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BIOCHEMICAL ASSOCIATION BETWEEN CALCIUM HOMEOSTASIS AND SERUM URIC ACID LEVELS IN PATIENTS WITH HYPOTHYROIDISM: A COMPARATIVE EVALUATION WITH 25-HYDROXYVITAMIN D. 甲状腺功能减退患者钙稳态与血清尿酸水平的生化关联:25-羟基维生素d的比较评价
Georgian medical news Pub Date : 2025-12-01
S Hussein, Sh Murad, O Dawod, E Ali, Sh Elsiddig, R Elshaikh, A Alsubhi, T Yousif, S Nagat, A Banaga, S Ali, M Ismail, A Alfeel
{"title":"BIOCHEMICAL ASSOCIATION BETWEEN CALCIUM HOMEOSTASIS AND SERUM URIC ACID LEVELS IN PATIENTS WITH HYPOTHYROIDISM: A COMPARATIVE EVALUATION WITH 25-HYDROXYVITAMIN D.","authors":"S Hussein, Sh Murad, O Dawod, E Ali, Sh Elsiddig, R Elshaikh, A Alsubhi, T Yousif, S Nagat, A Banaga, S Ali, M Ismail, A Alfeel","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and aim: </strong>The relationship between calcium, 1,25-dihydroxyvitamin D and serum uric acid levels in thyroid patients involves complex physiological mechanisms. This study aimed to evaluate the association of serum calcium and 25-hydroxyvitamin D with serum uric acid concentrations in individuals with hypothyroidism.</p><p><strong>Methodology: </strong>A Cross-sectional study conducted in Thumbay Hospital in Ajman UAE on 180 male and female with hypothyroidism and normal individuals, the study subjects divided into five age categories: 21-30, 31-40, 41-50, 51-60 and >60 years. The concentrations of calcium and uric acid in the samples measured by Beckman Coulter and DxI Analyzer, for the thyroid hormones and 25-hydroxyvitamin D (25-OH Vitamin D) tests used DxI Analyzer. The results analyzed by SPSS version 26, the mean and SD obtained, and \"t\" test independent, one-way ANOVA and Linear regression used for correlation and P value obtained to assess the significance of the results (p value of <0.05 was significant).</p><p><strong>Results: </strong>Among 180 participants, no significant difference age was seen between hypothyroid patients and controls (p=0.959). Hypothyroid patients showed markedly elevated TSH (p<0.001) and reduced FT4 (p = 0.001), calcium (p < 0.001), and vitamin D (p=0.012) levels, while uric acid increased significantly (p=0.015). Correlation analysis showed a weak negative association between uric acid and TSH (r=-0.082). Uric acid was higher in males (p=0.016), while calcium revealed significant differences across age groups (p=0.011), showed age-related alterations in calcium metabolism.</p><p><strong>Conclusion: </strong>This study showed significant associations between calcium, 25-hydroxyvitamin D and serum uric acid levels in individuals with hypothyroidism. The negative correlations between uric acid and both calcium and 25-hydroxyvitamin D underscore the complex metabolic interactions characteristic of hypothyroidism.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 369","pages":"174-179"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE PRIORITY OF CONTEMPORARY MEDICAL UNIVERSITY MODELS IN SUBSTANTIATING BENCHMARKING OF MARKETING SOCIO-ETHICAL STANDARDS. 当代医科大学模式在确立市场营销社会伦理标准方面的优先地位。
Georgian medical news Pub Date : 2025-12-01
T Zarginava, Z Sopromadze
{"title":"THE PRIORITY OF CONTEMPORARY MEDICAL UNIVERSITY MODELS IN SUBSTANTIATING BENCHMARKING OF MARKETING SOCIO-ETHICAL STANDARDS.","authors":"T Zarginava, Z Sopromadze","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The contemporary landscape of medical education faces profound transformations driven by globalization of healthcare systems, intensified competition among medical universities, and evolving societal expectations regarding institutional accountability. These developments necessitate comprehensive examination of operational models adopted by medical universities and their implications for socio-ethical marketing standards-encompassing transparency in institutional communications, ethical conduct in student recruitment, responsible representation of training outcomes, and accountability for healthcare workforce preparation quality.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To systematically identify and analyze contemporary operational models of medical universities, establish explicit selection criteria for model prioritization, define socio-ethical marketing standards applicable to medical education contexts, and examine how different institutional frameworks shape implementation of these standards with specific reference to Georgian medical education.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Material and methods: &lt;/strong&gt;Systematic literature review methodology with clearly defined parameters. Literature search conducted across PubMed, Scopus, and Web of Science databases covering 2015-2024. Search strategy utilized combinations of keywords: 'medical university models', 'academic medicine', 'healthcare innovation', 'medical education transformation', 'clinical entrepreneurship', 'socio-ethical standards', 'healthcare marketing ethics'.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Inclusion criteria: &lt;/strong&gt;peer-reviewed English-language articles, institutional reports from accredited universities, policy documents from regulatory bodies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Exclusion criteria: &lt;/strong&gt;non-peer-reviewed sources, pre-2015 publications except foundational works, studies without institutional-level analysis. Initial search: 247 articles; after screening: 52 articles plus 22 institutional/regulatory documents analyzed. Model selection employed four explicit criteria: prevalence in literature (minimum 10 institutions), documented regional healthcare impact, alignment with contemporary challenges, and applicability to diverse contexts including Georgia.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Analysis identified four priority models: (1) Clinical-entrepreneurial model (34 institutions, 12 countries) integrating education with innovation commercialization; (2) Community-engaged model (28 institutions) prioritizing health equity and regional workforce development; (3) Network-based model (19 institutions) leveraging collaborative partnerships; (4) Traditional research-intensive model (15 institutions) maintaining biomedical research focus. Socio-ethical marketing standards were defined across five domains: transparency and disclosure, truthfulness in outcomes representation, conflict of interest management, stakeholder accountability, and mission integrity protection. Comparative analysis revealed clini","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 369","pages":"224-230"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PHENOTYPIC CHARACTERIZATION OF FIVE PHAGES ACTIVE AGAINST ANTIBIOTIC-RESISTANT KLEBSIELLA PNEUMONIAE. 五种抗耐药肺炎克雷伯菌噬菌体的表型分析。
Georgian medical news Pub Date : 2025-12-01
L Leshkasheli, D Bolkvadze, L Askilashvili, M Chichashvili, M Khanishvili, G Tsertsvadze, N Balarjishvili, L Kvachadze, E Zaldastanisvhili
{"title":"PHENOTYPIC CHARACTERIZATION OF FIVE PHAGES ACTIVE AGAINST ANTIBIOTIC-RESISTANT KLEBSIELLA PNEUMONIAE.","authors":"L Leshkasheli, D Bolkvadze, L Askilashvili, M Chichashvili, M Khanishvili, G Tsertsvadze, N Balarjishvili, L Kvachadze, E Zaldastanisvhili","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Widespread antibiotic resistance represents an increasingly significant burden for healthcare systems worldwide. One of the primary contributors to this pressing issue is Klebsiella pneumoniae, a pathogen of major clinical concern. Here we describe five distinct phages that infect antibiotic-resistant K. pneumoniae strains. A total of 100 clinical bacterial strains were systematically assessed for their antibiotic- and phage susceptibility profiles. Notably, 94 of these strains demonstrated high levels of antibiotic resistance across multiple drug classes. The five described phages, which target nearly all studied strains, were comprehensively characterized regarding their virion morphology, their lytic spectra, their intracellular growth parameters, and their potential to trigger development of phage-resistant bacterial forms. Two Siphoviridae phages exhibited remarkably low rates of phage-resistant form development during the study period. While such rates were comparatively higher for the three Myoviruses tested, bacterial forms that acquired resistance to these particular phages subsequently became sensitive to other phages in the collection. In conclusion, the studied phages effectively targeted 93 out of 100 bacterial strains tested. Such broad coverage of diverse clinical strains by these phages strongly underscores their considerable potential in therapeutic settings, particularly for treating multidrug-resistant infections.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 369","pages":"102-112"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COEXISTENCE OF APLASTIC ANEMIA AND PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: DIAGNOSTIC CHALLENGES AND THERAPEUTIC STRATEGIES - CASE REPORT. 再生障碍性贫血和阵发性夜间血红蛋白尿共存:诊断挑战和治疗策略-病例报告。
Georgian medical news Pub Date : 2025-12-01
S Baidurin, K Ybraiym, S Akhmetzhanova, V Tkachev, A Moldabayeva, Z Eshmagambetova, A Darybayeva
{"title":"COEXISTENCE OF APLASTIC ANEMIA AND PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: DIAGNOSTIC CHALLENGES AND THERAPEUTIC STRATEGIES - CASE REPORT.","authors":"S Baidurin, K Ybraiym, S Akhmetzhanova, V Tkachev, A Moldabayeva, Z Eshmagambetova, A Darybayeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH) are rare clonal bone marrow disorders. AA is characterized by autoimmune destruction of bone marrow stem cells and pancytopenia. In PNH, acquired genetic mutation and impaired glycoprotein synthesis leads to hemolysis and thrombus formation. The combination of both diseases represents a diagnostic and therapeutic dilemma, since increasing evidence suggests the connection between autoimmunity in AA clonal expansion of PNH. The purpose of this publication is to illustrate the pathogenetic relationship between AA and PNH by review of available literature regarding the mechanisms of immune-mediated destruction of bone marrow and clonal expansion in combination of these hematological pathologies. A clinical case is presented as an example of this phenomenon.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 369","pages":"96-101"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ANTIBIOGRAM OF URINARY CATHETER-ASSOCIATED BACTERIAL PATHOGENS IN INTENSIVE CARE UNIT, KING KHALID GENERAL HOSPITAL, HAFER AL-BATEN, SAUDI ARABIA. 沙特阿拉伯哈夫阿尔巴滕哈立德国王总医院重症监护病房导尿管相关细菌病原体抗生素谱。
Georgian medical news Pub Date : 2025-12-01
F Al-Anazi, A Talha
{"title":"ANTIBIOGRAM OF URINARY CATHETER-ASSOCIATED BACTERIAL PATHOGENS IN INTENSIVE CARE UNIT, KING KHALID GENERAL HOSPITAL, HAFER AL-BATEN, SAUDI ARABIA.","authors":"F Al-Anazi, A Talha","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Patients in intensive care units are more susceptible to catheter-associated urinary tract infections (CAUTIs) caused by drug resistant bacteria.</p><p><strong>Methods: </strong>This retrospective study was done to determine the antibiogram of Urinary Catheter-associated Bacterial Pathogens in the Intensive Care Unit, at King Khalid General Hospital, Saudi Arabia, using full automated MicroScan walkaway 96 plus Beckman Coulter.</p><p><strong>Results: </strong>Among the identified bacteria, Escherichia coli and Klebsiella pneumoniae were the most prevalent, accounting for 33.7% (29/86) and 23.3% (20/86), respectively. High resistance was documented against ciprofloxacin 75.6% (65/86), cefuroxime 69.8% (60/86), levofloxacin 68.6% (59/86) and amoxicillin/clavulinic acid 65.1% (56/86), but Colistin showed high activity against the isolated bacteria with low resistance rate 5.81 % (5/86). Frequency of multi-drug-resistant bacteria revealed a rate of 65.1% (56/86). Resistance to piperacillin/tazobactam and cefuroxime was significantly associated with length of stay in the intensive care unit, duration of antimicrobial use, and catheterization duration with a p<0.05. Also, the results strongly indicated that resistance to all cephalosporins examined was significantly associated with long stay in ICU.</p><p><strong>Conclusion: </strong>The identified bacteria among CAUTIs displayed resistance to at least one agent in three or more antimicrobial groups, indicating high resistance of common prescribed antibacterial agent in the study area.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 369","pages":"87-95"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FACTORS AFFECTING MORTALITY IN PATIENTS WITH HIP FRACTURES AND SHAH HIP FRACTURE MORTALITY SCORE: A RISK QUANTIFICATION TOOL. 影响髋部骨折患者死亡率的因素和髋部骨折死亡率评分:一种风险量化工具。
Georgian medical news Pub Date : 2025-12-01
F Shah, R Clough, F Saleh, M Poustie, I Balanos, A Najjar
{"title":"FACTORS AFFECTING MORTALITY IN PATIENTS WITH HIP FRACTURES AND SHAH HIP FRACTURE MORTALITY SCORE: A RISK QUANTIFICATION TOOL.","authors":"F Shah, R Clough, F Saleh, M Poustie, I Balanos, A Najjar","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Hip fractures are serious injuries of elderly associated with 6.2% mortality in first 30-days and 22% mortality in first year. We aim to identify the key risk factors affecting mortality and to produce a score to predict 30 and 365-day mortality risk in patients with hip fracture.</p><p><strong>Methods: </strong>689 hip fractures managed at our hospital between 2016 and 2019 were analysed. Mortality at 30 and 365-days was obtained for factors like age, gender, American Society of Anaesthesiologists physical status classification (ASA grade), residence, pre-fracture ambulatory status, Abbreviated Mental Test Score (AMTS), fracture classification, treatment method, time to surgery and anaesthesia used. This data was analysed using univariate and then multivariate regression analysis and a 7-point (5 Factor) score was devised to predict mortality in the first month and first year following hip fracture.</p><p><strong>Results: </strong>6.7% and 25.3% of the 689 patients died within 30 and 365-days of suffering a hip fracture. Older age, Male sex, ASA Class IV/V, Non-operative management, and housebound/bedbound status, were all found to be associated with increased mortality at 30 and 365-days post-fracture.</p><p><strong>Conclusions: </strong>This study identified Age, Sex, ambulation, ASA grade and non-operative management as key factors influencing 30 and 365-day mortality. Patients with the non-operative management and ASA grade 4/5 had the worst mortality risk. We devised a scoring system to predicts the 30-day and 365-day mortality which shows an almost linear relationship between the score and mortality rates.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 369","pages":"153-159"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CASE REPORT OF INFLUENZA A (H1N1) PDM 09 STRAIN / KARAGANDA/ 06/2022 IN A CHILD AGED 3 YEARS. 1例3岁儿童感染甲型h1n1流感PDM 09株/ karaganda / 06/2022病例报告
Georgian medical news Pub Date : 2025-12-01
R Begaidarova, G Alshynbekova, I Kadyrova, Z Alshimbayeva, G Nassakayeva, O Zolotaryova, G Omarova
{"title":"CASE REPORT OF INFLUENZA A (H1N1) PDM 09 STRAIN / KARAGANDA/ 06/2022 IN A CHILD AGED 3 YEARS.","authors":"R Begaidarova, G Alshynbekova, I Kadyrova, Z Alshimbayeva, G Nassakayeva, O Zolotaryova, G Omarova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The article presents epidemiological data characterizing the development of the influenza A epidemic in Kazakhstan. The rates of increase and decrease of influenza morbidity are shown. During most of the COVID-19 pandemic (2020-2022), influenza circulation in Kazakhstan and neighbouring Russia declined, but then returned with higher transmission rates in autumn 2022. While H3N2 strains dominated the 2022-2023 season as a whole, in autumn 2022, A/H1N1 pdm09 strains dominated in Russia. В December 2022 г. we detected the strain /Karaganda/ 06/2022 (H1N1) pdm09 in the nasopharyngeal swab of a patient (age=3 years, 3 months, sex=male) admitted to the Infectious Disease Centre of the Regional Clinical Hospital of Karaganda city with clinical symptoms of respiratory disease. A detailed description of this clinical case in a child is given.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 369","pages":"79-86"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EVALUATION OF THE DEEP INSPIRATION BREATH-HOLD TECHNIQUE TO IMPROVE DOSIMETRIC OUTCOMES IN RADIOTHERAPY FOR STAGE III NON-SMALL CELL LUNG CANCER. 深吸气屏气技术改善iii期非小细胞肺癌放射治疗剂量学结果的评价。
Georgian medical news Pub Date : 2025-12-01
U Nabizade, O Isayev, G Haci, K Kazimov, G Nasirova, R Kaziyeva, E Guliyev, I Isayev
{"title":"EVALUATION OF THE DEEP INSPIRATION BREATH-HOLD TECHNIQUE TO IMPROVE DOSIMETRIC OUTCOMES IN RADIOTHERAPY FOR STAGE III NON-SMALL CELL LUNG CANCER.","authors":"U Nabizade, O Isayev, G Haci, K Kazimov, G Nasirova, R Kaziyeva, E Guliyev, I Isayev","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Radiotherapy is a key treatment for stage III non-small cell lung cancer (NSCLC), but tumor proximity to critical structures-such as the heart, esophagus, and spinal cord and respiratory motion complicates dose delivery. The Deep Inspiration Breath Hold (DIBH) technique actively controls respiratory motion, potentially improving treatment precision.</p><p><strong>Methods: </strong>This retrospective study included 56 patients with stage III NSCLC. Each underwent two CT scans: one during free breathing (FB) and one using DIBH. Dosimetric parameters for organs at risk (OARs) were compared between FB (with a 6 mm internal target volume margin) and DIBH plans using paired Student's t-tests.</p><p><strong>Results: </strong>DIBH increased total lung volume by 28% and reduced heart volume by 12.5%. Lung dose metrics improved significantly with DIBH, including V5, V20, and mean lung dose (all P < 0.001). Heart dose parameters (V10, V40, mean dose) also decreased. DIBH significantly reduced both maximum and mean doses to the esophagus and maximum dose to the spinal cord.</p><p><strong>Conclusions: </strong>In stage III NSCLC, DIBH significantly lowers radiation exposure to OARs and enhances dose delivery accuracy. By expanding lung volume, it may reduce the risk of radiation-induced pneumonitis.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 369","pages":"248-252"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AUDIOGENIC SEIZURE SUPPRESSION BY VENTRAL TEGMENTAL AREA STIMULATION. 腹侧被盖区刺激抑制听源性癫痫发作。
Georgian medical news Pub Date : 2025-12-01
I Bilanishvili, M Barbakadze, N Nikabadze, G Andronikashvili, Z Nanobashvili
{"title":"AUDIOGENIC SEIZURE SUPPRESSION BY VENTRAL TEGMENTAL AREA STIMULATION.","authors":"I Bilanishvili, M Barbakadze, N Nikabadze, G Andronikashvili, Z Nanobashvili","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The audiogenic seizure (AGS) model is one of several experimental models used to study epilepsy and identify underlying mechanisms. Dopamine plays an important role in epileptogenesis and dopaminergic neurons of ventral tegmental area (VTA) have extensive connections with many brain structures. Despite of this there are no data on the influence of this structure on the audiogenic seizure responses of the brain. The main aim of our study was to investigate the influence of the VTA on the development of audiogenic seizure reactions in genetically epilepsy-prone rats. The novelty of these article lies not only in the observation of changes in the development/course of audiogenic seizure reactions caused by stimulation of the VTA, but also in taking into account the localization of the epileptogenic focus, which, in our opinion, is especially important for the scientific analysis of this type of research. The inferior and superior colliculus has prominent descending projections to several areas of the reticular formation, which may sub serve the direct AGS efferent pathway. The experiments conducted showed that in response to stimulation of the VTA, the latency and duration of the first wild run do not undergo significant changes. The experiments showed a significant increase in the duration of the pause between the first and second wild runs and a significant decrease in the duration of the second wild run. Furthermore, we observed a significant decrease in behavioral seizure activity after the second wild run, leading to its complete disappearance. Structures receiving synaptic inputs from the ventral tegmental area deserve special attention. One such structure is the reticular nucleus of the thalamus (TRN). It has been shown that stimulation of TRN causes inhibition of neurons in those brainstem structures that are involved in motor reactions of the spinal cord. Therefore, it can be hypothesized that the TRN modulate the brainstem regions responsible for motor responses during audiogenic seizures. From our results we can conclude: The VTA plays an important role in epileptogenesis, which is apparently associated with the inhibitory effect of dopamine on the motor manifestations of seizures. Therefore, VTA as a brain dopaminergic nucleus, may be a suitable target for DBS anticonvulsant action.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 369","pages":"31-37"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RESEARCH OF HEMATOLOGICAL CHANGES IN INDIVIDUALS EXPOSED TO IRRADIATION FROM THE CHERNOBYL NUCLEAR POWER PLANT. 受切尔诺贝利核电站辐射个体血液学变化的研究。
Georgian medical news Pub Date : 2025-12-01
A Karapetyan, T Ulusyan, M Danielyan, E Avetisyan, A Petrosyan, S Petrosyan, V Grigoryan
{"title":"RESEARCH OF HEMATOLOGICAL CHANGES IN INDIVIDUALS EXPOSED TO IRRADIATION FROM THE CHERNOBYL NUCLEAR POWER PLANT.","authors":"A Karapetyan, T Ulusyan, M Danielyan, E Avetisyan, A Petrosyan, S Petrosyan, V Grigoryan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The impact of pathogenic factors caused by the consequences of the Chernobyl disaster on the blood system and hemostasis is of great interest. Deviations identified in the first years after exposure to ionizing radiation are primarily restorative and adaptive in nature. This paper presents the results of the monitoring of the changes in each separately studied indicator in the early (1987-1988) and late (2019-2020) periods after the exposure to radiation. Regression equations were obtained that describe the dynamics of changes in certain blood indicators, which make it possible to predict changes over many years after the accident. The hemoglobin and erythrocyte content, compared with the control group (donors), remained within the physiological norm until 1991. A significant decrease in the number of erythrocytes from 1991 to 1997, naturally, should have been reflected in the hemoglobin content, which was manifested in a decrease in their content. In the subsequent years of observations until 2001, a significant decrease in the number of erythrocytes corresponded to a decrease in the hemoglobin content. From 2001 to the present day, the content of erythrocytes and hemoglobin is approaching the boundaries of the physiological norm, albeit with some lag. Changes in blood counts are also influenced by factors that determine a liquidator's susceptibility to certain illnesses. Despite the fluctuating nature of changes in white blood cell counts, an overall trend of decline is nevertheless observed. Stable moderate leukopenia has been observed since 1995. A left shift of granulocytes is observed due to a decrease in the agranulocyte component of blood cells. Thus, it can be concluded that blood cells remain affected by the radiation caused by the Chernobyl accident even at late observation times.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 369","pages":"68-71"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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