Georgian medical news最新文献

{"title":"MODERN METHODS OF SURGICAL TREATMENT OF DIABETIC FOOT SYNDROME.","authors":"T Toleutayev, A Dyussupov, M Imanbaev, D Toleutaeyva, N Omarov, Zh Kozhakhmetov, Y Kazymov, A Masalov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article discusses the problems of surgical tactics in diabetic foot syndrome and its complications, both in the early postoperative and remote periods. The above complications require surgeons to search for the most optimal method of surgical treatment.</p><p><strong>Aim of the work: </strong>to evaluate the results of surgical treatment using different revascularization and non-revascularization methods in patients with diabetic foot syndrome.</p><p><strong>Study design: </strong>non-randomized controlled clinical trial.</p><p><strong>Materials and methods: </strong>The article presents the experience of treatment at the University Hospital of NCJSC 'SMU' in the period from 2021 to 2024, where 93 patients were operated on. All patients had narrowing or complete occlusion of arteries of the lower limbs on the background of decompensated diabetes mellitus, which required surgical intervention. The patients were divided into 2 groups based on the results of computed tomography or angiography. The first group consisted of 45 patients who underwent revascularization interventions, while in the second group 48 patients underwent nonrevascularization interventions. The most frequently performed revascularization interventions were balloon angioplasty (53.33%), femoral-pelvic bypass (31.1%), bifurcation aorto-femoral bypass (11.1%); profundoplasty of the deep femoral artery and stenting of the superficial artery were performed less frequently (2.2%). Lumbar sympathectomy (89.58%) and revascularisation osteotrepanation (10.42%) were performed in the group of non-revascularisation interventions.</p><p><strong>Results: </strong>Most complications were observed in revascularisation interventions. 2 complications were in patients who underwent balloon angioplasty, and 3 complications in patients who underwent femoral-popliteal bypass. In other interventions, as well as in non-vascularisation treatment methods, there were no complications. However, wound healing, and the management of lower limb ischaemia were much better in patients who underwent revascularisation intervention.</p><p><strong>Conclusions: </strong>This study found that revascularisation therapies such as angioplasty and bypass surgery demonstrate higher efficacy rates in the treatment of patients with diabetic foot syndrome compared to non-revascularisation techniques. Revascularisation improves blood flow, reduces the risk of amputations and accelerates wound healing, which is supported by data on low complication rates in the group of patients who received these interventions. However, despite the clear advantages of revascularisation, the choice of treatment method should be based on individual indications, taking into account the degree of vascular damage, the presence of comorbidities and the general clinical characteristics of the patient. In some cases, for example, in less severe circulatory disorders, non-revascularisation methods may be equally effective and less invasive","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"6-10"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GRAHAM-LITTLE-PICCARDI-LASSEUR SYNDROME IN A BULGARIAN PATIENT: CASE REPORT AND SHORT PATHOGENETIC UPDATE IN RELATION TO THE CONNECTION TO ANTIGEN/ MOLECULAR MIMICRY.","authors":"S Kordeva, V Broshtilova, G Tchernev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Graham-Little-Piccardi-Lasseur syndrome (GLPLS) is a rare lichenoid dermatosis classified as a variant of follicular lichen planus, also known as classic lichen planopilaris. The condition is characterized by the triad of cicatricial scalp alopecia, noncicatricial alopecia in the axillary and groin regions, and numerous follicular papules distributed across the body. We present a 64-year-old female with clinically and histologically confirmed GLPLS. Two biopsies were conducted, resulting in lichen planopilaris/ pseudopelade Brocq and lichen planus hypertrophicus. Initial therapy included loratadine and topical clobetasol propionate. Due to the suspicion of possible drug-induced reaction, the antihypertensive therapy, which consisted of valsartan, bisoprolol, spironolactone, and chlorthalidone, was discontinued and replaced with moxonidine. Urinary infection caused by Escherichia coli and dental infection were noted. Prescribed outpatient treatment included acitretin, bilastine, and topical prednisolone for the scalp. Improvement was observed in the lesions located on the trunk and upper and lower extremities following betamethasone/salicylic acid ointment was prescribed, and methylprednisolone aceponate cream. Re-application or return of the old systemic medication on an outpatient basis resulted in a worsening/exacerbation of the clinical picture and a re-need to change medication. It is this fact that suggests that polymedication could also be considered as a trigger of lichen planus and its subforms such as GLPLS. The hypothesis surrounding alterations in tissue homeostasis as a potential trigger factor for autoimmunity is being discussed, with a specific focus on infectious and drug-induced forms of lichen planus, as well as Graham-Little-Lasseur syndrome.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"61-67"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPROVEMENT OF COGNITIVE FUNCTION IN WISTAR RATS UNDER CHRONIC STRESS CONDITIONS WITH MELATONIN.","authors":"M Ramazanov, D Bogaevskaya, D Sobolev, A Riabov, I Vysokikh, A Makhmudova, A Eremenko, G Motskobili, A Sadkovskaia, G Alibekov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Stress is a significant factor affecting cognitive functions such as memory, attention and learning ability. This paper examined the effects of melatonin at different dosages on cognitive performance compared to choline alphoscerate on wistar line rats under chronic stress conditions. The studied rats were subjected to stress - Porsolt's forced swim test. Before and after the stress test, blood was collected from the tail vein of the rats. Cortisol levels increased in all groups, including the control group. However, the melatonin levels in each group changed to a different degree as each group was offered different levels of melatonin dosage and the drug, choline alphoscerate. In the result, it was found that rats receiving low doses of melatonin did not improve the results, increasing the time from 29.7 to 38.2 seconds. The rats receiving high doses of melatonin performed the best, with virtually no increase in time to complete the maze (increasing the time from 29.6 to 33.5 seconds). The group receiving choline alphoscerate showed similar results to the control group, significantly increasing the maze time from 29.4 to 47.4 seconds.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"178-180"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INDIVIDUAL CHARACTERISTICS OF HIGHER NERVOUS ACTIVITY AS A FACTOR IN ADAPTATION AND RECOVERY OF THE CARDIOVASCULAR SYSTEM IN ATHLETES.","authors":"O Kim, Z Mavlyanova, B Doniyorov, M Khamdamova, F Khalimova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to examine the influence of higher nervous activity (HNA) types on heart rate variability (HRV) parameters in athletes after physical exertion. The primary objective was to identify the relationship between HNA types and the body's adaptive capacity, as well as to assess stress resilience and recovery efficiency.</p><p><strong>Material and method: </strong>The study involved 144 male athletes aged 17-20 years (mean age: 18.5±1.5 years) engaged in football and track and field. Participants were classified into groups based on their higher nervous activity (HNA) types using the Eysenck Personality Questionnaire (EPQ) and the \"Psychotest\" software, categorizing them as sanguine, choleric, phlegmatic, or melancholic. Six heart rate variability (HRV) parameters (RMSSD, SDNN, LF/HF, TP, pNN50, HF) were analyzed before and after the Cooper test (12-minute run) using the \"Biomouse\" hardware-software complex and the specialized \"Varicard-2.51\" program.</p><p><strong>Results: </strong>The study revealed significant differences in the cardiovascular system's response to physical exertion among athletes with different higher nervous activity (HNA) types (p<0.05). Sanguine individuals exhibited a moderate decrease in RMSSD, SDNN, and TP, indicating balanced regulation of sympathetic and parasympathetic activity. Phlegmatic individuals showed minimal changes, confirming their high adaptive reserves and resilience to physical stress. In contrast, choleric and melancholic individuals demonstrated a significant reduction in RMSSD, SDNN, and TP, along with an increase in LF/HF, suggesting predominant sympathetic activity and heightened regulatory system strain. These findings highlight greater stress resilience and better adaptive capacities in sanguine and phlegmatic individuals, whereas choleric and melancholic athletes exhibit reduced adaptive potential. Furthermore, following the Cooper test, choleric and melancholic individuals displayed changes characteristic of sympathetic nervous system activation, including an increase in LF/HF and a decrease in pNN50 (p<0.01). These results emphasize the importance of considering HNA types when designing individualized training and recovery programs.</p><p><strong>Conclusion: </strong>The results demonstrate the influence of higher nervous activity (HNA) types on adaptation to physical exertion, emphasizing the importance of a personalized approach to training and recovery programs. This is crucial for enhancing athletic performance and preventing overload and burnout.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"119-124"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION BETWEEN SERUM LEVELS OF ADIPOKINES IN PATIENTS WITH PROSTATE CANCER.","authors":"S Zbaar, I Kamal, A Alchalabi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Adipokines were proved to be the most important mediators involved in the development and progression of several types of obesity-associated cancers. This study aims to demonstrate the relationship between adipokines and prostate cancer to evaluate the possibility of using adipokines as an early marker for diagnosis of PC and monitoring its development and progression.</p><p><strong>Methods: </strong>The study was conducted with a total of 82 men aged between 45 years and 76 years. The study is divided into two groups: group 1 prostate cancer (n=42) and group 2 healthy control subjects (n=40). The prostate cancer group divided into 3 subgroups according to their Gleason's grading, group 1 of low level (10) group 2 of moderate level (14) and group 3 of high level (18).</p><p><strong>Results: </strong>Prostate cancer patients had significantly lower levels of adiponectin (2.87±0.73 ng/mL; P<0.001) than did controls (9.9±1.25 ng/mL). the level of Resistin was a significantly high in prostate patient group than control group (14.65±3.43 ng/mL and 10.63±1.37 ng/mL), respectively, when compared to controls (11.6±1.79 ng/mL), the visfatin level in patients with prostate cancer was significantly greater (20.5±4.54 ng/mL) regarding the level of chemerin there was a significantly increased in patients' group (979±149.6 pg/mL) than control group (204±41pg/mL) also, the present study confirm that there is a significant correlation between the parameters serum level and PSA as well as BMI.</p><p><strong>Conclusion: </strong>Our findings showed that the levels of adiponectin were strongly reduced in the patients' group. other parameters were significantly higher compared with control group. Also, there are strong correlation between the levels of chemerin/ adiponectin ratio and the severity of the disease, suggesting the importance of this ratio to monitoring response to the treatment of prostate cancer, predicating the possibility of using these findings as PCa markers in early stage of disease.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"173-177"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SURGICAL TREATMENT STRATEGIES OF DEEP STERNAL WOUND INFECTION FOLLOWING CARDIAC SURGERY.","authors":"K Lipatov, A Asatryan, I Vinokurov, A Kazantcev, G Melkonyan, E Solov'eva, I Gorbacheva, D Sotnikov, A Vorotyntsev, A Emelyanov, E Komarova, E Avdienko, I Sarkisyan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Deep sternal wound infection (DSWI) is a life-threatening complication following cardiac surgery. This study aimed to evaluate different surgical treatment approaches for DSWI.</p><p><strong>Methods: </strong>We retrospectively analysed the treatment outcomes of 70 DSWI patients treated at two hospitals within the same region. Hospital 1 admitted patients shortly after the onset of complications, applying surgical debridement supplemented by negative pressure wound therapy (NPWT), with rewiring used predominantly to close the sternal wound. Patients in Hospital 2 experienced delayed hospitalization and underwent simultaneous surgical treatment and reconstruction, most often using pectoralis major flap reconstruction. The duration of hospitalization, 30-day and 1-year mortality rates, and recurrence of infection were evaluated.</p><p><strong>Results: </strong>The incidence of DSWI following cardiac surgery was 1.5%. Staphylococcus spp. was the most commonly isolated pathogen. The median treatment delay for patients in Hospital 1 was 1 day [IQR: 1-2], compared to 13 days [IQR: 8-24] in Hospital 2. Consequently, patients in Hospital 2 often had significant sternal defects post-debridement, necessitating flap reconstruction. In Hospital 1, prompt surgical intervention allowed preservation of a substantial portion of the sternum, with NPWT facilitating rapid control of acute inflammation. Sternal reconstruction predominantly involved rewiring, which restored chest stability. The mean hospitalization duration was 25 days [IQR: 16-30] in Hospital 1 and 22 days [IQR: 16-29] in Hospital 2. 30-day mortality rates were 5% in Hospital 1 and 6% in Hospital 2, with 1-year mortality rates of 10.5% and 4.3%, respectively. Infection recurrence rates were 15% in Hospital 1 and 24% in Hospital 2.</p><p><strong>Conclusions: </strong>The timing of surgical debridement is crucial in managing DSWI. When sufficient sternal tissue is preserved, rewiring is a viable option. Flap reconstruction is effective, particularly in cases involving extensive bone destruction.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"11-17"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF CHALLENGES AND POSSIBILITIES OF USING ARTIFICIAL INTELLIGENCE IN MEDICAL DIAGNOSTICS.","authors":"T Fartushok, D Bishchak, I Bronova, O Barabanchyk, Y Prudnikov","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>This study aims to analyze the geographical distribution of different AI types and applications, document implementation challenges, and assess outcomes of interest as well as potential opportunities for increasing healthcare efficiency.</p><p><strong>Methodology: </strong>A systematic review analyzed 24 studies (2019-2024) from IEEE Xplore, PubMed, and Google Scholar using MeSH keywords, following specific inclusion and exclusion criteria.</p><p><strong>Results: </strong>Results show that AI was applied to almost all spheres of life, with multi-modal AI, deep learning and machine learning models having promising applications in precision medicine, early diagnostics and integration of work processes. Common challenges included data shortages, bias in the algorithm, ethics and regulation, which indicated the need for appropriate guidelines and cross-disciplinary partnerships. Trends, however, included multi-modal data integration, increased automation and international convergence of standards. AI's benefits, advanced diagnostic accuracy, greater clinical predictability, and clinical processing efficiency are evidence of its ability to change the face of healthcare while removing significant barriers to its broader use.</p><p><strong>Conclusion: </strong>AI can improve diagnostic processes in medicine by increasing their accuracy, improving their speed, and further adapting them to individual patients.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"42-53"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHRONIC INFECTION WITH SCHISTOSOMA HAEMATOBIUM LEADS TO THE DEVELOPMENT OF SQUAMOUS CELL CARCINOMA OF THE BLADDER.","authors":"A Altwairgi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Schistosoma haematobium (S. haematobium) infection is a significant global health concern, impacting over 200 million individuals worldwide. Chronic infection with S. haematobium is closely associated with the development of squamous cell carcinoma (SCC) of the bladder. This pathological link arises from the intricate interplay of molecular pathways and cellular processes, including persistent inflammation, deoxyribonucleic acid (DNA) damage, altered signaling pathways, and epigenetic dysregulation. Chronic immune responses to S. haematobium infection, combined with environmental carcinogen exposure, create a pro-inflammatory environment that drives DNA damage, mutagenesis, and epigenetic alterations in urothelial cells. These changes culminate in uncontrolled cell proliferation, angiogenesis, and tissue remodeling, which collectively promote tumorigenesis. This study investigates the molecular and inflammatory mechanisms underlying SCC development in chronic S. haematobium infection, providing insights into its complex pathogenesis.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"99-103"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CORRELATION BETWEEN RHYTHMOGENESIS OF THE RAT URETERS UNDER HISTAMINE EXPOSURE.","authors":"K Kazaryan, N Hunanyan, M Danielyan, R Chibukchyan, Y Trofimova, A Mkrtchyan, K Karapetyan, T Piliposyan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The work is devoted to the study of the interrelationship between the characteristics of spontaneous electrical activities in paired ureters in norm and after isolation. Analysis was conducted by detecting the amplitude (A), rise rate (V), rise-time (T/2), half-width (t), and frequency of rhythmogenesis (F) of pacemaker activity. In norm, the amplitude value exceeds in the left ureter that of the right ureter. Sequential isolation of the organs (left ureter, then right) results in a decrease in the action potential amplitude by 26%, which indicates a certain interconnection between them. Additionally, histamine exposure leads to a synchronous increase in both ureters in norm. Subsequent isolation of the left ureter leads to a significant increase in the amplitude - up to 171%, and rise rate - up to 158%, of the right ureter. These findings suggest that histamine contributes to the increased excitability and regulation between the two ureters. Thus, this hormone, by enhancing rhythmogenesis in the right ureter, may indicate certain potential for the overall functioning of the urinary system.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"88-94"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES OF THE POSTOPERATIVE COURSE IN PATIENTS WITH DIABETIC FOOT SYNDROME AND SYSTOLIC MYOCARDIAL DYSFUNCTION AFTER LOWER LIMB AMPUTATION.","authors":"O Levytska, S Dubivska","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot syndrome is a serious complication of diabetes mellitus, often requiring amputations and associated with high mortality. In patients with diabetic foot syndrome and systolic myocardial dysfunction on the background of obesity, surgical treatment is complicated by systemic inflammation, circulatory disorders and tissue perfusion.</p><p><strong>Objective: </strong>To evaluate the effect of optimizing systolic cardiac function on the postoperative period in patients with diabetic foot syndrome and systolic left ventricular dysfunction in lower limb amputations above and below the knee.</p><p><strong>Materials and methods: </strong>The study included 38 patients with type 2 diabetes mellitus, obesity (BMI >30 kg/m2) and systolic myocardial dysfunction (EF <50%). All patients underwent lower limb amputation (25 at the hip level, 13 at below the knee level). Patients were divided into 2 groups: control (n=20), which received standard therapy, and main (n=18), where hyperosmolar solutions and inotropic therapy were additionally used.</p><p><strong>Results: </strong>72 hours after surgery, patients in the main group showed a significant improvement in hemodynamic and metabolic parameters. The mean blood pressure in the main group was 75±12 mm Hg vs. 62±7.1 mm Hg in the control group. The number of patients who required vasopressor infusion after 72 hours was lower in the main group (11% vs. 40% of patients). The dynamics of blood lactate levels ranged from 3.7±0.4 to 2.9±0.5 mmol/l in patients in the control group and from 3.5±0.08 mmol/l to 1.5±0.2 mmol/l in the main group. Acute kidney injury and wound complications in patients of the main group were observed three times less often (22% vs. 60% and 22% vs. 65%, respectively) (p<0.05).</p><p><strong>Conclusions: </strong>Optimization of myocardial systolic function through the use of hyperosmolar solutions and inotropic therapy effectively reduces the risk of complications and mortality in patients with diabetic foot ulcers and systolic myocardial dysfunction.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 357","pages":"83-87"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}