Georgian medical news最新文献

{"title":"POST-CT-GUIDED BIOPSY PNEUMOTHORAX, ACCORDING TO THE COAXIAL TECHNIQUE WITH AN 18-GAUGE NEEDLE: EPIDEMIOLOGICAL, DIAGNOSTIC AND THERAPEUTIC ASPECTS.","authors":"A Boukat, M Hamoummi, Y Sarboute, B Mohamed, A Emilie, E Meryem, E Kabiri","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Transthoracic CT-guided biopsy performed with the coaxial technique is a minimally invasive procedure that facilitates the diagnosis of lung lesions (nodules or masses) and/or mediastinopulmonary lesions suspected of malignancy. This procedure is the source of several complications, the most frequent of which is pneumothorax.</p><p><strong>Objective: </strong>To describe the epidemiological, diagnostic, and therapeutic aspects of iatrogenic pneumothorax after CT-guided biopsy performed using the coaxial technique.</p><p><strong>Patients and methods: </strong>Prospective longitudinal study, conducted over a period of 2 years and 10 months, from April 1, 2023, to February 1, 2026, at the Mohammed V Military Teaching Hospital in Rabat, including all patients who presented with a pneumothorax following a transthoracic CT-guided biopsy, according to the coaxial technique, confirmed clinically and/or radiologically.</p><p><strong>Results: </strong>The study included 30 cases of pneumothorax following CT-guided biopsy according to the coaxial technique. Biopsies were performed in 217 patients, and the incidence of pneumothorax was 13.8%. The median age was 68 years [58.8-71.5], with a predominance of males (90%). The most frequent characteristics observed among patients with pneumothorax were pulmonary emphysema (73.3%), lower-lobe lesions (33.3%), and central lesions with a median depth of 3.6 cm [2.9-4.2]. Procedure-related characteristics included practitioner status and biopsy needle diameter (18-gauge). Most patients were asymptomatic (60%). Diagnosis was established by chest CT during the procedure in 26.7% of cases and by chest X-ray after the procedure in 73.3% of cases. Small pneumothorax was the most common presentation (40%). Treatment was conservative in 53.3% of cases, and intervention was required in 46.7% (7 cases drained and 7 cases exsufflated). A complication was observed in 5 cases, after initial treatment. Only one patient underwent thoracoscopic pleurodesis after 14 days of chest drainage. The median length of hospital stay was 4 days [2-5.75].</p><p><strong>Conclusion: </strong>Pneumothorax is a major complication of CT-guided transthoracic biopsy, whether performed coaxially or non-coaxially. In our descriptive series, pulmonary emphysema, lower-lobe location, and lesion depth were frequent characteristics among patients who developed pneumothorax. We believe that the radiologist's experience is a determining factor in preventing a very high incidence of pneumothorax cases.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 371","pages":"156-161"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147813896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETICULOCYTE SUBPOPULATION ANALYSIS AND ITS CORRELATION WITH IRON DEFICIENCY ANEMIA: A RETROSPECTIVE STUDY IN A PREDOMINANTLY FEMALE POPULATION.","authors":"M Madi, H Awad, M Ismail, M Butaboyev, J Bobokalonzoda, A Gaybiev, E Ali, H Elzein, R Babiker, A Banaga, S Hussein, A Alfeel, A Osman, A Babker","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Serum ferritin and iron have high inter-individual variability and inflammatory sensitivity, limiting its diagnostic value in several clinical settings. The Reticulocyte Subpopulation Analysis may indicate iron availability during erythropoiesis in real time.</p><p><strong>Aim: </strong>This study investigated the associations between reticulocyte parameters and various hematological and iron-related biomarkers in Iron Deficiency Anemia.</p><p><strong>Methods: </strong>In this retrospective study, 150 patients with IDA (Iron Deficiency Anemia) were included (146 females, 97.3%; 23 pregnant, 15.8%; 12 on iron treatment, 8.0%), RET-He, LFR/MFR/HFR, and IRF were correlated with iron markers. Associations between anemia severity and treatment status were examined using Spearman correlation, Kruskal-Wallis, and Mann-Whitney U analyses.</p><p><strong>Results: </strong>While other reticulocyte indices exhibited minor connections, RET-He showed strong positive correlations with ferritin (r=0.430, p<0.001), serum iron (r=0.364, p<0.001), and transferrin saturation (r=0.350, p<0.001 A significant decrease in RET-He was seen in mild anemia (24.6 pg) and severe anemia (15.2 pg, p<0.001). RET-He was marginally reduced (p=0.0750) while serum iron and transferrin saturation were considerably lower in iron-treated subjects (p=0.0023). Reticulocyte and iron characteristics did not correlate with age (p>0.05).</p><p><strong>Conclusion: </strong>A sensitive, independent biomarker of iron status, RET-He measures functional iron availability during erythropoiesis. Strong correlation and severity-stratified discrimination support in populations where inflammation confounds ferritin interpretation, RET-He inclusion into iron deficient diagnostic methods. Prospective studies are needed to establish clinical thresholds and validate RET-He in chronic renal disease, inflammatory conditions, and pregnancy-related iron metabolism.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 371","pages":"170-176"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147813925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE DYNAMICS OF PERCEPTIONS AND EVALUATION OF THE COMPONENTS OF THE IMAGE OF AN IDEAL TEACHER DURING THE COVID-19 PANDEMIC.","authors":"O Batiuk, M Shkabarina, A Manko, S Cherneta, I Bychuk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A renewed reforming of the higher education system is taking place in the conditions of the Covid-19 pandemic, as well as the perception of the essence and content of the pedagogical profession is changing in the changing conditions of today, as well as new requirements are being put forward to the personality of the teacher. The purpose of the article was to study the dynamics of perceptions and evaluation of the components of the image of an ideal teacher by students in the process of traditional (full-time) and remote (online) learning in a higher education institution. Diagnostic methods were used in the research: free description method on the topic \"Portrait of a teacher whom I respect\", content analysis, \"Educational-cognitive interaction between a student and a teacher of the university\" method (author I.I. Snyadanko), methods of statistical data processing. The authors conducted two experimental sections: the first section was conducted during traditional full-time learning before the Covid-19 pandemic, the second section was conducted during the remote learning period during the Covid-19 pandemic. As a result of the research, it was determined that, in general, first-year students prefer strict and demanding teachers, but at the same time value such teacher qualities as kindness and sacrifice. The personal characteristics of the teacher and the ability to perceive the student as a person are more important for second-year students. A comparison of the data of the two sections made it possible to conclude that the ideal teacher should meet much greater characteristics in the process of remote learning than in the process of traditional learning. The results of the article can be used to optimize the educational and cognitive interaction between students and teachers of the university, to improve the professional training of pedagogical personnel.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 371","pages":"67-75"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UNDERSTANDING FACTORS CONTRIBUTING TO PATIENTS' NON-ADHERENCE TO A LIFESTYLE MODIFICATION PLAN: A CROSS-SECTIONAL STUDY AMONG VISITORS OF LIFESTYLE CLINICS IN KING ABDUL-AZIZ MEDICAL CITY, JEDDAH.","authors":"B Alamri, R Alnemari, A Alharbi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study is to understand the factors contributing to patients' non-adherence to lifestyle modification plans among visitors of the Lifestyle Clinics in King Abdul-Aziz Medical City, Jeddah. Adherence to these plans is crucial for improving health outcomes and preventing chronic diseases.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at the Lifestyle Clinics within the Primary Healthcare department of King Abdulaziz Medical City, Jeddah. Participants were adults referred for weight reduction. Data were collected using a questionnaire covering sociodemographic characteristics, adherence to lifestyle modifications, and barriers to adherence. The adherence level was assessed using a validated 13-item questionnaire, and the data were analyzed using IBM SPSS Statistics.</p><p><strong>Results: </strong>A total of 380 participants were included, with a median age of 42 years (IQR: 32-50 years). Approximately 45.5% were adherent to the lifestyle modification plan, while 54.5% were non-adherent. Significant positive correlations were found between age and adherence (Correlation Coefficient=.205, p<.001), with healthcare workers showing higher adherence levels (p=0.027). Common barriers to adherence included lack of willpower (74.5%), energy (70.8%), and time (68.9%). Statistically significant associations were identified between lack of energy (p=0.019) or time (p=0.023) and non-adherence.</p><p><strong>Conclusion: </strong>This study identified key factors associated with non-adherence to lifestyle modification plans, particularly younger age, non-healthcare occupations, and perceived barriers such as lack of energy and lack of time. Despite high levels of knowledge regarding healthy lifestyle practices, adherence remained suboptimal, highlighting the gap between awareness and behavioral implementation. Addressing practical barriers through targeted, behavior-focused interventions may improve adherence and long-term health outcomes.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 371","pages":"194-201"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147813718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISOLATION AND IDENTIFICATION OF Β-SITOSTEROL FROM ZYGOPHYLLUM FABAGO L. HERB USING SUBCRITICAL CO₂ EXTRACTION.","authors":"D Ostemirkyzy, E Kapsalyamova, D Tjahjono, G Ustenova, E Simaremare","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>The aim of study: </strong>β-Sitosterol is a bioactive phytosterol with recognized anti-inflammatory, hypocholesterolemic, and immunomodulatory properties. While Zygophyllum fabago L. is known to contain steroidal compounds, systematic studies on the isolation of pure β-sitosterol from this species are limited, particularly regarding the use of green extraction technologies and the achievement of high-purity yields for industrial applications. This study aimed to isolate and identify β-sitosterol from the herb of Z. fabago L. utilizing subcritical CO2 extraction as an environmentally sustainable and selective methodology for nonpolar compounds.</p><p><strong>Materials and methods: </strong>β-Sitosterol was isolated from the herb of Zygophyllum fabago L. using subcritical CO2 extraction (57-65 atm, 18-27 °C, 6 L/h). The crude extract was purified via vacuum liquid chromatography (VLC) on silica gel 60 and recrystallized from methanol, with purity monitored by TLC (UV 254/366 nm and H2SO4 visualization). Identification was performed using 1H and 13C NMR spectroscopy and the structure was confirmed by comparison with literature data.</p><p><strong>Results: </strong>The subcritical CO2 extraction yielded 20 g of crude extract (2.3% yield). The purification process resulted in 1.0 g of pure β-sitosterol, representing a 5% yield relative to the crude extract. TLC analysis showed a single characteristic spot, and NMR data definitively confirmed the structure, identifying key signals such as the C-3 hydroxyl group, the Δ5 double bond, and the characteristic branched aliphatic side chain.</p><p><strong>Conclusion: </strong>These results demonstrate that Z. fabago L. is a high-yielding natural source of β-sitosterol. Furthermore, the study validates subcritical CO2 extraction as a highly effective and selective approach for the preparative isolation of phytosterols from plant matrices, offering significant advantages in terms of purity and environmental impact.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 371","pages":"60-66"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147813847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF TRIVALENT CHROMIUM ON METABOLIC SYNDROME: A NARRATIVE REVIEW.","authors":"A Kairgali, R Aringazina, M Jakanov, A Haghpanah, M Sarkulov","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Trivalent chromium is an essential trace element involved in carbohydrate and lipid metabolism. The widespread global prevalence of metabolic syndrome and its close association with cardiovascular diseases and type 2 diabetes mellitus have increased scientific interest in the potential metabolic effects of chromium. However, currently available evidence regarding its clinical significance remains inconsistent.</p><p><strong>Methods: </strong>This narrative review describes the role of trivalent chromium in the context of metabolic syndrome. A systematic literature search was conducted in the Scopus and Web of Science databases for studies published between 2015 and 2025. The review included randomized controlled trials, observational studies, experimental studies, systematic reviews, and meta-analyses that investigated chromium intake, supplementation, or the association between chromium levels and components of metabolic syndrome.</p><p><strong>Results: </strong>The reviewed studies reported heterogeneous findings regarding the effects of trivalent chromium on components of metabolic syndrome. While some studies demonstrated improvements in glucose metabolism, insulin sensitivity, and lipid profiles, other studies reported no clear or statistically significant effects. The inconsistency of results has been attributed to differences in study design, studied populations, types and dosages of chromium supplementation, and duration of interventions.</p><p><strong>Discussion: </strong>The lack of uniform research methodologies, limited sample sizes, and the absence of standardized protocols for chromium supplementation hinder the comparability of results. In addition, the heterogeneity of the studied populations limits the reliability of the available data.</p><p><strong>Conclusion: </strong>Available evidence does not support the widespread clinical use of trivalent chromium. Therefore, further large-scale studies are required to determine its efficacy and safety.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 371","pages":"162-169"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147813177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DOUBLE LUMEN TECHNIQUE - ENDOTRACHEAL TUBE GUIDED LEVIN TUBE INSERTION TECHNIQUE.","authors":"Jo Sion","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This described the Double Lumen Technique (DLT) - an endotracheal tube-guided Levin tube insertion technique, which was originally introduced in 1987. It is designed for patients who have repeatedly failed due to kinking of the Levin tube in their oropharyngeal cavity, caused by incooperation of swallowing a Levin tube, particularly in those with stupor or comatose mentality. The main concept of the DLT is to reinforce the flexibility of a Levin tube by inserting it into a more elastic tube, the endotracheal tube (E-tube). The combination of the Levin tube and the E-tube allow it to pass through the oropharyngeal cavity into the esophagus successfully. For stuporous or comatose patients who have repeatedly failed Levin tube insertion, if passage through an oropharyngeal cavity to the esophagus is difficult, the novel technique, DLT, may be a worthwhile option to try at the bedside.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 371","pages":"50-53"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147813806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POSTOPERATIVE MORPHINE USE IN ABDOMINAL SURGERY: CLINICAL INSIGHTS FROM A ONE-YEAR SINGLE-CENTER RETROSPECTIVE STUDY.","authors":"P Krasniqi, L Hajdari, F Sada, E Daku","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Effective postoperative pain management is essential in abdominal surgery. Morphine remains a cornerstone opioid analgesic, yet variability in dosing and its clinical implications warrant further evaluation.</p><p><strong>Objective: </strong>To evaluate postoperative morphine, use in patients undergoing abdominal surgery over a one-year period, with emphasis on dose distribution, patient characteristics, underlying diagnoses, surgical procedures, and hospital length of stay (LOS).</p><p><strong>Methods: </strong>This retrospective single-center study included adult patients undergoing abdominal surgery who received postoperative morphine. Data on demographics, diagnoses, surgical procedures, morphine dose and route of administration, and LOS were extracted from medical records. Morphine dosing was individualized according to clinical judgment. Continuous variables are presented as mean ± standard deviation (SD) or median with interquartile range (IQR).</p><p><strong>Results: </strong>The cohort comprised 39 patients (24 females, 61.5%) with a mean age of 46.7±18.5 years. Bariatric surgery for obesity was the most common procedure (n 22). Morphine doses ranged from 4-10 mg per administration, predominantly given subcutaneously, with a median dose of 6 mg (IQR 5-7 mg); 5 mg was the most frequently administered dose. Higher doses were more commonly observed in oncologic cases. The overall median hospital length of stay (LOS) was 3 days and differed by surgical approach, with a median of 3 days after laparoscopic procedures and 7 days after open surgery. Adverse events were infrequent and mainly included postoperative nausea and vomiting (PONV), while no cases of respiratory depression were recorded.</p><p><strong>Conclusion: </strong>Morphine remains a widely used option for postoperative analgesia in abdominal surgery and, in this cohort, was predominantly administered subcutaneously with individualized dosing. Dose variability appears influenced by patient and procedural factors. Although minimally invasive procedures were associated with shorter hospital stays, this observation should be interpreted cautiously due to differences in underlying diagnoses and surgical complexity. Larger prospective studies are needed to further optimize postoperative opioid use.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 371","pages":"187-193"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147813819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GENDER DIFFERENCES IN EMOTIONAL REGULATION AMONG ADOLESCENTS WITH ELEVATED ADHD SYMPTOMS: A SCHOOL-BASED STUDY.","authors":"L Isufi, D Kelmendi, A Pronaj","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Executive function deficits are consistently associated with attention-deficit/hyperactivity disorder (ADHD), yet the expression of specific executive domains may differ across genders. Emotional regulation difficulties have been increasingly recognized as an important component of ADHD, particularly among adolescent girls, although evidence from large community-based samples remains limited.</p><p><strong>Objective: </strong>This study examined gender differences across executive function domains in adolescents, with particular emphasis on emotional regulation among those with elevated ADHD symptoms.</p><p><strong>Methods: </strong>A school-based cross-sectional study was conducted with 1,260 adolescents aged 11-18 years. Executive functioning was assessed using the Behavior Rating Inventory of Executive Function - Self Report (BRIEF-SR), and ADHD symptoms were measured with the Youth Self Report (YSR). Participants scoring in the clinical range on the YSR Attention Problems scale were classified as the high ADHD symptom group. A subsample underwent neurocognitive testing using the Stroop Color-Word Test and the Go/No-Go task. Group comparisons, correlational analyses, and interaction models were used to examine executive function domains and the influence of gender.</p><p><strong>Results: </strong>ADHD symptoms were strongly associated with global executive dysfunction (r=0.703, p<0.001). Adolescents in the high ADHD symptom group showed substantially greater impairment across behavioral, emotional, and cognitive regulation domains compared with peers below the clinical threshold. A gender difference was observed specifically in the emotional regulation domain, with females reporting higher levels of impairment than males, while overall ADHD symptom scores did not differ significantly by gender. Neurocognitive testing in the subsample indicated longer reaction times in the incongruent condition of the Stroop task among adolescents with elevated ADHD symptoms.</p><p><strong>Conclusions: </strong>Emotional dysregulation appears to represent a particularly salient executive difficulty among female adolescents with elevated ADHD symptoms. These findings support the inclusion of emotional regulation measures in routine assessment and highlight the potential value of gender-sensitive approaches in the identification and intervention of adolescents with ADHD-related difficulties.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 371","pages":"101-105"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147813780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RISK MANAGEMENT AND HEALTH SUPPORT FOR PREGNANT WOMEN USING INOSITOLS.","authors":"S Issenova, A Rakhimzhanova, M Shukirgaliyeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the association between myo-inositol supplementation and the risk of fetal macrosomia in pregnant women with a history of large-for-gestational-age infants, and to assess its relationship with gestational weight gain in women with overweight or obesity.</p><p><strong>Methods: </strong>A prospective observational study was conducted in antenatal clinics and the Almaty Center for Perinatology and Pediatric Cardiac Surgery. Myo-inositol supplementation was recommended as part of routine clinical practice and taken daily for up to 6 months. Participants attended four visits: baseline (<12 weeks), 20 weeks, 30 weeks, and delivery. The main group included women with a BMI of 25-35 kg/m² and a history of delivering infants weighing >4000 g. The comparison group was formed using a clinical risk scoring system to improve group comparability.</p><p><strong>Results: </strong>Gestational weight gain was significantly lower in the myo-inositol group (11.82 kg) compared with the comparison group (17.85 kg; p<0.001). The incidence of macrosomia was lower in women who used myo-inositol supplementation (5.9% vs. 55.9%). Mean neonatal birth weight was also lower in the supplementation group (3658.9 g vs. 3972.5 g), with a mean difference of 313.6 g (95% CI 173.5-453.8). Emergency cesarean delivery occurred less frequently in the supplementation group (3.9% vs. 15.7%), indicating improved obstetric outcomes.</p><p><strong>Conclusion: </strong>In this high-risk cohort, the use of myo-inositol supplementation was associated with lower gestational weight gain and a lower incidence of fetal macrosomia. These findings suggest a potential beneficial role of myo-inositol in the prevention of excessive fetal growth; however, randomized controlled trials are needed to confirm causality.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 371","pages":"93-100"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}