BMI), waist circumference (WC), serum free thyroxin (FT4) and thyroid stimulating hormone (TSH) levels, fasting glycemia (FG), baseline insulinemia, lipid profile, liver function, and body composition, assessed by bioelectrical impedancemetry. We assessed insulin resistance and pancreatic activity by calculating the Homeostasic Model Assessment for Insulin Resistance (HOMA-IR) and the Homeostasic Model Assessment to quantify Beta-cell function (HOMA-B) respectively.</p><p><strong>Results: </strong>The mean BMI and WC were 41,2±9,3 kg/m² and 120±17,7 cm, respectively. The mean body fat percentage (BF) was 43,4±7,1%. The mean FT4 and TSH levels were 16,6±4,7 pmol/L and 2,4±1 IU/L, respectively. Two patients had subclinical hypothyroidism. Glycoregulation abnormalities were noted in 54%. The mean insulinemia, HOMA-IR and HOMA-B were 23,4±14,8 mIU/L, 6,5±5,1 and 230,4±162,1 respectively. Most patients had insulin resistance (96%). TSH was not correlated with cardiometabolic risk parameters nor with BF. FT4 was correlated with age (r=-0,3, p=0,017), FG (r=-0,29, p=0,019), insulinemia (r=-0,42, p=10-3), cholesterol (r=0,24, p=0,04) and high-density lipoprotein (r=0,24, p=0,002). It was not correlated with BF (r=-0,14, p=0,32).</p><p><strong>Conclusion: </strong>In our population of obese women, FT4 seems to be more correlated than TSH with cardiometabolic risk parameters.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"158-162"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFICACY AND TOLERABILITY OF JANUS KINASE INHIBITOR TOFACITINIB IN JUVENILE LINEAR SCLERODERMA. CASE SERIES OF 5 PATIENTS.
Georgian medical news Pub Date : 2025-01-01
M Osminina, N Podchernyaeva, V Seraya, S Kurbanova, O Batureva, S Chebusheva, O Shpitonkova, A Polyanskaya, A Skakodub, N Ziskina
{"title":"EFFICACY AND TOLERABILITY OF JANUS KINASE INHIBITOR TOFACITINIB IN JUVENILE LINEAR SCLERODERMA. CASE SERIES OF 5 PATIENTS.","authors":"M Osminina, N Podchernyaeva, V Seraya, S Kurbanova, O Batureva, S Chebusheva, O Shpitonkova, A Polyanskaya, A Skakodub, N Ziskina","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>to analyze the efficacy of the Janus kinase inhibitor tofacitinib (TF) in children with linear form of juvenile localized scleroderma (JLSL).</p><p><strong>Materials and methods: </strong>5 patients with JLSL were treated with TF, we evaluated the efficacy of therapy retrospectively.</p><p><strong>Results: </strong>The mean disease duration prior to TF therapy was high at 71 months. All patients did not respond well to glucocorticosteroid (Glu) and methotrexate (MTX) therapy, two did not respond to combination therapy of Glu, MTX, mycophenolate mofetil (MFM), which prompted the initiation of TF therapy. All patients received TF in combination with MFM or MTX or GCS. The mean duration of TF therapy was 12.8±1.78 months. From 3 to 6 months of TF therapy, we observed positive changes in scleroderma skin and joint involvement. The positive results continued to increase up to the 12th month of treatment, as evidenced by the reduction of the mLoSSI and LoSDI indices. We decided to continue treatment for up to 18 months. The patients tolerated TF well, there were no serious infections, abnormalities in liver function.</p><p><strong>Conclusion: </strong>Our case series showed a significant improvement in skin and joint damage after 12 months of TF therapy in resistant JLSL patients. Further experience with TF is needed to determine its place in the treatment of juvenile scleroderma.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ANATOMICAL FEATURES OF THE OSTIOMEATAL COMPLEX AND THEIR IMPACT ON COMPLICATIONS IN DENTAL IMPLANTATION.
Georgian medical news Pub Date : 2025-01-01
R Nazaryan, L Sosonna, O Iskorostenska, M Storozheva, Y Fomenko, S Heranin, O Ohurtsov, A Nikonov, V Alekseeva
{"title":"ANATOMICAL FEATURES OF THE OSTIOMEATAL COMPLEX AND THEIR IMPACT ON COMPLICATIONS IN DENTAL IMPLANTATION.","authors":"R Nazaryan, L Sosonna, O Iskorostenska, M Storozheva, Y Fomenko, S Heranin, O Ohurtsov, A Nikonov, V Alekseeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The anatomical structure of the ostiomeatal complex (OMC) plays a crucial role in the success of dental implantation procedures, particularly in the maxillary region. This study examines the anatomical variations of the OMC and their impact on postoperative complications in dental implantation. A total of 400 spiral computed tomography (CT) scans of patients aged 18 to 95 years were analyzed to assess key anatomical structures, including the maxillary sinus, concha bullosa, uncinate processes, and sinus ostium dimensions. Findings revealed significant anatomical variability, with concha bullosa observed in 33.2% of cases, uncinate process variations in 31.6%, and a narrowed maxillary sinus ostium in 6.25% of cases. These structural differences were found to influence sinus ventilation and drainage, thereby increasing the risk of postoperative complications such as sinusitis and impaired osseointegration. Statistical analysis highlighted strong correlations between sinus volume, bone thickness, and OMC components, reinforcing the need for thorough preoperative assessment. The study underscores the importance of personalized surgical planning and advanced imaging techniques in mitigating complications and optimizing dental implantation outcomes.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 358","pages":"163-167"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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